Vitamin D Tag
18 Apr Severe Obesity Linked to Vitamin D Deficiency
MedicalResearch.com Interview with: Tomás Ahern MB, BCh, BAO St Columcille's Hospital and St Vincent's University Hospital Dublin, Ireland MedicalResearch.com: What are the main findings of the study? Answer: More than 40% of severely obese people, who make up 6.5% of American adults, are at risk of vitamin D deficiency. Severely obese people with low vitamin D...
04 Apr Vitamin D: Evidence for Widespread Supplementation Weak
MedicalResearch.com Interview with: Evropi Theodoratou School of Molecular, Genetic and Population Health Sciences University of Edinburgh MedicalResearch.com: What are the main findings of the study? Answer: We identified 268 studies either meta-analyses or systematic reviews of plasma vitamin D concentrations or meta-analyses of randomised trials of vitamin D supplementation. The relation between vitamin D and 137...
15 Mar Calcium-Vitamin D Supplementation: Effects on Vitamin D and Cholesterol Levels
MedicalResearch.com Interview with:
Peter F. Schnatz, D.O.
Associate Chair & Residency Program Director
The Reading Hospital
Department of OB/GYN
Reading, PA 19612-6052
MedicalResearch.com: What are the main findings of the study?
Dr. Schnatz: In a subsample of 576 women from the parent WHI CaD (calcium plus vitamin D supplementation) trial* , there was a significant (38%) increase in mean serum 25OHD3 concentrations after two years (95% CI 1.29-1.47, p< 0.001) for women randomized to CaD (24.3ng/mL vs. 18.2 ng/mL).
Women randomized to CaD had a 4.5 mg/dL mean decrease in LDL-C which was statistically significant. After accounting for serum 25OHD3 concentration, the effect of CaD was attenuated, suggesting that higher concentrations of 25OHD3, in response to CaD supplementation, are associated with improved LDL-C.
In observational analyses, higher concentrations of 25OHD3 were associated with significantly higher HDL-C along with significantly lower LDL-C and TG concentrations.
* 1,000 mg of elemental calcium plus 400 IU of vitamin D3 daily
19 Feb Pre-Op Vitamin D and Infection Risk Following Gastric Bypass Surgery
MedicalResearch.com Interview with:
Sadeq A. Quraishi, MD, MHA
Massachusetts General Hospital, Harvard Medical School
Boston, Massachusetts
MedicalResearch.com: What are the main findings of the study?
Dr. Quraishi: Our retrospective study suggests that there is an association between pre-operative 25-hydroxyvitamin D [25(OH)D] levels and the risk of hospital-acquired infections after gastric bypass surgery. In particular, patients with 25(OH)D levels <30 ng/ml before surgery were almost 4 times more likely to develop a surgical site infection within 30 days of surgery than patients with pre-operative 25(OH)D levels at 30 ng/ml or higher.
14 Feb Coronary Artery Disease: Vitamin D Did Not Affect Disease Progression
MedicalResearch.com Interview with:
Eirik Magnus Meek Degerud
Department of Clincal Medicine University of Bergen
MedicalResearch.com: What are the main findings of the study?
Answer: That among patients with established coronary artery disease there was no observable relationship between the amount of vitamin D circulating in their blood and the extent of disease progression during the following year.
24 Jan Vitamin D: Study Finds Little Justification For Prescribing For Most Disease Prevention
MedicalResearch.com Interview with: Professor Mark Bolland Senior Research Fellow in the Department of Medicine University of Auckland, New Zealand MedicalResearch.com: What are the main findings of the study? Prof. Bolland: We pooled data from randomised controlled trials of vitamin D supplements in traditional meta-analyses and trial sequential analyses to assess the effect on important health outcomes. We found that vitamin D supplements (with or without calcium) had no effect on myocardial infarction, stroke, total cancer, or total fracture, and further similar trials are unlikely to alter these conclusions. For hip fracture, the results were more complicated. There was uncertainty as to whether vitamin D by itself increased the risk of hip fracture or had no effect, whereas the combination of vitamin D with calcium had no effect on hip fracture in people living in the community, but reduced hip fracture risk in two trials of elderly women living in residential care.24 Oct Pediatric Anemia and Vitamin D Levels
MedicalResearch.com Interview with:
Meredith Atkinson, MD, MHS
Assistant Professor of Pediatrics
Division of Pediatric Nephrology
Johns Hopkins University School of Medicine
Baltimore, MD 21287
MedicalResearch.com: What are the main findings of the study?
Dr. Atkinson: First, among a healthy cross-section of U.S. children, vitamin D deficiency defined as levels below 30 ng/mL (the currently accepted threshold for adequate vs. inadequate vitamin D) were associated with nearly twice the risk for anemia compared to those with sufficient vitamin D levels. Secondly, when we looked specifically at Caucasian and African-American children, we found that children with the lowest vitamin D levels were at increased risk for anemia in both groups, but that the specific vitamin D level below which the anemia risk started to increase was much lower in the African-American children (12 ng/mL) than in the Caucasian children (20 mg/mL).
14 Aug Vitamin D Supplementation: No Significant Blood Pressure Reduction
MedicalResearch.com Interview with: Miles D. Witham, PhD
Aging and Health, University of Dundee, Dundee, United Kingdom
MedicalResearch.com: What are the main findings of the study?
Answer: We gave high dose vitamin D3 (100,000 units) or placebo every 3 months to people aged 70 or over, who all had isolated systolic hypertension (ISH). The main focus of the trial was to test whether vitamin D supplementation could reduce blood pressure in this group of patients – this pattern of blood pressure, whether the systolic (top number) is high, and the diastolic (bottom number) is normal, is very common in older people. Previous studies have suggested a link between low vitamin D levels and higher blood pressure, but no trial has yet tested this idea in older patients with ISH.
Despite the treatment causing a significant increase in circulating vitamin D levels, we saw no significant reduction in blood pressure with vitamin D supplementation, despite the trial running for a year. We tested whether certain groups might still benefit – e.g. those with very high blood pressure or very low vitamin D levels, but even these groups did not show a reduction in blood pressure.
We also tested whether vitamin D supplementation reduced the health and stiffness of arteries – both important predictors of future heart attack or stroke. Unfortunately, vitamin D did not affect these measures either, and didn’t reduce cholesterol or glucose levels.
On the more positive side, vitamin D supplements did appear safe, and the number of falls in the vitamin D group was slightly lower than in those people who received placebo. This is reassuring, as an earlier study (Sanders et al) had suggested that very high doses of vitamin D might make falls more likely, in contrast to previous low dose studies that show a protective effect of vitamin D against falls.
06 Aug Vitamin D Supplementation: White-Black Young Women May Need Different Doses
MedicalResearch.com Interview with: Christopher J Gallagher MD Bone Metabolism Unit, Creighton University Medical Center, Omaha, Nebraska MedicalResearch.com: What are the main findings of the study? Dr. Gallagher: Vitamin D 400 IU daily will meet the RDA ( Recommended Dietary Allowance for 97.5% of population) for young white women age 25-45 years. Black women may need more- 800-1600 IU, however,the number of black women in study was small and this dose needs confirmation. This data is based on exceeding a serum 25 hydroxyvitamin D level of 20ng/ml ( 50nmol/l)20 Jun Study: Oral Probiotic Supplement Significantly Increased Circulating Vitamin D Levels
MedicalResearch.com Interview with:
Dr. Mitchell Jones, MD, PhD
Faculty of Medicine at McGill University in Montreal
MedicalResearch.com: What are the main findings of the study?
Dr. Jones: We had previously reported on the cholesterol lowering efficacy of bile salt hydrolase active L. reuteri NCIMB 30242 due to reduced intestinal sterol absorption.
However, the effects of bile salt hydrolase active L. reuteri NCIMB 30242 on fat soluble vitamins was previously unknown and was the focus of the study.
03 Apr Researcher finds that vitamin D deficiency is associated with increased mortality in intensive care patients
Posted at 23:08h
in Vitamin D
Scientists have long believed that vitamin D, which is naturally absorbed from sunlight, has an important role in the functioning of the body's autoimmune system. Now Prof. Howard Amital of Tel Aviv University'sSackler Faculty of Medicine and Sheba Medical Center has discovered that the vitamin may also affect the outcomes of patients in intensive...