Author Interviews, Surgical Research, Weight Research / 30.04.2014

Mr. David Bowrey, MD FRCS (Gen Surg) MMedEd FHEA  Consultant General / Oesophagogastric Surgeon & Honorary Senior Lecturer, Dept Cancer Studies, Training Programme Director for Core Surgery, East Midlands South  University Hospitals of Leicester NHS Trust, Leicester Royal InfirmaryMedicalResearch.com Interview with: Mr. David Bowrey, MD FRCS (Gen Surg) MMedEd FHEA  Consultant General / Oesophagogastric Surgeon & Honorary Senior Lecturer, Dept Cancer Studies, Training Programme Director for Core Surgery, East Midlands South University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary MedicalResearch.com: What are the main findings of this study? Dr. Bowrey: Of 103 patients who had undergone Roux en Y gastric bypass surgery, changes in appetite, taste and smell were noted in 97%, 73% and 42% respectively. Seventy-three percent of patients developed aversions to certain types of foods, most frequently meat, starch and dairy produce. The change in taste sensation for the three common modalities of "sweet", "salt" and "sour" was decreased in some patients and increased in other patients. Patients who experienced food aversions typically experienced more weight loss than patients not developing aversions. (more…)
Author Interviews, JAMA, Statins, Weight Research / 29.04.2014

Takehiro Sugiyama, MD, MSHS, PhD Project Director, Diabetes Policy Planning Office Management and Planning Bureau Fellow, Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine Shinjuku-ku, Tokyo JapanMedicalResearch.com Interview with: Takehiro Sugiyama, MD, MSHS, PhD Project Director, Diabetes Policy Planning Office Management and Planning Bureau Fellow, Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine Shinjuku-ku, Tokyo Japan MedicalResearch.com: What are the main findings of the study? Dr. Sugiyama: In the US nationally representative sample from the National Health and Nutrition Examination Survey 1999-2010, we found that statin users in 2009-2010 eat 9.6% more calories and 14.4% more fat than statin users in 1999-2000. These increases were not observed in statin non-users; the trends of caloric and fat intake were statistically different between statin users and non-users. In 1999-2000, caloric and fat intake was significantly less for statin users compared with non-users, but the difference between the groups because smaller as time went by and there was no statistical difference in 2009-2010. Body mass index increased more rapidly for statin users compared to non-users. (more…)
Author Interviews, OBGYNE, Weight Research / 18.04.2014

MedicalResearch.com Interview with: Sneha Sridhar, MPH Kaiser Permanente, Division of Research 2000 Broadway, 3rd Floor Oakland, CA  94612 MedicalResearch.com: What are the main findings of the study?   Answer: We found that women whose weight gain during pregnancy exceeded the current Institute of Medicine (IOM) recommendations were 46% more likely to have an overweight or obese child at ages 2-5, compared to women who met the recommendations. The association was stronger among women who were of normal weight before pregnancy. These normal weight women were more likely to have an overweight or obese child if they gained either below or above the IOM recommendations. (more…)
Author Interviews, Nutrition, Weight Research / 16.04.2014

MedicalResearch.com Interview with: Jeffrey R. Parker Assistant Professor of Marketing Robinson College of Business - Georgia State University MedicalResearch.com: What are the main findings of the study? Mr. Parker: Recently, there has been quite a bit of debate about the effectiveness of providing dish-specific calorie information (a practice called “calorie posting”) on restaurant menus in terms of the healthiness of consumers’ food choices. Some results suggest that such labels lead to lower-calorie choices, while other research shows that there is no effect. We examined one factor that might impact the effectiveness of calorie posting: the practice of grouping low-calorie options on a menu and labeling this category accordingly (i.e., incorporating a low-calorie menu/category in the menu)—which we call “calorie organizing”—as opposed to simply allowing them to appear in their natural categories with the caloric content appearing in the dish descriptions (e.g., Sandwiches, Salads, Pastas, etc.). On the surface it seems obvious that making low-calorie options easier to find—by giving them their own labeled category on the menu—would bolster the positive effects of calorie posting. However, we found the opposite: additionally calorie organizing an already calorie-posted menu regularly eliminates the benefits that calorie posting can have. We argued and found evidence indicating that the underlying cause of this effect stems from how consumers make decisions. Restaurant menus are often too large for a consumer to seriously consider all of the dishes. Some consumers typically eliminate large portions of the menu on the basis of simple criteria (e.g., “I don’t like seafood.”, “It’s too early to eat pasta.”, etc. ). Since consumers generally make negative inferences about low-calorie dishes (e.g., “They don’t taste good.”, “They are small dishes.”, etc.) they are likely to summarily dismiss all of the low-calorie options early in the decision process when the menu is calorie-organized (i.e., has grouped the low-calorie dished and labeled the new category accordingly). Thus, they are likely to choose as poorly as they would were they given no calorie information. In contrast, when the menu is just calorie-posted, and the low-calorie dishes appear in their natural categories, these dishes are unlikely to be dismissed in the early choice-simplification stages. Thus, low-calorie dishes are likely to be seriously considered in the final decision process, during which the pros and cons of dishes can be more comprehensively traded off, and are therefore more likely to be chosen. (more…)
Author Interviews, JAMA, OBGYNE, Weight Research / 15.04.2014

MedicalResearch.com Interview with: Dagfinn Aune MS Department of Epidemiology and Biostatistics School of Public Health Imperial College London St. Mary's Campus Norfolk Place, Paddington, London W2 1PG, UK MedicalResearch.com: What are the main findings of the study? Answer: We conducted a systematic review and meta-analysis of studies examining the association between maternal body mass index (BMI) and risk of fetal death, stillbirth, neonatal, perinatal and infant death. We found that the risk of all these outcomes increased with greater BMI in a dose-response fashion. For example even within the high end of what is considered the normal BMI range (BMI of 24-25) there was a 10-20% increase in the relative risk, but the strongest relations were seen for those who were obese and morbidly obese with 30-60% and 2-3 fold increases in the relative risk respectively (depending on the outcome examined). (more…)
Author Interviews, Weight Research / 10.04.2014

MedicalResearch.com Interview witih: Dr. Constance Tom Noguchi, Ph.D. Molecular Medicine Branch National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892  and Dr. Mawadda Al-Naeeli Department of Biological Sciences, Ohio University MedicalResearch.com: What are the main findings of the study? Answer: The main findings of our study are: 1) EPO treatment has an anti-inflammatory effect on white adipose tissue macrophage population during diet-induced obesity in addition to its associated metabolic improvements on glucose tolerance and insulin sensitivity in vivo. 2) In this model of obesity, EPO treatment was found to reduce M1-like [pro-inflammatory] and increased M2-like [anti-inflammatory] macrophages in visceral white adipose tissue depot. 3) In addition, EPO decreased circulating inflammatory monocytes. 4) These anti-inflammatory effects of EPO were found to be driven, at least in part, by direct EPO-R response in macrophages via Stat3 activation, where EPO effects on M2 but not M1 macrophages required interleukin-4 receptor/Stat6 axis. 5) The anti-inflammatory effects of EPO are not restricted to treatment with exogenous high dose EPO (1000U/kg), but also include endogenous physiological EPO levels as demonstrated by the series of studies conducted using ΔEpoR mice with EPO-R restricted to erythroid cells. (more…)
Author Interviews, BMJ, Eating Disorders, Weight Research / 09.04.2014

Ulla Räisänen Senior Researcher HERG Health Experiences Research Group Department of Primary Care Health Sciences University of Oxford Oxford OX1 2ETMedicalResearch.com  Interview with Ulla Räisänen Senior Researcher HERG Health Experiences Research Group Department of Primary Care Health Sciences University of Oxford Oxford OX1 2ET MedicalResearch.com : What are the main findings of the study? Answer: We conducted a qualitative interview study exploring how young men (aged 16-25) recognise eating disorder symptoms and decide to seek help, and to examine their experiences of initial contacts with primary care in the UK. Our data suggest that the widespread perception of eating disorders as uniquely or predominantly a female problem led to an initial failure by young men to recognise their behaviours as symptoms of an eating disorder. Many presented late in their illness trajectory when eating disorder behaviours and symptoms were entrenched, and some felt that opportunities to recognise their illness had been missed because of others’ lack of awareness of eating disorders in men. In addition, the men discussed the lack of gender-appropriate information and resources for men with eating disorders as an additional impediment to making sense of their experiences, and some felt that health and other professionals had been slow to recognise their symptoms because they were men. (more…)
Author Interviews, Gastrointestinal Disease, General Medicine, Weight Research / 02.04.2014

Shanthi Srinivasan, M.D. Associate Professor of Medicine Division of Digestive Diseases Department of Medicine Emory University Atlanta, GA 30322MedicalResearch.com Interview with: Shanthi Srinivasan, M.D. Associate Professor of Medicine Division of Digestive Diseases Department of Medicine Emory University Atlanta, GA 30322   MedicalResearch.com: What are the main findings of the study? Dr. Srinivasan: The main findings of this study are that the neurotrophic factor GDNF is was able to protect against the weight gain induced by mice on a high fat diet. The mice that had overexpression of GDNF showed less weight gain while eating the same high fat diet as the control mice. GDNF seems to have effects on the genes regulating fat metabolism and energy expenditure and this could be the mechanism of prevention of weight gain. (more…)
Mediterranean Diet, NIH, Nutrition, Weight Research / 02.04.2014

Dr. Milan K Piya NIHR Clinical Lecturer in Diabetes and Endocrinology Warwick Medical School, University of Warwick; University Hospitals Coventry and Warwickshire NHS Trust Coventry, UKMedicalResearch.com Interview with: Dr. Milan K Piya NIHR Clinical Lecturer in Diabetes and Endocrinology Warwick Medical School, University of Warwick; University Hospitals Coventry and Warwickshire NHS Trust Coventry, UK MedicalResearch.com: What are the main findings of the study? Answer: Our studies have identified two main findings: Firstly that the size or frequency of the meal doesn’t affect the calories we burn in a day, but what matters most for losing weight is counting calories. Secondly, by carrying more weight, more endotoxin enters the circulation to cause inflammation and eating more often will exacerbate this risk which has been linked to metabolic diseases such as type-2 diabetes. (more…)
Dermatology, PNAS, Weight Research / 02.04.2014

Professor Rodney Sinclair University of Melbourne and Epworth Hospital Melbourne, VIC, AustraliaMedicalResearch.com Interview with: Professor Rodney Sinclair University of Melbourne and Epworth Hospital Melbourne, VIC, Australia   MedicalResearch.com: What are the main findings of the study? Answer: Activation of Wnt signalling promoted hair growth and fat growth.  Inhibition of Wnt signalling reduces fat growth and hair growth.  We looked at the fat layer on the scalp.  It was reduced by 50% over the bald areas of alopecia areata.  The patch of alopecia areata we looked at was new- only appeared a few days earlier and so the changes in fat thickness are rapid. What is interesting is that the fat layer is dynamic, and significant fluctuations can occur in a rapid period of time in sync with the hair cycle.  It is also interesting that ligands for BMP6 and IGF2 are pro-adipogenic. There are a couple of bigger questions that earlier media reports did not focus on- namely upstream factors regulating the hair cycle clock and the beauty of synchronization of fat and hair growth for seasonal thermal insulation. (more…)
Author Interviews, Nutrition, Weight Research / 28.03.2014

Barbara J. Rolls, PhD Department of Nutritional Sciences The Pennsylvania State University, 226 Henderson Building University Park, PA 16802-6501MedicalResearch.com Interview with: Barbara J. Rolls, PhD Department of Nutritional Sciences The Pennsylvania State University, 226 Henderson Building University Park, PA 16802-6501 MedicalResearch.com: What are the main findings of the study? Dr. Rolls:  We found that as we reduced the flake size of a breakfast cereal so that it filled a smaller volume, individuals ate a greater weight and more calories of the cereal. On four occasions, we served a popular wheat flake cereal, or the same weight of cereal crushed to 80%, 60%, or 40% of its volume, to 41 adults for breakfast. As the flake size was reduced, people made reductions in the volume of cereal they poured, but they still took a greater amount of weight and calories. They ended up eating 72 more calories at breakfast when they ate the cereal with the smallest flake size, an increase of 34%. These findings show that variations in food volume due to the size of individual food pieces affect the portion of food that people take, which in turn affects how much they eat. (more…)
Author Interviews, Cancer Research, OBGYNE, Weight Research / 25.03.2014

Dr. Kristy Ward Department of Reproductive Medicine UCSD School of MedicineMedicalResearch.com Interview with: Dr. Kristy Ward Department of Reproductive Medicine UCSD School of Medicine   MedicalResearch.com: What are the main findings of this study? Dr. Ward: As the second leading cause of preventable death, obesity is one of the nation’s most serious public health problems.  Over two-thirds of the US population is currently overweight or obese and the prevalence continues to increase.  A number of studies have linked obesity with an overall elevated risk of cancer and with many individual cancer types. Among obesity related cancers in women, endometrial cancer is most strongly associated with increasing body mass, with 39% of cases in the US attributable to obesity. In patients with clinically severe obesity (BMI ≥ 40 kg/m2), bariatric surgery results in rapid weight loss and has greater long-term success when compared to non-surgical weight loss methods. Surgical weight loss procedures have been found to reduce obesity-related comorbidites and improve outcomes in clinically severe obese populations. In addition to improved cardiovascular risk factors and mitigation of physical symptoms, there is increasing evidence that cancer risk is reduced after bariatric surgery. (more…)
Accidents & Violence, Author Interviews, Endocrinology, Pediatrics, Weight Research / 23.03.2014

MedicalResearch.com Interview with: Christos S. Mantzoros, MD, DSc, PhD Beth Israel Deaconess Medical Center and the VA Boston HealthcareChristos S. Mantzoros, MD, DSc, PhD Beth Israel Deaconess Medical Center and the VA Boston Healthcare Cynthia R. Davis PhD Judge Baker Children’s Center in Boston, MA.Cynthia R. Davis PhD Judge Baker Children’s Center in Boston, MA.     MedicalResearch.com: What are the main findings of this study? Answer: These results highlight that chronic stressors in childhood, like child abuse and family violence, parental substance abuse, divorce and separation from a parental figure, can potentially have a long standing impact on brain structures and functioning, such as the hypothalamic-pituitary-adrenal axis.  Our work supports the notion of allostatic load, and is the first of its kind to demonstrate links between childhood adversity and central obesity later in life which leads to increased cardio metabolic risk. This study describes the role of these novel molecules in mediating metabolic dysregulation highlighting them as a novel mechanism linking childhood adversity to obesity. We have also used more sensitive assessments of childhood adversity, not typically employed in biomedical research, that incorporate the severity of adversities and their chronicity across childhood.  Assessments of this nature are better able to detect severe and chronic adversity, and are critical in the measurement of stress, its role in allostatic load and its impact on the brain.  Furthermore, the current study and others from our lab show that severe and chronic adversity in childhood is associated with metabolic dysregulation and obesity in adulthood, regardless of lifestyle factors such as diet and exercise and psychosocial factors like depression and social support. Clinicians and patients need to be aware of the fact that subjects exposed to early life adversity are at increase risk for central obesity and cardio metabolic risk. (more…)
Author Interviews, BMJ, Brigham & Women's - Harvard, Genetic Research, Medical Research Centers, Nutrition, Weight Research / 19.03.2014

Prof. Lu Qi, Assistant Professor, Department of Nutrition Harvard School of Public Health and Channing Division of Network Medicine Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MAMedicalResearch.com Interview with: Prof. Lu Qi, Assistant Professor, Department of Nutrition Harvard School of Public Health and Channing Division of Network Medicine Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA MedicalResearch.com: What are the main findings of the study? Dr. Lu Qi: In this study, we for the first time provide reproducible evidence from three large cohort studies to show that the association between regular consumption of fried foods and higher BMI was particularly pronounced among people with a greater genetic predisposition to obesity. On the other hand, the adverse genetic effects on BMI were also amplified by consuming more fried foods, the effects among those who ate fried foods more than four times a week was about twice as large compared with those who ate them less than once a week. (more…)
Author Interviews, Nutrition, Pediatrics, Vanderbilt, Weight Research / 19.03.2014

Dr. Eliana M. Perrin, MD, MPH Associate Vice Chancellor for Research, and Director, Office of Research Development University of North Carolina at Chapel Hill  and Associate Professor Department of Pediatrics, Division of General Pediatrics and Adolescent Medicine University of North Carolina at Chapel Hill, School of Medicine Chapel Hill, NC 27599-7225MedicalResearch.com Interview Invitation with: Dr. Eliana M. Perrin, MD, MPH Associate Vice Chancellor for Research, and Director, Office of Research Development University of North Carolina at Chapel Hill  and Associate Professor Department of Pediatrics, Division of General Pediatrics and Adolescent Medicine University of North Carolina at Chapel Hill, School of Medicine Chapel Hill, NC 27599-7225 MedicalResearch.com: What are the main findings of the study? Dr. Perrin: The study included a large, diverse sample of 863 low-income parents of two-month-olds participating in Greenlight, an obesity prevention trial taking place at four medical centers: UNC, New York University, Vanderbilt University and the University of Miami.  Among all of the parents, behaviors that are thought to be related to later obesity were highly prevalent. Exclusive formula feeding was more than twice as common (45 percent) as exclusive breastfeeding (19 percent). Twelve percent had already introduced solid food, 43 percent put infants to bed with bottles, 23 percent propped bottles instead of holding the bottle by hand (which can result in overfeeding), 20 percent always fed when the infant cried, and 38 percent always tried to get their children to finish their milk.  In addition, 90 percent of the infants were exposed to television and 50 percent actively watched TV (meaning parents put their children in front of the television in order to watch).  There were differences in these behaviors by race and ethnicity, and study results show that culturally-tailored counseling should be offered to parents of different backgrounds who may feed and play with their children differently. (more…)
Author Interviews, Blood Pressure - Hypertension, Nutrition, Weight Research / 06.03.2014

Beverly B. Green, MD, MPH GroupHealth Research Institute Seattle WAMedicalResearch.com Interview with: Beverly B. Green, MD, MPH GroupHealth Research Institute Seattle WA   MedicalResearch.com: What are the main findings of the study? Dr. Green: We found that Group Health patients who were overweight and had hypertension were more likely to have lost 10 pounds in six months if they had secure online access to a dietitian than if they received only information and usual care. The patients really loved this intervention—and having access to a dietitian to work with them toward a healthier lifestyle. Although blood pressure and heart risk trended lower in the intervention group, the differences weren’t significant—unlike their weight. (more…)
Author Interviews, CMAJ, Weight Research / 04.03.2014

Dr. Laurie K. Twells, PhD School of Pharmacy, Memorial University, St. John’s Faculty of Medicine, Memorial University St. John’sNewfoundland and LabradorMedicalResearch.com Interview with: Dr. Laurie K. Twells, PhD School of Pharmacy, Memorial University, St. John’s Faculty of Medicine, Memorial University St. John’s Newfoundland and Labrador MedicalResearch.com: What are the main findings of the study? Dr. Twells: Obesity rates in Canada tripled between 1985 and 2011. Although class I obesity (BMI ≥ 30) appears to have increased at a slower rate, obese classes II (BMI ≥  35) and III (BMI ≥40) continued to increase disproportionately. Over the last decade, every province in Canada experienced increases in obesity rates. Overall obesity rates were lower in the west and higher in the eastern provinces and people over age 40 years were more likely to be overweight/obese than younger people. By 2019 it is projected that twenty-one per cent of Canadians will be obese but this will vary by province from 15.7% in British Columbia to 34.6% in Newfoundland and Labrador. (more…)
Author Interviews, JAMA, Weight Research / 25.02.2014

MedicalResearch.com Interview with: Cynthia L. Ogden, PhD, MRP Epidemiologist and Analysis Branch Chief NHANES Program/NCHS/CDC Hyattsville, MD 20782 MedicalResearch.com: What are the main findings of the study? Dr. Ogden: We continue to track obesity levels in the US population using data from the National Health and Nutrition Examination Survey. New data are now available for 2011-2012. We found that 17% of youth and 35% of adults were obese.  Overall there has been no change in obesity levels among either youth or adults in the last 10 years. The prevalence of obesity among youth was 16.9% - exactly the same as in 2009-2010.  In separate age groups analyses we found a decrease in obesity among 2-5 year olds and an increase in obesity among older women 60+ years. (more…)
Author Interviews, PLoS, Weight Research / 25.02.2014

Nir Y. Krakauer Ph.D Assistant Professor Department of Civil Engineering The City College of New York New York, New YorkMedicalResearch.com Interview with: Nir Y. Krakauer Ph.D Assistant Professor Department of Civil Engineering The City College of New York New York, New York MedicalResearch.com: What are the main findings of the study? Dr. Krakauer: We studied the association between the recently proposed body shape index (ABSI) -- which combines waist circumference, height and weight measurements -- and risk of death in a United Kingdom population sample. We found that high ABSI predicted greater mortality hazard, with death rates increasing by about 13% per standard deviation increase in ABSI. Further, ABSI was a stronger predictor of early death than BMI, waist circumference, or other indices based on waist circumference such as waist to height ratio and waist to hip ratio. For a given starting ABSI value, reducing A Body Shape Index over a 7-year period was associated with lowered mortality risk, . (more…)
Author Interviews, Genetic Research, JAMA, Weight Research / 18.02.2014

Dr Clare Llewellyn PhD Cpsychol Lecturer in Behavioural Obesity Research Health Behaviour Research Centre Department of Epidemiology and Public Health University College London, LondonMedicalResearch.com Interview with: Dr Clare Llewellyn PhD Cpsychol Lecturer in Behavioural Obesity Research Health Behaviour Research Centre Department of Epidemiology and Public Health University College London, London  MedicalResearch.com: What are the main findings of the study? Dr. Llewellyn:This study indicated that appetite – and, in particular, satiety sensitivity (how quickly you feel full during eating, or how long you remain full after eating) – could be one of the mechanisms through which ‘obesity genes’ influence body weight. We know that body weight has a strong genetic basis, but the mechanisms through which ‘obesity genes’ influence weight are largely unknown. We showed that children with a higher genetic predisposition to obesity (estimated from a score comprising 28 known obesity-related genes) not only had more body fat (a larger BMI and waist circumference), but importantly they were also less sensitive to satiety. (more…)
Author Interviews, Diabetes, PLoS, Weight Research / 14.02.2014

Dorte Vistisen Senior researcher, MSc PhD 469 - Epidemiology DK-2820 Gentofte DenmarkMedicalResearch.com Interview with: Dorte Vistisen Senior researcher, MSc PhD 469 - Epidemiology DK-2820 Gentofte Denmark MedicalResearch.com: What are the main findings of the study? Dr. Vistisen: Our study highlights the complexity of type 2 diabetes. We show that in most people the development of type 2 diabetes is preceded by many years of overweight and not by massive weight gain. (more…)
Author Interviews, Colon Cancer, General Medicine, PLoS, University of Michigan, Weight Research / 09.02.2014

Jenifer I Fenton Assistant Professor Department of Food Science and Human Nutrition Michigan State University East Lansing, MI 48824MedicalResearch.com Interview with: Jenifer I Fenton Assistant Professor Department of Food Science and Human Nutrition Michigan State University East Lansing, MI 48824 MedicalResearch.com: What are the main findings of the study? Dr. Fenton: This was a cross-sectional study, and thus, a snapshot in time. Although it cannot infer cause or temporality of obesity and colon polyp risk in men, it does show that obese men were more likely to have a polyp than their lean counterpart. In addition, there were serum biomarkers also associated with this risk. This could eventually lead to future blood tests to identify individuals at greater risk for polyps and inform screening recommendations. (more…)
Author Interviews, Depression, Diabetes, Diabetologia, Weight Research / 07.02.2014

Dr Peter de Jonge Interdisciplinary Center for Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, NetherlandsMedicalResearch.com Interview with: Dr Peter de Jonge Interdisciplinary Center for Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, Netherlands MedicalResearch.com: What are the main findings of the study? Dr. de Jonge: The main findings were that depression and impulse control disorders, in particular binge eating and bulimia were associated with diabetes. (more…)
Author Interviews, Lancet, Weight Research / 28.01.2014

Professor Sally Wyke Deputy Director, Institute of Health and Wellbeing Professor (Institute of Health and Wellbeing Social Sciences) The University of GlasgowMedicalResearch.com Interview with: Professor Sally Wyke Deputy Director, Institute of Health and Wellbeing Professor (Institute of Health and Wellbeing Social Sciences) The University of Glasgow MedicalResearch.com: What are the main findings of the study? Prof. Wyke: The FFIT programme was very effective.  The men who did the programme lost nine times as much weight as the men who did not.  On average, they lost over 5.5kg  (11lbs)and kept it off for the full 12 months. In addition, we found highly significant differences in favour of the intervention objectively-measured waist, percentage body-fat, systolic and diastolic blood pressure, and self-reported physical activity, diet and indicators of well-being and physical aspects of quality of life. (more…)
Author Interviews, Sleep Disorders, University of Pittsburgh, Weight Research / 06.12.2013

Dr G. Neil Thomas, 
Regional Director, NIHR Research Design Service West Midlands 
 Deputy Director, Master of Public Heath Programme 
Reader in Epidemiology Department of Public Health, Epidemiology and Biostatistics
 School of Health and Population Sciences
 College of Medical and Dental Sciences The University of Birmingham
 Edgbaston, Birmingham, B15 2TTMedicalResearch.com Interview with: Dr G. Neil Thomas, 
Regional Director, NIHR Research Design Service West Midlands Deputy Director, Master of Public Heath Programme 
Reader in Epidemiology Department of Public Health, Epidemiology and Biostatistics
 School of Health and Population Sciences
 College of Medical and Dental Sciences The University of Birmingham
 Edgbaston, Birmingham, B15 2TT MedicalResearch.com: What are the main findings of the study? Dr. Thomas: This population of severely obese individuals (mean BMI 47kg/m2) from a regional specialist weight management service poor sleep quality (Pittsburgh Sleep Quality Index, PSQI) and daytime sleepiness (Epworth Sleepiness Scale) were strongly associated with poorer quality of life (Impact of Quality of Life-Lite (IWQOL-Lite) (more…)
Author Interviews, Diabetes, Weight Research / 25.11.2013

Ira Tabas, M.D., Ph.D. Richard J. Stock Professor and Vice-Chair of Research Department of Medicine Professor of Anatomy & Cell Biology  (in Physiology and Cellular Biophysics) Columbia University New York, NY 10032MedicalResearch.com Interview with: Ira Tabas, M.D., Ph.D. Richard J. Stock Professor and Vice-Chair of Research Department of Medicine Professor of Anatomy & Cell Biology  (in Physiology and Cellular Biophysics) Columbia University New York, NY 10032 MedicalResearch.com: What are the main findings of the study?  Dr. Tabas: We discovered a new pathway in the liver, relevant to humans, that controls the two hallmarks of type 2 diabetes (T2D), namely, excessive glucose production and defective insulin signaling.  Thus, if drugs could be developed to inhibit this pathway, they could be very effective at treating or preventing T2D. (more…)
Author Interviews, Diabetes, Heart Disease, JCEM, Weight Research / 21.11.2013

Carlos Lorenzo, MD Department of Medicine, University of Texas Health Science Center 7703 Floyd Curl Drive San Antonio, Texas 78229MedicalResearch.com Interview with: Carlos Lorenzo, MD Department of Medicine, University of Texas Health Science Center 7703 Floyd Curl Drive San Antonio, Texas 78229 MedicalResearch.com: What are the main findings of the study? Dr. Lorenzo: Metabolically healthy obese individuals are at increased risk of developing of diabetes and cardiovascular disease. These findings were demonstrated in men and women and in Mexican Americans and non-Hispanic whites. Management of excess weight and any metabolic abnormality appears to be important for all individuals. Our study is also in agreement with previous studies that indicate that metabolically unhealthy normal weight individuals are at increased risk of developing of diabetes and cardiovascular disease. (more…)
Author Interviews, Heart Disease, JAMA, Weight Research / 21.11.2013

MedicalResearch.com Interview with: Prof. Prashanthan SandersMedicalResearch.com Interview with: Prof. Prashanthan Sanders Director, Centre for Heart Rhythm Disorders University of Adelaide | Royal Adelaide Hospital | SAHMRI NHMRC Practitioner Fellow Centre for Heart Rhythm Disorders Department of Cardiology | Royal Adelaide Hospital Adelaide 5000 | Australia MedicalResearch.com: What are the main findings of the study? Answer: Aggressive treatment of risk factors and weight reduced the symptom burden associated with atrial fibrillation. It is therefore important that in a similar manner to how we treat coronary artery disease, in atrial fibrillation there should be management directed at the reasons why these individuals got AF in the first place. (more…)