Weight Research
15 Oct Fatty Liver At Least Partially Mediated By Epigenetic Influences
Posted at 12:37h
in Author Interviews, Gastrointestinal Disease, Genetic Research, Hepatitis - Liver Disease, Weight Research
MedicalResearch.com Interview with:
[caption id="attachment_28898" align="alignleft" width="180"]
Dr. Annette Schürmann[/caption]
Annette Schürmann PhD
Department of Experimental Diabetology
German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE)
Nuthetal
Germany German Center for Diabetes Research (DZD
München-Neuherberg Germany
MedicalResearch.com: What is the background for this study?
Response: The aim of our study was to clarify why genetically identical mice respond very different to a high fat diet. Some of the mice react with an elevated body weight, others not. We analyzed the expression pattern
of liver at two time points, at the age of 6 weeks, (the earlierst time
point to distiguish between those that respond to the diet (responder
mice) and those that did not (non-responders)), and at the age of 20
weeks. One transcript that was significantly reduced in the liver of
responder mice at both time points was Igfbp2. The reason for the
reduced expression was an elevated DNA-methylation at a position that is
conserved in the mouse and human sequence. The elevated DNA-methylation
of this specifc site in human was recently described to associate with
elevated fat storage (hepatosteatosis) and NASH. However, as 6 weeks old
mice did not show differences in liver fat content between responder and
non-responder mice we conclude that the alteration of Igfbp2 expression
and DNA metyhlation occurs before the development of fatty liver.
Our data furthermore showed that the epigenetic inhibition of Igfbp2
expression was associated with elevated blood glucose and insulin
resistance but not with fatty liver.
08 Oct Irisin Exerts Dual Effects on Browning and Adipogenesis of Human White Fat
MedicalResearch.com Interview with: [caption id="attachment_28653" align="alignleft" width="200"]
Dr. Li-Jun Yang[/caption]
Li-Jun Yang MD
Professor, Hematopathology
University of Florida
MedicalResearch.com: What is the background for this study?
Response: Irisin, an exercise-induced myokine, promotes converting subcutaneous (sc) fat-storing adipocytes into fat-burning adipocytes, namely “browning”. Although beneficial effects of irisin such as browning and weight loss in obese animal have been observed in mice, the effect of irisin in human adipocytes is controversial. Moreover, the mechanisms of irisin’s anti-obesity are not clear and systemic studies are not available using human adipose tissues. In our study, we aimed at exploring at the multiple levels in the mechanisms of irisin’s anti-obesity effects using human adipocytes and human adipose tissues.
27 Sep Can Low Dose Oral Nicotine Have Beneficial Health Effects?
MedicalResearch.com Interview with: [caption id="attachment_28356" align="alignleft" width="132"]
Dr. Ursula H. Winzer-Serhan[/caption]
Ursala. H. Winzer-Serhan Ph.D.
Associate Professor
Department of Neuroscience and Experimental Therapeutics
Texas A&M Health Science Center
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Nicotine is a plant alkaloid that is naturally occurring in the tobacco plant. Smoking delivers nicotine to the brain where it acts as a stimulant. Tobacco and electronic cigarette smoking delivers many other chemicals to the body, which are harmful and can cause cancer.
However, the drug nicotine by itself is relatively benign and poses few health risks for most people. Nicotine acts in the brain on nicotinic receptors, which are ion channels that are widely expressed in the brain. They play an important role in cognitive functions. Research with rodents and in humans has shown that nicotine can enhance learning and memory, and furthermore, can protect neurons during injuries and in the aging brain. With the increasingly older population, it becomes more and more important to delay cognitive decline in the elderly. Right now, there is no drug available that could delay aging of the brain.
22 Sep Brain RAP is a Critical Mediator of Leptin Resistance and Obesity
Posted at 01:23h
in Author Interviews, Baylor College of Medicine Houston, Biomarkers, Weight Research
MedicalResearch.com Interview with:
[caption id="attachment_28232" align="alignleft" width="144"]
Dr. Makoto Fukuda[/caption]
Makoto Fukuda Ph.D.
Assistant Professor
Children's Nutrition Research Center
Department of Pediatrics
Baylor College of Medicine
Houston, Texas 77030
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: A hallmark characteristic of obesity is diminished actions of metabolic hormones that are critically required to maintain whole body energy balance and glucose homeostasis. Leptin is a crucial and powerful hormone that keeps body weight normal. It was hoped that leptin might be a “magic bullet” that could cure obesity. Shortly after the discovery, however, obese individuals were found to have little or no response to exogenously administered leptin, a state of “leptin resistance”. These observations created a central question to be addressed in the field, which would help our understanding of the core of pathophysiology of obesity. While we and other groups previously demonstrated that Epac, a signaling molecule known as a GTP/GDP exchange factor directly activated by cAMP, is involved in cellular leptin resistance, the role of brain Epac signaling in the whole body metabolism has not yet established.
We approached this question by using brain-specific knockout mice of Rap1, a direct activator of Epac. As expected from previous results, mice with brain-specific deficiency of Rap1 failed to develop leptin resistance even when they were challenged with a hypercaloric diet. What impressed us most in this study was that Rap1 in the brain plays a key role in the whole body metabolic control, beyond its role in controlling leptin sensitivity. Loss of brain Rap1 protects mice from diet-induced obesity and disordered glucose balance, whereas these knockout mice maintained a similar body weight to that of control mice on a normal regular diet. Further, pharmacological inhibition of this pathway reversed leptin resistance and reduced the body weight of dietary obese mice. At the cellular level, we found an unexpected link between Rap1 and endoplasmic reticulum (ER) stress that has emerged as a causative contributor to the development of leptin resistance.
21 Sep Intestinal Microbiome Linked to Obesity and Fat Storage in Children
MedicalResearch.com Interview with: [caption id="attachment_28185" align="alignleft" width="133"]
Dr. Nicola Santoro[/caption]
Nicola Santoro, MD, PhD
Associate Research Scientist in Pediatrics (Endocrinology)
Yale University
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The study start from previous observations showing an association between the gut microbiota and obesity.
Similarly to what previously described in adults and in children, we found an association between the gut microbiota and obesity. We took a step further and also observed that the gut flora is associated to body fat partitioning (amount of fat in the abdomen). Moreover, we observed that the effect of microbiota could be mediated by the short chain fatty acids a product of gut flora.
19 Sep FTO Gene Make Obesity More Likely But Doesn’t Prevent Weight Loss
MedicalResearch.com Interview with: [caption id="attachment_28116" align="alignleft" width="135"]
Prof. John C. Mathers[/caption]
Prof. John C. Mathers
Director, Human Nutrition Research Centre
Institute of Cellular Medicine and
Newcastle University Institute for Ageing
Newcastle University
Biomedical Research Building
Campus for Ageing and Vitality
Newcastle on Tyne
MedicalResearch.com: What is the background for this study?
Response: More than 90 different genetics variants are associated with body fatness and, of these, the FTO gene has the biggest effect. People who are homozygous for the unusual variant of FTO i.e. carry two copies of the risk allele, are on average 3kg heavier than those not carrying the risk allele. In addition, they have 70% greater risk of being obese. Since the FTO gene is associated with being heavier, we wondered whether it made it more difficult for people to lose weight.
17 Sep Healthy Eating in Adolescence Sets Pattern For Less Weight Gain As Young Adult
MedicalResearch.com Interview with: [caption id="attachment_28058" align="alignleft" width="133"]
Dr. David R. Jacobs, Jr.[/caption]
David R. Jacobs, Jr., PhD
Mayo Professor of Public Health
Division of Epidemiology and Community Health, School of Public Health
University of Minnesota
Minneapolis MN 55454-1075
MedicalResearch.com: What is the background for this study?
Response: Project EAT (Eating and Activity in Teens and Young Adults) is on ongoing longitudinal study which began by screening middle and secondary school students in the Minneapolis and St Paul Metropolitan are. Students were the 11-18 years old (average age 15), then followed up at average ages 20 and 25. We had devised an eating pattern in about 2006, which
a) predicts a lot of things in several different studies (including total mortality in the Iowa Women's Health Study) and b) looks a great deal like the recently released 2015 Dietary Guidelines for Americans (DGA).
We call our diet pattern A Priori Diet Quality Score (APDQS) and think of it as close to or in the style of a Mediterranean/prudent/healthy diet.
We hypothesized that this pattern would be associated with lower weight (in general with better long term health, but the focus in Project EAT was weight and BMI), probably least so at age 15. The minimal hypothesized effect in adolescence relates to the very large energy expenditure in adolescent growth years; we thought that diet composition would be less important for body weight at that time than energy intake (and APDQS is about diet composition).
16 Sep Socio-Economic Factors Influence Genetic Tendency Toward Obesity
MedicalResearch.com Interview with: [caption id="attachment_27851" align="alignleft" width="200"]
Prof. Timothy Frayling[/caption]
Professor Timothy Frayling PhD
Professor of Human Genetics
University of Exeter Medical School
Exeter, UK
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: We know that genes and environmental factors influence our Body mass index. We know less about if and how they interact.
We wanted to answer the question of whether or not aspects of the environment and our lifestyles accentuate any genetic predisposition to obesity. The question is important as it may highlight aspects of the environment that cause some people to be particularly susceptible to gaining weight. Previous, separate, studies have suggested that specific aspects of the environment are to blame. These included sugary drinks, fried food and TV watching.
13 Sep Body Mass Index Linked to LV Mass in Career Male Firefighters
MedicalResearch.com Interview with: [caption id="attachment_27860" align="alignleft" width="200"]
Maria Korre[/caption]
Maria Korre, ScD
Post-Doctoral Research Fellow
Environmental & Occupational Medicine & Epidemiology Program
Department of Environmental Health
Harvard T.H. Chan School of Public Health
MedicalResearch.com: What is the background for this study?
Response: Cardiovascular disease (CVD) is the leading cause of on-duty death among firefighters (45% of on-duty fatalities) and a major cause of morbidity. It is crucial to note though, that the risk of on-duty CVD events is not evenly distributed among all firefighters, but is highly concentrated among the most susceptible individuals. Given that firefighting is an inherently dangerous occupation and many of its hazards cannot be engineered out of the job, we have concentrated our efforts on understanding what can make an individual firefighter susceptible.
As in the general population, these cardiovascular events are largely due to coronary heart disease (CHD), however, there is an increasing recognition of the role of left ventricular (LV) hypertrophy/cardiomegaly in the risk of sudden cardiac death (SCD) independent of the presence of CHD. Evidence suggests an improved prognostic value, when LV hypertrophy is based on the accurate assessment of LV mass.
LV mass is a strong predictor of CVD events and despite it’s critical prognostic significance, it’s measurement and role in clinical practice has yet to be established.
In this paper we aimed to identify the most important predictors of LV mass after indexing for height among career male firefighters as assessed by both echocardiography and cardiac magnetic resonance.
06 Sep Overweight Girls, Underweight Boys May Be At Greater Risk of Adult Asthma
MedicalResearch.com Interview with: Professor Charlotte Suppli Ulrik MD DMSc et al. Dept. of Respiratory Medicine Hvidovre Hospital Copenhagen, Denmark MedicalResearch.com: What is the background for this study? Response: Obesity is a risk factor for new-onset asthma, but the association is incompletely understood. Our aim was, therefore, to investigate the association between body mass index (BMI) BMI in childhood and asthma admissions in early adulthood (until age 45 years). We used data on BMI measured annually (age 7-13 years) in 321,830 children enrolled in the Copenhagen School Health Records Registry. During the 36-years of follow-up, a total of 2,059 first-time ever hospital admissions for asthma were observed.02 Sep Most Gastric Bypass Patients Keep Weight Off After Surgery
MedicalResearch.com Interview with: [caption id="attachment_27481" align="alignleft" width="156"]
Dr. Matt Maciejewski[/caption]
Matthew Leonard Maciejewski, PhD
Professor in the Division of General Internal Medicine
Department of Medicine
Duke University School of Medicine
Research Career Scientist and Director of the Health Economics and Policy Unit in the Center for Health Services Research in Primary Care
Durham VA Medical Center
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: No study based on a US cohort undergoing current procedures has examined weight change comparing surgical patients and nonsurgical patients for as long as we have. This is the first study to report 10-year outcomes on gastric bypass patients and compare them to matched patients who did not get surgery. At 1 year, gastric bypass patients lost 31% of their baseline weight compared controls who only lost 1.1% of their baseline weight. At 10 years, gastric bypass had lost 28% of their baseline weight.
We also compared weight loss at 4 years for Veterans who received the 3 most common procedures (gastric bypass, sleeve gastrectomy, and adjustable gastric banding). At 4 years, patients undergoing gastric bypass lost more weight than patients undergoing sleeve gastrectomy or gastric banding. Given that few high quality studies have examined sleeve gastrectomy to 4 years, the 4-year sleeve outcomes contribute to filling this important evidence gap as the sleeve gastrectomy is now the most commonly performed bariatric procedure worldwide.
02 Sep Low Uptake of Medicare Obesity Counseling Benefit
MedicalResearch.com Interview with: [caption id="attachment_27587" align="alignleft" width="125"]
Dr. John Batsis[/caption]
John A. Batsis, MD, FACP, AGSF
Associate Professor of Medicine and The Dartmouth Institute
Geisel School of Medicine at Dartmouth
Section of General Internal Medicine - 3M
Dartmouth-Hitchcock Medical Center
Lebanon, NH
MedicalResearch.com: What is the background for this study?
Response: In 2011, the Centers for Medicare and Medicaid implemented a regulatory coverage benefit to cover 22 brief, targeted 15-minute counseling visits by clinicians over the course of a 12-month period for Medicare beneficiaries with a body mass index exceeding 30kg/m2. This was an important policy determination in tackling the obesity epidemic in the United States. An emphasis on the importance of counseling, or intensive behavioral therapy, in a primary care setting set the foundation for this benefit.
Yet, it was unclear how and if this benefit (which would be free of charge without a copay or deductible for beneficiaries) was being implemented in clinical care. We therefore identified fee-for-service Medicare claims for the years 2012 and 2013 to determine whether the G0477 code (Medicare Obesity benefit code) was billed. We additionally explored the rate of uptake of the Medicare benefit in relation to the prevalence of obesity using the 2012 Behavior Risk Factor Surveillance System data.
31 Aug Parents Likely To Use Food To Soothe Fussy Infants
MedicalResearch.com Interview with: [caption id="attachment_27521" align="alignleft" width="133"]
Dr. Kai Ling Kong[/caption]
Kai Ling Kong, PhD, MS
Assistant Professor
Division of Behavioral Medicine
Department of Pediatrics
School of Medicine and Biomedical Sciences
State University of New York at Buffalo
MedicalResearch.com: What is the background for this study?
Response: Infant temperament, or individual behavior styles, can be reliably measured and is related to weight status. However, we know very little about the association of infants’ temperament and their motivation to eat versus engage in other activities (relative food reinforcement). Examining such associations is an important step given the need to use behavioral strategies in obesity prevention in early life. The purpose of our study was to determine if infant temperament, specifically the factors that have been linked with obesity risk, are associated with infant relative food reinforcement.
25 Aug Number of Cancers Linked to Obesity More Than Doubled
MedicalResearch.com Interview with: [caption id="attachment_27327" align="alignleft" width="125"]
Dr. Beatrice Lauby-Secretan[/caption]
Beatrice Lauby-Secretan, PhD
IARC – Section IMO (International Agency for Research on Cancer)
Lyon, France
MedicalResearch.com: What is the background for this study?
Response: The IARC Handbook of Cancer Prevention Series perform systematic reviews and evaluations of the cancer-preventive effects of interventions and strategies. The summary article published today presents the conclusions of a Working Group of experts who examined and assessed the currently available literature on the link between overweight/obesity and cancer. Thus this is not a single study, but the report on more than 1000 individual studies.
25 Aug Simple Changes in Cooking Methods May Reduce Inflammatory Stress and Decrease Insulin Resistance
MedicalResearch.com Interview with: [caption id="attachment_27302" align="alignleft" width="125"]
Dr. Jaime Uribarri[/caption]
Jaime Uribarri, MD
Professor, Nephrology
Icahn School of Medicine
Mt. Sinai Medical Center
MedicalResearch.com: What is the background for this study?
Response: We have been doing research in the area of dietary advanced glycation end-products (AGEs) for many years.
AGEs are chemical compounds that form normally in the body in small amounts and also in food when cooking under high heat and dry conditions; a percent of AGEs in food is absorbed and part of it is retained in the body leading to increased smoldering inflammation and oxidative stress that eventually produce most of modern chronic diseases such as diabetes, cardiovascular disease, dementia, etc. We have previously demonstrated that a diet low in AGEs, which essentially means changing the cooking methods to include less application of heat, plenty of water,etc, decreases inflammation of oxidative stress in people with diabetes, chronic kidney disease and in healthy subjects. In the current study we applied the same low dietary AGE intervention to a group of obese patients with the so-called Metabolic syndrome, a risk factor for Diabetes Mellitus.
19 Aug Maternal Gestational Diabetes Increased Risk of Childhood Obesity
MedicalResearch.com Interview with: [caption id="attachment_26918" align="alignleft" width="200"]
Dr. Gang Hu[/caption]
Dr. Gang Hu, Associate Professor
LSU’s Pennington Biomedical Research Center & Director
Chronic Disease Epidemiology Lab
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Some studies have found that maternal gestational diabetes mellitus (GDM) places offspring at increased risk of long-term adverse outcomes, including obesity. However, most of studies are from high income countries, with limited data from low to middle income countries. The present study, conducted at urban and suburban sites in 12 countries, found that the increased risk for children of GDM mothers compared with non-gestational diabetes mellitus mothers was 53% for obesity, 73% for central obesity, and 42% for high body fat.
18 Aug Vagal Nerve Blocking (vBloc) for the Treatment of Obesity Demonstrates Meaningful Weight Loss
MedicalResearch.com Interview with: [caption id="attachment_27115" align="alignleft" width="145"]
Dr. Katherine Tweden[/caption]
Katherine Tweden Ph.D.
Vice President, Clinical and Regulatory
EnteroMedics® Inc
St. Paul, Minnesota 55113
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: This report summarizes 2 year outcomes of the pivotal study that evaluated the safety and efficacy of EnteroMedics’ vagal blockade (vBloc Therapy) delivered by our Maestro Rechargeable System neuromodulation device for the treatment of obesity. The study demonstrates that the device continues to have a promising safety profile and that the weight loss achieved through 2 years is clinically meaningful as shown by the positive impact of vBloc Therapy on participant’s co-morbid conditions, quality of life, and eating behaviors.
Specifically, the study showed 21% excess weight loss and approximately 50% reduction in pre-diabetes and metabolic syndrome for those participants who presented with the syndrome at baseline.
In addition, cardiovascular parameters improved in those at risk with approximately 10 mmHg drop in systolic and diastolic blood pressure compared to baseline in participants with elevated blood pressure and 16 and 46 mg/dL drop in LDL and triglycerides, respectively, in participants with elevated lipids compared to baseline. In addition, metabolic parameters improved with a reduction in hemoglobin A1c of 0.3 percentage points. Participants’ quality of life improved by 20 units compared to baseline and their control over their eating behavior, such as hunger and the ability to control the amount they eat, was significantly improved by approximately 50% compared to baseline.
16 Aug Focusing on Eating Healthy Foods You Enjoy May Be Your Path To More Successful Dieting
Posted at 00:03h
in Author Interviews, Baylor University Medical Center Dallas, Nutrition, Weight Research
MedicalResearch.com Interview with:
Meredith E. David
Marketing Department
Hankamer School of Business
Baylor University
Waco, TX 76798
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: In the midst of the ongoing “obesity epidemic” in the United States and many other developed nations, programs and advice abound for encouraging individuals to manage their health and well-being through changes in food consumption. One common approach resurfaces time and time again: suggesting to the would-be dieter what foods they should avoid eating (e.g., “The following 10 foods should never be eaten . . . ,”) and/or what foods they should eat (e.g., “10 foods everyone should include in a healthy diet,”). Our research investigates the commonly heralded advice given to consumers to either focus on avoiding unhealthy foods, such as cake, or approaching and consuming healthy foods, such as kale. We demonstrate important differences in the implementation of and outcomes of these approach versus avoidance strategies for meeting one’s health-related goals.
Individuals who have high self-control are generally better at reaching their goals. We investigate how individuals with varying levels of general self-control differ in the way that they apply approach and avoidance dieting strategies. Our findings, as detailed below, reveal a novel explanation of the better outcomes observed by individuals who are generally more successful in their goal pursuit. The key findings are as follows:
12 Aug Factors Identifying Risk of Poor Weight Loss After Bariatric Surgery Identified
MedicalResearch.com Interview with: [caption id="attachment_26834" align="alignleft" width="143"]
Dr. Michelle Lent[/caption]
Dr. Michelle R. Lent, PhD
Geisinger Obesity Institute
Geisinger Clinic
Danville, Pennsylvania
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: More than one-third of adults in the United States live with obesity. Currently, the most effective treatment for obesity is bariatric surgery. Bariatric surgery patients are expected to lose 30 to 40 percent of their body weight, but not all patients are able to lose this amount of weight and others experience weight regain. Why some patients succeed in weight loss over time, while others are less successful, remains unclear.
In this study, we evaluated over 200 patient characteristics in relation to long-term weight loss after bariatric surgery (7 years or longer), including gender, age and weight at the time of surgery, lab tests, medical conditions and medications, among others. We found that patients who used insulin, had a history of smoking, or used 12 or more medications before surgery lost the most weight, while patients with high cholesterol, older patients and patients with higher body mass indexes at the time of surgery lost the least amount of weight after surgery.
06 Aug Obesity Linked To Prematurely Aged Brains
MedicalResearch.com Interview with: [caption id="attachment_26781" align="alignleft" width="153"]
Dr. Lisa Ronan[/caption]
Dr. Lisa Ronan, PhD
Department of Psychiatry
University of Cambridge Neuroscience
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: A growing body of literature relates common markers of aging to those observed in obesity and supports the hypothesis that obesity may accelerate or advance the onset of brain aging. To investigate this relationship at a population level we analysed the white matter volume of the brain in 473 adult subjects ages 20 - 87 years and contrasted these volumes between subjects who were lean (BMI between 18.5 - 25) and those who were overweight / obese (BMI > 25).
Our results suggest that the latter group had significantly smaller white matter volumes when compared to their lean age-matched counterparts. We found that this difference in volume equated to a brain-age increase of 10 years in the overweight / obese group. We found no evidence that obesity impacted on cognitive ability.
04 Aug Obesity Raises Risk of Diabetes But Not Heart Attacks in Twins
MedicalResearch.com Interview with: [caption id="attachment_26704" align="alignleft" width="150"]
Prof. Peter Nordstrom[/caption]
Prof. Peter Nordström PhD
Department of Community Medicine and Rehabilitation
Geriatrics, Umeå University
Umeå, Sweden
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Numerous studies has shown an association between BMI, CVD and death. However, it is not known to what extent genetic factors influence this relationship. We used over 4000 monozygous twin pairs that had different BMI. This mean that the difference in BMI must be due to environmental factors since the genetic setup is similar in monozygous twins.
Since the fatter twin did not have a higher risk of myocardial infarction (MI) or death, environmental factors that increase BMI is very unlikely to increase the risk of myocardial infarction or death. By inference the strong association between BMI, MI and death must be explained by the fact that the same genes control both obesity, MI and death. By contrast, the fatter twin had a higher risk of diabetes.
03 Aug Whole Grains and Pasta Linked To Better Diet and Lower Body Weight
MedicalResearch.com Interview with: Yanni Papanikolaou PhD Candidate, Masters in Public Health Nutrition Nutritional Strategies Inc. Paris, ON, Canada MedicalResearch.com: What is the background for this study? What are the main findings? Response: We used data from the National Health and Nutrition Examination Survey (NHANES) 2005–2010, which consisted of information from more than 14,000 U.S. adults 19 years old and older. We looked at dietary eating patterns and compared those individuals that consumed grain and grain-based foods (both in whole and enriched forms) and compared to those who omit main grain foods from their diet. We examined nutrient intakes, diet quality and various health measures, including body weight and waist circumference, within each grain group and compared to adults not eating grain foods. We found that people consuming certain grain foods had better overall diet quality, lower average body weight and a smaller waist circumference. Specifically, adults consuming pasta, cooked cereals and rice weighed 7.2 pounds less and had waist circumferences that were 1.2 inches smaller compared to adults who didn’t eat grains. Although the public is quick to demonize enriched grains, our findings show that enriched grains provide vital nutrients many Americans fall short on, such as fiber, folate, calcium, iron, and magnesium. Eliminating grain-based foods can have negative effects on diet quality and intake of essential nutrients.21 Jul Hormone Overcomes Genetic Cause of Morbid Obesity
MedicalResearch.com Interview with: Dr. Peter Kühnen MD Institute for Experimental Pediatric Endocrinology Charité–Universitätsmedizin Berlin Berlin, Germany MedicalResearch.com: What is the background for this study? What are the main findings? Dr. Kühnen: The patients, which were included in this study, are suffering from a genetic defect in a gene called POMC. This gene is cleaved into different hormones as e.g. MSH (melanocyte stimulating hormone). MSH is very important for the regulation of satiety by activation of the MC-4 receptor. For this reason these patients are persistent hyperphagic due to the lack of MSH and they gain weight very fast in the first months of their life. Setmelanotide activates the MC-4 receptor, which is important for the activation of satiety. By restoring the lost function Setmelanotide leads to a reduction of hyperphagia and to a reduction of body weight in this POMC deficient patients.15 Jul Animal Study Shows Gastric Bypass Surgery May Reverse Diabetes
MedicalResearch.com Interview with: Xiang Gao, PhD State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Nanjing Biomedical Research Institute and the Collaborative Innovation Center of Genetics and Development Nanjing University MedicalResearch.com: What is the background for this study? Response: Duodenum-jejunum gastric bypass (DJB) surgery has been used to treat morbid diabetic patients. However, neither the suitability among patients nor the mechanisms of this surgical treatment is well understood. Our research is based on a new mouse strain named Timo as type 2 diabetes model caused by brain-derived neurotrophic factor (Bdnf) deficiency. We hope to figure out whether DJB surgery can reverse the metabolic defects in this type of diabetes. If yes, what is the possible mechanisms. MedicalResearch.com: What are the main findings? Response: Our research showed that duodenum-jejunum gastric bypass surgery could cure diabetes of genetic (mutation) origin. We also showed that the alteration of gut microflora abundance and improved metabolism preceded the inflammation alleviation and BDNF protein levels increase after DJB surgery.15 Jul More Meals At Home Linked To Reduced Risk of Obesity and Diabetes
Posted at 01:33h
in Author Interviews, Brigham & Women's - Harvard, Diabetes, Nutrition, PLoS, Weight Research
MedicalResearch.com Interview with:
Dr. Qi Sun Sc.D, M.D., M.M.S.
Dr. Geng Zong, Ph.D., a research fellow
Assistant Professor in the Department of Nutrition
Harvard T.H. Chan School of Public Heath
Boston
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: There is growing trend of eating meal prepared out of home in many countries. For example, energy intake from out-of-home meals has increased from less than 10% in mid 60s to over 30% in 2005-2008 among Americans, and average time spent on cooking has decreased by one third. In the meantime, the prevalence of diabetes and obesity of this country keep on growing. In the current study, we followed nearly 100 thousands middle-aged men and women for 26 years. In 1986, we asked people how often their lunch and dinner were prepared at home per week, which will be 14 meals in maximum, and updated this information during follow-up.
We found men and women with 11-14 meals prepared at home per week had 14% lower risk of diabetes compared to those had 6 or less meals prepared at home. If we look at lunch and dinner separately, people with 5 or more lunch prepared at home per week had 9% lower risk of diabetes, and those with 5 or more dinner prepared at home had 15% lower risk of diabetes compared to the group who had 2 or less than lunch or dinner at home per week.
We further investigated whether people with more meals prepared at home had lower risk of obesity or weight gain in our study. In the first eight years of follow-up, participants with 11-14 meals prepared at home had 14% lower risk of developing obesity compared to people had 0-6 meals prepared at home. For men, these people had 1.2kg less weight gain, and for women they had 0.3 kg less weight gain. Furthermore, we found potential impact of having meals at home and risk of diabetes became weaker. This suggest that weight gain could be one gearwheel that links eating meals prepared at home and diabetes risk.
15 Jul Any Amount of Excess Body Weight Associated With Higher Risk of Premature Death
MedicalResearch.com Interview with: [caption id="attachment_26066" align="alignleft" width="103"]
Dr. Shilpa Bhupathiraju[/caption]
Dr. Shilpa Bhupathiraju, PhD
Harvard T.H. Chan
School of Public Health
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: We wanted to investigate the association between body mass index (BMI) and mortality across major global regions. In doing so, we wanted to take into account important methodological limitations which plagued prior reports of BMI and mortality. One such limitation is reverse causality where a low body weight is the result of an underlying illness rather than the cause. Another major problem is confounding due to smoking where smokers have lower body weights than non-smokers but have much higher mortality rates.
Therefore, to obtain an unbiased association between BMI and mortality, our primary pre-specified analysis was restricted to never smokers and those who had no existing chronic diseases at the start of the study.
In this group, we found that those with a BMI of 22.5-<25 kg/m2 (considered a healthy weight range) had the lowest mortality risk during the time they were followed. The risk of mortality increased significantly with excess body weight. A BMI of 25-<27.5 kg/m2 (in the overweight range) was associated with a 7% higher risk of premature death; BMI of 27.5-<30 kg/m2 (also in the overweight range) was associated with a 20% higher risk; a BMI of 30.0-<35.0 kg/m2 was associated with a 45% higher risk; a BMI of 35.0-<40.0 kg/m2 was associated with a 94% higher risk; and a BMI of 40.0-<60.0 kg/m2 was associated with a nearly 3-fold risk. In general, we found that the association of excess body weight with mortality was greater in younger than older people and in men than women. Most importantly, the associations were broadly consistent in the major global regions we examined, including Europe, North America, Australia and New Zealand, East Asia, and South Asia.
12 Jul MRI Images Demonstrate Why Drinking Water Sometimes Curbs Appetite
MedicalResearch.com Interview with: [caption id="attachment_26058" align="alignleft" width="160"]
Guido Camps[/caption]
Guido Camps, MSc PhD candidate
Wageningen University and Research Centre
The Netherlands
Editor's note: The researcher would like readers to be aware that this work is preliminary and has not yet been published in a peer-reviewed journal.
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The background was that we wanted to study gastric distension with actual food. Because using different foods would also change the caloric content, we added water. We wanted to see if we could measure both the stomach and the brain, and what the added distension would feel like to the subjects and what brain effects we could see.
10 Jul Study Identifies Pathway Linking Obesity With Pancreatic Cancer Progression
[caption id="attachment_23151" align="alignleft" width="144"]
Dr. Rakesh Jain[/caption]
MedicalResearch.com Interview with;
Dr. Rakesh K. Jain, PhD
A.W.Cook Professor of Radiation Oncology (Tumor Biology)
Director, E.L. Steele Laboratory
Department of Radiation Oncology
Harvard Medical School and
Massachusetts General Hospital
Boston, MA 02114
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death worldwide, and more than half of patients diagnosed with PDAC are overweight or obese. Among patients with PDAC, obesity more than doubles the already high risk of death, and our work aims to reveal the underlying mechanisms. Specifically, we identified that obesity increases desmoplasia – an accumulation of connective tissue and inflammation – hallmark of Pancreatic ductal adenocarcinoma and discovered underlying mechanisms.
In our report published online in Cancer Discovery, we describe how interactions among fat cells, immune cells and connective tissue cells in obese individuals create a microenvironment that promotes tumor progression while diminishing the response to chemotherapy. We demonstrated the negative impact of obesity on numerous aspects of tumor growth, progression and treatment response in several animal models of pancreatic ductal adenocarcinoma and confirmed some of our findings in samples from cancer patients. Along with finding that tumors from obese mice or patients exhibited elevated levels of adipocytes or fat cells and of desmoplasia, both of which fuel tumor progression and interfere with treatment response, we identified the underlying causes.
The elevated desmoplasia in obese mouse models of PDAC was caused by the activation of pancreatic stellate cells through the angiotensin II type-1 receptor (AT1) signaling pathway. This activation was induced by interleukin-1 beta (IL-1ß) produced by fat cells as well as the immune cells called neutrophils within tumors. Inhibiting AT1 signaling with losartan, which is used clinically to treat hypertension, or the blockade of IL-1ß reduced obesity-associated desmoplasia and tumor growth and increased the response to chemotherapy in the obese mouse model but not in normal weight animals. Analysis of tumors from human PDAC patients revealed increased desmoplasia and fat deposits in samples from obese patients, and data from more than 300 patients showed that excess weight was associated with a reduction in patients.
09 Jul Obese Black Patients With Abnormal Sleep Have Greater Stroke Risk Than Whites
Posted at 19:44h
in Author Interviews, NYU/NYMC, Race/Ethnic Diversity, Sleep Disorders, Stroke, Weight Research
MedicalResearch.com Interview with:
[caption id="attachment_25960" align="alignleft" width="144"]
Dr. Azizi Seixas[/caption]
Azizi Seixas, Ph.D.
Post-Doc Fellow
Department of Population Health
Center for Healthful Behavior Change
NYU School of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Compared with whites, blacks are disproportionately affected by strokes. The overwhelming prevalence of obesity among blacks compared to whites has been suggested as a possible explanation for the disproportionate rates of strokes among blacks compared to whites. Recent findings linking insufficient sleep and stroke as well as the disproportionate burden of insufficient sleep among blacks compared to whites might provide a unique mechanism explaining why blacks have higher rates of stroke. However, it is unclear whether insufficient sleep and obesity contributes to the higher rates of stroke among blacks compared to whites.
To test our hypothesis, we utilized data from the National Health Interview Survey from 2004-2013 with a sample size of 288,888 individuals from the United States. Using Bayesian Belief Network (BBN) analysis, a form of machine learning analysis, we assessed the mediating effects of BMI on the relationship between short sleep duration (≤6 hrs. total sleep duration), long sleep duration (≥9 hrs. total sleep duration), and stroke, and whether race/ethnicity differences in obesity moderated these relationships.