MedicalResearch.com Interview with:
Professor Marianna VirtanenPhD
Unit of Expertise for Work and Organizations
Finnish Institute of Occupational Health
Helsinki, Finland.
Medical Research: What is the background for this study? What are the main findings?Professor Virtanen: Risky alcohol use is common among working populations but the contribution of work-related factors such as long working hours has rarely been studied. In the present study we performed the first systematic analysis on published studies regarding long working hours and risky alcohol use and added unpublished individual participant data to the analyses. Altogether 61 studies were included in the cross sectional analysis and 20 studies in the prospective analysis. The pooled cross sectional analysis showed 11% higher alcohol use associated with long working hours. In the prospective analysis we found that working 49-54 hours a week was associated with a 13% increase in the probability of new-onset risky alcohol use and working 55 hours or more with a 12% increased risk.
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MedicalResearch.com Interview with:
Michael Nadorff, PhD, Assistant professor
Mississippi State University
Starkville, Miss.
Medical Research: What is the background for this study? What are the main findings?
Dr. Nadorff: A growing literature has found that insomnia symptoms are associated with suicidal behavior, and several studies suggest that this relation may be independent of several different forms of psychopathology. However, little research has examined the role sleep disorders, such as insomnia, play in explaining why known risk factors, such as alcohol use, are associated with suicidal behavior. In our study, we examined whether insomnia symptoms explained a significant portion of the relation between alcohol symptoms and suicide risk. We found that for both men and women insomnia symptoms explained a significant amount of the variance in the relation between alcohol use and suicide risk.(more…)
MedicalResearch.com Interview with:
R. Dayne Mayfield PhD and Sean Farris Post Doc Fellow
Harris Lab
Waggoner Center for Alcohol and Addiction Research
University of Texas at Austin
MedicalResearch: What is the background for this study? Response: Alcoholism is psychiatric disorder adversely affecting the health of millions of individuals worldwide. Despite considerable research efforts, alcoholism cannot be attributed to any individual gene. We sought out to identify coordinately regulated gene networks, rather than a single candidate gene, that may be collectively driving the consumption of alcohol.
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MedicalResearch.com Interview with: Kirsten Mehli
Department of Public Health and Community Medicine,
Sahlgrenska Academy, University of Gothenburg,
Gothenburg, Sweden
Medical Research:What is the background for this study?Dr. Mehlig: Many studies found that the ‘good’ HDL-cholesterol is associated with lower risk for atherosclerosis, and cardiovascular risk. This finding has not been translated into clinical practice because medical trials with HDL-cholesterol rising medication did rise the HDL-cholesterol but did not prevent CVD. One possible explanation could be that a high level of HDL-cholesterol is but a marker for other factors that truly contribute to reduced cardiovascular risk. One such factor is alcohol consumption, and ethanol intake in grams / day is associated with higher HDL-C in our study, too. Another factor is a certain genotype that has been found to modulate HDL-cholesterol levels. The fact that co-called ‘moderate’ alcohol consumption is beneficial wrt. CVD has been observed and discussed often, and is confirmed in our study. Here, we asked whether the beneficial effect of alcohol was further strengthened by having a favorable CETP genotype wrt. HDL-cholesterol.
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MedicalResearch.com Interview with:
Sharon G. Curhan, MD, ScM
Channing Division of Network Medicine
Department of Internal Medicine
Brigham and Women's Hospital
Harvard Medical School Boston, MA 02115
Medical Research: What is the background for this study?Dr. Curhan: Hearing loss is a highly prevalent and disabling chronic condition that can impair communication, quality of life, and health. Although it is often perceived as an inevitable companion of aging, recent evidence suggests modifiable factors can potentially aid in prevention or slow progression of hearing loss. Alcohol consumption may influence several mechanisms that have been proposed to underlie age-related hearing decline. Although chronic excess alcohol intake has been associated with irreversible hearing loss and acute alcohol intake may temporarily impair auditory function, some evidence suggests that long-term moderate alcohol intake may protect against hearing loss.
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MedicalResearch.com: Interview with: Matthew B. Schabath, Ph.D
Assistant Member, Department of Cancer Epidemiology
Moffitt Cancer Center Tampa, Florida
Medical Research: What are the main findings of the study?Dr. Schabath: Overall, the results from these analyses demonstrated that men who consumed the highest amounts of alcohol were associated with an increased risk for genital human papillomavirus (HPV) infections.
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MedicalResearch.com Interview with:Keren Lehavot, PhD
Research Clinical Psychologist
VA Puget Sound Health Care System
Assistant Professor
Department of Psychiatry & Behavioral Sciences
University of Washington
Medical Research: What are the main findings of the study?Dr. Lehavot:Alcohol misuse is a significant public health concern among women living in the U.S. Women who have served in the military are a unique population who report relatively high rates of hazardous drinking, and those who identify as lesbian or bisexual (LB) may be at especially high risk for alcohol misuse. While previous research suggests that lesbian or bisexual veterans report higher rates of alcohol misuse than their heterosexual counterparts, mediators that might explain this disparity have not been identified. To that end, we examined the role of civilian and military traumas and mental health symptoms (i.e., depression, post-traumatic stress disorder) in explaining disparities in alcohol misuse between sexual minority and heterosexual women veterans across the U.S. Women veterans were recruited using the Internet to participate in an online, anonymous, national survey.
Findings indicated that lesbian or bisexual veterans scored significantly higher on an alcohol misuse measure than heterosexual women veterans. LB veterans also reported higher rates of childhood trauma, physical victimization in adulthood both during the military and as a civilian, and mental health symptoms, partly accounting for their higher rates of alcohol misuse.
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MedicalResearch.com Interview with: Magdalena Cerdá, DrPH MPH
Assistant Professor, Department of Epidemiology
Mailman School of Public Health
Columbia University
New York, NY 10032-3727
Medical Research: What are the main findings of the study?Dr. Cerdá: We evaluated 1,095 Ohio National Guard soldiers, who had primarily served in Iraq and Afghanistan between 2008 and 2009 to determine the effect of civilian stressors and deployment-related traumatic events and stressors on post-deployment alcohol use disorder.
Participants were interviewed three times over 3 years about alcohol use disorder, exposure to deployment-related traumatic events like land mines, vehicle crashes, taking enemy fire, and witnessing casualties, and about experiences of civilian life setbacks since returning from duty, including job loss, legal problems, divorce, and serious financial and legal problems.
We found that having at least one civilian stressor or a reported incident of sexual harassment during deployment raised the odds of alcohol use disorders. In contrast, combat-related traumatic events were only marginally associated with alcohol problems.(more…)
MedicalResearch.com Interview with: Sharon Levy, M.D., M.P.H.
Director, Adolescent Substance Abuse Program
Assistant Professor in Pediatrics
Boston Children’s Hospital
Medical Research: What are the main findings of the study?Dr. Levy: We found that questions that asked about the frequency of alcohol, tobacco and drug use accurately triaged adolescents into "risk categories". In other words, kids who reported using alcohol or marijuana "once or twice" last year were unlikely to have a substance use disorder, those who reported "monthly" use were very likely to meet diagnostic criteria for a "mild" or "moderate" substance use disorder while those who reported use weekly or more were very likely to meet diagnostic criteria for a "severe" substance use disorder.
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MedicalResearch.com Interview with: Michael A. Collins PhD
Professor of Molecular Pharmacology
Loyola University Chicago
Stritch School of Medicine
Maywood IL 60153
Medical Research: What are the main findings of your study?Dr. Collins: There were several:
First, we found that a cadre of neuroinflammatory proteins which promote or are stimulated by increased oxidative stress were significantly altered in a brain neurodegeneration model involving high alcohol binges in adult (male) rats. Most surprising was that the alterations were selectively evident in the three brain regions that contain a lot of dying neurons, and not in regions lacking neurodamage.
Additionally, in an alcohol-binged adult rat brain cultures, the same neuroinflammatory protein alterations, along with the neuronal damage, were replicated.
We further observed that binging the cultures depleted a key omega-3 fatty acid, termed DHA, in brain membranes. When these binged brain cultures were then supplemented with DHA, the neuroinflammatory protein changes and the neurodegeneration were largely or completely inhibited.
The results link specific oxidative stress-associated neuroinflammatory routes to the brain neuronal demise arising from high binge alcohol exposures.
They also reveal that supplementation with an omega-3 fatty acid reported to be neuroprotective with respect to other insults may be effective as well in suppressing the brain-damaging effects of excessive alcohol binges.
MedicalResearch.com: Interview with: Dr. Darryl P. Leong MBBS(Hons) MPH PhD FRACP FESC
Hamilton General Hospital
237 Barton Street East Canada
MedicalResearch: What are the main findings of the study?Dr. Leong:The main findings of this study are that while low-moderate levels of alcohol use are associated with a reduced risk of myocardial infarction, this protective association was not seen in peoples of all ethnicities.
Secondly, heavy alcohol use (≥6 drinks) within a 24 hour period was associated with a significant increase in the immediate risk of myocardial infarction.
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MedicalResearch.com Interview with:Osvaldo P. Almeida, MD, PhD, FRANZCP, FFPOA
Professor & Winthrop Chair of Geriatric Psychiatry | School of Psychiatry & Clinical Neurosciences | University of Western Australia.
Consultant | Department of Psychiatry | Royal Perth Hospital.
MedicalResearch.com: What are the main findings of this study?Prof. Almeida: This study used the principles of Mendelian randomisation to clarify whether alcohol use is a direct cause of cognitive impairment in later life. The rationale behind this approach is that the genetic variation associated with lower risk of alcohol abuse or dependence should also be associated with lower risk of cognitive impairment if alcohol misuse is a direct cause cognitive impairment. We found no evidence for such an association.
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MedicalResearch.com Interview with: Camilla Nykjaer, PhD Student
School of Food Science and Nutrition
University of Leeds, Leeds, UK
MedicalResearch.com: What are the main findings of the study?Answer:In our study, there was an association between the mother drinking alcohol during early pregnancy and being born preterm or small for gestational age. Babies of women who drank more than 2 units of alcohol per week in the first trimester were more likely to be born preterm, small for gestational age and with lower birth weight compared to non-drinkers, even after adjusting for a range of confounders including cotinine levels as a biomarker for smoking status. The association with preterm birth was present even in those mothers who reported drinking less than 2 units/week.
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MedicalResearch.com: Interview with:Sylvia Lui
Tommy’s Maternal and Fetal Health Research Centre
The University of Manchester
MedicalResearch.com: What are the main findings of the study?Answer:The research shows women who drink alcohol at moderate or heavy levels in the early stages of their pregnancy might damage the growth and function of their placenta – the organ responsible for supplying everything that a developing infant needs until birth
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MedicalResearch.com with:Dr John Holmes PhD, MA, BA (Hons) (York)
Section of Public Health, ScHARR,
University of Sheffield,
Sheffield S1 4DA, UK
MedicalResearch.com: What are the main findings of the study?Dr. Holmes:The study aimed to examine which groups in society would be affected by a 45p minimum unit price for alcohol. This was in response to concerns expressed by, among others, the UK Government that the policy may not tackle harmful drinking and may penalise responsible drinkers.
We found no support for these concerns. As the policy targets the cheap alcohol which is disproportionately purchased by those drinking at harmful levels, the effects are mainly felt by those at greatest risk of suffering harm from their drinking. On the other hand, moderate drinkers, including those on low incomes, buy very little of this cheap alcohol so are relatively unaffected.
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MedicalResearch.com Interview with: Andrea Bellavia MSc
Institute of Environmental Medicine, Karolinska Institutet
Stockholm, Sweden
Dr. Montgomery: What are the main findings of the study?Answer: We evaluated for 15 years a cohort of Swedish men and women and observed, after taking into account various socio-demographic, dietary, and lifestyle factors, that a low daily consumption of alcoholic beverages is tied with longer survival.
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MedicalResearch.com Interview with: Séverine Sabia, PhD
Epidemiology & Public Health, Div of Population Health
University College London - Gower Street - London
MedicalResearch.com: What are the main findings of the study?Dr. Sabia: The present study shows a detrimental effect of heavy alcohol consumption on cognitive ageing, and the effects are seen as early as 55 years old.
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MedicalResearch.com Interview with: Professor Karen Hughes
Professor in Behavioural Epidemiology
Centre for Public Health
Liverpool John Moores University
Liverpool L3 2ET
MedicalResearch.com: What are the main findings of the study?Answer: We used trained actors to test whether servers in pubs, bars and nightclubs would sell alcohol to people showing signs of extreme intoxication, despite this being illegal in the UK. In over four fifths (83.6%) of purchase attempts, bar servers sold alcohol to the pseudo-drunk actors – even though many clearly identified the actors as being drunk. We also collected data on bar environments, looking specifically at ten factors that have been associated with alcohol-related harm in previous studies: low levels of seating, loud noise, crowding, poor lighting, dirtiness, cheap drink promotions, young bar staff, young customers, rowdiness, and customer drunkenness. We found that the more of these characteristics bars had, the more likely they were to sell alcohol to drunks, with 100% of bars with 8 or more of these characteristics serving the pseudo-drunk actors. However, even in bars with none of these characteristics, two thirds of purchase attempts resulted in an alcohol sale. Having security staff managing entrance to the premises was also associated with alcohol service; possibly suggesting that bar servers in premises with door staff believe responsibility for vetting customers lies with such staff.
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MedicalResearch.com Interview with:Ying Liu, MD, PhD
Instructor, Division of Public Health Sciences
Department of Surgery
Washington University School of Medicine
660 South Euclid Ave Campus Box 8100
St. Louis, MO 63110
MedicalResearch.com: What are the main findings of the study?Answer: Alcohol intake between menarche (first menstrual period) and first pregnancy was consistently associated with increased risks of breast cancer and proliferative benign breast disease. For every 10 gram/day alcohol intake (approximately a drink a day) during this specific time period, the risk for breast cancer increased by 11% and the risk for proliferative benign breast disease increased by 16%.
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MedicalResearch.com: Interview with Peter Nordström Ph.D
Umeå University in Sweden
MedicalResearch.com: What are the main findings of the study?Answer: I would say that the main finding of our study is the nine independent risk factors identified for Young-Onset Dementia.
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