Caffeine May Make Other Foods Taste Less Sweet

MedicalResearch.com Interview with:

MedicalResearch.com Interview with: Robin Dando, PhD Assistant Professor Director, Cornell Sensory Evaluation Facility Department of Food Science Cornell University Ithaca, NY 14853 MedicalResearch.com: What is the background for this study? What are the main findings? Response: The study arose from a previous paper I authored in the Journal of Neuroscience, where we found Adenosine receptors in taste. We managed to prove that they were there to amplify sweet signals. This led us to wonder, what about the foods we consume, that would come into contact with these receptors in taste buds. It just happens that a lot of us habitually consume a powerful blocker of adenosine receptors every morning. Caffeine. So is our coffee impairing sweet signals? It turns out when we gave people sweetened coffee containing caffeine, they judged it as less sweet than the same coffee without the caffeine, sampled on a different day. Interestingly, this persisted, and sweet solutions they tested afterwards were still a little less sweet. Finally, just for kicks, we asked them to rate how much caffeine they thought was in either coffee, and how much more alert it made them feel. Turns out, there was no difference. They couldn’t tell which was deacf, and either coffee gave them just as much of an alertness boost. MedicalResearch.com: What should clinicians and patients take away from your report? Response: Readers should consider that they may be altering how their food tastes when consuming coffee. And perhaps also, they could be drinking decaf, and getting just as good a jolt from it (as long as someone else was preparing it for them, so they didn’t know). MedicalResearch.com: What recommendations do you have for future research as a result of this study? Response: We’re interested in how many factors we encounter in our every day lives change our perception, from the foods we’re consuming themselves, to our own bodies. We’re currently looking into how obesity, pregnancy and sleep can change our sense of taste, and the foods we crave. If you’d like to hear more about what we do, you can follow our work on twitter @DandoLab. MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community. 1.Citation: Ezen Choo, Benjamin Picket, Robin Dando. Caffeine May Reduce Perceived Sweet Taste in Humans, Supporting Evidence That Adenosine Receptors Modulate Taste. Journal of Food Science, 2017; DOI: 10.1111/1750-3841.13836 Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

Dr. Dando

Robin Dando, PhD
Assistant Professor
Director, Cornell Sensory Evaluation Facility
Department of Food Science
Cornell University
Ithaca, NY 14853 

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: The study arose from a previous paper I authored in the Journal of Neuroscience, where we found Adenosine receptors in taste.  We managed to prove that they were there to amplify sweet signals.  This led us to wonder, what about the foods we consume, that would come into contact with these receptors in taste buds.

It just happens that a lot of us habitually consume a powerful blocker of adenosine receptors every morning.  Caffeine.  So is our coffee impairing sweet signals?  It turns out when we gave people sweetened coffee containing caffeine, they judged it as less sweet than the same coffee without the caffeine, sampled on a different day.  Interestingly, this persisted, and sweet solutions they tested afterwards were still a little less sweet.

Finally, just for kicks, we asked them to rate how much caffeine they thought was in either coffee, and how much more alert it made them feel.  Turns out, there was no difference.  They couldn’t tell which was deacf, and either coffee gave them just as much of an alertness boost.

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Moderate Caffeine Not Linked to Arrhythmias In Heart Disease Patients

MedicalResearch.com Interview with:

Luis E. Rohde, MD, ScD Postgraduate Program in Health Science: Cardiology and Cardiovascular Sciences, Medical School, Federal University of Rio Grande do Sul, Cardiovascular Division, Hospital de Clínicas de Porto Alegre

Dr. Luis E. Rohde

Luis E. Rohde, MD, ScD
Postgraduate Program in Health Science: Cardiology and Cardiovascular Sciences, Medical School, Federal University of Rio Grande do Sul,
Cardiovascular Division, Hospital de Clínicas de Porto Alegre

MedicalResearch.com: What is the background for this study?

Response: Caffeine-rich beverages have been implicated as a common cause of several cardiac-related symptoms, such as palpitations, tachycardia, or irregular heartbeats.

Because of this “intuitive” assumption, counseling to reduce or avoid caffeine consumption is still widely recommended in clinical practice by most physicians for patients with any heart disease.
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Caffeine May Slow Progression of Liver Fibrosis in Chronic Hepatitis C

MedicalResearch.com Interview with:

Sikarin Upala MD, MS, LLB Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, New York Preventive and Social Medicine Mahidol University, Bangkok, Thailand

Dr. Sikarin Upala

Sikarin Upala MD, MS, LLB
Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, New York
Preventive and Social Medicine
Mahidol University, Bangkok, Thailand

MedicalResearch.com: What is the background for this study? What are the main findings?

Dr. Upala: Chronic hepatitis C virus infection is the most common cause of chronic liver disease and cirrhosis as well as the most common cause of liver transplantation in the United States. As caffeine has been found to be related to decreased liver enzymes, chronic liver disease,cirrhosis, and risk of hepatocellular carcinoma in several liver disease pathologies. There is inconclusive findings on the effect of caffeine on hepatitis C infected patients. Thus, we conducted a systematic review and meta-analysis to summarize the effect of caffeine consumption in patients with chronic hepatitis C.

We found that caffeine consumers have a 61% reduced risk of developing advanced hepatic fibrosis, which is one of the consequence of chronic hepatitis C. Our meta-analysis result is in the same way with other studies who found that coffee consumption could prevent the development of hepatic fibrosis in patients with liver disease. However, we cannot conclude about the effect of caffeine on HCV viral load as there is not enough information.

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Miscarriage Risk Reduced by Daily Multivitamins Before and After Conception

MedicalResearch.com Interview with:

Germaine M. Buck Louis, Ph.D., M.S. Office of the Director, Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development Rockville, Maryland 20852.

Dr-Germaine M. Buck-Louis

Germaine M. Buck Louis, Ph.D., M.S.
Office of the Director
Division of Intramural Population Health Research
Eunice Kennedy Shriver National Institute of Child Health and Human Development
Rockville, Maryland 20852.

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: To understand the association between couples’ lifestyles and risk of pregnancy loss.  Couples were recruited upon discontinuing contraception to try for pregnancy and followed daily for up to one year of trying or until pregnancy.  Pregnant women were followed daily for 7 weeks following conception then monthly.

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Early Use of Caffeine In Premature Infants

Dr. Abhay Lodha, MBBS, MD, DM, MSC Assistant Professor, Department of Pediatrics and Community Health Sciences, University of Calgary, Staff Neonatologist and Clinical Epidemiologist, Section of Neonatology, Alberta Health Services, Chairman, CME Foothills Medical Centre, Calgary, Alberta, CanadaMedicalResearch.com Interview with:
Dr. Abhay Lodha, MBBS, MD, DM, MSC
Assistant Professor, Department of Pediatrics and Community Health Sciences, University of Calgary,
Staff Neonatologist and Clinical Epidemiologist, Section of Neonatology, Alberta Health Services, Chairman, CME
Foothills Medical Centre, Calgary, Alberta, Canada

Medical Research: What is the background for this study? What are the main findings?

Dr. Lodha: Apneic episodes (cessation of breathing) occur in the premature infants. Caffeine is the most commonly used medication for apnea of prematurity. Normally caffeine started on day 3 of life for apnea. However, there is no strong evidence that starting caffeine on day 1 or 2 life has some extra advantages in premature infants. Our study has a large number of premature infants. Our study determined the association of early initiation of caffeine therapy in very preterm neonates and neonatal outcomes.

The main finding of our study was that early use of caffeine was associated with a reduction in the rate of death or bronchopulmonary dysplasia and patent ductus arteriosus. We did not find any adverse impact on any other outcomes.
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Cafffeine Intake Associated With Reduced Kidney Stone Risk

Pietro Manuel Ferraro, MD PhD Candidate Division of Nephrology Catholic University of the Sacred Heart Rome ItalyMedicalResearch.com Interview with:
Pietro Manuel Ferraro, MD PhD Candidate
Division of Nephrology
Catholic University of the Sacred Heart
Rome Italy

Medical Research: What are the main findings of the study?

Dr. Ferraro: We analyzed the association between caffeine intake and the risk of developing kidney stones in three large cohorts of U.S. health professionals. The 217,883 participants included did not have any history of kidney stones when follow-up began. During 20 years of follow-up, 4,982 of them developed a kidney stone. In all three cohorts, participants with higher intakes of caffeine had a reduced risk of developing kidney stones. Intake of caffeine from sources other than coffee was also associated with reduced risk of kidney stones. Among 6,033 participants with 24-hour urine data, intake of caffeine was associated with higher excretion of calcium but also higher urine volume and lower likelihood of calcium and uric acid stone formation. Continue reading

How Much Caffeine Should Kids and Teens Ingest?

MedicalResearch.com Interview with:
Naman Ahluwalia, PhD, DSc, FACN
Nutrition Monitoring Advisor
Office of the Director
Division of Health and Nutrition Examination Surveys, NCHS, CDC
Hyattsville, MD 20782

Medical Research: What are the main findings of the study?

Dr. Ahluwalia: Health Canada has put forth caffeine intake guidelines for children and adolescents in absolute amounts (mg) and in mg/kg body weight for teens. The maximal caffeine intakes of 45, 63, and 85 mg/day are suggested for children ages 4-6, 7-9, and 10-12 years and for teens (13 y and over) Health Canada suggests that caffeine intake be no more than 2.5 mg/kg body weight/day. Although no such recommendations have been set in the US, the American Academy of Pediatrics (AAP) underlines that “caffeine and other stimulant substances contained in energy drinks have no place in the diet of children.”

This study provides national estimates of dietary caffeine intake in US children 2-19 y of age, both in absolute amounts (mg) and in relation to body weight (mg/kg), to update estimates that were published in another study in 2005 based on older data from the Continuing Survey of Food Intakes by individuals in 1994-96 and 1998.

The key findings were:

1. Majority (71%) of children in the survey reported consuming caffeine on a given day; over one-half of US children aged 2-5 y and 3 in 4 children ages 6 y and over consumed caffeine on a given day.

2. Certain socio-demographic patterns in caffeine intake were observed. More non-Hispanic white and Mexican American children reported consuming caffeine than non-Hispanic black children; in addition, the amount of caffeine consumed by non-Hispanic white and Mexican American children was higher than that consumed by non-Hispanic black children. Caffeine intake increased with age. For instance, 2-5 year-old caffeine consumers reported 5 mg of caffeine intake on a given day, compared to 9 mg for 6-11 y olds and ~ 40 mg for teens (12-19 y). For reference, a 8 fl oz can of soda contains about 24-50 mg of caffeine.

3. Another finding was that on a given day one in ten children (6-19 y) had caffeine intakes that exceeded the Canadian maximal guidelines.

4. Caffeine intake (mg or mg/kg) stayed relatively constant among teens over the last decade, but trends towards decreased intake were noted in younger (2-11 y old) children.
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Hot Flashes? Nightsweats? It May Be Your Caffeine….

Stephanie Faubion, M.D Director of the Women’s Health Clinic Mayo Clinic in RochesterMedicalResearch.com Interview with:
Stephanie Faubion, M.D
Director of the Women’s Health Clinic
Mayo Clinic in Rochester

 

Medical Research: What are the main findings of the study?

Dr. Faubion: In this study that included over 1800 women, we found that caffeine intake was associated with more bothersome hot flashes and night sweats in postmenopausal women.
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Could Caffeine Slow Progression of Alzheimer’s Disease?

Prof. Dr. Christa E. Müller University of Bonn Pharmaceutical Institute Pharmaceutical Chemistry I An der Immenburg 4  D-53121 Bonn (Endenich) Germany  MedicalResearch.com Interview with:
Prof. Dr. Christa E. Müller
University of Bonn Pharmaceutical Institute Pharmaceutical
Chemistry I An der Immenburg 4  D-53121 Bonn (Endenich) Germany

MedicalResearch.com: What are the main findings of the study?

Prof. Dr. Christa E. Müller: Genetically altered mice which show an aggregation of Tau protein and many symptoms of Alzheimer’s Disease which progressively worsen with time was used.

Caffeine was given to one group of mice at an early stage, when the symptoms were still moderate.

The caffeine-treated mice showed better memory and less inflammation and brain damages in comparison to the non-treated control mice. This means that caffeine protected the mice to some extent. The side effects were moderate.

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The Impact of Green Tea and Coffee Consumption on the Reduced Risk of Stroke

MedicalResearch.com Interview with:
Yoshihiro Kokubo, MD, PhD, FACC, FAHA, FESC

Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, 5-7-1, Fujishiro-dai, Suita, Osaka,

MedicalResearch.com: What are the main findings of the study?

Dr. Kokubo:  In this study, higher green tea (2 or more cups/day) and coffee (3 to
6 times/week, 1 or more cups/day) consumption were found to be
inversely associated with the incidences of cardiovascular disease and
stroke. Higher green tea (2 or more cups/day) or coffee (1 or more
cups/day) consumption reduced the risks of cardiovascular disease,
strokes, and its subtypes, especially in intracerebral hemorrhage (P
for interaction between green tea and coffee=0.04).
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