Annals Thoracic Surgery, Author Interviews, Dental Research, Heart Disease, Infections, Mayo Clinic / 01.03.2014

Dr. Kendra J. Grim Department of Anesthesiology Mayo Clinic, Rochester, MN 55905 MedicalResearch.com Interview with: Dr. Kendra J. Grim Department of Anesthesiology Mayo Clinic, Rochester, MN 55905 MedicalResearch.com: What are the main findings of the study? Dr. Grim: “The current guidelines say that if possible, treating the dental problems that patients have before heart surgery is best, to try to prevent both early and late heart infections. But the data is very unclear, because it’s very difficult to study. We found in our study that their risk of serious complications after having teeth removed may be higher than we thought. We were primarily looking at stroke, heart attack, renal failure and death. We found that actually the incidence of having one of those major morbidities was 8 percent. Of that 8 percent, we had six patients, or 3 percent, of the total group who died between their dental surgery and scheduled heart surgery, so these patients never made it to their heart surgery. An additional 3 percent of patients died after heart surgery. “ (more…)
Annals Internal Medicine, Author Interviews, Cost of Health Care, Heart Disease, UCSF / 25.02.2014

Dhruv S. Kazi, MD, MSc, MS Assistant Adjunct Professor Division of Cardiology San Francisco General Hospital Department of Medicine, and Department of Epidemiology and Biostatistics University of California San Francisco MedicalResearch.com Interview with: Dhruv S. Kazi, MD, MSc, MS Assistant Adjunct Professor Division of Cardiology San Francisco General Hospital Department of Medicine, and Department of Epidemiology and Biostatistics University of California San Francisco MedicalResearch.com: What is the background of your study? Dr. Kazi: When we first asked the research question -what is the role of genotyping among patients receiving a stent for ACS, we quickly realized that there were no RCTs that had directly compared ticagrelor with prasugrel. But in our opinion, that was precisely the reason to build a model and systematically synthesize the available literature. There are nearly half a million PCIs for ACS in the US each year, and each time, the physician and patients have to examine the trade-offs between the various alternatives. What our model does is that it explicates the trade-offs - makes them transparent, and quantifies them. So patients and physicians can make an informed decision on what is the optimal therapy for them. (more…)
Author Interviews, Heart Disease, JAMA / 22.02.2014

Carlos A. Morillo, MD, FRCPC, FACC, FHRS, FESC Professor Department of Medicine, Cardiology Division Program Director Cardiac Electrophysiology and Autonomic Physiology Fellowship Arrhythmia & Pacing Service McMaster University-HHSC Director Syncope and Autonomic Disorder Unit Senior Investigator, Arrhythmia & Global Health, Population Health Research Institute Hamilton, ON, Canada MedicalResearch.com Interview with: Carlos A. Morillo, MD, FRCPC, FACC, FHRS, FESC Professor Department of Medicine, Cardiology Division Program Director Cardiac Electrophysiology and Autonomic Physiology Fellowship ,Hamilton, ON, Canada MedicalResearch.com: What are the main findings of the study? Dr. Morillo: The main findings were that Ablation of atrial fibrillation was superior to conventional antiarrythmic drug therapy in patients with Paroxysmal atrial fibrillation that had not been treated with Antiarrhythmic medications. Ablation extended the time to first recurrence of atrial fibrillation within the 2 year follow-up of the study and significantly reduced the recurrence of repeated episodes of AF. (more…)
Author Interviews, Heart Disease, Surgical Research / 19.02.2014

Sammy Elmariah, MD, MPH Massachusetts General Hospital Boston, MA MedicalResearch.com Interview with: Sammy Elmariah, MD, MPH Massachusetts General Hospital Boston, MA   MedicalResearch.com: What are the main findings of the study? Dr. Elmariah: Within the randomized PARTNER I trial, we evaluated the effect of left ventricular (LV) dysfunction on clinical outcomes after transcatheter and surgical aortic valve replacement (TAVR and SAVR, respectively) and the impact of valve replacement technique on recovery of LV function. We found that LV dysfunction, defined as an LV ejection fraction < 50%, had no impact on 30-day and 1-year mortality after either TAVR or SAVR. In those with baseline LV dysfunction, marked improvement in LV ejection fraction was observed within 30-days of valve replacement in approximately half of patients, with an equivalent degree of improvement observed after TAVR and SAVR. Permanent pacemaker at study entry, low mean aortic valve gradient, and high LV ejection fraction were associated with reduced odds of LV functional recovery after valve replacement. (more…)
Annals Internal Medicine, Author Interviews, General Medicine, Heart Disease / 18.02.2014

MedicalResearch.com Interview with: Caroline A. Kim, MD, MS; Beth Israel Deaconess Medical Center Boston, MA 02215. MedicalResearch.com: What are the main findings of the study? Dr. Kim: We conducted a systematic review of 62 studies that examined functional status and quality of life in patients who underwent transcatheter aortic valve replacement (AVR) for their symptomatic severe aortic valve stenosis. In 11,205 patients who underwent TAVR, a clinically meaningful improvement was seen in physical functional measures and disease-specific quality of life measures, whereas improvement in psychological measures or more general health measures were modest and inconsistent. Given the dismal prognosis of severe aortic stenosis treated conservatively, it was clear that transcatheter AVR improved functional status and quality of life. However, there was insufficient evidence that compares these patient-centered outcomes between transcatheter AVR and surgical AVR. (more…)
Author Interviews, Heart Disease, Vitamin D / 14.02.2014

Eirik Magnus Meek Degerud Department of Clincal Medicine University of Bergen MedicalResearch.com Interview with: Eirik Magnus Meek Degerud Department of Clincal Medicine University of Bergen MedicalResearch.com: What are the main findings of the study? Answer: That among patients with established coronary artery disease there was no observable relationship between the amount of vitamin D circulating in their blood and the extent of disease progression during the following year. (more…)
Author Interviews, Heart Disease / 10.02.2014

Bríain ó Hartaigh, Ph.D. Assistant Research Professor of Epidemiology Dalio Institute of Cardiovascular Imaging Weill Cornell Medical College MedicalResearch.com Interview with: Bríain ó Hartaigh, Ph.D. Assistant Research Professor of Epidemiology Dalio Institute of Cardiovascular Imaging Weill Cornell Medical College MedicalResearch.com: What are the main findings of the study? Answer: Sustained elevations in resting heart rate measured longitudinally over the course of 6 years were strongly and independently associated with a greater risk of death from all causes in adults aged 65 years or older. (more…)
Author Interviews, Heart Disease, JAMA, Nutrition, Sugar / 03.02.2014

MedicalReseach.com Interview with: Quanhe Yang, PhD Division for Heart Disease and Stroke Prevention Centers for Disease Control and Prevention, Atlanta, GA 30341 MedicalReseach.com: What are the main findings of the study? Dr. Yang: The majority of US adults consume more added sugar than is recommended for a healthy diet. On average, Americans consume about 15% of daily calories from added sugar. About 70% of adults consume more than 10%of calories from added sugar and another 10% consume more than 25% of calories from added sugar. When you compare those who consume 7.5% (lowest quintile) of calories from added sugar with participants who consume between 17%-21% (quintile 4) of calories from added sugar, the latter group has a 38% higher risk of CVD mortality. But the risk of CVD death more than doubles for those who consume ≥21% (highest quintile) of calories from added sugar. (more…)
Author Interviews, Heart Disease / 31.01.2014

Professor Gregory Y.H. Lip MD, FRCP (London, Edinburgh, Glasgow), DFM, FACC, FESCUniversity of Birmingham, Centre for Cardiovascular Sciences, City Hospital Consultant Cardiologist & Professor of Cardiovascular Medicine, Director - Haemostasis Thrombosis & Vascular Biology Unit Birmingham, United Kingdom MedicalResearch.com Interview with: Professor Gregory Y.H. Lip MD, FRCP Consultant Cardiologist & Professor of Cardiovascular Medicine, Director - Haemostasis Thrombosis & Vascular Biology Unit Birmingham, United Kingdom MedicalResearch.com: What are the main findings of the study? [GYHL] In this large-scale nationwide cohort study, we found that switching to dabigatran increased the risk of MI compared to continued warfarin usage in the early period after switching. Caution may be warranted especially when switching prior VKA-experienced patients with atrial fibrillation to dabigatran. This risk was not evident in the warfarin-naïve cohort newly started on dabigatran. (more…)
Author Interviews, BMJ, Heart Disease, Nutrition / 15.01.2014

Dr Victoria J Burley Senior Lecturer in Nutritional Epidemiology School of Food Science and Nutrition University of Leeds Biostatistics, University of Leeds, UK MedicalResearch.com Interview with: Prof. Victoria J Burley Senior Lecturer in Nutritional Epidemiology School of Food Science and Nutrition University of Leeds Biostatistics, University of Leeds, UK MedicalResearch.com: What are the main findings of the study? Prof. Burley: Although it’s been suggested for a long time that foods rich in dietary fiber may protect individuals from having a heart attack or stroke because they lower some of the risk factors for these diseases, trying to determine how much dietary fibre might be beneficial and whether these benefits are apparent in all populations around the world has been less easy to research. Our research at the University of Leeds has pooled the results of published large-scale follow-up studies and has demonstrated a consistent lowering of risk of cardiovascular and coronary heart disease with increasing dietary fiber intake. This dose-response trend suggests that even small additional increments in intake may be beneficial in the long term. (more…)
Author Interviews, CMAJ, Heart Disease / 02.01.2014

MedicalResearch.com Interview with: Laura Maclagan, MSc. Epidemiologist, Cardiovascular Program ICES Central Toronto, Ontario M4N 3M5 MedicalResearch.com: What are the main findings of the study? Answer: We developed the CANHEART health index in order to measure the cardiovascular health of the Canadian population. The index is based on the prevalence of six health factors and behaviours known to be associated with cardiovascular health; being a non-smoker, being physically active, consuming at least 5 fruits and vegetables per day, having a low body mass index (BMI <25 kg/m²) and being free of diabetes and hypertension. The factors were summed to create an index ranging from 0 (worst) to 6 (best/ideal). We found that only 9.4% of Canadian adults age 20 and older met our definition of ideal cardiovascular health. 53.3% of adults were in intermediate cardiovascular health (4-5 healthy behaviours/factors) and 37.3% were in poor cardiovascular health (0-3 healthy behaviours). We found that the cardiovascular health of Canadians was stable over the 2003-2011 study period. (more…)
Author Interviews, Heart Disease, Kidney Disease / 31.12.2013

Dr Amitava Banerjee NIHR Clinical Lecturer in Cardiovascular Medicine University of Birmingham UK MedicalResearch.com Interview with: Dr Amitava Banerjee NIHR Clinical Lecturer in Cardiovascular Medicine University of Birmingham UK MedicalResearch.com: What are the main findings of the study? This was the first long-term study in individuals with atrial fibrillation to consider the impact of renal function, as measured by eGFR, on stroke/thromboembolism, mortality and bleeding in the same population concurrently. Answer: There were three main findings of our study.
  • First, patients with worsening renal function had more severe risk factor profiles and had higher rates of stroke/thromboembolism, mortality and bleeding.
  • Second, individuals receiving oral anticoagulation had lower rates of stroke/thromboembolism and mortality than those not receiving anticoagulation at all levels of renal function measured by eGFR, suggesting that anticoagulation has benefit in even patients with low eGFR.
  • Third, renal function was not an independent predictor of stroke/thromboembolism at 1 year after adjustment for baseline characteristics. (more…)
Author Interviews, Heart Disease, Rheumatology / 18.12.2013

MedicalResearch.com Interview with: M Mushfiqur Rahman, MSc. PhD candidate School of Population and Public Health University of British Columbia, Statistical Analyst Arthritis Research Centre of Canada 5591 No. 3 Road, Richmond BC, Canada, V6X 2C7; MedicalResearch.com: What are the main findings of the study? Author’s response: Using 18 years of administrative health records from British Columbia, Canada, our aim was to determine whether osteoarthritis increases the risk of cardiovascular disease in a longitudinal study. We also examined the risks of specific cardiovascular conditions such as, myocardial infarction, ischemic heart disease, congestive heart failure, and stroke after adjusting for age, sex, socio-economic status, diabetes, hypertension, hyperlipidemia, chronic obstructive pulmonary disease, and a co-morbidity score. We observed a significant increase in the risk of cardiovascular disease, ischemic heart disease, and congestive heart failure among individuals with osteoarthritis compared with age-sex matched non-osteoarthritis individuals. Our data suggests that adult women and men aged 65 years and older with osteoarthritis had higher risks of developing these conditions. The risks were also higher among severe osteoarthritis patients who had undergone total joint replacement surgeries. Men aged between 20-64 years with osteoarthritis did not show higher risks of developing these conditions. (more…)
Author Interviews, Coffee, Heart Disease / 22.11.2013

MedicalResearch.com Interview with: Masato Tsutsui, MD, PhD, FAHA Professor and Chairman Department of Pharmacology Graduate School of Medicine University of the Ryukyus Okinawa 903-0215, Japan MedicalResearch.com: What are the main findings of the study? Dr. Tsutsui: A recent large prospective study reported that coffee consumption is associated with reduced mortality for cardiovascular disease (NEJM 2012). However, its precise mechanisms remain to be clarified. Our double-blind, placebo-controlled, crossover study demonstrated, for the first time, that caffeine contained in a cup of coffee ameliorates microvascular endothelial function in healthy individuals. These findings may explain, at least in part, the association of coffee consumption with reduced mortality for cardiovascular disease. (more…)
Author Interviews, Diabetes, Heart Disease, JCEM, Weight Research / 21.11.2013

Carlos Lorenzo, MD Department of Medicine, University of Texas Health Science Center 7703 Floyd Curl Drive San Antonio, Texas 78229 MedicalResearch.com Interview with: Carlos Lorenzo, MD Department of Medicine, University of Texas Health Science Center 7703 Floyd Curl Drive San Antonio, Texas 78229 MedicalResearch.com: What are the main findings of the study? Dr. Lorenzo: Metabolically healthy obese individuals are at increased risk of developing of diabetes and cardiovascular disease. These findings were demonstrated in men and women and in Mexican Americans and non-Hispanic whites. Management of excess weight and any metabolic abnormality appears to be important for all individuals. Our study is also in agreement with previous studies that indicate that metabolically unhealthy normal weight individuals are at increased risk of developing of diabetes and cardiovascular disease. (more…)
Author Interviews, Heart Disease, JAMA, Weight Research / 21.11.2013

MedicalResearch.com Interview with: Prof. Prashanthan Sanders MedicalResearch.com Interview with: Prof. Prashanthan Sanders Director, Centre for Heart Rhythm Disorders University of Adelaide | Royal Adelaide Hospital | SAHMRI NHMRC Practitioner Fellow Centre for Heart Rhythm Disorders Department of Cardiology | Royal Adelaide Hospital Adelaide 5000 | Australia MedicalResearch.com: What are the main findings of the study? Answer: Aggressive treatment of risk factors and weight reduced the symptom burden associated with atrial fibrillation. It is therefore important that in a similar manner to how we treat coronary artery disease, in atrial fibrillation there should be management directed at the reasons why these individuals got AF in the first place. (more…)
Allergies, Author Interviews, Heart Disease, Metabolic Syndrome, Pediatrics, Sleep Disorders, Surgical Research / 16.11.2013

MedicalResearch.com Interview with: Nina Berentzen Centre for Nutrition, Prevention and Health Services National Institute for Public Health and the Environment Bilthoven The Netherlands MedicalResearch.com: What are the main findings of the study? Answer: This study in 11-12 year old children shows that self-reported characteristics of sleep quality were not associated with blood pressure and HbA1c; and that in girls, but not in boys, some sleep characteristics were associated with anthropometric outcomes (BMI, waist circumference) and cholesterol levels. More specifically, in girls, longer time in bed was associated with lower BMI and waist circumference; having night-time awakenings with higher total cholesterol, going late to bed while rising early with higher total and HDL cholesterol; and feeling sleepy/tired during daytime with lower HDL cholesterol and with higher total-to-HDL cholesterol ratio. We report new findings for daytime outcomes of sleep quality that were not studied before in relation to cardiometabolic risk; e.g. difficulty with getting up in the morning, feeling rested after waking, and feeling sleepy or tired during the day. Our study therefore offers insight not only in characteristics of sleep at night, but also in consequences of sleep during the day. (more…)
Author Interviews, Heart Disease, Pediatrics / 10.11.2013

MedicalResearch.com interview with: Martha Mullett, MD MPH Neonatology West Virginia Universty Ped&Neo 1 Medical Center Dr Morgantown, WV 26506 Martha Mullett, MD MPH Neonatology West Virginia Universty Ped&Neo 1 Medical Center Dr Morgantown, WV 26506   MedicalResearch.com: What are the main findings of the study? Dr. Mullett: The unique findings in this study relate to differences in triglycerides (TG) in premature infants and small for gestational age (SGA) infants when in 5th grade, at which time the children are approximately 11 years old. Premature infants have higher triglyceride levels in 5th grade than term infants.(p<.05) This difference appears in those premature infants who become overweight/obese by this age, but this reaches only a trend level. (p=.058) SGA infants who become overweight/obese by 5th grade (BMI ≥ 85th percentile) have TG that are significantly higher than all other 5th grade groups. (more…)
Author Interviews, Calcium, Gender Differences, Heart Disease / 09.11.2013

Joshua Lewis, Ph.D Raine Foundation / Alan Robson Fellow Bone and Vascular Research Group School of Medicine and Pharmacology University of Western Australia Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital Hospital Avenue, Nedlands 6009 MedicalResearch.com Interview with: Joshua Lewis, Ph.D Raine Foundation / Alan Robson Fellow Bone and Vascular Research Group School of Medicine and Pharmacology University of Western Australia Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital Hospital Avenue, Nedlands 6009 www.boneandvascularresearch.org.au MedicalResearch.com: What are the main findings of the study? Dr. Lewis: The paper reports the findings from an ancillary study of the effects of 1200 mg per day of calcium supplementation on a major predictor of heart disease risk, carotid artery intima-medial thickness and atherosclerosis. The principle study was a large five-year double blind randomized controlled trial of calcium supplements or a placebo. After 3 years of calcium supplementation or placebo measures of carotid artery intima-medial thickness were identical in the placebo and calcium treated patients. Atherosclerotic plaque was reduced in calcium treated patients when analysed as total calcium intake. These findings argue strongly against an adverse effect of high dose calcium tablets on cardiovascular risk. (more…)
Author Interviews, Heart Disease, JAMA, Wake Forest / 05.11.2013

Elsayed Z Soliman MD, MSc, MS, FAHA, FACC Director, Epidemiological Cardiology Research Center (EPICARE) Wake Forest School of Medicine Medical Center Blvs, Winston Salem, NC 27157 MedicalResearch.com Interview with: Elsayed Z Soliman MD, MSc, MS, FAHA, FACC Director, Epidemiological Cardiology Research Center (EPICARE) Wake Forest School of Medicine Medical Center Blvs, Winston Salem, NC 27157 Atrial Fibrillation and the Risk of Myocardial Infarction MedicalResearch.com: What are the main findings of the study? Dr. Soliman: Using data from the REGARDS study, one of the largest US cohorts, we examined the risk of incident myocardial infarction (MI) associated with atrial fibrillation (AF). Overall, AF was associated with almost double the risk of MI. When we adjusted for common cardiovascular risk factors and potential confounders, the risk remained significantly high; about 70% increased risk. When we looked at women, men, blacks, and whites separately, we found significant differences between races and sex. AF in women and blacks was associated with more than double the risk of MI. This compares to less than 50% increased risk of heart attack associated with AF in men and whites . So AF is basically bad for all, but the risk of MI associated with AF is more pronounced in women and blacks. (more…)
Author Interviews, Gastrointestinal Disease, Heart Disease, Weight Research / 01.11.2013

Gianluca Iacobellis MD PhD Professor of Clinical Medicine Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA MedicalResearh.com Interview with: Gianluca Iacobellis MD PhD Professor of Clinical Medicine Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA MedicalResearch.com: What are the main findings of the study? Dr. Iacobellis: Our study suggests that epicardial fat, the fat pad in direct contiguity to the heart, is a good predictor of liver steatosis in obese subjects (more…)
Author Interviews, Heart Disease, Mayo Clinic, Rheumatology / 30.10.2013

Eric Matteson, M.D. Rheumatology Chair Mayo Clinic in Rochester, Minn. MedicalResearch.com Interview with: Eric Matteson, M.D. Rheumatology Chair Mayo Clinic in Rochester, Minn. MedicalResearch.com: What are the main findings of the studies? Dr. Matteson: “The main finding is that patients with severe rheumatoid arthritis have a higher risk of heart disease. Further, women who experience early menopause also have a higher risk of heart disease.” (more…)
Author Interviews, Heart Disease, Rheumatology / 29.10.2013

MedicalResearch.com Interview with: Lotta Ljung, MD, PhD Umeå University, Umeå and Karolinska Institute Stockholm, Sweden MedicalResearch.com: What are the main findings of the study? Dr. Ljung: In this observational study we observed a lower risk of acute coronary syndromes in a cohort of patients with rheumatoid arthritis (RA) exposed to tumor necrosis factor inhibitors (TNFi) compared with the risk among patients without this exposure. The adjusted relative risk (HR) was 0.73-0.82 among TNFi exposed patients compared with the biologics-naive RA cohort, depending on the time frame evaluated, which can be concluded as a moderately lower risk. Compared with the risk in the general population, the risk in RA patients was higher, whether exposed to TNFi or not. (more…)
Diabetes, Diabetes Care, Heart Disease / 28.10.2013

MedicalResearch.com Interview with: Marcin Sadowski Świętokrzyskie Cardiology Center, Kielce, Poland MedicalResearch.com: What are the main findings of the study? Dr. Sadowski: In multivariable analysis, diabetes was an independent risk factor of in-hospital and 1-year mortality in women treated for STEMI. In women with STEMI and diabetes one-year mortality was significantly lower in those treated with primary percutaneous coronary intervention than in those on optimal medical therapy. Early and long-term prognoses after STEMI were the worst in diabetic women, compared with non-diabetic women and diabetic men. (more…)
Author Interviews, Diabetes, Heart Disease, Nutrition, Omega-3 Fatty Acids / 22.10.2013

MedicalResearch.com Interview wit: Elin Strand

Researcher, Department of Clinical Science University of Bergen, Norway MedicalResearch.com: What are the main findings of this study? Answer: The main findings in this prospective observational cohort study among patients with established coronary artery disease were that a very high intake of omega-3 fatty acids was associated with a reduced risk of acute myocardial infarction in patients with diabetes, but with an increased risk of fatal acute myocardial infarction and with lower glycosylated hemoglobin in those without impaired glucose metabolism. (more…)
Author Interviews, Heart Disease / 18.10.2013

Dr. med. Jelena Kornej Department of Electrophysiology, Heart Center, University of Leipzig, Leipzig, Germany & University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom MedicalResearch.com Interview with: Dr. med. Jelena Kornej Department of Electrophysiology, Heart Center, University of Leipzig, Leipzig, Germany & University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom MedicalResearch.com: What are the main findings of the study? Answer: The main finding of our analysis was that thromboembolic events after atrial fibrillation (AF) catheter ablation are rare, but all three stroke risk stratification scores, i.e. CHADS2, CHA2DS2-VASc, and R2CHADS2 were associated with thromboembolic risk in anticoagulated population. Furthermore, patients with AF recurrences had increased risk for thromboembolic complications. (more…)
Author Interviews, Heart Disease, Hospital Readmissions, JACC, Outcomes & Safety / 18.10.2013

Saul Blecker, MD, MHS Department of Population Health, NYU School of Medicine, New York, NY Department of Medicine, NYU School of Medicine, New York, NY MedicalResearch.com Interview with: Saul Blecker, MD, MHS Department of Population Health, NYU School of Medicine Department of Medicine, NYU School of Medicine, New York, NY   MedicalResearch.com: What are the main findings of the study? Dr. Blecker: Inpatient quality of care has focused primarily on patients with acute heart failure, commonly identified by principal discharge diagnosis code. However, patients with heart failure are commonly hospitalized for other causes and should benefit from many of the same treatments. We found that in our sample, as compared to patients with a principal diagnosis of heart failure, heart failure patients hospitalized with a non–heart failure diagnosis had lower rates of guideline-concordant care, including assessment of left ventricular function and prescription for an ACE inhibitor or ARB, at time of discharge. This is important as our study suggests that these therapies were associated with reduced mortality for patients hospitalized with heart failure, regardless of the reason for hospitalization. (more…)
Author Interviews, Cancer Research, Heart Disease, Radiology / 16.10.2013

Prof. Dr. Gunnar Brix Division of Medical and Occupational Radiation Protection Federal Office for Radiation Protection Institut für Med. Strahlenhygiene 85764 Neuherberg MedicalResearch.com: Prof. Dr. Gunnar Brix Division of Medical and Occupational Radiation Protection Federal Office for Radiation Protection Institut für Med. Strahlenhygiene 85764 Neuherberg MedicalResearch.com: What are the main findings of the study? Answer: We investigated the cumulative radiation exposure and cancer risk of more than 1200 patients with ischemic heart diseases (IHD) from diagnostic and therapeutic imaging procedures performed 3 month before and 12 month after the date of diagnosis. The major findings were:
  • ­ 87% of patient exposure resulted from heart catheter procedures.
  • ­ The average cumulative effective dose was 13.3 mSv in males and 10.3 mSv in females. The highest dose was nearly 100 mSv.
  • ­ The estimated average attributable life-time risk of male and female patients to develop a radiation-induced cancer in their remaining life was 0.09 % and 0.07 %, respectively. This correspond to 1 excess cancer in about 1100 male and 1400 female IHD patients. The highest risk was 0.9 %.
  • ­ The effective dose is inadequate to characterize individual radiation risks, since neither the age nor the sex of the patient is taken into account. According to our results, cancer risks can vary by a factor of more than 10 for comparable values of the effective dose. (more…)
Author Interviews, Exercise - Fitness, Heart Disease, Weight Research / 14.10.2013

MedicalResearch.com Interview with: Christian K. Roberts Exercise and Metabolic Disease Research Laboratory, Translational Sciences Section, School of Nursing University of California, Los Angeles, CA MedicalResearch.com: How would you best summarize the main findings/results of this study? Answer: Our main finding was that HDL functioned better in its antioxidant role in subjects who participated in resistance exercise training (i.e. weight training) a minimum of 4 days a week, regardless of their weight—one group was lean (BMI <25) and the other overweight/obese (BMI >27) —than those who didn’t exercise (overweight, BMI >27, and untrained). In addition, HDL had similar effectiveness as an antioxidant in the overweight-trained group as in the as lean-trained group. Although indices of weight were associated with dysfunctional HDL, differences in fitness may be a better measure of who has healthier functioning HDL. (more…)
Author Interviews, Heart Disease, Mineral Metabolism, Stroke / 14.10.2013

Abhishek Sharma, M.B.B.S. Maimonides Medical Center in Brooklyn, N.Y. MedicalResearch.com Interview with: Abhishek Sharma, M.B.B.S. Maimonides Medical Center in Brooklyn, N.Y.   MedicalResearch.com: What are the main findings of the study? Answer: Evidence from RCT's and observational studies suggests a significantly increased risk of atrial fibrillation (AF) requiring hospitalization, but no increase in risk of stroke or cardiovascular mortality with the use of bisphosphonate. (more…)