Heart Disease / 24.09.2013
Severe Aortic Stenosis: Flow-Gradient Patterns after Aortic Valve Replacement
MedicalResearch.com Interview with:
Mackram Eleid, MD
Division of Cardiovascular Diseases and Internal Medicine
MedicalResearch.com: What are the main findings of the study?
Dr. Eleid: Our study investigated the characteristics, outcomes and impact of aortic valve replacement in a large series of 1704 patients with severe aortic stenosis (aortic valve area < 1 cm2) and preserved ejection fraction (EF > 50%) according to the flow-gradient classification that incorporates both stroke volume index and mean aortic valve gradient. The primary findings were that patients with low flow, low gradient AS have lower survival than other flow-gradient patterns (a 3.2-fold increase risk of mortality compared to normal flow, low gradient), and their survival is improved with aortic valve replacement. Conversely, patients with normal flow and low gradient had a favorable survival with medical management, suggesting a less advanced stage of disease compared to the other groups. Additionally, a novel observation from this study is that patients with low flow had a higher prevalence of atrial fibrillation and previous heart failure events compared to other groups.
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