Alcohol, Author Interviews, Breast Cancer, JNCI, OBGYNE / 30.08.2013 Interview with:Ying Liu, MD, PhD Instructor, Division of Public Health Sciences Department of Surgery Washington University School of Medicine 660 South Euclid Ave Campus Box 8100 St. Louis, MO 63110 What are the main findings of the study?Answer: Alcohol intake between menarche (first menstrual period) and first pregnancy was consistently associated with increased risks of breast cancer and proliferative benign breast disease. For every 10 gram/day alcohol intake (approximately a drink a day) during this specific time period, the risk for breast cancer increased by 11% and the risk for proliferative benign breast disease increased by 16%. (more…)
Author Interviews, NEJM, OBGYNE / 29.08.2013 Interview with: Ms. Mølgaard-Nielsen Statens Serum Institut Artillerivej 5, 2300 Copenhagen S, Denmark are the main findings of the study?Answer: Use of oral fluconazole during early pregnancy did not increase the risk of birth defects overall in common therapeutic doses. We also looked at 15 individual birth defects of previous concern and oral fluconazole was not associated with an increased risk for 14 of these birth defects. However, we did see an increase in the risk of tetralogy of Fallot, an uncommon congenital heart defect, but the number of exposed cases was few. (more…)
Author Interviews, Diabetes, JCEM, OBGYNE, Obstructive Sleep Apnea, Sleep Disorders / 22.08.2013

Sirimon Reutrakul MD Section of Endocrinology Department of Medicine Rush University Medical Center Chicago, Illinois Interview with Sirimon Reutrakul MD Section of Endocrinology Department of Medicine Rush University Medical Center Chicago, Illinois 60612 What are the main findings of the study?Answer: We found a strong association between obstructive sleep apnea and gestational diabetes mellitus. In pregnant women diagnosed with gestational diabetes, the risk of obstructive sleep apnea is increased nearly 7-fold compared to those without gestational diabetes. In addition, we found that in non-diabetic women, pregnancy is associated with more disrupted sleep. (more…)
Author Interviews, BMJ, OBGYNE, Weight Research / 15.08.2013 Interview with: Rebecca M Reynolds, Professor of Metabolic Medicine Endocrinology Unit, BHF/University Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh EH14 6TJ, UK What are the main findings of the study?Answer: We found that the adult offspring of women who were obese at the start of pregnancy were 35% more likely to die prematurely than offspring of normal-weight women. We also found that children born to mothers who were overweight when they became pregnant had an 11% increased risk of premature death. Adult offspring of mothers who were obese were also at increase risk of hospital admissions for cardiovascular events. (more…)
Author Interviews, Cancer Research, OBGYNE / 01.08.2013 Interview with:: Marcela G. del Carmen, M.D., M.P.H Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology Massachusetts General Hospital, 55 Fruit Street, Yawkey 9 E Boston, Massachusetts What are the main findings of the study? Answer: The study sample included 7,973 women, including 7,363 (92.3%) whites and 610 (7.7%) AA, diagnosed with vulvar cancer from 1973 to 2009. African American women were younger and had a higher rate of distant metastasis compared to white women. African American women were more likely to be treated by radiaton therapy and less likely to receive survival therapy. Although the study found that compared to white women, African Americans were more likely to be younger and have more advanced disease upon diagnosis, they had lower rates of vulvar cancer related mortality compared to white women. (more…)
Author Interviews, Menopause, OBGYNE / 26.07.2013 Interview with:Catherine A. Matthews, MD Associate Professor and Division Chief Urogynecology and Reconstructive Pelvic Surgery University of North Carolina, Chapel Hill What are the main findings of the study?Dr. Matthews: Women under 50 should try and preserve their ovaries at the time of hysterectomy for benign disease; however, women over 50 should consider elective ovarian removal as a way to reduce ovarian cancer. There is no adverse impact on cardiovascular, bone or sexual health in women over 50 who elect ovarian removal. (more…)
OBGYNE, Thromboembolism / 24.07.2013 Interview with: Sheree Boulet, DrPH, MPH Assisted Reproductive Technology Surveillance and Research Team Women's Health and Fertility Branch Division of Reproductive Health Centers for Disease Control and Prevention What are the main findings of the study?Dr. Boulet: Between 1994-2009, the rate of pregnancy-related hospitalizations with venous thromboembolism (VTE) increased by 14%. We also found that the prevalence of hypertension, obesity, diabetes, and heart disease increased over the same time period for pregnancy hospitalizations with VTE. (more…)
Author Interviews, Cost of Health Care, OBGYNE / 19.07.2013 Interview with: Robert E. Garfield, PhD Department of Perinatology, Division of Obstetrics and Gynecology University Medical Centre Ljubljana, Slovenia Costs of Unnecessary Admissions and Treatments for “Threatened Preterm Labor” :What are the main findings of the study?Dr. Garfield: Unnecessary admissions and treatments for “threatened preterm labor” are still part of everyday clinical practice and contribute to exploding healthcare costs. This happens despite substantial evidence that measuring CL by trans-vaginal ultrasound can help to avoid needless interventions due to the high negative predictive values of this test. (more…)
Author Interviews, Heart Disease, OBGYNE / 18.07.2013 Interview with Prof. Eyal Sheiner MD PhD Senior Obstetrician

Soroka Medical Center, Israel What are the main findings of the study?Dr. Sheiner:The study was aimed to investigate whether a history of preterm delivery (PTD) poses a risk for subsequent maternal long-term cardiovascular morbidity. During the study period 47,908 women met the inclusion criteria; 12.5% (n=5992) patients delivered preterm. During a follow-up period of more than ten years, patients with PTD had higher rates of simple as well as complex cardiovascular events and higher rate of total cardiovascular related hospitalizations. A linear association was found between the number of previous PTD and future risk for cardiovascular hospitalizations (5.5% for two or more PTD, 5.0% for one PTD vs. 3.5% in the comparison group; P<0.001). The association remained significant for spontaneous vs. induced PTD and for early (<34 weeks) as well as late (34-36+6 weeks) PTD. In a Cox proportional hazards model that adjusted for pregnancy confounders such as labor induction, diabetes mellitus, preeclampsia and obesity, PTD was independently associated with cardiovascular hospitalizations (adjusted HR 1.4, 95% CI 1.2-1.6). (more…)
Author Interviews, Nutrition, OBGYNE, Race/Ethnic Diversity / 06.07.2013 Interview with: Dr. Lauren A. Wise Slone Epidemiology Center 1010 Commonwealth Avenue Boston, MA What are the main findings of the study?Dr. Wise: We found that the strong inverse association between dairy and uterine fibroids in black women in the Black Women's Health Study is not explained by percent European ancestry. (more…)
Anemia, Author Interviews, BMJ, OBGYNE, Pediatrics / 04.07.2013 Interview with Batool Haider, MD, MS, DSc candidate Departments of Epidemiology and Nutrition School of Public Health Harvard University Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and What are the main findings of the study?Dr. Haider: The main findings of the study are that iron use in the prenatal period increased maternal mean haemoglobin concentration by 4.59 (95% confidence interval 3.72 to 5.46) g/L compared with controls and significantly reduced the risk of anaemia (relative risk 0.50, 0.42 to 0.59), iron deficiency (0.59, 0.46 to 0.79), iron deficiency anaemia (0.40, 0.26 to 0.60), and low birth weight (0.81, 0.71 to 0.93). The effect of iron on preterm birth was not significant (relative risk 0.84, 0.68 to 1.03). Analysis of cohort studies showed a significantly higher risk of low birth weight (adjusted odds ratio 1.29, 1.09 to 1.53) and preterm birth (1.21, 1.13 to 1.30) with anaemia in the first or second trimester. Exposure-response analysis indicated that for every 10 mg increase in iron dose/day, up to 66 mg/day, the relative risk of maternal anaemia was 0.88 (0.84 to 0.92) (P for linear trend<0.001). Birth weight increased by 15.1 (6.0 to 24.2) g (P for linear trend=0.005) and risk of low birth weight decreased by 3% (relative risk 0.97, 0.95 to 0.98) for every 10 mg increase in dose/day (P for linear trend<0.001). Duration of use was not significantly associated with the outcomes after adjustment for dose. Furthermore, for each 1 g/L increase in mean haemoglobin, birth weight increased by 14.0 (6.8 to 21.8) g (P for linear trend=0.002); however, mean haemoglobin was not associated with the risk of low birth weight and preterm birth. No evidence of a significant effect on duration of gestation, small for gestational age births, and birth length was noted. (more…)
Author Interviews, Nutrition, OBGYNE, Pediatrics / 17.03.2013 Interview with : Verena Sengpiel, researcher Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg What are the main findings of the study?Response: 1. Coffee, but not caffeine, consumption was associated with marginally increased gestational length but not with the risk of spontaneous preterm delivery. 2. Caffeine intake was consistently associated with decreased birth weight and increased odds of SGA (small for gestational age). This might have clinical implications as even caffeine consumption below the recommended maximum (200 mg/d in the Nordic countries and USA, 300 mg/d according to WHO) was associated with increased risk for SGA. (more…)