- Women with irregular menses had a statistically significant 2.4 fold increase in risk of death due to any form ovarian cancer, and a statistically significant 3-fold increase in risk of death due to late stage serous disease. Consistent with these findings, the incidence of late stage disease at diagnosis, and late stage serous cancer was increased about 2-fold in women with irregular menses.
- Irregular menses was defined as irregular cycles (variation of 10 days or more) or infrequent cycles (>35 days) or history of annovulatory cycles identified during an in-person interview with women at an average age of 26 years or mentioned in their medical records. (more…)
MedicalResearch.com Interview with: Dr. Hong-Mei Xiao M.D.,Ph.D. Cognition Section Professor of Gynecology，Reproductive Medicine The Institute of Reproduction and Stem Cell Engineering Xiangya School of Medicine, Central South University Vice director, Reproduction and Genetics Hospital of CITIC-Xiangya China, ChangshaMedicalResearch.com: What are the main findings of the study? Dr. Xiao: The study presents the first cases of human primary infertility due to mutation in a zona pellucida gene. We have identified a homozygous frameshift mutation in ZP1 ( GenBank accession number, KJ489454) resulting in the aberrant ZP1, which affects the formation of zona pellucida. We detected an autosomal-recessive pattern of inherited infertility. (more…)
MedicalResearch.com Interview with: Dr. Andrea Parriott MPH, PhD Department of Epidemiology Fielding School of Public Health University of California Los AngelesMedicalResearch.com: What are the main findings of the study? Dr. Parriott: We wanted to know whether hospital and provider volume (i.e. the number of deliveries performed by each hospital and provider per quarter) and cesarean section rates were predictors of the risk of methicillin-resistant Staphylococcus aureus (MRSA) infection before discharge from the hospital (after delivering a baby). We did not find an association between any of these variables and risk of MRSA infection. (more…)
- Anonymous sperm donation may lead to unions between relatives, especially between half-siblings and to an increase of both consanguinity and the frequencies of recessive diseases. We made an evaluation of the actual consequences of anonymous sperm donation in France and we concluded that they can be considered as negligible when compared to those due to false paternities, four times higher.
- The risk of inadvertent unions between half-sibs is often advocated and we showed that it may be estimated to as few as one case every 10 years. Consequently, the main level of consanguinity in the French population is not modified and unions between first cousins within the sub-population from Mediterranean origin remain the main source of consanguinity.