Alzheimer's - Dementia, Author Interviews, JAMA, UC Davis / 25.03.2024
With Better Health Comes Bigger Brains In US Population
MedicalResearch.com Interview with:
[caption id="attachment_61484" align="alignleft" width="150"]
Dr. DeCarli[/caption]
Charles DeCarli, MD, FAAN, FAHA
Victor and Genevieve Orsi Chair in Alzheimer's Research
Distinguished Professor of Neurology
Director, Alzheimer's Disease Research Center
and Imaging of Dementia and Aging (IDeA) Laboratory
Department of Neurology and Center for Neuroscience
University of California at Davis
Sacramento, CA 95817
MedicalResearch.com: What is the background for this study?
Response: The overall health of the U.S. population has improved dramatically over the last 100 years, Individuals are also living longer resulting in an increasing percentage of the population at risk for Alzheimer’s disease and related dementias (ADRD). Recent data from the Framingham Heart study, however, finds that dementia incidence may be declining. While many factors such as greater educational achievement and medical management of vascular risk factors may explain part of this effect, early life environmental differences also likely contribute.
Dr. DeCarli[/caption]
Charles DeCarli, MD, FAAN, FAHA
Victor and Genevieve Orsi Chair in Alzheimer's Research
Distinguished Professor of Neurology
Director, Alzheimer's Disease Research Center
and Imaging of Dementia and Aging (IDeA) Laboratory
Department of Neurology and Center for Neuroscience
University of California at Davis
Sacramento, CA 95817
MedicalResearch.com: What is the background for this study?
Response: The overall health of the U.S. population has improved dramatically over the last 100 years, Individuals are also living longer resulting in an increasing percentage of the population at risk for Alzheimer’s disease and related dementias (ADRD). Recent data from the Framingham Heart study, however, finds that dementia incidence may be declining. While many factors such as greater educational achievement and medical management of vascular risk factors may explain part of this effect, early life environmental differences also likely contribute.
Dr. Pierce[/caption]
John Pierce, PhD
Professor Emeritus
Department of Family Medicine and Public Health
Moores Cancer Center Director for Population Sciences
Co-leader of the Cancer Prevention program
UC San Diego
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Graphic Warning Labels are to be implemented in the US in July 2022, depending on litigation. This will be about 10 years after they were first proposed. Meanwhile, 120 other countries have implemented them already.
The FDA states that their purpose for the warnings is to provide a constant reminder to smokers about the health consequences of smoking, not to force them to quit.
In our study, 3 months of having cigarettes repackaged into graphic warning packs was associated with smokers thinking more about quitting and not getting as much pleasure out of their cigarettes. However, thinking about quitting is only the first step to conquering a nicotine addiction.
Dr. Longo[/caption]
Valter Longo, PhD
Edna M. Jones Professor of Gerontology
Professor of Biological Sciences
Leonard Davis School of Gerontology
Director of the USC Longevity Institute
USC
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The use of a low calorie diet that mimics fasting for 4 days twice a month starting at middle age can extend lifespan and rejuvenate mice.
In humans a similar diet once a month causes improvements in cholesterol, blood pressure , inflammation, fasting glucose etc consistent with rejuvenation














