Author Interviews, Gastrointestinal Disease, Hepatitis - Liver Disease, Weight Research / 07.05.2025

MedicalResearch.com Interview with: Dr. Katilyn Gernhard DO Internal Medicine Resident Allegheny Health Network Pittsburgh MedicalResearch.com: What is the background for this study? Response: The background for this study is the steadily rising prevalence of obesity in the United States, which has been accompanied by an increase in related comorbid conditions, including Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD). Bariatric surgery and GLP-1 receptor agonists are two commonly used treatment options to address obesity and its associated complications. While both have demonstrated benefits in weight loss and metabolic improvement, there has been limited direct comparison of their effectiveness specifically in patients with MASLD. Our study aimed to address this gap by comparing clinical outcomes in patients with MASLD treated with GLP-1 receptor agonists versus those treated with bariatric surgery. (more…)
Weight Research / 09.04.2025

For decades, achieving the dream body has been a pursuit often tangled in unrealistic expectations and unsustainable methods. We're told to count calories meticulously, follow strict workout regimens, and sacrifice joy at the altar of discipline. And while nutrition and physical activity remain foundational, the modern wellness world has evolved enter weight loss injections. This innovative approach is not a miracle cure, nor is it a shortcut for laziness. Rather, it's an evidence-based tool helping thousands break through biological barriers, hormonal blocks, and metabolic plateaus that once seemed insurmountable. The dream body? It's not about six-pack abs or size-zero jeans. It’s about confidence, vitality, and the freedom to live without constantly battling your body. In today’s fast-paced society, where time is scarce and stress is abundant, traditional fitness models are no longer sufficient for everyone. Despite the most valiant efforts, some bodies resist change. Genetics plays a role. So do hormones, age, medical conditions, and mental health. That’s where medically supervised interventions like weight loss injections provide a spark of hope. They don't erase the importance of healthy living they enhance it. They optimize your body’s potential to burn fat, curb hunger, and recalibrate metabolism. More than anything, they level the playing field. (more…)
Author Interviews, Weight Research / 20.03.2025

MedicalResearch.com Interview with: Prof. Marwan EL GHOCH Professore Associato in Scienza dell'Alimentazione e Tecniche Dietetiche Applicate MEDS-08/C Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze Università di Modena e Reggio Emilia Modena, 41125, Italy MedicalResearch.com: What is the background for this study? Response: Body mass index (BMI) is an easy-to-use tool to determine an individual’s by classifying him/her as having normal weight, overweight, or obesity, and this is based on universal cut-off points suggested by the World Health Organization (WHO) for all age groups. Not taking into account the potential changes that may occur to body composition compartments during the individual’s lifespan. In fact, little is still known about this topic in people with overweight and obesity. For this reason our study aimed to compare the body composition compartments between three different age groups (young, middle-age, and older adults), adopting a design that matched these 3 age groups by BMI. (more…)
Diabetes / 14.01.2025

Diabetes is one of the most prevalent chronic conditions globally, affecting millions of people. Whether it's Type 1 or Type 2 diabetes, managing blood sugar levels effectively is crucial to preventing complications and maintaining a high quality of life. With advancements in medical science, the landscape of diabetes management has evolved significantly, offering patients more options than ever before. 

Understanding Type 1 and Type 2 Diabetes

Before diving into modern medications, it's essential to understand the fundamental differences between Type 1 and Type 2 diabetes, as these differences often dictate the type of treatment required.

Type 1 Diabetes

Type 1 diabetes is an autoimmune condition where the body mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. This results in little or no insulin production, making individuals with Type 1 diabetes reliant on insulin therapy to regulate their blood glucose levels. It usually manifests early in life, although it can develop at any age. Managing Type 1 diabetes requires careful monitoring and adjusting of insulin doses, often with the help of advanced tools like insulin pumps and continuous glucose monitors (CGMs).

Type 2 Diabetes

Type 2 diabetes, on the other hand, is primarily characterized by insulin resistance, where the body does not respond to insulin as effectively as it should. Over time, the pancreas may struggle to produce enough insulin to overcome this resistance, leading to elevated blood glucose levels. Type 2 diabetes is more common in adults, though increasing rates are now being observed in younger populations due to lifestyle factors like poor diet and lack of exercise. In addition to lifestyle changes, medications are often required to help manage the condition. Understanding these distinctions is crucial because it helps in determining the most appropriate medications and treatment plans for each type of diabetes. (more…)
Weight Research / 26.12.2024

Weight loss medications have become such a game-changer. For years, weight loss was all about diet and exercise, which can be a real uphill battle for most folks. But now, with medications like Mounjaro showing such promising results real progress has been made in the fight against obesity. Even with a game-changing drug like Mounjaro, there's still a learning curve. And one of the most common questions patients ask is: "Where's the best place to inject this medication?"

What is Mounjaro?

Mounjaro, also known by its generic name Tirzepatide, is a relatively new medication making waves in the weight loss world. It mimics the effects of two naturally occurring hormones in the body: GLP-1 and GIP. These hormones regulate blood sugar levels, appetite, and metabolism. Semaglutide class of medications on the other hand like Ozempic for weight loss, contain a GLP-1 receptor agonist. Mounjaro is actually FDA-approved for treating type 2 diabetes. But it also has an impressive side effect: weight loss. And not just a little bit of weight loss, either. We're talking double-digit percentages here. So, while Mounjaro isn't officially approved for weight loss, many doctors are prescribing it off-label to help patients achieve their weight loss goals.  (more…)
Weight Research / 22.11.2024

In a world consumed by quick fixes and trendy diets, it can often be challenging to pinpoint a strategy for weight loss that is both effective and enduring. Sustainable weight loss shifts focus from drastic short-term losses to gradual, long-term lifestyle adjustments. These modifications promote weight reduction and overall better health and vitality for numerous individuals in bustling regions like Texas. Sustainable weight management solutions such as Weight Loss Texas offer tailored guidance and support options that accommodate diverse personal health needs. This approach underscores balance and sustainability, ensuring that changes can be permanently woven into daily life.

Understanding Your Baseline

A foundational stage in any effective weight loss plan is clearly understanding your starting point. Determining your Body Mass Index (BMI) and daily caloric requirements equips you with the knowledge to set realistic, personalized goals. Your baseline acts as a living document that can evolve as you progress, adjusting plans to reflect changes in your body composition. Setting attainable short and long-term objectives is paramount to sustaining motivation and seeing tangible results. Resources such as the CDC's guide on BMI provide informative insights on establishing these benchmarks, steering you towards an educated path in your weight loss journey. (more…)
Semaglutide, Weight Research / 19.10.2024

In recent years, injectable weight loss medications have surged in popularity, becoming a preferred choice for individuals seeking effective and sustainable weight management solutions. This trend is driven by advancements in medical science, increased awareness of obesity-related health risks, and the convenience offered by online healthcare platforms. Among the various options available, medications like semaglutide and tirzepatide have gained significant attention for their efficacy in promoting weight loss.

Understanding Injectable Weight Loss Medications

Injectable weight loss medications are typically prescribed for individuals struggling with obesity or those who have not achieved desired weight loss results through diet and exercise alone. These medications work by targeting specific hormones and receptors in the body that regulate appetite, metabolism, and fat storage. Unlike oral weight loss pills, injectables often provide more consistent and potent effects, making them a viable option for long-term weight management. (more…)
Surgical Research, Weight Research / 14.10.2024

  Maintaining a healthy weight is important at any age, but it becomes even more crucial as we grow older. For seniors, managing weight can help improve overall well-being, reduce the risk of chronic diseases, and increase mobility and independence.   However, weight loss strategies that might work for younger people aren’t always appropriate for older adults. Seniors need safe, effective methods tailored to their unique physical, mental, and nutritional needs.   This article will explore some safe and effective weight loss strategies for seniors, focusing on ways to stay fit and healthy while maintaining energy and strength. (more…)
Semaglutide, Weight Research / 23.09.2024

Ozempic (semaglutide) is a prescription medication designed to help manage type 2 diabetes. It belongs to a class of drugs called GLP-1 receptor agonists, which work by increasing insulin production, reducing blood sugar levels, and slowing digestion to help improve glucose control. Ozempic has also gained attention for its potential role in weight management, but its primary use is for patients with type 2 diabetes who need help controlling their blood sugar. ozempic-weightloss To get the best results from Ozempic, following the correct dosing schedule is critical. A structured approach to dosage allows the body to adjust to the medication, reduces the likelihood of side effects, and ensures that patients achieve optimal blood glucose control over time. Many people also explore options to buy Ozempic from Canada as a way to save on costs while maintaining their treatment regimen In this article, you will learn about Ozempic dosing, how to follow the dosing schedule, where to inject, what to do if you miss a dose, and more. Read on to find out how you can also save on Ozempic when you order through BuyCanadianInsulin.com. Editor' note: If you are purchasing Ozempic from Canada, please ensure it is legal where you live and that you are not purchasing a counterfeit product. (more…)
Semaglutide, Weight Research / 18.09.2024

If you’ve been hearing a lot of buzz about the Wegovy pen and are curious about what it can do for weight loss, you're in the right place. There’s a lot to understand, but we’re going to break it down into simple, easy-to-follow information. Whether you're exploring your options or have already made up your mind about giving it a try, here's everything you need to know about the Wegovy pen.

What is the Wegovy Pen?

Let’s start with the basics. The Wegovy pen is a once-weekly injectable medication that’s used to support weight loss in adults. It contains the active ingredient semaglutide, which is designed to help regulate appetite. In simple terms, it helps you feel fuller for longer, so you're less likely to overeat. Semaglutide mimics a hormone called GLP-1 (glucagon-like peptide-1), which plays a role in controlling hunger. By imitating this hormone, Wegovy helps reduce food cravings and manages how much you eat. (more…)
Author Interviews / 17.09.2024

Editor's note: If you purchase semaglutide or similar medications, be sure to be followed by your health care provider and verify that the supplier is reputable before your purchases. When it comes to weight loss, it often feels like everyone has an opinion. Some swear by keto, while others say it's all about intermittent fasting. And let’s not forget the ever-popular crash diets that promise instant results but leave you feeling sluggish and starving. With so much conflicting advice, how can you figure out what actually works? This post attempts to break down the science behind weight loss, cutting through the noise and getting to the core of what really makes a difference in shedding those extra pounds—without the fads. weight-obesity-scale

Calories In, Calories Out: The Basics

At its most fundamental level, weight loss comes down to one basic principle: calories in versus calories out. The idea is simple—if you consume fewer calories than your body needs, you'll lose weight. This is known as creating a calorie deficit. Your body has to find energy somewhere, and when you're not giving it enough through food, it starts to use stored fat. However, it's not always as straightforward as it seems. People have different metabolic rates, meaning some burn calories faster than others. Plus, hormones, genetics, and lifestyle factors can all affect how easy or difficult it is to drop pounds. This is why two people on the same diet might experience different results. Key takeaway: To lose weight, you need to consistently eat fewer calories than you burn. But keep in mind that individual factors can influence how quickly (or slowly) this happens for you. (more…)
Weight Research / 09.09.2024

Tirzepatide is an innovative medication recently making waves in the treatment of type 2 diabetes and obesity. Known by its brand names, Mounjaro and Zepbound, this medication is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. While its efficacy in managing blood glucose levels and supporting weight loss is noteworthy, it’s crucial for patients and healthcare providers to fully understand the potential side effects associated with tirzepatide. This article delves into the detailed aspects of tirzepatide side effects, providing key insights for those considering this medication.

What is Tirzepatide?

Tirzepatide belongs to a new class of medications designed to manage blood sugar in adults with type 2 diabetes. It works by mimicking the action of two incretin hormones—GIP and GLP-1—which help regulate insulin secretion, slow down gastric emptying, and reduce appetite. These combined effects make tirzepatide particularly effective for controlling blood sugar levels and promoting weight loss, making it a dual-action treatment option. (more…)
Nutrition, Weight Research / 04.09.2024

Semaglutide has emerged as a promising medication for weight loss, offering significant results for many users. Wegovy's semaglutide , a glucagon-like peptide-1 (GLP-1) receptor agonist, works by mimicking a natural hormone that regulates appetite and food intake. Combining semaglutide with healthy lifestyle changes can accelerate weight loss and improve overall outcomes. While semaglutide alone can lead to impressive weight reduction, there are strategies to enhance its effectiveness. Eating a nutritious, low-calorie diet rich in fiber and protein can complement the appetite-suppressing effects of the medication. Regular physical activity further supports weight loss efforts and overall health improvements. It's important to note that the full effects of semaglutide may take several weeks to become noticeable. Patience and consistency are key when using this medication for weight management. As with any weight loss journey, individual results may vary, but many users experience significant reductions in body weight over time.

Key Takeaways

  • Semaglutide mimics GLP-1 to regulate appetite and food intake
  • Combining the medication with a healthy diet and exercise enhances weight loss
  • Consistency and patience are crucial for optimal results with semaglutide
(more…)
Surgical Research, Weight Research / 03.09.2024

Making the decision to seek bariatric surgery is one to make only once you are sure you are ready for it. This is a life-changing experience and one that requires a significant amount of work. Yet, the results are often highly desirable and could even extend your life while improving your well-being. To determine if weight loss surgery is the best decision for you, take the time to learn as much as you can about the process and the results. Take into consideration your health and long-term well-being. The first step is to meet the medical guidelines required by most doctors and surgeons to obtain bariatric surgery. These typically include:
  • Body mass index (BMI) rating of 40 or higher, though some doctors may consider 35 or higher.
  • Have a lower BMI but health complications that make losing weight quickly helpful
  • For those who are younger, including adolescents, you may need to have a BMI of at least 40 to qualify
While your bariatric surgeon will offer insight into when this type of care is best suited for you, it helps to consider the other factors that may also play a role in whether or not you are ready for weight loss surgery. (more…)
Diabetes, Weight Research / 28.08.2024

Editor's note:  Compounding is allowed when there is a shortage of the drug involved, but legal restrictions should be followed.  In recent years, the world of diabetes management has seen a major breakthrough with GLP-1 receptor agonists like Tirzepatide. These cutting-edge therapies aren't just about controlling blood sugar levels; they represent a fundamental shift in how we manage chronic diseases. Tirzepatide and other GLP-1 drugs have captured the attention of the medical community and patients alike because of their potential to enhance overall health and promote longevity. Thanks to recent studies, we're seeing a future where diabetes management goes beyond traditional approaches. Instead, we're moving into a world of comprehensive metabolic health where we can hope for a healthier, longer life. It's exciting to think about what these new therapies could mean for people living with diabetes and how they could change the broader landscape of healthcare. Tirzepatide is an incredible medication that boasts a unique dual action mechanism as both a GLP-1 and GIP receptor agonist. This one-of-a-kind attribute means that Tirzepatide is able to offer an array of benefits in regards to glucose control. By increasing insulin secretion and reducing glucagon levels, Tirzepatide assists with blood sugar regulation in a powerful way.  Tirzepatide has also been shown to be a valuable tool in managing obesity, which is a common comorbidity in type 2 diabetes. The weight loss properties of this medication have been linked to improved metabolic outcomes and reduced cardiovascular risk. Truly, Tirzepatide is a force to be reckoned with in the medical community. (more…)
Surgical Research, Weight Research / 27.08.2024

Gastric balloons are a popular non-surgical treatment for weight loss, thanks to their effectiveness in helping patients lose weight by restricting food intake and experiencing a feeling of fullness. Although the procedure might be similar regardless of the option chosen by the patient, Spatz3 is the only gastric balloon in the market that has the possibility of adjusting its size. This proposes various benefits that make the success rate score higher than with non-adjustable gastric balloons.

WHAT IS A GASTRIC BALLOON

To understand the differences between an adjustable and non-adjustable gastric balloon, first, we need to understand how they work. A gastric balloon is made of silicone rubber that’s inserted through the mouth and placed in the stomach using an endoscope. Once it’s in the stomach, it’s filled with saline solution to take up space. Because of the lack of space around it once filled, the patient will feel satiated quicker, eat less, and therefore, lose weight. The procedure usually takes 15 minutes, and the patient can go home once the sedation wears off. The first two weeks after the procedure, the patient will be on a liquid diet and gradually transition to solid food. Usually, the healthcare professionals will offer other guidelines, such as a recommended diet or workout plan, so that the patient continues losing weight not only while the gastric balloon is inside but also after it’s been removed. Unless there is any intolerance issue, the balloon will remain in the patient’s stomach for six months. Once it’s removed, he or she is expected to continue practicing the same healthy habits to maintain the weight loss. (more…)
Pharmacology, Semaglutide / 11.08.2024

Oral Semaglutide has emerged as a significant advancement in the realm of weight loss treatments. As an alternative to traditional injectable options, oral Semaglutide offers convenience and effectiveness. This guide provides an in-depth look at oral Semaglutide, its benefits, how to access it through prescriptions, and explores compounded semaglutide online.

What is Oral Semaglutide?

Oral Semaglutide is an oral form of the medication Semaglutide, which was originally available only as an injection. It is used to manage weight loss and control blood sugar levels in individuals with obesity or type 2 diabetes.
  • Mechanism of Action: Semaglutide mimics a hormone called GLP-1, which helps regulate appetite and insulin secretion. By enhancing these processes, it can support significant weight loss and better blood sugar control.
  • Approval and Usage: The oral version is approved by the FDA for weight management and is typically prescribed as part of a comprehensive weight loss plan that includes diet and exercise.
(more…)
Weight Research / 15.07.2024

Let's talk about something we all think about but rarely understand deeply—obesity and metabolism. There's a lot of noise out there, and it's easy to get lost in the myths. So, let's cut through the confusion. Get ready to get real information about how our bodies work and why we gain weight.

Obesity: An Overview

Obesity isn't just about carrying a few extra pounds; it's a chronic condition characterized by an excessive accumulation of body fat. It's typically measured using the Body Mass Index (BMI). A BMI of 30 or higher indicates obesity. This excess body fat can have serious consequences for your health. It increases the risk of many health conditions, including type 2 diabetes, heath disease, and varicose veins. Seeking a nutrition and considering a vein treatment in Philadelphia can provide targeted treatments for obesity-related issues. 

Causes of Obesity

Some of the factors that increase the risk of obesity include: - Poor diet - Lack of physical activity - Genetics - Psychological factors (more…)
Weight Research / 10.06.2024

Key Takeaways
  • Personalized weight management is crucial in achieving sustainable results.
  • Combined data from multiple sources enhances personalization.
  • Maintaining a relationship between providers and consumers boosts success rates.
The Need for Personalization in Weight Management Personalized weight management plans are essential in today's health-focused world, and research consistently shows their effectiveness over generic approaches. According to a study by the Centers for Disease Control and Prevention (CDC), customized weight management strategies lead to tremendous long-term success in weight loss. Additionally, platforms like BuildMyBod offer providers a turnkey solution to offer diverse services that cater to personal health needs, showing how personalization is becoming a cornerstone in weight management. (more…)
Weight Research / 01.02.2024

Bariatric surgery has a long history of proven successes. It helps to lose excess weight and empowers the individual to enjoy a fulfilling life. Losing weight is one of the prime benefits that propel people to undergo the knife. When considering Denver bariatric surgery services, patients experience other benefits. The benefits include better pain relief, cardiovascular health, hypertension, diabetes management, and mental health. When a person suffers from obesity and weight-associated health issues, bariatric surgery enhances the quality of life. Reverse Serious Diseases and Health Issues Several clinical studies show that bariatric surgery reverses long-term Type 2 diabetes. Weight loss helps lower blood cholesterol and blood sugar and reduce the risk of strokes and heart diseases. The surgery gives hope to several patients with Type 2 diabetes to stop using insulin and medications. One simple surgery reverses serious health issues and enhances overall well-being. Individuals enjoy leading more active lives by eliminating long-term health conditions. To maintain a high-quality life, patients must maintain their lifestyle to experience the benefits of bariatric surgery in the long term. (more…)
Alzheimer's - Dementia, Author Interviews, Weight Research / 28.11.2023

MedicalResearch.com Interview with:

Mahsa Dolatshahi, M.D., M.P.H. Post-doctoral research fellow Mallinckrodt Institute of Radiology (MIR) Washington University School of Medicine St. Louis MedicalResearch.com: What is the background for this study? Response: Obesity at midlife is recognized as a risk factor for developing Alzheimer disease decades afterwards. However, body mass index on its own does not adequately represent the risks associated with obesity. In this study, we went beyond BMI and considered anatomical distribution of body fat, including the metabolically active visceral fat in the belly, and showed its association with Alzheimer pathology in the form of amyloid proteins. In addition, visceral fat along with obesity and insulin resistance were associated with thinning of brain cortex, as early as midlife. (more…)
Author Interviews, Mediterranean Diet, Nutrition / 01.11.2023

pexels.com/photo/fried-fish-in-vegetables-18750045US News & World Report announced  that the Mediterranean style of eating is the best overall diet for 2023.  Only 24 diets were ranked instead of 40 that were analyzed in the past years. Vegan, vegetarian, Nordic, traditional Asian and the glycemic index were integrated into the Mediterranean because of the ‘underlying plant-based principles.’ According to managing editor Gretel Schueller who oversees the annual diet ranking, they are always looking for more health conditions that they can address, but the lack of scientific data for examining other types of diets is a constraint.
Why Aim for Healthy Eating?
The specific recommendations for a healthy diet may differ, but the common approaches include consumption of a variety of fruits and veggies, whole grains, lean proteins, and healthy fats. Added sugars, salt, and saturated fats must be limited. For example, a healthy mouth is part of overall health. Research has demonstrated the link between gum disease and chronic health conditions such as heart disease, and diabetes, among others. Thus, it is vital to consume healthy foods that promote good gum health which are the foundation of solid teeth.
(more…)
Author Interviews, Exercise - Fitness / 19.09.2023

WeightControl.com Interview with: Tongyu Ma, Ph.D., MBBS, ACSM EP-C Assistant Professor of Exercise Physiology Franklin Pierce UniversityTongyu Ma, Ph.D., MBBS, ACSM EP-C Assistant Professor of Exercise Physiology Franklin Pierce University WeightControl.com:  What is the background for this study?  Response: The benefit of Moderate-to-Vigorous Physical Activity (MVPA) on weight management is widely recognized. We found that timing also matters. Individuals who accumulated MVPA in the early morning had lower BMI and WC, compared to those whose MVPA were in the midday or evening. (more…)
Author Interviews, Diabetes, Karolinski Institute, Pediatrics, Weight Research / 28.02.2023

MedicalResearch.com Interview with: Yuxia Wei | PhD Student Unit of Epidemiology Institute of Environmental Medicine Karolinska Institutet Stockholm | Sweden   MedicalResearch.com: What is the background for this study? Response: Diabetes is traditionally known for having two types (type 1 diabetes and type 2 diabetes). However, it is becoming increasingly clear that diabetes is much more complex than this traditional classification. Several attempts have been made to address this heterogeneity and in 2018, a  Swedish ground-breaking study proposed that there are five distinct subtypes of diabetes in adults. They have been replicated in different populations and it has been shown that there are differences between the subtypes in terms of genetics and risks of complications. Another way of elucidating the relevance of these subtypes is to investigate whether the influence of known risk factors for diabetes is different on different subtypes. Our study is one of the first attempts to address this. We used a study design known as Mendelian randomization, to investigate the influence of childhood obesity on these diabetes subtypes that typically occur after age 35. This work was a collaboration between Karolinska institutet in Stockholm, University of Bristol in the UK and Sun Yat-Sen University in China. (more…)
Author Interviews, Diabetes, Sleep Disorders, Weight Research / 26.09.2022

MedicalResearch.com Interview with: Steven K. Malin, PhD, FACSM (he/him) Associate Professor Department of Kinesiology and Health | School of Arts and Sciences Division of Endocrinology, Metabolism and Nutrition | Robert Wood Johnson Medical School Institute of Translational Medicine and Science New Brunswick, NJ 08901 MedicalResearch.com: What is the background for this study? Response: Type 2 diabetes is a condition where blood glucose (sugar) is elevated in the  blood. This can be problematic as it leads to blood vessel damage and the promotion of cardiovascular disease. Nearly 30 million people  in the U.S. have type 2 diabetes, making it a major public health issue. The cause is not entirely clear, but many, including our team view insulin resistance as a central culprit. Insulin resistance is when the body does not respond well to the hormone insulin. Insulin is vital because it promotes glucose uptake into tissues, like skeletal muscle. Two reasons that are often used to explain the development of insulin resistance include: poor diet (e.g. high sugar and/or high fat coupled with excess calories) and a lack of physical activity. However, more recently, a lack of sleep has been raised as another critical behavioral factor contributing to insulin resistance. Thus, targeting a healthy diet, activity and sleep pattern is thought to prevent the transition from health to insulin resistance and type 2 diabetes. (more…)
Author Interviews, Breast Cancer, JACC, Weight Research / 18.05.2022

MedicalResearch.com Interview with: Dr. Amy Kirkham, PhD Assistant Professor of Clinical Cardiovascular Health Faculty of Kinesiology & Physical Education University of Toronto Affiliate Scientist at Toronto Rehabilitation Institute MedicalResearch.com:  What is the background for this study?  Response: Women who have had a breast cancer diagnosis are at least two-fold and often higher risk of cardiovascular or heart disease compared to women without a history of breast cancer. Older age, higher body mass index, and receipt of chemotherapy treatment that can injure the heart are risk factors for cardiovascular death after a breast cancer diagnosis. Time-restricted eating is a type of intermittent fasting that appears to be easy to follow and to improve some measures of metabolic health but has not been studied in populations with a cancer history. Time-restricted eating simply involves consuming all calorie intake within a specific time window, commonly 8 hours, like between 12 and 8 pm, and then only consuming water or black coffee outside of those hours. We enrolled breast cancer survivors who were aged 60 or older, had an overweight or obese mass index, and were finished chemotherapy treatment in a single-arm trial of time-restricted eating for 8 weeks. We asked participants to restrict their calorie intake between 12 and 8 pm from Monday to Friday with no restrictions on weekend and no further instructions on what to eat. (more…)
Author Interviews / 04.05.2022

MedicalResearch.com Interview with: Louis Aronne, MD Co-Founder and Chief Medical Advisor at Intellihealth The Sanford I. Weill Professor of Metabolic Research Weill Cornell Medicine Medical Director of the Comprehensive Weight Control Center MedicalResearch.com:  What is the mission of Intellihealth?  Response: The mission of Intellihealth is transforming healthcare to help millions of people live healthier, happier lives through the medical treatment of obesity. Almost half of the US population has obesity but less than 2% are able to get treatment. The lack of available treatment and the stigmatized perception of obesity is what we aim to eliminate. (more…)
Author Interviews, Nature, Weight Research / 07.04.2022

MedicalResearch.com Interview with: Lee Roberts PhD Professor and Chair of Molecular Physiology and Metabolism Department of Discovery and Translational Science Leeds Institute of Cardiovascular & Metabolic Medicine School of Medicine University of Leeds MedicalResearch.com:  What is the background for this study?  What are the main findings?  Response: Obesity rates have nearly tripled worldwide since 1975. In 2016, there were more than 650 million adults aged 18 and above with obesity. Obesity can lead to increased fat in the blood which damages tissues and organs, contributing to the development of cardiovascular and metabolic diseases including type 2 diabetes. This elevated blood fat can damage the cellular organelle responsible for making protein, the endoplasmic reticulum, causing the cell to come under stress and potentially resulting in the cell dying. When this occurs in skeletal muscle it can contribute to features of the metabolic syndrome including metabolic dysfunction and insulin resistance. (more…)
Author Interviews, JAMA, Johns Hopkins, Weight Research / 25.11.2021

MedicalResearch.com Interview with: Alejandra Ellison-Barnes, MD MPH General Internal Medicine Johns Hopkins Medicine MedicalResearch.com: What is the background for this study? What are the main findings?  Response: Emerging adulthood is a unique period of development that ultimately leads to the formation of adult identity, but how this stage contributes to obesity is relatively understudied. The prevalence of obesity has been increasing in the United States population as a whole, and we wanted to know how mean body mass index and the prevalence of obesity have changed over the past several decades specifically among emerging adults. We found that among emerging adults aged 18 through 25, mean BMI has increased from 23.1 kg/m2 in 1976-1980 to 27.7 kg/m2 in 2017-2018. In the same period, the prevalence of obesity increased from 6.2% to 32.7%. (more…)
Author Interviews, Weight Research / 07.11.2021

MedicalResearch.com Interview with: Neha Agrawal PhD Department of Physiology Development and Neuroscience University of Cambridge MedicalResearch.com: What is the background for this study? Response: Obesity levels are rising rapidly around the world and are a major risk factor for diseases such as Type 2 diabetes, cancers and recently, COVID-19. New strategies to understand obesity are thus needed to prevent and treat obesity and associated disease. Genetic studies in humans have shown that 40-70% of variation in body weight depends on our genes. Therefore, identifying genes linked to obesity and understanding their function can be a useful way to both understand how we gain weight and identify potential targets for weight loss therapy. However, human genetic obesity studies face significant limitations in identifying causal obesity genes and understanding their relationship to weight gain in human patients. The model system Drosophila melanogaster (Fruit flies) has provided vital insights into fundamental biology and human diseases for over a century. It is a powerful genetic model with well conserved metabolic pathways. Fruit flies also gain weight when fed a high-sugar or high-fat diet and develop heart disease and diabetes. We therefore decided to use fruit flies to identify novel obesity genes and their site of action in the body. (more…)