Complementary Medicine, Dermatology / 28.08.2024

[caption id="attachment_62978" align="aligncenter" width="500"]natural-products Image Source[/caption] As more people become aware of the potential health risks associated with synthetic chemicals, there is a growing interest in natural products. These alternatives offer a simple way to enhance your well-being by reducing exposure to harmful substances. Incorporating natural products into your daily routine doesn’t have to be complicated or expensive—it’s about making mindful choices that align with a healthier lifestyle. Starting Your Day with Natural Personal Care Products One of the easiest ways to begin incorporating natural products into your life is by updating your personal care routine. The products you use on your skin daily can significantly impact your overall health. Many conventional skincare products contain synthetic chemicals that can be harsh on your skin and may even lead to long-term health concerns. Switching to natural skincare products can help you avoid these risks while providing your skin with nourishing, organic ingredients. For example, you can replace your regular facial cleanser with one made from natural ingredients like aloe vera or chamomile, which are gentle and soothing. Moisturizers that use coconut oil or shea butter offer hydration without the need for synthetic additives. When it comes to sun protection, natural sunscreens with zinc oxide provide effective UV protection while being kinder to your skin and the environment. Your morning routine is another area where you can easily swap out conventional products for natural alternatives. Start by choosing a natural toothpaste free of artificial flavors and colors. Natural deodorants, which avoid aluminum and synthetic fragrances, can help you stay fresh without compromising your health. For body care, opt for natural body washes and soaps made with essential oils and plant-based ingredients. For those looking to switch to natural products, Melaleuca.com offers a wide range of options. Founded by Frank VanderSloot, who grew up on a farm and values natural, sustainable practices, Melaleuca has become a valuable source for wellness products. VanderSloot's commitment to quality and sustainability is reflected in the products offered on the site, making it easier for individuals to make healthier choices.
Dermatology / 20.08.2024

[caption id="attachment_62900" align="alignright" width="134"]face-facecream_pexels-greta-hoffman-9475732 Source[/caption] Dark spots, also known as hyperpigmentation, can be pretty distressing and are often caused by factors such as prolonged sun exposure, aging, hormonal changes, and inflammation. Melanin, the pigment responsible for skin tone, is overproduced in response to solar radiation and subsequently aggregates to form dark patches. Similarly, hormonal changes, particularly during pregnancy or due to oral contraceptives, can trigger melanin overproduction. Inflammatory responses, such as those from acne or eczema, also contribute to dark spots. One product to explore for reducing dark spots is Gundry MD Dark Spot Diminisher. You can learn more about Gundry MD Dark Spot Diminisher Reviews for insight into how it may help reduce dark spots.
Dermatology, Exercise - Fitness / 19.08.2024

Have you ever experienced the discomfort of scratched skin and wondered what activities might be causing it? Skin chafing is a common issue that can affect anyone, and understanding its triggers can help in prevention. Let’s explore the everyday activities that can lead to this irritating condition and how to manage them effectively.

Exercise and Physical Activity

[caption id="attachment_62883" align="alignleft" width="300"]exercise-running-chafing-pexels Image Source[/caption] Exercise is one of the most common culprits for chafed skin. Activities like running, cycling, and even walking can cause friction between the skin and clothing or between skin surfaces, leading to chafing. High-impact movements increase sweating, which further exacerbates the problem. Wearing moisture-wicking, well-fitting athletic wear can help reduce friction and keep the area dry. Applying anti-chafing balms or powders before exercising can also prevent irritation. Staying hydrated and choosing appropriate gear are essential to avoiding chafing during workouts.
Dermatology / 05.08.2024

MedicalResearch.com Interview with: Hannah CederHannah Ceder Department of Dermatology and Venereology Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg, Sweden   MedicalResearch.com: What is the background for this study? Response: Many facial basal cell carcinomas (BCCs) are currently excised without prior biopsy, often resulting in incomplete surgical excisions. This practice is concerning because histopathologically high-risk BCCs have an increased risk of postoperative recurrence, necessitating a more meticulous surgical approach. For facial high-risk BCCs, Mohs micrographic surgery is the recommended treatment method. Given these challenges, there is a clear need for simple, preoperative methods to help physicians identify high-risk tumors. By improving preoperative assessment, these methods could enhance treatment planning, reduce incomplete excisions, and optimize the use of Mohs micrographic surgery for high-risk cases.
Dermatology / 02.08.2024

Editor's note:  Not all dark or discolored areas on the skin are benign.  Some may be cancerous or precancerous.  Please consult your dermatologist or  health care provider before beginning any depigmenting treatment and  follow up as the provider directs. Depigmenting treatments are not FDA approved and may have side effects, including allergic reactions and hyperpigmentation. They should not be used if pregnant, nursing or planning to become pregnant.  Please consult your provider for specific medical advice. What Are Dark Spots and Why Do They Appear? [caption id="attachment_62710" align="alignleft" width="200"]Photo by Linda Prebreza: https://www.pexels.com/photo/woman-applying-lotion-on-hand-286951/ Image Source[/caption] Hyperpigmentation, or "dark spots," are patches of skin that seem darker than the surrounding tissue. Although it can affect any region of the body, the face, arms, and hands are the most frequently affected areas. These spots form when cells known as melanocytes, which produce melanin, are overactive. The overproduction of melanin, the pigment responsible for skin color, leads to patches or spots that appear darker. Several factors contribute to the development of dark spots. One of the main causes is sun exposure since UV rays hasten the formation of melanin. Hyperpigmentation can also be brought on by hormonal changes, such as those brought on by birth control drugs or pregnancy. Additionally, skin injuries, acne, and other forms of inflammation can result in post-inflammatory hyperpigmentation. Using a dark spot remover can help mitigate these spots, but understanding their root causes is crucial for effective prevention and treatment.
Dermatology, Mental Health Research / 26.07.2024

Hair loss can have profound psychological effects, impacting self-esteem and overall well-being. However, advancements in hair loss treatments, such as Minoxidil, offer hope by not only addressing physical symptoms but also improving mental health outcomes. Understanding the psychological benefits of these treatments is crucial for individuals seeking to regain confidence and emotional balance.

Addressing the Emotional Impact of Hair Loss

Hair loss is more than a cosmetic concern; it can significantly affect mental health. Many individuals experience feelings of embarrassment, anxiety, and reduced self-confidence due to changes in their appearance. Effective hair loss treatments play a pivotal role in alleviating these psychological burdens, fostering a positive outlook and enhancing quality of life.

How Minoxidil Works

[caption id="attachment_62607" align="alignleft" width="200"]hairloss-minoxidil_pexels-zvolskiy-1570807 Image source[/caption] Minoxidil, a topical medication approved by the FDA for hair loss treatment, stimulates hair follicles' growth phase and increases hair density. It promotes blood flow to the scalp, revitalizing dormant follicles and encouraging new hair growth. Minoxidil hair treatment offers a proactive approach that not only addresses thinning hair but also restores confidence in one's appearance.
Dermatology / 25.07.2024

Have you ever wondered about the best treatment options for HAE patients? How do you decide which treatment is right? Understanding the trade-offs is essential. This article explores the benefits and risks of various HAE treatments. Let's delve into the specifics.

What is HAE?

Hereditary Angioedema (HAE) is a rare genetic disorder. It causes sudden swelling in various parts of the body. These swelling episodes can be painful and dangerous. Knowing the details of this condition is crucial. It helps in making informed treatment decisions. Effective management is vital for improving patient outcomes.

Types of HAE Treatments

HAE treatments can be categorized. They include acute treatments and prophylactic treatments. Acute treatments are used during an attack. Prophylactic treatments are used to prevent attacks. Each treatment type has its own set of benefits and risks. The choice of treatment depends on individual patient needs. Understanding these treatments helps in better patient care.
Dermatology / 03.07.2024

home-remedies-eczemaEczema, also known as atopic dermatitis, is a chronic skin condition characterized by dry, itchy, and inflamed skin. While there are various treatments available, many people turn to home remedies to manage their symptoms. In this article,  several natural remedies for eczema are explored, some remedies that should be avoided are discussed and tips for treating eczema in babies and children are identified.

Natural Remedies for Eczema

Home natural remedy for eczema may provide significant relief and improve the condition of the skin. Colloidal oatmeal, for instance, is renowned for its soothing properties, helping to alleviate itching and irritation. Simply adding it to a warm bath can create a calming treatment. Another effective remedy is coconut oil, which hydrates the skin and may contain antibacterial properties that help prevent infection. Applying it directly to affected areas twice daily may make a noticeable difference. Additionally, sunflower seed oil may strengthen the skin barrier and reduce inflammation when used as a moisturizer. Bleach baths, although sounding harsh, may reduce bacteria on the skin and are beneficial when used sparingly. Lastly, using a cool compress can provide immediate relief from severe itching and inflammation. These natural remedies are gentle yet effective ways to manage eczema symptoms and enhance overall skin health. Contact a healthcare professional before using any natural remedy. They can help ensure the remedy fits safely within a treatment plan. Remember allergic reactions can occur or develop to any product so be sure to monitor your skin for any new or unexpected reactions. Test any new product on a small area before applying to larger areas.
Dermatology / 02.07.2024

Want to achieve that radiant, healthy glow? You’re in the right place. In this guide, we’re sharing five essential dermatology tips, straight from the experts, to help you get the skin of your dreams. From the best skincare routines to insider secrets on keeping your skin youthful and vibrant, we’ve got you covered. 

1. Sunscreen: Your Skin’s Best Friend

skincare_pexels-karolina-grabowska-4210657I can’t stress this enough - sunscreen is a must! Here’s why:
  • Protects against harmful UV rays
  • Prevents premature aging
  • Reduces risk of skin cancer
Dr. Shari Lipner from Weill Cornell Medicine says, “The single most important tip for healthy, glowing skin is to apply a broad spectrum sunscreen with SPF 30 or higher every single day”. Pro tip: Don’t forget often-missed spots like your ears, neck, and the backs of your hands!
Author Interviews, Dermatology, JAMA, Salt-Sodium / 12.06.2024

MedicalResearch.com Interview with: [caption id="attachment_61942" align="alignleft" width="200"]Katrina Abuabara, MD, MA, MSCEAssociate Professor of Dermatology, UCSF Associate Adjunct Professor of Epidemiology UC Berkeley School of Public Health Dr. Abuabar[/caption] Katrina Abuabara, MD, MA, MSCE Associate Professor of Dermatology, UCSF Associate Adjunct Professor of Epidemiology UC Berkeley School of Public Health MedicalResearch.com: What is the background for this study? Response: Eczema (also known as atopic dermatitis) has become increasingly common over recent decades, especially in industrialized countries, suggesting that environmental or lifestyle factors like diet could impact rates of disease. It is well established that sodium, consumed primarily in the form of salt, increases the risk of hypertension and heart disease through pro-inflammatory mechanisms. The role of sodium on other chronic inflammatory conditions like eczema has been less well-studied.
Author Interviews, Dermatology, Melanoma, Race/Ethnic Diversity / 24.05.2024

MedicalResearch.com Interview with: [caption id="attachment_61776" align="alignleft" width="125"]Andrew F. Alexis, MD, MPHVice-Chair for Diversity and Inclusion Department of Dermatology Dermatologist Center for Diverse Skin Complexions Weill Cornell Medicine – NY Dr. Alexis[/caption] Andrew F. Alexis, MD, MPH Vice-Chair for Diversity and Inclusion Department of Dermatology Dermatologist Center for Diverse Skin Complexions Weill Cornell Medicine – NY MedicalResearch.com: What are the main types of skin cancer?  Is the incidence changing? Response: The 3 main types of skin cancer are melanoma, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Skin cancer is the most common cancer in the United States1 and 1 in 5 Americans will develop skin cancer in their lifetime. (2) The overall incidence has changed as follows: • Melanoma: Rates doubled over past 30 years from 1982 to 2011.3 It differs by age group. o Adolescents and adults age 30 and younger: incidence rate is declining o Older age groups (e.g. 80 and older): incidence rate is increasing • Squamous Cell Cancer: o Incidence increased 263% between 1976-1984 and 2000-20104 • Basal Cell Cancer: o Incidence increased 145% between 1976-1984 and 2000-20104
Dermatology / 17.05.2024

Our skin is subject to a multitude of internal and external influences that can affect its thickness and texture over time. Factors such as aging, environmental aggressors, lifestyle choices, and genetics can contribute to the gradual thinning and deterioration of skin quality. However, the good news is that there are various approaches to address these concerns and promote the restoration of skin thickness and texture. In this article, we'll explore a few crucial factors that, according to research, play pivotal roles in this rejuvenation process.

The Proliferation and Migration of Skin Cells

skin-care-dermatologyAccording to the National Institutes of Health, at the core of skin thickness and texture restoration lies the process of cell proliferation and migration. The epidermis, the outermost layer of the skin, constantly undergoes renewal through a process known as epidermal turnover. Stem cells within the basal layer of the epidermis divide and differentiate into keratinocytes. These gradually migrate upward to the skin's surface, replacing old, damaged cells. According to Beyond CellCare, stem cell therapy differs from traditional treatments, which only target the symptoms of skin aging. By fostering cellular repair and renewal, it targets the fundamental mechanisms of aging. Furthermore, certain skincare ingredients and treatments, such as chemical exfoliants and professional procedures like microdermabrasion and chemical peels, can accelerate cell turnover. You’ll also find the use of exosome injection and similar therapy methods involving exosomes becoming popular in this regard. Exosomes facilitate skin cell proliferation and migration by transferring growth factors and signaling molecules. (Please note that exosomes are currently not approved by the Food and Drug Administration (FDA) to treat or diagnose any disease).
Dermatology / 04.05.2024

Key Takeaways:
  • Understanding the groundbreaking science behind laser facial hair removal and its multifaceted benefits.
  • Key steps to consider in preparation for a laser hair removal session to ensure safety and effectiveness.
  • Essential post-treatment care strategies to enhance results and maintain skin health after the procedure.
  • The role of continuous technological advancements in improving laser hair removal treatments.
What Is Laser Hair Removal and How Does It Work? face-hair-hairremovalLaser hair removal is a long-lasting alternative to traditional hair removal methods for unwanted facial hair in both men and women. Laser treatments disrupt the normal growth cycle of hair follicles by utilizing highly concentrated beams of light designed to be absorbed by the pigment within the hair shafts. This state-of-the-art technique has quickly found favor in metropolises like Chicago, where grooming and self-care are highly prioritized. Laser facial hair removal in Chicago is primarily sought for its ability to facilitate a seamless, hair-free complexion, symbolic of the city's cosmopolitan lifestyle.
Author Interviews, Dermatology, Genetic Research, Nature, Rheumatology / 28.03.2024

MedicalResearch.com Interview with: [caption id="attachment_61503" align="alignleft" width="150"]Chelisa Cardinez PhDPostdoctoral Researcher The Burr Laboratory- Cancer Immunology and Epigenetics Genome Sciences and Cancer Division The John Curtin School of Medical Research The Australian National University Canberra, Australia Dr. Cardinez[/caption] Chelisa Cardinez PhD Postdoctoral Researcher The Burr Laboratory- Cancer Immunology and Epigenetics Genome Sciences and Cancer Division The John Curtin School of Medical Research The Australian National University Canberra, Australia   MedicalResearch.com: What is the background for this study? Response: Psoriasis is a skin inflammatory disease that affects approximately 2-3% of the population. Previous research had identified that the cytokine IL-17 drives the development of this disease. However, key questions that remained unknown about psoriasis included where did the IL-17 come from, and why do some patients with psoriasis also go on to develop systemic inflammatory conditions such as arthritis. Our research aimed to address these questions using a gain of function (GoF) mouse model that carried a genetic variant in a gene called IKBKB.
Author Interviews, Dermatology, Kidney Stones, NEJM / 28.03.2024

[caption id="attachment_61496" align="alignleft" width="125"]Thomas Robert, MD, AIXAssociate Professor of Nephrology APHM (Assistance Publique - Hopitaux de Marseille) Marseille, Provence-Alpes-Côte d'Azur, France  Dr. Thomas Robert[/caption] MedicalResearch.com Interview with: Thomas Robert, MD, AIX Associate Professor of Nephrology APHM (Assistance Publique - Hopitaux de Marseille) Marseille, Provence-Alpes-Côte d'Azur, France   [caption id="attachment_61498" align="alignleft" width="132"]Prof. Emmanuel Letavernier, MD PhDNephrologist at Tenon Hospital Paris, France Dr. Letavernier[/caption] Prof. Emmanuel Letavernier, MD PhD Nephrologist at Tenon Hospital Paris, France MedicalResearch.com: What is the background for this study? Response: Our work was prompted by emerging concerns surrounding the potential nephrotoxic effects of hair-straightening products containing glyoxylic acid. This inquiry was instigated by a patient who experienced three repeated acute episodes of kidney injury in June 2020, April 2021, and July 2022, each occurring shortly after a hair-straightening procedure. Notably, these episodes resolved with hydration. Upon examining the composition of the hair product used by the patient, which contained glyoxylic acid, and considering the patient's report of  painful ulcer scalp during application and subsequent scalp scarring, we suspected a potential link between exposure to glyoxylic acid and kidney injury. Consulting with my colleague, Professor Emmanuel Letavenier, a specialist in crystalline nephropathy at Paris, confirmed this suspicion. In summer 2023, cases series have been reported by an Israeli team (https://pubmed.ncbi.nlm.nih.gov/36610611/), who described 26 patients presenting with acute renal injuries after hair straightening treatments. Biopsies revealed calcium oxalate crystals in the kidneys. The Israeli researchers suspected an effect of formaldehyde and glycolic acid, another substance found in many cosmetic products, including hair straightening products, but were unable to provide conclusive evidence.
ADHD, Author Interviews, Dermatology, JAMA, Mental Health Research / 08.03.2024

MedicalResearch.com Interview with: [caption id="attachment_61409" align="alignleft" width="125"]Dr. Joy Wan M.D., M.S.C.E.Assistant Professor of Dermatology Johns Hopkins University School of Medicine Dr. Wan[/caption] Dr. Joy Wan M.D., M.S.C.E. Assistant Professor of Dermatology Johns Hopkins University School of Medicine MedicalResearch.com: What is the background for this study? Response: There has been a growing body of literature linking atopic dermatitis with diagnoses such as ADHD and learning disabilities, but studies focusing on symptoms of cognitive impairment (in contrast to relying on reported diagnoses as proxy measures of such) have been fewer and demonstrate inconsistent findings. Thus, we were interested in using data from this nationally representative sample of U.S. children to examine whether atopic dermatitis was associated with symptoms of learning or memory difficulties. Moreover, we wanted to examine how this relationship is influenced by known neurodevelopmental conditions to further characterize whether specific subgroups of children with atopic dermatitis are more susceptible to cognitive impairments.
Aging, Author Interviews, Dermatology / 19.02.2024

MedicalResearch.com Interview with: [caption id="attachment_61338" align="alignleft" width="150"]Frank Wang Dr. Frank Wang[/caption] Frank Wang MD William B. Taylor Endowed Professor of Clinical Dermatology Associate Professor, Dermatology Associate Chair for Education Assistant Program Director, Dermatology Residency Program University of Michigan Ann Arbor, Michigan MedicalResearch.com: What is the background for this study? How is the cross-linked hyaluronic acid obtained? Where was it injected? Response: As the skin undergoes photoaging due to chronic exposure to ultraviolet light, it loses dermal collagen, which in turn leads to wrinkling, lines, and loss of support. The loss of collagen is, in large part, due to reduced function of the skin’s collagen-producing cells, dermal fibroblasts. We wanted to investigate whether it was possible to reverse the decreased function of fibroblasts in photodamaged skin, by introducing a space-filling material into the dermis, injected CL-HA dermal filler. The CL-HA filler we used was donated to us for research purposes. We performed injections of CL-HA into the mid-dermis (as is normally done when injected into the face) of severely photoaged forearm skin of human participants over the age of 60. We then examined skin samples at various time points, including 1, 2, 3 and 4 weeks and 3, 6, 9, and 12 months post-injection.
Allergies, Author Interviews, Dermatology, University of Michigan / 16.11.2023

MedicalResearch.com Interview with: [caption id="attachment_61065" align="alignleft" width="150"]Charles Schuler, MDAssistant Professor Allergy and Clinical Immunology & Mary H. Weiser Food Allergy Center University of Michigan Dr. Schuler[/caption] Charles Schuler, MD Assistant Professor Allergy and Clinical Immunology & Mary H. Weiser Food Allergy Center University of Michigan MedicalResearch.com: What is the background for this study? Response: Anaphylaxis is a severe allergic reaction that may include a skin rash, nausea, vomiting, difficulty breathing, and shock. Food anaphylaxis sends 200,000 people to the emergency room annually in the United States. Oral food challenges are when a patient ingests increasing doses up to a full serving of the suspected food allergen under supervision of a medical provider, usually an allergist. These oral food challenges are the diagnostic standard for food allergy/anaphylaxis as skin and blood allergy tests have high false positive rates. Although a highly accurate test, patients often experience anaphylaxis during oral food challenges necessitating an epinephrine injection.
Author Interviews, Dermatology, JAMA, Surgical Research / 16.11.2023

MedicalResearch.com Interview with: [caption id="attachment_61061" align="alignleft" width="142"]Peter C. Minneci, MDChair of Surgery at Nemours Children’s Health Delaware Valley Dr. Minneci[/caption] Peter C. Minneci, MD Chair of Surgery at Nemours Children’s Health Delaware Valley MedicalResearch.com: What is the background for this study?  Would you briefly explain the symptoms/course of pilonidal disease?  Response: Pilonidal disease is relatively common and affects up to 1% of the population starting in adolescence and up until young adulthood. Pilonidal disease occurs when cysts or sinuses form between the buttocks. It is believed to be an inflammatory reaction to hair or debris that gets caught in the crease of the buttocks. Risk factors for the condition include a sedentary lifestyle, hygiene and obesity. [caption id="attachment_61062" align="alignleft" width="150"] Pilonidal Cyst
DermNet Image[/caption] Pilonidal disease can be intermittent or chronic and recurs about 33% of the time, with 80% of recurrences taking place within a year of initial treatment. These recurrences contribute to a high degree of psychosocial stress in patients, who often miss school or sports and may avoid social activities. Pilonidal cysts may become infected, in which case patients must take antibiotics or undergo surgery.   Standard treatment for pilonidal disease involves removal of hair with razors or creams, as well as recommendations such as keeping the area clean. In recent years, some practitioners have begun using laser epilation as an additional strategy to prevent recurrence by providing more durable hair removal. However, it’s important to point out that this is not covered by insurance. In addition, as a provider, I have found that my patients that do have the means to pay often don’t comply with the number of sessions needed to fully remove the hair due to many different factors including pain and discomfort during the procedure.  
Annals Internal Medicine, Author Interviews, Dermatology / 14.11.2023

MedicalResearch.com Interview with: Ying Li MD, PhD Graduate School Chengdu University of Traditional Chinese Medicine Chengdu, China MedicalResearch.com: What is the background for this study? Response: Chronic spontaneous urticaria (CSU) is a prevalent dermatological condition affecting approximately 1% of the global population. It is characterized by persistent itching and the development of hives, significantly impairing patients' quality of life. More than 90% of patients with CSU require urgent medical treatment to relieve itching. However, few therapies are specifically designed to treat pruritus in The management of pruritus is one of the main goals in the treatment of chronic spontaneous urticaria . Antihistamines are a common treatment of CSU, and current guidelines recommend second-generation antihistamines as first-line therapy. However, nearly 40% of patients do not respond to second-generation antihistamines, even when the dose is increased 2- to 4-fold. Omalizumab as a second-line treatment is effective in controlling urticaria, but it is costly and is not reimbursed in many countries, limiting its use to most patients worldwide. Given the shortcomings of existing therapies for pruritus in CSU, novel therapeutic interventions or strategies are emerging. Acupuncture, a traditional physical therapy with a rich historical background spanning over a millennium, has been regarded as an effective treatment for urticaria in China. However, previous randomized controlled trials investigating acupuncture's efficacy have been marred by methodological limitations, thereby undermining the credibility of the evidence. To address this gap, we conducted a multicenter randomized controlled trial to comprehensively evaluate the effectiveness of acupuncture in the management of CSU.
Author Interviews, Dermatology, Diabetes, Heart Disease, Weight Research / 28.08.2023

MedicalResearch.com Interview with: [caption id="attachment_60815" align="alignleft" width="150"]Dr. Alexis Elias MalavazosEndocrinology Unit Clinical Nutrition and Cardiovascular Prevention Service, IRCCS Policlinico Unit of Radiology, IRCCS Policlinico San Donato, San Donato Milanese, Italy Dr. Malavazos[/caption] Dr. Alexis Elias Malavazos Endocrinology Unit Clinical Nutrition and Cardiovascular Prevention Service, IRCCS Policlinico Unit of Radiology, IRCCS Policlinico San Donato, San Donato Milanese, Italy   MedicalResearch.com: What is the background for this study? Response: Psoriasis is a systemic inflammatory disease often associated with obesity and type-2 diabetes (T2D). The inflammatory process of psoriasis can target adipose tissue depots, particularly those surrounding the heart and the coronary arteries, exposing them to an increased risk of cardiovascular disease.
Author Interviews, Dermatology, Immunotherapy / 18.07.2023

MedicalResearch.com Interview with: [caption id="attachment_60633" align="alignleft" width="150"]Emma Guttman-Yassky Dr. Guttman-Yassky[/caption] Emma Guttman-Yassky, M.D., PhD, Lead investigator of this study Waldman Professor and System Chair Kimberly and Eric J. Waldman Department of Dermatology Icahn School of Medicine at Mount Sinai, NY   MedicalResearch.com: What is the background for this study? Response: The idea to test how spacing out treatment or even stopping it affects treatment responses once patients are well controlled. Lebrikizumab it is a potent biologic agent with a relatively long-lasting effect.
Author Interviews, Dermatology, Eli Lilly, Immunotherapy / 18.05.2023

MedicalResearch.com Interview with: [caption id="attachment_60437" align="alignleft" width="200"]Lotus Mallbris, MD PhDDermatologist andSenior Vice President Global Immunology Development and Medical Affairs  Lilly Dr. Mallbris[/caption] Lotus Mallbris, MD PhD Dermatologist andSenior Vice President Global Immunology Development and Medical Affairs  Lilly   MedicalResearch.com: What is the background for this study?  Would you briefly describe what is meant by atopic dermatitis and types treated in this study? Response: First, this study specifically evaluated lebrikizumab, a novel, investigational, monoclonal antibody that selectively binds to interleukin 13 (IL-13) with high-affinity and high potency. Inflammation due to over-activation of the IL-13 pathway plays a central role in the pathogenesis of moderate-to-severe atopic dermatitis, commonly called eczema. This secondary analysis focused on patients treated with lebrikizumab from the 16-week induction periods of the ADvocate 1 and ADvocate 2 studies and the ADhere study. In the trials, we assessed the presence or absence of face or hand dermatitis in patients with moderate-to-severe atopic dermatitis. If present at baseline, at 16 weeks, clinicians assessed the change from baseline on a scale of cleared, improved, no change, or worsened. Only patients with face and hand dermatitis were evaluated as part of the analysis.
Author Interviews, Dermatology, JAMA / 15.05.2023

MedicalResearch.com Interview with: [caption id="attachment_60425" align="alignleft" width="151"]Matthew Zirwas, MDFounder, Bexley Dermatology Research Clinic Bexley, OH 43209 Dr. Zirwas[/caption] Matthew Zirwas, MD Founder, Bexley Dermatology Research Clinic Bexley, OH 43209 MedicalResearch.com: What is the background for this study? How does Roflumilast differ from other treatments for seb derm? Response: Seborrheic dermatitis affects up to 5% of the population globally and can have major impacts on quality of life. Treatment regimens are often complicated given the association of seborrheic dermatitis to hair bearing areas of the body, requiring multiple treatments for different parts of the body. Our phase 2 study aimed to understand the efficacy and safety of once-daily roflumilast foam 0.3% in adults with seborrheic dermatitis on their scalp, face and trunk. Roflumilast foam is a selective and highly potent phosphodiesterase (PDE) 4 inhibition that is being studied for a range of inflammatory skin conditions.
Author Interviews, Dermatology, Melanoma, USPSTF / 27.04.2023

MedicalResearch.com Interview with: [caption id="attachment_60371" align="alignleft" width="133"]John M. Ruiz, Ph.DAssociate Professor of Clinical Psychology Department of Psychology University of Arizona Dr. Ruiz is the incoming editor-in-chief of the American Psychological Association (APA) journal, Health Psychology Dr. Ruiz joined the U.S. Preventive Services Task Force in January 2022 Dr. Ruiz[/caption] John M. Ruiz, Ph.D Associate Professor of Clinical Psychology Department of Psychology University of Arizona Dr. Ruiz is the incoming editor-in-chief of the American Psychological Association (APA) journal, Health Psychology Dr. Ruiz joined the U.S. Preventive Services Task Force in January 2022     MedicalResearch.com: What is the background for this study? What are the main findings? Response: Skin cancer is the most common type of cancer in the United States, but it often does not cause serious complications or death. The Task Force’s recommendation on screening for skin cancer focuses on the effectiveness of visual skin exams for children and adults who do not have any symptoms. When reviewing the latest research, we found that there is currently not enough evidence to tell us whether or not screening people without signs or symptoms is beneficial. This is an I statement.
Author Interviews, Dermatology, Eli Lilly, NEJM / 26.03.2023

MedicalResearch.com Interview with: [caption id="attachment_24142" align="alignleft" width="128"]Dr. Jonathan L. Silverberg MD PhD MPH Assistant Professor in Dermatology Medical Social Sciences and Preventive Medicine Northwestern University, Chicago, Illinois Dr. Jonathan Silverberg[/caption] Jonathan Silverberg, MD, PHD, MPH Professor Director of Clinical Research Director of Patch Testing George Washington University School of Medicine and Health Sciences Washington, DC MedicalResearch.com: What is the background for this study? What are the main findings? Response: Lebrikizumab was previously shown to be safe and effective as a treatment for moderate-severe atopic dermatitis in a phase 2 study. These Phase 3 randomized placebo-controlled trials are the largest studies to date of lebrikizumab in AD. They showed that lebrikizumab was safe and highly effective for the treatment of moderate-severe atopic dermatitis. These studies will hopefully support the approval of lebrikizumab in the United States later this year.
Allergies, Author Interviews, Cancer Research, Dermatology, Melanoma / 17.03.2023

MedicalResearch.com Interview with: Jenni Komulainen University of Eastern Finland | UEF MedicalResearch.com: What is the background for this study? Response: The background for this study comes from the earlier findings that the skin cancer risk and atopic status have some connection, but the results have been inconsistent. The connection between atopy and skin cancers may be related to the stimulation of protective immune response or the predisposition to carcinogenesis through chronic inflammation. The aim of this study was to investigate if atopic disorders associate with skin cancers.