Hand-Foot-Mouth Disease – Enterovirus 71 Vaccine Study in Children
MedicalResearch.com eInterview with:
Fengcai Zhu
Deputy Director of the Jiangsu Provincial Center for Disease Prevention and Control, Jiangsu provincial center for disease prevention and control
MedicalResearch.com Editor's Note: HFMD = Hand Foot and Mouth Disease
MedicalResearch.com: What are the main findings of the study? Answer: From this trial, the inactivated alum-adjuvant EV71 vaccine showed a good protection for both the EV71-associated HFMD and EV71-associated disease. The vaccine gave 90% protection against clinical EV71-associated HFMD and 80.4% against EV71-associated disease (including neurological complications) for at least 12 months. The safety profile and immunogenicity of this vaccine is proved to be clinical acceptable. We also proposed a titre (1:32) of neutralization antibody as surrogate of protection against EV71-associated disease.