While CBD has a powerful effect on seizures, neuropathy, and even behavioral disorders, it is not a cure-all as some...
While CBD has a powerful effect on seizures, neuropathy, and even behavioral disorders, it is not a cure-all as some...
While CBD and CBG are both cannabinoids by nature, they do come from different parts of the cannabis plant, which...
Dr. Cuttler[/caption]
Carrie Cuttler, Ph.D.
Assistant Professor
Washington State University
Department of Psychology
Pullman, WA, 99164-4820
MedicalResearch.com: What is the background for this study?
Response: While many studies have examined the acute effects of cannabis on other mental health symptoms such as anxiety, depression, post-traumatic stress disorder (PTSD), and psychosis there is almost no research on acute effects of cannabis on symptoms of obsessive-compulsive disorder (OCD) in humans. Nevertheless, we have previously found that acute cannabis intoxication is associated with reductions in anxiety as well as with reductions in the intrusive thoughts characteristic of PTSD. Further previous research using a rodent model of compulsive behavior has provided pre-clinical evidence that cannabidiol (CBD) - which is the second most common constituent in the cannabis plant - reduces compulsive behavior.
Dr. Kaufmann[/caption]
Christopher Kaufmann, PhD
Co-first author of the study and assistant professor
Division of Geriatrics and Gerontology in the Department of Medicine
UC San Diego
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: We examined cannabis use by older patients seen in our geriatrics clinic at the University of California San Diego. We surveyed patients who came to our clinic for routine care, and found that 15% of those surveyed had used cannabis within the past 3 years. Half of users reported using cannabis regularly and most used for medical purposes. The most common targeted conditions were pain, problems sleeping, and anxiety, and patients found cannabis to be helpful in treating these conditions. We also found that 61% had initiated cannabis use after age 60, and these new users engaged in less risky consumption practices than current users who also used earlier in life.
Dr. Lanza[/caption]
Isabella Lanza, PhD
Associate Professor of Human Development
California State University, Long Beach
MedicalResearch.com: What is the background for this study? What are the main findings? Response: This is the first study to examine both nicotine vaping and cannabis vaping trajectories across adolescence and young adulthood, which allowed us to assess whether poly-substance vaping is common among adolescents and young adults. Poly-substance vaping (nicotine and cannabis vaping) was reported among a significant proportion of participants in the study (25% were identified as poly-substance vapers). For those that either escalated to frequent nicotine vaping use in adolescence or initiated frequent nicotine vaping use in young adulthood, the probability of engaging in cannabis vaping was very high (85%+).
Dr. Ellingson[/caption]
Jarrod Ellingson PhD
Assistant Professor
Department of Psychiatry
Anschutz Medical Campus
University of Colorado Denver
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: We know that cannabis use is associated with many negative outcomes, but there could be many of reasons for that. For example, socioeconomic factors and peer influences both affect adolescent cannabis use and poorer cognitive functioning. To account for some of those risk factors, we studied nearly 600 sibling pairs with moderate to heavy cannabis use. We found that, as a person uses more cannabis than their sibling, they tend to have worse memory recall than their sibling.
Response: This study found that recreational cannabis laws were associated with increases in traffic fatalities in Colorado (mean of 75 excess fatalities per year) but not in Washington State. These findings suggest that unintended effects of recreational cannabis laws can be heterogeneous and may be specific to variations in how these laws are implemented
(eg, density of recreational cannabis stores).
Amalie K. Kropp Lopez[/caption]
Amalie K. Kropp Lopez, MS
MD Candidate
Geisinger Commonwealth School of Medicine Class of 2023
Scranton, Pennsylvania
MedicalResearch.com: What is the background for this study?
Response: The opioid crisis is still affecting America, effecting millions of people from all walks of life. With the high risks of abuse and overtreatment with opioids, marijuana has been a newly reconsidered alterative for pain treatment. This study sought to quantify the changes in prescription opioid distribution using data reported by the Drug Enforcement Administration in Colorado after the legalization of recreational marijuana which gave the public increased access to its pain-relieving effects.
Response: It is well known that marijuana usage impairs driving ability, yet the early studies of the effects of recreational marijuana legalization on traffic fatalities were inconclusive.
MedicalResearch.com: What are the main findings?
Response: By analyzing data over a longer time period, we found that the legalization of recreational marijuana increased traffic deaths in the first four states to legalize. Traffic fatalities increased about 20% in those states. If we apply these numbers to the nation as a whole, nationwide legalization would be associated with about 7,000 excess traffic fatalities each year.
Dr. Vandrey[/caption]
Ryan Vandrey, Ph.D.
Associate Professor
Behavioral Pharmacology Research Unit
Johns Hopkins University School of Medicine
Baltimore, MD 21224
MedicalResearch.com: What is the background for this study?
Response: The background for this study is that 33 states in the U.S. have legalized medicinal cannabis use and millions of people are using cannabis for therapeutic purposes, but we have very little data on the broad health impacts of medicinal cannabis use.
We surveyed medicinal cannabis users and non-using controls who had a variety of health problems and found that the cannabis users reported better health, quality of life, and less healthcare utilization compared with controls. Because we worried about group characteristics accounting for the differences observed, we then did an analysis of people who switched groups over time (e.g. non-users who later initiated cannabis use or cannabis users who later quit) and found the same differences emerged in the same individuals over time. Important to note here is that not all individuals who used cannabis benefited from it and that most participants were using high CBD varieties of cannabis in conjunction with more traditional treatments.
Dr. Filbey[/caption]
Francesca Filbey, PhD
Associate Provost and Professor of Cognition and Neuroscience
Bert Moore Chair
The University of Texas at Dallas
MedicalResearch.com: What is the background for this study?
Response: Studies have reported differences in how males and females respond to cannabis and how they develop problems related to cannabis use. We sought to determine whether craving may underlie this difference in male and female cannabis users.
Dr. Hollingsworth[/caption]
Alex Hollingsworth PhD
Assistant Professor
O'Neill School of Public and Environmental Affairs
Indiana University
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: I've been working with Coady Wing and Ashley Bradford on a few different studies of the effects of recreational marijuana laws on drug and alcohol use.
Soon after EVALI became a major issue, the prevailing theory from the CDC and others was that EVALI was caused by the use of vitamin E acetate in illegal THC vaping products.
Our group read about this and we thought about some of the things that often happen in black markets for illegal drugs. For instance, during the alcohol prohibition era, bootleg alcohol producers often made and sold alcohol products that were not that safe to drink. In more recent years, there are cases where black market sellers of illegal drugs like heroin try to increase profit margins by adding other substances, which can be harmful.
We thought that maybe something like that could be happening in EVALI. Perhaps people in states where recreational marijuana is legal tended to purchase marijuana products from the legal market and the legal market was not selling any marijuana vaping products that included vitamin E acetate.
Dr. Bahji[/caption]
Anees Bahji, MD
PGY5, Department of Psychiatry, Queen’s University
M.Sc. Candidate, Department of Public Health Sciences,
Queen’s University
Kingston, ON, Canada
MedicalResearch.com: What is the background for this study?
Ryan J. McLaughlin, PhD
Assistant Professor
Department of Integrative Physiology & Neuroscience
College of Veterinary Medicine
Washington State University, Pullman, WA
MedicalResearch.com: What is the background for this study?
Response: The evolving legal landscape concerning the use of cannabis has increased urgency to better understand its effects on the brain and behavior. Animal models are advantageous in this respect; however, researchers traditionally use forced injections of synthetic cannabinoids which fails to capture the complex effects of volitional cannabis consumption.
In our study, we developed a novel model of cannabis self-administration using response-contingent delivery of vaporized cannabis extracts containing high concentrations of Δ9 tetrahydrocannabinol (THC) or cannabidiol (CBD).
Dr. Wallach[/caption]
Joshua D. Wallach, MS, PhD
Assistant Professor of Epidemiology (Environmental Health Sciences)
Yale School of Public Health
New Haven, CT
MedicalResearch.com: What is the background for this study?
Response: Over the past few years, there has been growing interest in the potential health benefits of cannabidiol (CBD), a chemical compound in cannabis. Although only one CBD-derived prescription drug has been approved by the US Food and Drug Administration (FDA) for the treatment of epilepsy, I recently started seeing products containing CBD advertised and sold across the US (e.g. CBD in foods, beverages, dietary supplements, and cosmetics). I noticed that many of these products were being marketed with unproven claims to prevent, cure, and treat various conditions, and became interested in learning more about the research supporting the use of CBD, the potential for misleading claims, and impact that the CBD-industry may be having on research that is being generated and disseminated to the public.
Research funding sources and other author conflicts of interests (e.g. consulting fees, honoraria, travel expenses) can influence the way that research is designed, conducted, and reported. Previous studies have consistently demonstrated associations between authors' conflicts of interest and proindustry conclusions in clinical research.
Given the growing number of companies invested in CBD's commercial success, we decided to analyze the disclosed funding sources, conflicts of interest statements, author employment details, and CBD-related conclusions in a large sample of published articles on the characteristics, use, and therapeutic effects of cannabidiol.
Dr. Han[/caption]
Benjamin H. Han, MD MPH
Assistant Professor
Division of Geriatric Medicine and Palliative Care
New York University School of Medicine
MedicalResearch.com: What is the background for this study?
Response: In the past, the prevalence of cannabis use (both for recreational and for medicinal purposes) was very low among adults age 65 and older. As a reference, the national prevalence rate of past-year cannabis use among adults age 65 and older in 2006-2007 was 0.4%, it has increased dramatically since then.
Dr. DeFilippis[/caption]
Ersilia DeFilippis, MD
Second-year cardiology fellow
Columbia University Irving Medical Center and
NewYork-Presbyterian
MedicalResearch.com: What is the background for this study?
Response: Marijuana use has been increasing significantly and is the most commonly illicit drug used in the United States. In recent years, more states have been legalizing its use for both recreational and medicinal purposes. We have all seen news reports regarding the rise of vaping-related health hazards. Yet, data are limited regarding the cardiovascular effects of marijuana which is what drove us to explore this topic.
Dr. Hongying (Daisy) Dai[/caption]
Hongying (Daisy) Dai, PhD
Associate Professor
Department of Biostatistics | College of Public Health
University of Nebraska Medical Center
MedicalResearch.com: What is the background for this study?
Response: E-cigarette use increased significantly from 2017 to 2019 among U.S. adolescents, and marijuana and other substances besides can be used in e-cigarettes. Meanwhile, restrictions on marijuana use have been relaxing and social acceptability of marijuana use is shifting among youth.
This study analyzed 38,061 middle and high school students from the 2017 and 2018 National Youth Tobacco Survey.
NATHAN CONNEALY[/caption]
Nathan J. Connealy
Doctoral student
John Jay College of Criminal Justice
CUNY
MedicalResearch.com: What is the background for this study?
Response: The background, or what prompted this study, is that research on this topic is pertinent right now as more states continue down a path towards legalization. A large share of the research base and public debate centers around the potential adverse effects of marijuana accessibility, consumer-based concerns, and health specific outcomes associated with usage.
This research instead focuses on a lesser explored question related to the potential for the physical dispensary locations to impact crime levels, which is also an important consideration when assessing the impact of recreational marijuana legalization.
Dr. Madras[/caption]
Bertha K. Madras PhD
Director, Laboratory of Addiction Neurobiology
Psychobiologist, Substance Use Disorders Division, Basic Neuroscience Division
Professor of Psychobiology, Department of Psychiatry
Harvard Medical School
MedicalResearch.com: What is the background for this study?
Parent use of marijuana is rising, and I wondered whether this could be associated with offspring use of specific substances and across several substances
Dr. Ayers[/caption]
John W. Ayers, PhD, MA
Vice Chief of Innovation | Assoc. Professor
Div. Infectious Disease & Global Public Health
University of California San Diego
MedicalResearch.com: What is the background for this study?
Response: Touted as a “cure all,” researchers have documented unfounded claims
that cannabidiol (CBD) treats acne, anxiety, opioid addiction, pain,
and menstrual problems. You can buy CBD droplets, massage oils,
CBD gummies, or even ice cream.
But public health leaders have been mostly silent on the subject because they lacked data
that demonstrates just how popular CBD is and the future trajectory might be.
To fill this data-gap we analyzed Google search queries that mentioned
“CBD” or “cannabidiol” emerging from the United States from January
2004 through April 2019 and forecasted searches through December 2019.
Rather than relying on self reports, where some might not be willing
to discuss CBD openly, our strategy allowed us to directly observed
millions of instances of people seeking out information or even
shopping for CBD online.
Ruibin Lu
Assistant Professor of Criminal Justice
Stockton University
Absecon, New Jersey
MedicalResearch.com: What is the background for this study?
Response: We are witnessing a trend of legalizing marijuana in the United States and in the world. Many states have either legalized recreational marijuana or are considering it. At the same time, there are concerns about what will happen to our society if weed is legal. One of the concerns is about crime rates: are we going to experience more or fewer crimes after legalizing recreational marijuana? This is a legitimate question that we should consider when making cannabis-related public policies. Our research provides a preliminary answer to this question. It analyzes crime rates before and after the legalization using rigorous scientific methods and provides more information on how marijuana legalization may affect crime rates.
Dr. Hongying (Daisy) Dai[/caption]
Hongying (Daisy) Dai, PhD
Associate Professor
Department of Biostatistics | College of Public Health
University of Nebraska Medical Center
MedicalResearch.com: What is the background for this study?
Response: Although marijuana is still classified as a Schedule I drug at the Federal level, as of June 2019, 33 states and the District of Columbia have legalized one or more forms of marijuana; 11 states and the District of Columbia have approved both medical and recreational uses. Public opinion on marijuana has changed dramatically over the last two decades and support for legalization has doubled since 2010. However, very little is known about the prevalence and patterns of marijuana use among adults with medical conditions.
This study analyzed the 2016 and 2017 Behavioral Risk Factor Surveillance System data to report the prevalence and patterns of marijuana use among adults with self-reported medical conditions.
Dr. Morgan Philbin[/caption]
Morgan Philbin, PhD MHS
Assistant Professor
Department of Sociomedical Sciences
Columbia University School of Public Health
MedicalResearch.com: What is the background for this study?
Response: Marijuana is the most frequently used substance in the United States (US) after alcohol and tobacco. In 2017, 15.3% of the US population ages 18 and up reported past-year marijuana use (MU) and 9.9% past month use. Individuals who identify as lesbian, gay, or bisexual (LGB), also report higher levels of marijuana use and marijuana use disorder than their heterosexual counterparts. Researchers have begun to explore potentially modifiable factors, such as state-level marijuana policies, that affect marijuana use and related outcomes at the population-level and within subgroups—though as of yet not among sexual minority populations.
We therefore examined whether LGB individuals living in states with medical marijuana laws (MMLs) have higher levels of marijuana use and marijuana use disorder compared to LGB individuals in states without MMLs.
Dr. Birnbaum[/caption]
Angela Birnbaum, Ph.D., FAES
Professor, Director of Graduate Studies
Experimental and Clinical Pharmacology
College of Pharmacy
University of Minnesota
MedicalResearch.com: What is the background for this study?
Response: Little was known about the effect food has on the amount of cannabidiol (CBD) that is actually absorbed into the body. Because of various state laws, CBD preparations vary from state to state. In Minnesota, however, the law only allows pure forms of cannabidiol providing a consistent supply of product including a purified CBD capsule formulation. Due to its pharmacological properties a low amount of a CBD dose reaches the blood stream and the effect of food had not been well described.
Our study was done to determine the amount of cannabidiol
that is absorbed with food as compared to an empty stomach at doses used in epilepsy patients, which can be higher than the dose often used for other conditions.
Dr. Midgette[/caption]
Greg Midgette, PhD
Assistant Professor
Department of Criminology and Criminal Justice
University of Maryland
MedicalResearch.com: What is the background for this study?
Response: This report estimates marijuana, cocaine, heroin, and methamphetamine use in the U.S. between 2006 and 2016 on three dimensions: the number of past-month chronic users per year, where "chronic" has previously been defined as consuming the drug at least four days in the past month, expenditure per drug among those users, and consumption of each drug. These measures are meant to aid the public and policy makers' understanding of changes in drug use, outcomes, and policies.