MedicalResearch.com Interview with:
Jean-Pascal Fournier, MD, PhD
Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital,
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada and
Laurent Azoulay, PhD
Centre for Clinical Epidemiology,
Lady Davis Institute, Jewish General Hospital, Montreal,
Department of Oncology, McGill University, Montreal, Quebec, Canada
Medical Research: What are the main findings of the study?
Response: Patients with type II diabetes and treated hypothyroidism showed a 55% increased risk for low levels of thyroid stimulating hormone (TSH) (below 0.4 mIU/L) when initiating
metformin, compared with those initiating sulfonylurea (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.09–2.20). In contrast, this effect of metformin was not observed in euthyroid patients, with an adjusted HR for low TSH of 0.97(95% CI 0.69–1.36).
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