Author Interviews, Diabetes, Diabetes Care, Kidney Disease / 30.07.2014
Insulin Sensitivity Predicts Kidney Health in Adolescent Diabetes
MedicalResearch.com Interview with:
Petter Bjornstad, M.D.
Children's Hospital Colorado
University of Colorado Denver
Aurora, CO 80045
Medical Research: What are the main findings of the study?
Dr. Bjornstad: Type 2 diabetes is the most common cause of end-stage renal disease in the Western world. It is therefore of paramount importance to develop a better understanding of the determinants of diabetic nephropathy risk and progression, to improve outcome in adolescents with type 2 diabetes.
We report high rates of microalbuminuria and renal hyperfiltration in adolescents with type 2 diabetes, which forecast early renal morbidity and mortality. In our observational study, insulin sensitivity measured by hyperinsulinemic-euglycemic clamp studies, rather than adiposity, blood pressure, lipid and glycemic control was associated with markers of renal health (albumin-to-creatinine ratio and estimated glomerular filtration rate).
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