Author Interviews, Diabetes, JAMA, Pharmacology / 01.03.2016
Combination Degludec/Liraglutide Reduced HgA1C and Insulin Side Effects in Type 2 Diabetes
MedicalResearch.com Interview with:
Dr. John Buse MD Ph.D
Professor, Medicine
Director, Diabetes Care Center
Chief, Division of Endocrinology
Executive Associate Dean, Clinical Research
University of North Carolina School of Medicine
Medical Research: What is the background for this study? What are the main findings?
Dr. Buse: Degludec is an longer acting basal insulin analog recently approved in the US. Liraglutide is a once-daily GLP-1 receptor agonist. Both are among the most powerful glucose lowering drugs available in the setting of type 2 diabetes. They have very different properties. Degludec is best at lowering fasting glucose. Liraglutide has effects on postprandial glucose as well. The major side effects of degludec are hypoglycemia and weight gain. Liraglutide on the other hand has not an inherent effect to cause hypoglycemia and does promote weight loss. Liraglutide does cause nausea and in fewer patients vomiting in a dose dependent manner. In developing the fixed dose combination the idea was to amplify glucose lowering efficacy and minimize the adverse effects of both components. Prior studies have basically shown that this has been accomplished. In this study we looked at the very common clinical scenario of the patient with type 2 diabetes inadequately controlled on basal insulin glargine and asked the question of whether switching from glargine to IDegLira (the combination product) would do better than continued titration of glargine.
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