03 Jan Prostate Cancer: Comparison of Outcomes for Black and White Men Treated with Radiation Therapy
Engaging Black men and increasing the representation of the Black population in cancer prevention and treatment studies should be a priority.
07 Nov Study of Fruit Flies Identifies Novel Human Obesity Genes
Obesity is an organism-level disorder that affects multiple organs and perturbs inter-organ communication.
11 Jul Pets Can Pass Genes for Antibiotic Resistance to Human Infections
We studied a large panel of antimicrobials besides Colistin, and we found evidence of sharing of the mcr-1 colistin resistance gene harbored by the similar multidrug resistant Escherichia coli clone colonizing the GI tract of both a dog with a skin infection and his owner.
23 Apr Mesothelioma: Prognostic Signature of 48 Genes Identified
We identify a 48-gene mesothelioma prognostic signature whose expression is highly predictive of patient survival. Some of these genes could be potential drug targets in treating malignant mesothelioma patients
22 Feb Glioblastoma: Inovio’s Novel Combination of DNA Medication Plus Immunotherapy Boosts Survival
Posted at 16:02h
in Author Interviews, Brain Cancer - Brain Tumors, Cancer Research, Immunotherapy, Pharmaceutical Companies
This is a first-of-its-kind clinical trial in which a DNA medicine encoding for tumor-specific antigens is combined with an immune checkpoint inhibitor, and given together with the standard of care, in patients with newly diagnosed glioblastoma.
05 Feb Identifying Cardiac Strain Early May Minimize Heart Failure in Chemotherapy Patients
The primary outcome was a comparison of change in heart function between pre-cancer treatment and 1 year later measured using LVEF.
17 Dec Icahn Researchers Find Cancer Immunotherapy Improved When Bystander Cells Killed
A common type of resistance to cancer immunotherapy (Antigen Escape) can likely be prevented.
05 Dec LENVIMA® (lenvatinib) Based Combination Therapy in Patients With Renal Cell Carcinoma
The study, in which 343 patients received LENVIMA plus everolimus, helps to contribute to the growing body of evidence supporting the role of this TKI-mTOR combination in the advanced RCC treatment paradigm.
03 Dec Hepato-Renal Syndrome Type 1: Treatment with Terlipressin Reduced Need for Renal Replacement Therapy
MedicalResearch.com Interview with: Khurram Jamil, MD Vice President, Clinical Research in Hepatology Critical Care Division, Mallinckrodt MedicalResearch.com: What is the...
22 Nov Rare Mutation in the PCSK9 Gene Confers Long Healthy Life
This study has utilized both clinical and biomedical approaches to better understand how a rare mutation in the PCSK9 gene can have a number of surprisingly protective effects on several different diseases.
07 Oct DetermaRx™ Stratification Test Identify Patients With Stage I-IIA Non-Squamous NSCLC Who May Benefit From Adjuvant Chemotherapy
DetermaRxTM is the only test available in lung cancer that can stratify patients based on their molecular risk of recurrence.
01 Oct Olaparib (Lynparza) Targeted Therapy for Metastatic Castration-Resistant Prostate Cancer
To understand the importance of these results, it is important to understand the patient population. Despite advances in treatment for men with metastatic castration-resistant prostate cancer, the disease continues to be very deadly and five-year survival remains low.
25 Sep Low Level Light Therapy Has Potential to Help Patients With Traumatic Brain Injury
On this small cohort of patients with acute moderate traumatic brain injury, we were able to demonstrate neuroreactivity in the patients who received light therapy.
20 Aug Tumor-Informed ctDNA Test Signatera Evaluates Immunotherapy Response Across Different Solid Tumors
The bespoke ctDNA test used in our study, Signatera, is customized to the unique genetic signature of a patient’s cancer.
30 Jul Wet AMD: Genentech’s Port Delivery System Can Allow Longer Intervals Between Ranibizumab Treatments
MedicalResearch.com Interview with: Carl D. Regillo, MD, FACS Chief, Retina Service Wills Eye Hospital MedicalResearch.com: What is the background for...
26 Jun Stage II Colon Cancer: Guardant Health Study Evaluates Predictive Value of Blood Biomarker in Adjuvant Chemotherapy
The NRG GI-005 trial is currently enrolling patients with low-risk stage IIA (T3N0) resected colon cancer across the United States, and has been activated in Canada as well.
01 Jun Photoaged Skin Therapy with Adipose-Derived Stem Cells
This study has demonstrated ADSC to remodeling the skin extra cellular matrix, mainly in the elastic system.
21 May Genes Linked to Melanoma of the Eye Identified
Though we don’t really understand why yet, there does seem to be a higher number of uveal melanoma cases in people with light colour irises.
19 May Metastatic Bladder Cancer: Study Evaluates Combination of Checkpoint Blocker with Chemotherapy
Response: This is the first randomized trial reporting results combining chemotherapy with immune checkpoint blockade in urothelial cancer versus chemotherapy alone or immune checkpoint blockade monotherapy versus chemotherapy.
04 May Metastatic Breast Cancer: Tumor Profiling by Liquid Biopsy Can Help Drive Therapy
Testing more broadly beyond PIK3CA and with a liquid biopsy can help identify potential mechanisms of resistance to therapy and determine those patients most likely to respond to a PI3K inhibitor.
18 Feb Clarus Therapeutics Lauches JATENZO® – Oral Testosterone Replacement Therapy
"We believe JATENZO addresses a long-standing need for a safe and effective oral testosterone replacement product that meets current day FDA safety and efficacy standards."
12 Feb Two-Drug Combo Induces Human Beta Cells to Regenerate and Make Insulin
MedicalResearch.com Interview with: Andrew F. Stewart MD Director, Diabetes Obesity and Metabolism Institute Irene and Dr. Arthur M. Fishberg Professor...
08 Jan Despite Better Chemotherapy, US Women Choosing More Rather Than Less TNBC Surgery
Posted at 20:32h
in Author Interviews, Breast Cancer, Brigham & Women's - Harvard, JAMA, Surgical Research
Why there is such a big difference between women who have the same treatment and information in the US versus the rest of the world?
08 Jan Pulse Ultrasound Therapy May Improve Memory in Alzheimer’s Patients
In contrast to electrophysiological brain stimulation techniques, the new technique allows also focal brain activation deep in the brain.
23 Dec The Wistar Institute Discovers New Therapeutic Strategy for Chemotherapy Resistance in Ovarian Cancer
MedicalResearch.com Interview with: Rugang Zhang, Ph.D Professor & Co-Leader, Gene Expression & Regulation Program Deputy Director, The Wistar Institute Cancer...
26 Sep Precision Medicine: Genetic Variants Predict Response of Eosinophilic Esophagitis to PPIs
For the pediatric EoE field, this is a landmark study that may eventually change how we prescribe PPIs for the treatment of EoE.
23 Sep Epigenetic Changes Linked to Hypersexual Disorder and Addictive Behaviors
Hypersexual disorder contains addictive elements, but is not to be seen as exclusively an addiction.
08 Aug Study Doubles Number of Genes Linked to Squamous and Basal Cell Skin Cancer
Our study is the world’s largest genetic study on keratinocyte cancers to date. In total we identified total of 79 independent genetic loci associated with keratinocyte cancer risk.