Author Interviews, Cannabis, Fertility / 30.11.2021

MedicalResearch.com Interview with: Kanako Hayashi PhD Associate Professor Associate Director, Center for Reproductive Biology Washington State University MedicalResearch.com: What is the background for this study? Response: There have been several correlative reports showing statistical associations between cannabis use and low sperm counts, dysregulated menstruation, abnormal placentation, preterm birth, stillbirth and offspring psychosis etc. However, the long-term consequences of cannabis use on reproductive functions and how it might impact the next generation have not been examined. In the present study, we examined the generational effects of cannabis vapor exposure on male reproductive function. Vaporization is the most common route of cannabis administration in humans. Therefore, in order to understand the generational effects of cannabis exposure on male reproductive functions, the present study was performed using an inhalation method as an administration route, by which adult male mice were exposed to dry cannabis plants to assess the toxicological effects of cannabis on F0, F1 and F2 male reproductive functions. (more…)
Author Interviews, Cannabis, JAMA, Pediatrics / 25.10.2021

MedicalResearch.com Interview with: Carmen Lim BSc(Hons), MSc, CStat PhD Candidate National Centre for Youth Substance Use Research Faculty of Health and Behavioural Sciences The University of Queensland Brisbane Australia MedicalResearch.com: What is the background for this study? What are the main findings? Response: This review has systematically summarized the trends and products used for cannabis vaping using 17 studies published globally between Jan 1, 2003 and August 19, 2020. The pooled prevalence has increased for lifetime use (6.1% in 2013 to 13.6% in 2020), past-year use (7.2% in 2017 to 13.2% in 2020) and past-month use (1.6% in 2013 to 8.4% in 2020). Adolescents' preference for cannabis products may be shifting from less potent products (e.g., herbal cannabis) to highly potent vape oil and concentrates. (more…)
Author Interviews, Cannabis / 17.09.2021

MedicalResearch.com Interview with: Sam Craft Addiction and Mental Health Group (AIM), Department of Psychology, University of Bath, Bath National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience King’s College London, London UK MedicalResearch.com: What is the background for this study? Response: Synthetic cannabinoid receptor agonists (SCRAs, also known as Spice or K2) are a group of synthetic drugs originally produced to mimic the effects of cannabis. As they are often more accessible or cheaper and cannot be detected on drugs tests, SCRAs may be used as an alternative to cannabis. However, although they act on the same receptors – cannabinoid receptor type 1 and 2 (CBR1; CBR2) – SCRAs are far more potent than cannabis which may make them more addictive and increase the severity of withdrawal (unpleasant symptoms experienced after cessation of a drug which has been used in large amounts for a long period of time) As part of the Global Drug Survey, in this study we asked participants who use both SCRAs and cannabis to compare their effects across different measures which indicate how likely a drug is to result in long-term harm. For example, how severe withdrawal symptoms are and how long the effects last. We also asked participants which withdrawal symptoms they experienced when attempting to stop.  (more…)
Author Interviews, Cannabis, JAMA / 07.09.2021

MedicalResearch.com Interview with: Mark Anderson, Ph.D. Associate Professor Department of Agricultural Economics and Economics Montana State University, IZA, and NBER  MedicalResearch.com: What is the background for this study? Response: In a previous study that was published in JAMA Pediatrics, we used Youth Risk Behavior Survey (YRBS) data and found that the adoption of recreational marijuana laws (RMLs) was associated with an 8% decrease in the odds of marijuana use among high school students.  This earlier study, however, had pre-legalization and post-legalization data from only 7 states and pre- and post-recreational sales data from only 3 states, calling into question the generalizability of our findings. (more…)
Author Interviews, Autism, Cannabis, JAMA, Pediatrics / 28.05.2021

MedicalResearch.com Interview with: Daimei Sasayama, M.D., Ph.D. Department of Psychiatry Shinshu University MedicalResearch.com: What is the background for this study? Response: The diagnosis of autism spectrum disorder (ASD) is increasing worldwide. A 2016 US survey reported a prevalence of 1.85% in 8-year-olds, and a birth cohort study in Denmark reported that the future cumulative incidence of ASD could exceed 2.8%. Our recent regional cohort study in Japan reported an even higher cumulative incidence of 3.1%. So we examined whether the cumulative incidence in our regional cohort represents the nationwide incidence in Japan.  (more…)
Accidents & Violence, Author Interviews, Cannabis, CMAJ / 06.04.2021

MedicalResearch.com Interview with: Sarah Windle, MPH PhD Student in Epidemiology Department of Epidemiology, Biostatistics, and Occupational Health McGill University (Montréal, Québec, Canada) MedicalResearch.com: What is the background for this study? Response: Concerns have been raised about the potential for increases in impaired driving following the legalization of recreational cannabis use in Canada in October 2018. Data from Statistics Canada suggest that cannabis use in the previous three months increased among adults (15 and older) from 14% before legalization in 2018 to 17% in 2019. Among those users with a driver’s license, 13% reported driving within two hours of cannabis use. While this proportion remained the same before and after legalization, this indicates that the absolute number of individuals who reported driving within two hours of use has increased following legalization (due to an increase in the number of users). (more…)
Author Interviews, Cannabis, JAMA, OBGYNE, Pediatrics / 08.03.2021

MedicalResearch.com Interview with: Erica M. Wymore, MD MPH Assistant Professor, Neonatal- Perinatal Medicine Department of Pediatrics, Section of Neonatology University of Colorado School of Medicine Children's Hospital Colorado Maya Bunik, MD, MPH  |  Professor, Pediatrics Medical Director, Child Health Clinic, Primary Care  |  Breastfeeding Management Clinic Adult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS) School of Medicine| University of Colorado Anschutz Medical Campus Children's Hospital Colorado MedicalResearch.com: What is the background for this study? Response: Marijuana legalization has been increasing in the United States, with increasing consumption of marijuana products. Currently, the American Academy of Pediatrics (AAP), American College of Obstetricians and Gynecologists (ACOG) and Academy of Breastfeeding Medicine (ABM) do not recommend marijuana use during pregnancy or lactation due to concerning though limited data on the effects of perinatal marijuana exposure. As there has been increasing prevalence of women using marijuana during pregnancy due to legalization and perceptions of safety, we sought to determine the duration of THC excretion in breast milk among women who had evidence of marijuana use at delivery and abstained post-partum.  (more…)
Author Interviews, Blood Pressure - Hypertension, Cannabis / 10.02.2021

MedicalResearch.com Interview with: Ran Abuhasira MD, PhD student Cannabis Clinical Research Institute and Clinical Research Center Soroka University Medical Center, and Faculty of Health Sciences Ben-Gurion University of the Negev Beer Sheva, Israel MedicalResearch.com: What is the background for this study? What are the main findings? cannabis marijuana weed pot Response: The background for the study is the steady rise of cannabis use as a therapeutic in Israel and in many countries around the world. This largest increasing population of patients treated with medical cannabis is the older adults. However, very little data was published about cannabis treatment in older adults, and specifically about the cardiovascular and metabolic implications. T he main finding of the study is that cannabis treatment for 3 months was associated with a reduction in both systolic and diastolic blood pressure values, as measured by consequent 24-hours ABPM tests. In addition, no significant changes were found in blood lipids profile, hemoglobin A1C, fasting insulin, C-reactive protein, kidney function tests, electrolytes, anthropometric measurements, and ECG parameters. (more…)
Author Interviews, Cannabis / 03.02.2021

MedicalResearch.com Interview with: Benjamin J. Warnick, PhD Assistant Professor of Entrepreneurship Carson College of Business Washington State University Vancouver MedicalResearch.com: What is the background for this study? Response: Popular culture has perpetuated a notion that cannabis users are more creative. Along these lines, some successful CEOs and entrepreneurs—like Steve Jobs, for example—have claimed that cannabis use has benefitted their creativity at work. Despite such claims and increased legalization and use of cannabis, the implications of cannabis use for entrepreneurs’ creativity has yet to be rigorously tested. My coauthors and I were very intrigued to dive into the implications of cannabis use for entrepreneurs, whether good or bad. This seemed all the more relevant given the increasing legalization, destigmatization, and use of cannabis.  (more…)
Author Interviews, BMJ, Cannabis, Opiods, Yale / 29.01.2021

MedicalResearch.com Interview with: Balázs Kovács PhD Associate Professor of Organizational Behavior Yale School of Management MedicalResearch.com: What is the background for this study? Response: Our study looks at the association between the prevalence of legal cannabis stores, called “dispensaries”, and opioid-related mortality rates in the U.S.  We find that higher cannabis dispensary counts are associated with reduced opioid-related mortality rates.   We find this relationship holds for both medical dispensaries, which only serve patients who have a state-approved medical card or doctor’s recommendation, as well as for recreational dispensaries, which sell to adults 21 years and older.  The statistical associations we find appears most pronounced with the class of opioids that includes fentanyl and its analogs.  (more…)
Author Interviews, Cannabis, UCSF / 15.01.2021

MedicalResearch.com Interview with: Eric R. Pedersen, Ph.D. Adjunct Behavioral Scientist, RAND Associate Professor of Psychiatry and Behavioral Sciences Keck School of Medicine University of Southern California MedicalResearch.com: What is the background for this study? Response: In November of 2016, CA voted to legalize cannabis for sale and possession to adults 21 and older for recreational use. It wasn’t until January of 2018 that stores in most parts of LA County (we call these “outlets”) were legally able to begin selling recreational cannabis. We were collecting data from about 2,500 young adults in LA County as part of a longitudinal study (Principal Investigator Elizabeth D’Amico at RAND) and were able to look at cannabis use and intentions assessed at a period prior to the opening of the recreational cannabis outlets (pre-January 2018) to a period when those outlets were open (after January 2018). It has been suggested that once cannabis was more available for recreational purchase (and not just for medical purposes among those enrolled in CA’s medical marijuana program), use of cannabis among young adults would increase.  (more…)
Accidents & Violence, Author Interviews, Cannabis, JAMA / 24.12.2020

MedicalResearch.com Interview with: Li Li, MS, PhD Candidate Division of Epidemiology, College of Public Health, Ohio State University Graduate Research Associate, Center for Injury Research and Policy The Abigail Wexner Research Institute at Nationwide Children’s Hospital MedicalResearch.com: What is the background for this study? Response: Marijuana use impairs cognitive abilities necessary for safe driving, including reaction time, road lane-tracking ability, and attention maintenance. Given increasing legalization of marijuana use in the US, our study aimed to estimate marijuana-impaired driving among teens at a national level and help to identify the current prevalence to guide future intervention programs. (more…)
Author Interviews, Cannabis, Ophthalmology, Race/Ethnic Diversity, Social Issues / 09.11.2020

MedicalResearch.com Interview with: Joshua Uhr MD Ophthalmologist Philadelphia, PA MedicalResearch.com: What is the background for this study? Response: Disparities in American society have been at the forefront of the public consciousness in recent months. As part of the larger discussion about inequality, disparities in health outcomes have received much attention. In light of the renewed recognition that these disparities are stark and widespread, we felt it important to evaluate disparities in our own field, ophthalmology. Previous studies have shown disparate outcomes for individual eye conditions, such as glaucoma, cataract, and retinal detachment. Although the common and relevant endpoint of these is visual impairment, few prior studies have examined disparities in visual impairment more broadly. Our aim was to provide an updated analysis of disparity in visual impairment among adults in the United States based on race and socioeconomic status.  (more…)
Author Interviews, Cannabis / 21.10.2020

MedicalResearch.com Interview with: Carrie Cuttler, Ph.D. Assistant Professor Washington State University Department of Psychology Pullman, WA, 99164-4820  MedicalResearch.com: What is the background for this study? Response: While many studies have examined the acute effects of cannabis on other mental health symptoms such as anxiety, depression, post-traumatic stress disorder (PTSD), and psychosis there is almost no research on acute effects of cannabis on symptoms of obsessive-compulsive disorder (OCD) in humans.  Nevertheless, we have previously found that acute cannabis intoxication is associated with reductions in anxiety as well as with reductions in the intrusive thoughts characteristic of PTSD. Further previous research using a rodent model of compulsive behavior has provided pre-clinical evidence that cannabidiol (CBD) - which is the second most common constituent in the cannabis plant - reduces compulsive behavior. (more…)
Author Interviews, Cannabis / 09.10.2020

MedicalResearch.com Interview with: Christopher Kaufmann, PhD Co-first author of the study and assistant professor Division of Geriatrics and Gerontology in the Department of Medicine UC San Diego  MedicalResearch.com: What is the background for this study? What are the main findings? Response: We examined cannabis use by older patients seen in our geriatrics clinic at the University of California San Diego. We surveyed patients who came to our clinic for routine care, and found that 15% of those surveyed had used cannabis within the past 3 years. Half of users reported using cannabis regularly and most used for medical purposes. The most common targeted conditions were pain, problems sleeping, and anxiety, and patients found cannabis to be helpful in treating these conditions. We also found that 61% had initiated cannabis use after age 60, and these new users engaged in less risky consumption practices than current users who also used earlier in life.  (more…)
Author Interviews, Cannabis, JAMA, Tobacco Research / 07.10.2020

MedicalResearch.com Interview with: Isabella Lanza, PhD Associate Professor of Human Development California State University, Long Beach   MedicalResearch.com: What is the background for this study? What are the main findings? Response: This is the first study to examine both nicotine vaping and cannabis vaping trajectories across adolescence and young adulthood, which allowed us to assess whether poly-substance vaping is common among adolescents and young adults. Poly-substance vaping (nicotine and cannabis vaping) was reported among a significant proportion of participants in the study (25% were identified as poly-substance vapers). For those that either escalated to frequent nicotine vaping use in adolescence or initiated frequent nicotine vaping use in young adulthood, the probability of engaging in cannabis vaping was very high (85%+).    (more…)
Author Interviews, Cannabis, Pediatrics / 02.10.2020

MedicalResearch.com Interview with: Heather Breeze Clayton, PhD, MPH Senior Scientist, National Center for Injury Prevention and Control CDC MedicalResearch.com: What is the background for this study? Response: Thirty-three states and the District of Columbia now have policies in place legalizing marijuana for medical or adult use. While the health effects of marijuana use continue to be studied, substantial evidence suggests that a number of health risks – including cognitive and mental health outcomes- are made worse by earlier initiation of marijuana, and heavier use patterns. Scientific knowledge about the association between marijuana use and other health and risk-taking behavior in youth is still evolving. Accordingly, we sought to use nationally representative data from the Youth Risk Behavior Survey to assess what the relationship is between different patterns of marijuana use in youth (more established use vs. non-established use patterns) and a number of risk-taking and violence related behaviors. (more…)
Author Interviews, Cannabis, JAMA, OBGYNE, Pediatrics / 25.09.2020

MedicalResearch.com Interview with: Sarah E. Paul, BA , Graduate Student and Ryan Bogdan, PhD, Associate Professor BRAIN Lab Washington University in St. Louis St. Louis, MO 63130 MedicalResearch.com: What is the background for this study? Sarah Paul: This study was motivated by several trends in cannabis use, its legal landscape, and people's perception of risk. As more states legalize recreational cannabis use, cannabis has become more accessible as well as more potent. Over the past couple of decades, the percentage of adolescents and adults who think that cannabis use is risky or harmful has fallen substantially. Cannabis dispensaries have been reported to actually recommend cannabis to pregnant women for the treatment of pregnancy-related nausea. And finally, between 2002/2003 and 2016/2017, the percentage of women reporting cannabis use during their pregnancies rose 106%. Given these trends and the mixed literature regarding the potential consequences associated with prenatal cannabis exposure, we aimed to comprehensively examine a range of outcomes in a large, representative sample while accounting for a host of important potentially confounding covariates. (more…)
Author Interviews, Cannabis, Cognitive Issues, Memory, Pediatrics / 04.09.2020

MedicalResearch.com Interview with: Jarrod Ellingson PhD Assistant Professor Department of Psychiatry Anschutz Medical Campus University of Colorado Denver  MedicalResearch.com: What is the background for this study? What are the main findings? Response: We know that cannabis use is associated with many negative outcomes, but there could be many of reasons for that. For example, socioeconomic factors and peer influences both affect adolescent cannabis use and poorer cognitive functioning. To account for some of those risk factors, we studied nearly 600 sibling pairs with moderate to heavy cannabis use. We found that, as a person uses more cannabis than their sibling, they tend to have worse memory recall than their sibling. (more…)
Accidents & Violence, Author Interviews, Cannabis, JAMA, NYU / 23.06.2020

MedicalResearch.com Interview with: Julian Santaella Tenorio, MSc DrPH Epidemiology Center for Opioid Epidemiology and Policy Division of Epidemiology, Department of Population Health New York University Langone School of Medicine, New York, New York MedicalResearch.com: What are the main findings? car-accident-traffic-accidentResponse: This study found that recreational cannabis laws were associated with increases in traffic fatalities in Colorado (mean of 75 excess fatalities per year) but not in Washington State.  These findings suggest that unintended effects of recreational cannabis laws can be heterogeneous and may be specific to variations in how these laws are implemented
(eg, density of recreational cannabis stores).   (more…)
Author Interviews, Cannabis, Opiods / 22.06.2020

MedicalResearch.com Interview with: Amalie K. Kropp Lopez, MS MD Candidate Geisinger Commonwealth School of Medicine Class of 2023 Scranton, Pennsylvania MedicalResearch.com: What is the background for this study? Response: The opioid crisis is still affecting America, effecting millions of people from all walks of life. With the high risks of abuse and overtreatment with opioids, marijuana has been a newly reconsidered alterative for pain treatment. This study sought to quantify the changes in prescription opioid distribution using data reported by the Drug Enforcement Administration in Colorado after the legalization of recreational marijuana which gave the public increased access to its pain-relieving effects. (more…)
Accidents & Violence, Author Interviews, Cannabis, JAMA / 22.06.2020

MedicalResearch.com Interview with: Russell Kamer, MD Department of Medicine, New York Medical College, Valhalla 15 North Broadway, Suite E White Plains, NY 10601 New York MedicalResearch.com: What is the background for this study? "marijuana apocalypse - weed is a stimulant !" by Blind Nomad is licensed under CC BY 2.0Response: It is well known that marijuana usage impairs driving ability, yet the early studies of the effects of recreational marijuana legalization on traffic fatalities were inconclusive. MedicalResearch.com: What are the main findings? Response: By analyzing data over a longer time period, we found that the legalization of recreational marijuana increased traffic deaths in the first four states to legalize. Traffic fatalities increased about 20% in those states. If we apply these numbers to the nation as a whole, nationwide legalization would be associated with about 7,000 excess traffic fatalities each year. (more…)
Author Interviews, Cannabis, Emergency Care / 20.06.2020

MedicalResearch.com Interview with: Ryan Vandrey, Ph.D. Associate Professor Behavioral Pharmacology Research Unit Johns Hopkins University School of Medicine Baltimore, MD 21224  MedicalResearch.com: What is the background for this study? Response: The background for this study is that 33 states in the U.S. have legalized medicinal cannabis use and millions of people are using cannabis for therapeutic purposes, but we have very little data on the broad health impacts of medicinal cannabis use. We surveyed medicinal cannabis users and non-using controls who had a variety of health problems and found that the cannabis users reported better health, quality of life, and less healthcare utilization compared with controls.  Because we worried about group characteristics accounting for the differences observed, we then did an analysis of people who switched groups over time (e.g. non-users who later initiated cannabis use or cannabis users who later quit) and found the same differences emerged in the same individuals over time.  Important to note here is that not all individuals who used cannabis benefited from it and that most participants were using high CBD varieties of cannabis in conjunction with more traditional treatments. (more…)
Author Interviews, Cannabis, Gender Differences / 21.05.2020

MedicalResearch.com Interview with: Francesca Filbey, PhD Associate Provost and Professor of Cognition and Neuroscience Bert Moore Chair The University of Texas at Dallas MedicalResearch.com: What is the background for this study? Response:  Studies have reported differences in how males and females respond to cannabis and how they develop problems related to cannabis use.  We sought to determine whether craving may underlie this difference in male and female cannabis users. (more…)
Author Interviews, Cannabis, CDC, JAMA, Pediatrics, Tobacco Research / 18.05.2020

MedicalResearch.com Interview with: Susan Hocevar Adkins, MD Lead Author, Senior Medical Officer, and Commander United States Public Health Service CDC MedicalResearch.com: What is the background for this study? Response: Since August 2019, the Centers for Disease Control and Prevention (CDC), the US Food and Drug Administration (FDA), and state, local, and territorial health departments have been investigating a national outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI). Although clinical presentation and outcomes of EVALI patients generally have been reported, data on adolescent patients are more limited. This article fills this gap by using data from national EVALI surveillance at CDC to examine demographic, substance use, and clinical characteristics of adolescent EVALI patients relative to young adult and adult EVALI patients. (more…)
Author Interviews, Cannabis, JAMA, Pulmonary Disease / 22.04.2020

MedicalResearch.com Interview with: Alex Hollingsworth PhD Assistant Professor O'Neill School of Public and Environmental Affairs Indiana University MedicalResearch.com: What is the background for this study? What are the main findings? Response: I've been working with Coady Wing and Ashley Bradford on a few different studies of the effects of recreational marijuana laws on drug and alcohol use. Soon after EVALI became a major issue, the prevailing theory from the CDC and others was that EVALI was caused by the use of vitamin E acetate in illegal THC vaping products. Our group read about this and we thought about some of the things that often happen in black markets for illegal drugs. For instance, during the alcohol prohibition era, bootleg alcohol producers often made and sold alcohol products that were not that safe to drink. In more recent years, there are cases where black market sellers of illegal drugs like heroin try to increase profit margins by adding other substances, which can be harmful. We thought that maybe something like that could be happening in EVALI. Perhaps people in states where recreational marijuana is legal tended to purchase marijuana products from the legal market and the legal market was not selling any marijuana vaping products that included vitamin E acetate. (more…)