09 Jul 6 Common Mistakes People Make While Taking SSRIs
Mental Health Notice: If you are experiencing significant depression, anxiety, or thoughts of self-harm, please speak with a qualified healthcare professional. You can contact the 988 Suicide & Crisis Lifeline by calling or texting 988 (24/7), or the Crisis Text Line by texting HOME to 741741. In a life-threatening situation, call 911.
Selective serotonin reuptake inhibitors (SSRIs) are among the most commonly prescribed medications for managing conditions like depression and anxiety. Drugs such as fluoxetine and sertraline work by increasing serotonin levels in the brain, helping regulate mood and emotional stability.
While SSRIs are generally effective, their success often depends on how they are used. Many individuals unknowingly make mistakes that can reduce effectiveness or increase side effects. Understanding these pitfalls is essential for achieving better mental health outcomes. For a deeper look at how SSRIs are being studied in clinical contexts, see this research overview on SSRI prescribing patterns and considerations for older adults.
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Photo by Ivan Babydov[/caption]
Dr. Spampinato[/caption]
Maria Vittoria Spampinato, MD
Neuroradiology Division Director
Department of Radiology and Radiological Science
Medical University of South Carolina
Charleston, SC 29425-3230
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Alzheimer’s disease (AD) represents a major public health crisis worldwide. More than 5 million people currently have AD in the United States. AD is a slowly progressing neurodegenerative brain disorder with a long preclinical phase. Many people with AD first suffer from mild cognitive impairment (MCI), a decline in cognitive abilities like memory and thinking skills that is greater than that associated with normal aging. A person with MCI is at an increased risk of developing AD or another dementia, although some individuals with MCI remain cognitively stable or improve.
Anxiety is frequently observed in individuals with MCI. The reported prevalence of anxiety in MCI patients varies between 10 and 50%. In this study we evaluated a cohort of 339 individuals with MCI participating in the Alzheimer’s Disease Neuroimaging Initiative study (ADNI2). During the five years of study participation, 72 patients experienced cognitive decline and were diagnosed with AD. We did not find difference in age, gender and education among patients with and without AD conversion. Patients who progressed had greater atrophy of the hippocampi and entorhinal cortex on their MRI scan, as expected (hippocampal atrophy is often used as a marker of neurodegeneration in AD), as well as greater prevalence of APOE4 is the strongest known genetic risk factor for AD. Patients who progressed to Alzheimer’s disease also had greater severity of anxiety during the study, as measured using the Neuropsychiatric Inventory-Questionnaire. Next we determined the effect of the MRI findings (hippocampal and entorhinal cortex atrophy), of the genetic risk factor (APOE4) and of the severity of anxiety on the time to progression to AD. We found that higher levels of anxiety were associated with faster progression from MCI to AD, independently of whether they had a genetic risk factor for Alzheimer’s disease or brain volume loss. We still need to understand better the association between anxiety disorders and cognitive decline. We do not know whether increased levels of anxiety are a consequence of cognitive decline or if anxiety exacerbates to cognitive decline. If we were able to find in the future that anxiety is actually contributing to cognitive decline, then we should more aggressively screen for anxiety disorders in the elderly population.