Health Care Systems, Pharmacology / 28.04.2026
Why medication management is getting harder in healthcare
Patient needs are getting more complex and that's starting to show in how medications are prescribed and managed. Patients are living longer, often with more than one condition at the same time and treatment plans now involve several drugs rather than just one or two. That makes medication decisions harder to manage in practice, especially when different conditions are being treated at once. It also explains why more advanced pharmacy training, such as obtaining a doctor of pharmacy degree, is becoming relevant across different healthcare settings.
More patients are on multiple medications at the same time. Recent data suggests that around with that number rising in older age groups. Among adults over 60, roughly one in three are taking five or more medications on a regular basis.
This affects how treatment is handled day to day. Each additional drug increases the chance of interactions, side effects and changes in how other medications behave in the body. It also makes monitoring harder, particularly when care is spread across different providers. A patient might receive prescriptions from a general practitioner, a specialist and a hospital team and those decisions don't always sit in one place.
Adherence is another issue. Dosing schedules don't always align and some medications have specific requirements around food or timing. It doesn't take much for something to go wrong. Missing doses, taking drugs too close together, or misunderstanding instructions can all affect how well a treatment works. In some cases, patients end up stopping medication altogether because the routine becomes too difficult to manage.
Dr. Shoichet[/caption]
Brian Shoichet, Professor
UCSF
http://www.bkslab.org/contact.php
MedicalResearch.com: What is the background for this study?
Response: Excipients are ubiquitous in drug formulations. What most people consider "drugs" are formulations of active and "inactive" ingredients--the excipients. These "inactive" ingredients, which you can find on the label of all of the drugs you use, play crucial roles in drug stability, as antioxidants, as colorants to help patients distinguish among them, as anti-microbials to keep them from getting infected with bacteria, helping to make the soluble in the patient, among other functions.
They are considered "inactive" because they do not have observable toxicity in animal and sometimes histological studies, but few of them have been evaluated in a modern way. This would involve testing the excipients for activity on individual receptors and enzymes that are involved in biological responses, which is what happens for drugs. Doing this was the focus of this study
Cara Tannenbaum, MD, MSc
Director | Directrice
Canadian Deprescribing Network
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The D-Prescribe trial was driven by the need to show that seniors can cut down on their medication in a safe and effective manner. Pharmacists intervened in a proactive way to flag patients who were on potentially risky meds such as sleeping pills, NSAIDs and glyburide and to inform them of the risks, using an educational brochure. Pharmacists also communicated with their physician using an evidence-based pharmaceutical opinion to spark conversations about deprescribing. As a result, 43% of patients succeeded in discontinuing at least one medication over the next 6 months.











