MedicalResearch.com Interview with:
Sirpa Soini, MHC, researcher
Department of General Practice and Primary Health Care
University of Helsinki
Medical Research: What is the background for this study? Response: Short-term weight loss is often successful, but he obtained results
are difficult to maintain. Therefore, a study focusing on obese people who successfully lost weight, with special emphasis upon methods applied and background factors,
is of major importance. Many people are successful in losing weight by
themselves without taking part in any organized group activity. The
knowledge about their success and the methods applied does not usually
reach the health care personnel and is one reason why it is difficult
to get reliable information about those who are successful in losing
weight.
(more…)
MedicalResearch.com Interview with: Pam R. Taub, MD, FACC
Assistant Professor of Medicine
UC San Diego Health System
Division of Cardiology Encinitas, CA 92024
Medical Research: What is the background for this study?Dr. Taub: Epidemiological studies indicate that the consumption of modest amounts of dark chocolate (DC), which contains the natural cacao flavanol (-)-epicatechin (Epi,) is associated with reductions in the incidence of cardiovascular diseases (CVD). The health benefits of dark chocolate have been attributed to Epi. Clinical studies using cocoa and/or DC in normal volunteers or subjects with CVD have reported improvements in peripheral and coronary vascular endothelial function, blood pressure, lipids, insulin resistance, and inflammatory markers. The mechanism underlying these improvements is thought to be due to increased nitric oxide levels and improved endothelial function. We have also shown that capacity of Epi to favorable impact mitochondria under normal and disease states.
We previously conducted pilot study in five patients with heart failure and type II diabetes, and showed that in skeletal muscle (SkM) biopsies there is a severe reduction in mitochondrial volume and cristae, as well as, in structural/functional proteins. After treatment with Epi rich dark chocolate , there was a significant recovery of SkM mitochondrial cristae, structural/functional proteins (e.g. mitofilin), as well as in regulators of mitochondrial biogenesis. However, no studies have examined the capacity of Epi rich dark chocolate to enhance exercise capacity in normal subjects and assess its impact on mitochondrial and oxidative control systems.
Medical Research: What are the main findings?Dr. Taub: Seventeen subjects were randomized to placebo (n=8) or DC groups (n=9) and consumed 2 squares of chocolate (20 g, provided by Hershey) for 3 months.
We showed in the chocolate group subjects had improved levels of HDL cholesterol and enhanced exercise capacity that is linked to the stimulation of SkM metabolic control endpoints which enhance mitochondrial function.
(more…)
MedicalResearch.com Interview with:
Juan Del Coso Garrigós
Profesor CC. de la Act. Física y del Deporte
Responsable del Laboratorio de Fisiología del Ejercicio
UNIVERSIDAD CAMILO JOSÉ CELA
MedicalResearch: What is the background for this study? What are the main findings?Response: From a scientific point of view, it is well known that salt (either in capsules or included in a drink) can improve physical performance and several other physiological factors such as plasma volume maintenance, thermoregulation, etc in endurance activities. These effects are more evident when the amount of salt ingested during exercise matches the amount of salt lost by sweating. By using only sports drinks, it is impossible to replace all the salt lost by sweating because they only contain a relatively small amount of salt in their compositions (between ½ and 1/3 of the amount of salt lost by sweating).
In fact, some of the investigations that determined the effectiveness of ingesting salt in sports have been financed by most popular sport drinks trademarks. However, sports drink companies only include a part of the salt lost by sweating because for them, taste is elemental for their markets! I suppose that, if they include more salt in their commercially available drinks, they would be more effective to prevent dehydration and performance decline, but at the same time, the taste of the drink would diminish the amount of beverage ingested worldwide.
In this case, in the sport drinks market there is a well- established balance between taste and physiological effectiveness.
As an example, most “salted” sport drinks contain 20-25 mM of sodium while it is well known that sweat sodium concentration ranges from 20 to 60 mM (salty sweater can reach 100 mM!!). This is not a regulatory limitation, because UE considers sports drinks to carbohydrate-electrolyte solutions that contain sodium between 20 and 50 mM.
Our main finding is: To ingest salt capsules, in addition to the habitual rehydration routines with sports drinks, improves performance in a triathlon. This ergogenic effect was mediated by better maintenance of body water and electrolytes balances.
(more…)
MedicalResearch.com Interview withChristopher C. Imes, PhD, RN
Assistant Professor, Acute and Tertiary Care
University of Pittsburgh, School of Nursing
MedicalResearch: What is the background for this study? Dr. Imes: Increased physical activity (PA) with reduced energy intake is the key strategy to achieve weight loss. However, in research, there are challenges to obtaining accurate PA data. Many studies rely on self-report, which is easily accessible and inexpensive but is known to have numerous limitations. Pedometers are a relatively inexpensive and accessible method to objectively measure certain aspects of physical activity. The purpose of this analysis was to examine the associations between self-reported physical activity, pedometer step count data and weight loss during the first 6-months of the Self-Efficacy Lifestyle Focus (SELF) trial. All participants in this trial were instructed to reduce their calorie and fat intake, were encouraged to engage in at least 150 minutes of moderately intense PA/week or 7500 steps/day, and to self-monitor their diet and physical activity.
MedicalResearch: What are the main findings?Dr. Imes: Change in self-reported physical activity from baseline to 6 months was not associated with weight change. However, average daily step count, derived from pedometers given to participants during the same time period, was associated with weight loss. More daily steps results in more weight loss. The participants who averaged over 7500 steps/day lost about 9.5% of their initial body weight; whereas, the participants who averaged less than 5000 steps/day only lost about 5.0%.
(more…)
MedicalResearch.com Interview with:
Prof. Scott Montgomery
Prof. Montgomery is a clinical epidemiologist, conducting research in life-course influences on chronic disease risk
Örebro Univeristy
Medical Research: What is the background for this study? What are the main findings?
Prof. Montgomery: Stress is thought to increase the risk of heart disease. However, an experience that is stressful for one person may not be so for another, as stress resilience varies. As we believe that stress resilience is influenced by childhood experiences, we examined whether teenagers with low stress resilience were more likely to have coronary heart disease in subsequent adulthood (they were followed to a maximum age of 58 years). In this study of 237,980 men, we found that low stress resilience in adolescence was associated with a raised risk of heart disease. A surprising result was that although higher levels of fitness in adolescence were associated with lower heart disease risk, the benefit of such fitness, in terms of heart disease risk, was not present in the men with low stress resilience.
(more…)
MedicalResearch.com Interview with:
Thomas W. Buford, PhD
Assistant Professor, Division of Clinical Research
Department of Aging and Geriatric Research, University of Florida College of Medicine
Director, Health Promotion Center
University of Florida Institute on Aging
Medical Research: What is the background for this study? What are the main findings?Dr. Buford: This study was a cross-sectional analysis of data collected from over 1000 older adults upon their entry into the Lifestyle Interventions and Independence for Elders (LIFE) study. Briefly, participants were recruited into the LIFE Study who were over 70 years of age, sedentary, and had mobility limitations. The objective of this study was to examine, at baseline prior to their participation in the study interventions, the association between daily physical activity habits and risk of major cardiovascular events (i.e. heart attack and coronary-related death). The study utilized accelerometers, devices designed to identify and quantify human movement, to measure participant’s daily activity. Predicted risk of cardiovascular events was determined using a risk score established in the Framingham Heart Study. As identified by accelerometry measures, participants spent on average 70% of their waking hours being sedentary. The major finding of the study, however, was that even extremely low-level activity was associated with an improved cardiovascular risk profile. For every 25-30 minutes a participant was sedentary per day, predicted risk was 1 percent higher. Conversely, But activity identified as slightly above sedentary — which could be light housework or slow walking — was associated with higher levels of the more beneficial kind of cholesterol, HDL, in people with no history of heart disease.(more…)
MedicalResearch.com Interview with:
Dan White PT , ScD, Msc
University of DelawareMedical Research: What is the background for this study? What are the main findings?
Dr. White: We know that diet and exercise are beneficial to reduce knee pain, however it is not known whether diet and exercise can actually prevent the development of knee pain in people at high risk. We found that an intensive program of diet and exercise had a small but statistically significant protective effect with preventing the development of knee pain in overweight and obese people with diabetes.
(more…)
MedicalResearch.com Interview with:
Tess Harris
St George’s University of LondonMedicalResearch: What is the background for this study?
Response: Physical activity is vital for both physical and mental health in older people, preventing at least 20 common health problems. Yet the majority of older people do not achieve the World Health Organisation physical activity guidelines for health of at least 150 minutes every week of at least moderate-to-vigorous intensity physical activity in bouts that each last at least 10 minutes. Brisk walking is a good way to achieve moderate intensity physical activity, with a low risk of harm. Pedometers can give you direct feedback on your step-count and accelerometers record both step-counts and the intensity of physical activity achieved. The PACE-Lift trial assessed whether an intervention to increase walking, comprising pedometer and accelerometer feedback, combined with physical activity consultations provided by practice nurses over a 3 month period, based on simple behaviour change techniques, could lead to sustained increases in physical activity in 60-75 year olds.
(more…)
MedicalResearch.com Interview with:
Dr Miranda ArmstrongM.Phil.
Physical Activity Epidemiologist
Cancer Epidemiology Unit University of Oxford
Oxford, UK
Medical Research: What is the background for this study? What are the main findings?
Dr. Armstrong: Physical activity has generally been associated with reduced risk of heart disease. However, there is limited evidence on the associations between the frequency and durations of various activities with stroke and blood clots, especially in middle-aged women.
This is a very large study of 1.1 million middle-aged women, which confirms the benefits of moderate activity for reducing the risk of heart disease and stroke. Further to this, it shows that benefits may be more wide ranging than previously thought as the risk of blood clots was also lower in women reporting moderate activity when compared to inactive women. We found little evidence to suggest that activity more frequent than a few times per week provided further benefits in relation to these diseases.
(more…)
MedicalResearch.com Interview with:
Molly B. Conroy MD, MPHAssistant Professor of Medicine, Epidemiology, and Clinical and Translational ScienceUniversity of Pittsburgh, Pittsburgh, PA,
Medical Research: What is the background for this study? What are the main findings?
Response: The background for the study is the fact that middle-aged women are at high risk for being physically inactive, which puts them at higher risk for heart disease, cancer, and other chronic health problems.
We compared an interventionist-led physical activity and weight loss program delivered in coordination with primary care to a booklet that women were asked to use to exercise by themselves at home. We found that women who received the interventionist-led program had significantly greater increases in physical activity at 3 months, compared to women who received booklet. At 12 months, women who received the interventionist-led program were still more active than they were before starting the program, although the difference between the 2 groups was no longer significant.
(more…)
MedicalResearch.com Interview with:Paula Iso-Markku, MD,
Department of Clinical Physiology and Nuclear Medicine,
HUS Medical Imaging Center,
Helsinki University Central Hospital and University of Helsinki
Helsinki , Finland
MedicalResearch: What is the background for this study? What are the main findings?Dr. Iso-Markku : The social, financial and humane burden of the dementia is extensive as the worldwide prevalence of dementia is estimated around 35.6 million. Finding efficient prevention strategies for dementia is crucial. Within the past decade vascular risk factors have been recognized as very potential risk factors of dementia. As physical activity is known to affect vascular risk factors, it might also be a potential preventive tool against dementia. Few comprehensive epidemiological studies on physical activity in middle age and dementia occurrence later in life have been conducted.
The comprehensive Finnish Twin Study offers a unique approach to the subjects as the shared growing up environment and genes can be taken into account. The study population is extensive and a good representation of the Finnish population. In this study the association of physical activity in adulthood and dementia mortality was investigated in a 29-year follow-up.
The main finding in this study was that persistent vigorous (i.e. more strenuous than walking) physical activity was significantly associated with lower dementia mortality. The results in the paired analysis, comparing twins to co-twins, were similar but remained non-significant. The analyses of the volume of physical activity were, however, controversial.
(more…)
MedicalResearch.com Interview with:
Xuemei Sui, MD, MPH, PhD
Assistant Professor Department of Exercise Science
Graduate Director Division of Health Aspects of Physical Activity
Arnold School of Public Health University of South Carolina
Columbia, SC 29208
Medical Research: What is the background for this study?
Dr. Sui: Previous studies have established that low levels of cardiorespiratory fitness (CRF), an indicator of regular physical activity, and body compositions with higher fat mass serve as risk factors for cardiovascular disease and predictors of deaths related to cardiovascular disease. These studies have examined long-term trends of fatness (i.e., body fat) and cardiorespiratory fitness in children, adolescents and men, but few have looked at these factors in female populations. Therefore, the aim of this study was to investigate secular change of cardiorespiratory fitness and body composition during 35 years in a large sample of women enrolled in the Aerobics Center Longitudinal Study.
13 037 women aged 20 to 64 were enrolled in our study from January first, 1970, through December 31st, 2004. We divided our participants into 2 age groups, and divided 35 years into 7 time groups. Cardiorespiratory fitness was assessed by maximal treadmill testing using a modified Balke protocol, and the percentage of body fat was assessed by hydrostatic weighing or the sum of 7 skinfold measures, following standardized protocols. According to percent body fat, we divided body composition into fat mass and fat free mass.
Medical Research: What are the main findings?
Dr. Sui: The data showed that body mass index (BMI) increased over the 35-year period even though cardiorespiratory fitness levels rose as well. By looking at the body composition of the participants along with their BMIs, the researchers were able to observe that their body fat did not increase. This finding suggests that the weight gains that led to higher BMIs over time were not necessarily comprised of body fat. Participants may have been putting on muscle mass due to their increased physical activity, as indicated by their higher cardiorespiratory fitness.
Another interesting finding was that when leisure-time physical activity (LTPA) reaches 668.5 MET min/wk, cardiorespiratory fitness stays at a higher level. So in order to improve cardiorespiratory fitness for physically inactive women, we should encourage them to meet this level. The drift downward in cardiorespiratory fitness among women indicates the need for continuing efforts to promote their physical activity and fitness.
(more…)
MedicalResearch.com Interview with:
Sarah Hanson
Norwich Medical School
University of East Anglia
Medical Research: What is the background for this study? What are the main findings?
Response: Physical inactivity is a global problem. Walking is an easy way to increase physical activity. One way to increase physical activity may be through the use of outdoor walking groups. Walking groups are increasingly popular but until now we have not known if there are wider health benefits from walking groups, apart from increasing physical activity.
Medical Research: What was the study method?Response: A systematic review and meta-analysis of outdoor walking group interventions found 42 studies which met the eligibility criteria. These studies involved 1,843 participants in 14 countries doing approximately 74,000 hours of walking.
(more…)
MedicalResearch.com Interview with:
Philipe de Souto Barreto (PhD)
Toulouse University Hospital (CHU Toulouse)
Gérontopole of Toulouse - Head of Department: Prof Bruno Vellas
Medical...
MedicalResearch.com Interview with:
Dr. Liana Machado PhD
Department of Psychology Brain Health Research Centre
University of Otago Dunedin New Zealand
Medical Research: What is the background for this study? What are the main findings?
Response:A large body of data indicates links between chronic physical activity levels and cognitive performance in healthy populations. Although the bulk of evidence comes from studies in older adults, a number of studies have established links in children and in young adults. However, the mechanisms supporting the exercise-cognition links have remained unclear. Finding from an earlier study of ours, published in the journal Neuropsychology, pointed toward cerebrovascular factors as potentially important. In our new study in Psychophysiology, we found evidence suggesting that higher oxygen availability in the brain is one of the cerebrovascular factors that helps support better cognitive performance in people who exercise more regularly, thus providing important insight toward understanding why cognitive performance improves with regular exercise.
(more…)
MedicalResearch.com Interview with:
David Alter, MD, PhD FRCPC Senior Scientist
Toronto Rehabilitation Institute-University Health Network and Institute for Clinical Evaluative Sciences
Research Director, Cardiac Rehabilitation and Secondary Prevention Program Toronto Rehabilitation Institute
Medical Research: What is the background for this study? What are the main findings?
Dr. Alter: We knew going into the study that exercise was an important lifestyle factor that improved health. We also knew from studies that sedentary time was associated with deleterious health-effects. What we didn’t know was whether the health-outcome effects of sedentary time and exercise were really one and the same (i.e., albeit opposite ends of the same spectrum) or alternatively, whether the health effects of each were independent of one another. We explored over 9000 published studies to quantify the health-outcome effects associated with sedentary behaviour and extracted only those which took into account both sedentary time and exercise. We found a consistent association between sedentary time and a host of health outcomes independent of exercise. Specifically, after controlling for an individual’s exercising behaviour, sitting-time was associated with a 15-20% higher risk of death, heart-disease, death from heart disease, cancer-incidence, and death from cancer. Sitting time was also independently associated with a marked (i.e., 90% increase) in the risk for diabetes after controlling for exercise. In short, sedentary times and exercise are each independently associated with health outcomes. We hypothesize that the two may have different mechanism, and may require different therapeutic strategies. But, the health-outcome implications of both are each important in their own right.
(more…)
MedicalResearch.com Interview with:
Scott M. Hayes, Ph.D. Associate Director
Neuroimaging Research for Veterans Center
Memory Disorders Research Center
VA Boston Healthcare System
Assistant Professor of Psychiatry
Boston University School of Medicine
Medical Research: What is the background for this study? What are the main findings?
Dr. Hayes: Studies with rodents have demonstrated that physical activity positively impacts memory, whereas human studies have tended to emphasize a relationship with executive function—which refers to one’s ability to plan, organize, and manipulate information in one’s mind. To clarify the relationship between fitness, cognition, and aging, we directly assessed cardiorespiratory fitness (heart and lung function) using the gold standard in the field, a graded treadmill test, and assessed both memory and executive functions in young and older adults. Our results showed that cardiorespiratory fitness was positively associated with memory and executive functions in older adults, but not young adults. In fact, on tests of executive functions, older adults with higher levels of cardiorespiratory fitness performed as well as younger adults. The impact of cardiorespiratory fitness may be age-dependent. Young adults, who are at their peak in terms of memory performance, may exhibit minimal associations with cardiorespiratory fitness. In contrast, cardiorespiratory fitness likely has a larger impact in older adults by attenuating age-related decline in memory.
(more…)
MedicalResearch.com Interview with:
Rania Mekary, MS, Ph.D.
Harvard School of Public Health
Nutrition Department
Boston, Ma 02115
Medical Research: What is the background for this study? What are the main findings?
Dr. Mekar: Findings on weight training and waist circumference (WC) change have been controversial. Moreover, a lot of people focus on aerobic and only aerobic workout... They are not to be blamed because aerobic workout (e.g. jogging) relies mostly on fat as a source of energy while anaerobic workout (e.g. resistance) relies mostly on carbohydrates. Our study, however, showed that resistance training over the long-term was the most inversely associated with waistline change (aka abdominal fat), even more than aerobic exercise. We also justified physiologically why it is the case... It has to do with the greater Excess Post-exercise Oxygen Consumption (EPOC) as compared with aerobic training and also to the muscle adaptation and its increase in mitochondria which leads to more lipid oxidation upon engaging in anaerobic workout over the long-term. (more…)
MedicalResearch.com Interview with:
Carl "Chip" Lavie MD, FACC
Medical Director, Cardiac Rehabilitation and Prevention
Director, Exercise Laboratories
John Ochsner Heart and Vascular Institute
Professor of Medicine
Ochsner Clinical School-UQ School of Medicine
Editor-in-Chief, Progress in Cardiovascular Diseases
Medical Research: What are the key points of your editorial?Dr. Lavie:
1) The importance of higher fitness to predict a lower rate of developing Heart Failure;
2) improvements in fitness over time predict a lower rate of developing Heart Failure, and
3) Once Heart Failure develops, higher fitness predicts a more favorable prognosis.
(more…)
MedicalResearch.com Interview with: Lauren Marie Sparks, PhD
Faculty Scientist at the Translational Research Institute for Metabolism and Diabetes
Florida Hospital and the Sanford-Burnham Medical Research Institute Orlando, FL
Medical Research: What is the background for this study? What are the main findings?Dr. Sparks: As a clinical scientist focused on exercise effects on muscle metabolism in diabetes, I have seen first-hand a significant minority of individuals with diabetes not improve their glucose control (HbA1c) after 9 months of supervised exercise. They poured their hearts out on those treadmills 3-4 days a week for 9 months and still ended up no better than when they started. I have also seen similar data from some of my colleagues’ studies. So I really want diabetes research to invest the intellect and dollars into discovering what these roadblocks are—I happen to believe it is in the DNA (genetics) and the way that DNA is “read” or expressed (epigenetics). So it’s a bit of a ‘call to action’ for researchers to start looking into some of their data to find these people and better understand this phenomenon and for hopefully the funding sources to recognize this as a viable area of research.
(more…)
MedicalResearch.com Interview with: Prof. Francesca Mallamaci
Professor of Nephrology
Head of the Hypertension Unit at the Department of Nephro-Urology, CNR-IBIM Research on Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Reggio Calabria, Italy
Medical Research: What is the background for this study? What are the main findings?Dr. Mallamaci: It is well known that physical activity is beneficial both in normal individuals and in patients with heart failure which represent a high risk category of patients. We have scanty information about physical activity in dialysis patients. So the aim of our study was to test the effectiveness of a low-intensity, easy to implement, home exercise program on physical performance in about 300 dialysis patients in a multicenter, randomized, controlled clinical trial (EXCITE, ClinicalTrials.gov NCT01255969). What we found in our study was that dialysis patients who performed exercise improved their physical performance and this was documented by 2 well known and validated performance tests such as the Six Minute Walking Test and the Sit-to-stand-to sit test. We found also that after 2 year follow-up dialysis patients who were in the active exercise arm had a lower rate of hospitalization and a trend to a better survival, compared to dialysis patients in the control arm of the study. (more…)
MedicalResearch.com: Interview Invitation
Dr. Wenji Guo
University of Oxford
Medical Research: What is the background for this study?Response: Previous studies report increased risk for breast cancer in postmenopausal women who have a higher Body Mass Index (BMI) – a measure of body fat based on height and weight. However, BMI is unable to distinguish between excess weight due to fat rather than muscle. More direct measures of fatness, such as body fat percentage, may be better indicators of disease risk. And although probable evidence for the relationship between physical activity and breast cancer now exists, questions still remain over the role of vigorous compared to lower intensity physical activity.
(more…)
MedicalResearch.com: Comments from
Virpi Kuvaja-Köllner and her team:
Project manager, teacher, M.Sc. (Health Economics), PhD Student
University of Eastern Finland
Faculty of Social Sciences and Business Studies
Department of Health and Social Management
Medical Research: What is the background for this study?Response: As we all know insufficient physical activity (PA) is associated with an increased risk of various chronic diseases and increases in health care expenditure. However, there are some economic evaluation studies related to physical activity interventions that have proved some of those interventions can offer “good value for money”. Unfortunately, most of these studies have focused on interventions at the individual or patient group level. It is easy to notice that there is a lack of studies related to cost-effectiveness of physical activity interventions at the population level. Somehow this is controversial because the need to increase physical activity in the population is urgent and the public funding for health care and other services is tighter than ever. We should remember that if we can increase physical activity among large population groups, especially among those whoare physically inactive, it might also have an impact on our healthcare costs.
(more…)
MedicalResearch.com Interview with: Paul D. Loprinzi, PhD
Center for Health Behavior Research
Department of Health, Exercise Science and Recreation Management
The University of Mississippi, University, MS.
Medical Research: What is the background for this study? What are the main findings?Dr. Loprinzi: COPD not only induces inflammation in the lung, but systemic inflammation as well. Therefore, individuals with COPD are at an increased risk of cardiovascular and metabolic disease as a result of increased systemic inflammation. Physical activity has been shown to reduce systemic inflammation in the general population, but the association between physical activity and systemic inflammation among those with COPD is less established. Our study demonstrated that individuals with COPD who were more active had less systemic inflammation than those who were less active.
(more…)
MedicalResearch.com Interview with:Professor Emrah Düzel
Director, Institute of Cognitive Neurology and Dementia Research, OvG Univ. Magdeburg, Germany
Institute of Cognitive Neuroscience
University College London
Medical Research: What are the main findings of the study?Professor Düzel:We found that even in old age, intensive and long-term (3 months) aerobic exercise can improve blood flow in the hippocampus, a brain structure that is of critical importance for memory. The increase in blood flow is evident during a resting state and this means that the exercise improves the overall perfusion of the hippocampus. Such effects had previously only been reported in young adults. As previously observed in young adults, the change in blood flow after exercise is related to the improvement of specific memory skills. We found the closest relationship between improved blood flow and recognition memory for complex objects. This is interesting because this type of memory is likely to benefit from “pattern separation”, a process that in animal studies of exercise is tightly associated with hippocampal neurogenesis.
However, we also found that the exercise-related improvement in hippocampal blood flow and in recognition memory was absent in the older seniors of our study cohort. Those who were beyond 70 did not show any improvement. We reasoned that this may have been due to higher levels of stress in the older seniors. Therefore, we investigated whether elevated serum cortisol levels dampened the benefits of exercise in the older seniors. But this was not the case making it unlikely that stress levels can account for these findings.
(more…)
MedicalResearch.com Interview with: Elvira Cicognani PhD
Department of Psychology
School of Psychology and Education, University of Bologna
Piazza Aldo Moro, 90 - Cesena, Italy -
Viale Berti Pichat, 5 - Bologna, Italy
Medical Research:What are the main findings of the study?Dr. Cicognani:The study is part of a larger project of the Italian National Transplant Center (Centro Nazionale Trapianti, CNT), started in 2008, in collaboration with Istituto Superiore di Sanità, Centro Studi Isokinetic, University of Bologna, Cimurri Impresa e Sport and Patients’ associations. The general aim is to encourage transplant patients to practice physical activity and even sport activity, in view of its benefits in enhancing recovery and quality of life after transplantation.
In this study we assessed Health-related quality of life on 118 active kidney transplant patients practicing different sports at low to moderate intensity and compared them with those of 79 sedentary kidney transplant patients and with 120 active healthy control subjects.
Active transplant patients reported higher levels of quality of life than sedentary patients on most dimensions of quality of life and similar to active healthy controls. In brief, practicing sports may allow patients to achieve a level of quality of life similar to the general population of active individuals.
(more…)
MedicalResearch.com Interview with: Jinjin Zheng Selin, MSc
Unit of Nutritional Epidemiology
Institute of Environmental Medicine
Karolinska Institutet Stockholm Sweden
Medical Research: What are the main findings of the study?Response: Our results suggest that higher levels of total physical activity, especially in the long-term, as well as specific types of physical activity including walking/bicycling and work/occupational activity, may be associated with decreased risk of age-related cataract among middle-aged and elderly women and men. On the other side, high levels of leisure time inactivity may be associated with increased risk of cataract.
(more…)
MedicalResearch.com Interview Invitation with:Dr. Yann C Klimentidis, PhD
Assistant professor of Epidemiology and Biostatistics
Mel and Enid Zuckerman College of Public Health
University of Arizona Medical Center
Medical Research: What are the main findings of the study?Dr. Klimentidis:The main finding is that the association of physical activity with type-2 diabetes risk is weakest among those who are at high genetic risk for type-2 diabetes. Furthermore, we find that this trend is stronger among women as compared to men, and that it appears to be driven mainly by genetic risk to insulin resistance, as opposed to genetic risk for reduced beta-cell function.
(more…)
MedicalResearch.com Interview with: Associate Professor Dafna MeromPh.D
Physical Activity and Health
University of Western Sydney
Penrith NSW Australia
Medical Research: What are the main findings of the study?Dr. Merom:In a cohort of 1667 older Australian men (mean age 76.8 years) data on incident falls were collected every four months by telephone interview. We compared the rate of falling over 48 months of follow-up of men who participated in golf, Calisthenics, lawn balls, aerobic machines and swimming. We found that only swimming was associated with 33% reduction in falls occurrence. We also found that swimmers performed better on balance tests in our baseline measurements. In particular on the postural stability test and for those whose leisure activity was only swimming, apart from walking and other lifestyle activities.
(more…)
MedicalResearch.com Interview with: Pietro Manuel Ferraro, MD PhD Candidate
Division of Nephrology
Catholic University of the Sacred Heart
Rome Italy
Medical Research: What are the main findings of the study?Dr. Ferraro: We analyzed the association between physical activity and energy intake and the risk of developing kidney stones in three large cohorts of U.S. health professionals. The 215,133 participants included did not have any history of kidney stones when follow-up began. During 20 years of follow-up, 5,355 of them developed a kidney stone. Initially, we found that participants with higher physical activity levels had a reduced risk of developing stones in two of the three cohorts. However, after accounting for a number of factors that could potentially confound the association such as age, body mass index and dietary intake, the association was no longer significant. Similarly, energy intake was not associated with a reduced risk of developing kidney stones. (more…)
This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish.AcceptRejectRead More
Privacy & Cookies Policy
Privacy Overview
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are as essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
