Author Interviews, Biomarkers, Sleep Disorders / 05.01.2014
Sleep Deprivation: Blood Markers of Brain Injury
MedicalResearch.com Interview with:
Jonathan Cedernaes PhD
Department of Neuroscience
Uppsala University Sweden
MedicalResearch.com: What are the main findings of this study?
Dr. Cedernaes: We found that two peripheral blood markers were modestly but significantly increased in healthy young participants after a single night of sleep deprivation, as compared with a normal night of sleep. These two markers, S-100B and NSE, are for example used as markers of acute ischemic injury in the brain, and are also increased following concussions. S-100B is produced mainly by glial cells and also increases after injury to the blood brain barrier. NSE is instead produced by neurons and is regarded as being more specific for neuronal damage, although it can also be produced by peripheral cells.
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