Author Interviews, Heart Disease, JACC, Statins / 17.05.2022
Before Initial Acute Coronary Syndrome: Study Finds Statin Therapy Reduced Heart Failure and Mortality
MedicalResearch.com Interview with:
Dr. Raffaele Bugiardini, UNIBO Professor & MD
Clinical cardiologist
Full Professor of Cardiology at the University of Bologna
MedicalResearch.com: What is the background for this study?
Response: Questions about the evidence base for primary prevention with statins continue to emerge from many quarters. It has been argued that prior estimates of statin effects were mainly based on information from both individuals with and without pre-existing cardiovascular disease, which may overestimate the true benefits of statins. Some investigators attempted to quantify the impact of statins on outcomes of women versus men and reported significantly different effect estimates.
Others have questioned the benefits of statins in adults 76 years and older as this age group was poorly represented in the randomized trials for primary prevention of cardiovascular disease.
There is little or no information on concomitant preventive medications in prior work. Thus, how large is the incremental benefit of statin, added to other standard preventive interventions? and is cholesterol a reliable surrogate endpoint to guide prevention of cardiovascular disease? (more…)