Author Interviews, C. difficile, Infections, Nutrition, Probiotics / 07.06.2013

MedicalResearch.com eInterview with: Dr. Reena Pattani MD Department of Medicine St. Michael’s Hospital 30 Bond Street, Toronto ON M5B 1W8 MedicalResearch.com: What are the main findings of the study? Dr. Pattani: We performed a meta-analysis of 16 studies that assessed the effectiveness of probiotics administered concurrently with antibiotics compared to the use of antibiotics alone. The use of probiotics among patients in these trials reduced the risk of antibiotic-associated diarrhea by almost 40% and decreased the rate of Clostridium difficile infection by 63%. On subgroup analysis, the reduction remained statistically significant for the subgroups of good quality trials, trials in which a primarily Lactobacillus-based regimen was used, and those studies which had a follow-up period of less than 4 weeks.
Author Interviews, Infections, Lancet, Vaccine Studies / 31.05.2013

MedicalResearch.com eInterview with: Fengcai Zhu Deputy Director of the Jiangsu Provincial Center for Disease Prevention and Control, Jiangsu provincial center for disease prevention and control

Fengcai Zhu

Deputy Director of the Jiangsu Provincial Center for Disease Prevention and Control, Jiangsu provincial center for disease prevention and control

MedicalResearch.com Editor's Note: HFMD = Hand Foot and Mouth Disease Hand Foot and Mouth Disease

MedicalResearch.com: What are the main findings of the study? Answer: From this trial, the inactivated alum-adjuvant EV71 vaccine showed a good protection for both the EV71-associated HFMD and EV71-associated disease. The vaccine gave 90% protection against clinical EV71-associated HFMD and 80.4% against EV71-associated disease (including neurological complications) for at least 12 months. The safety profile and immunogenicity of this vaccine is proved to be clinical acceptable. We also proposed a titre (1:32) of neutralization antibody as surrogate of protection against EV71-associated disease.

Author Interviews, HIV / 27.04.2013

MedicalResearch.com eInterview with Dr. Sara Gianella Weibel, M.D. Center For Aids Research (CFAR) University of California San Diego La Jolla CA, 92093-0679 Email: gianella@ucsd.edu MedicalResearch.com: What are the main findings of the study? Answer: In this study we evaluated a large number of seminal samples from HIV-infected sexually active gay men treated with antiretroviral therapy (ART) using an extensive battery of tests for viral and bacterial co-infections. Around 10% of enrolled subjects presented detectable levels of HIV RNA in semen despite being on suppressive ART.
Author Interviews, Infections, PLoS / 11.03.2013

MedicalResearch.com Author Interview: Dr. Donald K. Milton, MD, Dr.P.H dr_donalk_k_miltonDr. Donald K. Milton, MD, Dr.P.H Professor and Director Maryland Institute for Applied Environmental Health University of Maryland MedicalResearch.com: What are the main findings of the study? Dr. Milton: We found that total viral copies detected by molecular methods were 8.8 times more numerous in fine (≤5 µm) than in coarse (>5 µm) aerosol particles and that the fine particles from cases with the highest total number of viral RNA copies contained infectious virus. Surgical masks reduced the overall number of RNA copies by 3.4 fold.
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