Medical Research Journals

24 Nov Hepatitis C: Sofosbuvir/Ledipasvir Combination Treatment

Posted at 23:52h in Author Interviews, Hepatitis - Liver Disease, Lancet

MedicalResearch.com Interview with: Prof Eric Lawitz MD Vice President of Scientific and Research Development at The Texas Liver Institute Clinical professor of Medicine San Antonio University of Texas Health Science Center. MedicalResearch.com: What are the main findings of the study? Dr. Lawitz: Currently available treatments for HCV involve weekly injections of pegylated interferon and daily doses of oral antivirals that must be taken for up to a year. These regimens are not only burdensome for patients, but are not always effective and can cause serious and debilitating side effects, including anemia. So there is a significant need for new tablet-based treatment regimens for HCV that eliminate interferon and ribavirin, are more effective, better tolerated and easier for patients to take.

24 Nov Dabigatran: Comparison Mini-Sentinel Clinical Trials and GI Bleeding

Posted at 23:44h in Author Interviews, Blood Clots, Case Western, Cleveland Clinic, JAMA

MedicalResearch.com Interview with: Ilke Sipahi, MD Department of Cardiology Acibadem University Medical School, Istanbul, Turkey Harrington Heart and Vascular Institute, University Hospitals Case Medical Cente, Case Western Reserve University School of Medicine, Cleveland, Ohio MedicalResearch.com: Were you surprised at the extreme difference between these 2 analyses? Answer: I was surprised. However, it is not unusual to find completely contradictory results in medical studies. I was more surprised at the fact that FDA paid more attention to it administrative observational dataset rather than the huge large randomized clinical trials, all showing excess GI bleeds with dabigatran (Pradaxa). Anyone who is even slightly familiar with the medical literature knows that randomized trials are the gold standard in medical studies.

24 Nov HER2-positive Breast Cancer and Adjuvant Chemotherapy

Posted at 22:25h in Author Interviews, Breast Cancer, Chemotherapy, Lancet, MD Anderson

MedicalResearch.com Interview with: Dr. Kelly K. Hunt, M.D., F.A.C.S. Professor, Department of Surgical Oncology, Division of Surgery Chief, Breast Surgical Oncology Section, Department of Surgical Oncology The University of Texas MD Anderson Cancer Center, Houston, TX MedicalResearch.com: What are the main findings of the study? Dr. Hunt: The primary endpoint of the Z1041 trial was the proportion of patients who had pathological complete response in the breast, defined as the percentage of women who started the neoadjuvant treatment with no histological evidence of disease in the breast at surgery. We found that high pathologic response rates were observed in both treatment groups with similar cardiac safety profiles in both arms of the trial. Specifically, 56.5% of patients in the sequential group (fluorouracil, epirubicin and cyclophosphamide on day one of a 21-day cycle for four cycles followed by paclitaxel plus trastuzumab weekly for 12 weeks) had a complete pathological response versus 54.2% of the patients who received the concurrent regimen (paclitaxel and trastuzumab weekly for 12 weeks followed by fluorouracil, epirubicin and cyclophosphamide on day one of a 21-day cycle with trastuzumab on days one, eight and 15 of the 21-day cycle for four cycles). The difference in pathologic complete response rates between the treatment arms was not statistically significant. Cardiac safety was a secondary endpoint of the trial and we found that both regimens had acceptable cardiac safety profiles.

24 Nov Venous Thromboembolism: Risk of First Blood Clots in Hospitalized Pregancy Women

Posted at 22:20h in Author Interviews, Blood Clots, BMJ

MedicalResearch.com Interview with: Alyshah Abdul Sultan, doctorate student Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building Phase 2, City Hospital, Nottingham NG5 1PB, UK MedicalResearch.com: What are the main findings of the study? Answer: Overall, we found that hospitalisation during pregnancy was associated with an excess risk of 16.6 cases per 1,000 person-years compared with time outside hospital (17.5-fold increase in risk). There was also an excess risk of 5.8 cases per 1,000 person years in the 28 days after discharge with VTE events more likely to occur in the third trimester of pregnancy and in women aged 35 years and over.

24 Nov Thyroid Cancer: Increase in BRAF, RAS Mutations

Posted at 21:43h in Author Interviews, Genetic Research, Nature, Thyroid

MedicalResearch.com Interview Yuri E. Nikiforov, M.D., Ph.D. Professor of Pathology, Vice Chair for Molecular Pathology Director, Division of Molecular & Genomic Pathology Department of Pathology, University of Pittsburgh Pittsburgh, PA MedicalResearch.com: What are the main findings of the study? Dr. Nikiforov: This is examined temporal changes in mutational profiles and standardized histopathologic features of thyroid cancer in the U.S. over the last four decades. It showed a significant change in molecular profiles of thyroid cancer during the past 40 years as it determined two major trends in changing the mutational make-up of thyroid cancer: a rapid increase in the prevalence of RAS mutations, particularly for the last 10 years, and continuous decrease in frequency of RET/PTC rearrangement. The rising incidence of RAS mutations points to new and more recent etiologic factors, probably of a chemical or dietary nature. The decreasing incidence of RET/PTC rearrangements, a known marker of high-dose environmental and medical radiation, suggest that the impact of ionizing radiation, at least as related to high-dose environmental exposures and historical patterns of radiation treatment for benign conditions, is diminishing.

23 Nov Testosterone Levels: Middle Range Better for Older Men

Posted at 11:37h in Author Interviews, Endocrinology, JCEM, Testosterone

MedicalResearch.com Interview with: Dr Bu Beng Yeap MBBS, FRACP, PhD Professor, School of Medicine and Pharmacology, University of Western Australia Endocrinologist, Department of Endocrinology and Diabetes, Fremantle Hospital. MedicalResearch.com: What are the main findings of the study? Answer: We found that older men with testosterone levels in the middle of the range had the lowest mortality risk. Having a low testosterone level predicted higher mortality, and there was no benefit of having a high-normal testosterone level. Men with optimal rather than high testosterone levels lived longest. The other important finding was that men with higher dihydrotestosterone levels had lower mortality from ischaemic heart disease, suggesting that androgens may protect against heart disease in older men.

23 Nov Pancreatic Cancer: Frequent Nut Consumption May Reduce Risk

Posted at 11:13h in Antioxidants, Author Interviews, Brigham & Women's - Harvard, Medical Research Centers, Nature, Nutrition, Pancreatic

MedicalResearch.com Interview with:

Ying Bao, MD, ScD Department of Medicine, Brigham and Women's Hospital and Harvard Medical School Boston, MA. MedicalResearch.com: What are the main findings of the study? Dr. Bao: Frequent nut consumption is inversely associated with risk of pancreatic cancer in women, independent of other potential risk factors for pancreatic cancer.

22 Nov Burkitt’s Lymphoma: Effectivenss of Low-Intensity Therapy

Posted at 16:36h in Author Interviews, Cancer Research, Lymphoma, NEJM

MedicalResearch.com Interview with Kieron M. Dunleavy, M.D. Metabolism Branch Lymphoma Therapeutics Section Center for Cancer Research National Cancer Institute, Bethesda, MD 20892 MedicalResearch.com: What are the main findings of the study? Dr. Dunleavy: We found that low-intensity therapy was highly effective in Burkitt's lymphoma and cured over 95% of patients with the disease.

21 Nov Type 2 Diabetes: Ambulatory Treatment in US

Posted at 18:57h in Author Interviews, Diabetes, Diabetes Care, Johns Hopkins

MedicalResearch.com Interview with: Caleb Alexander, MD, MS Department of Epidemiology, Bloomberg School of Public Health Center for Drug Safety and Effectiveness Johns Hopkins Bloomberg School of Public Health Division of General Internal Medicine, Johns Hopkins Medicine, Baltimore, Maryland MedicalResearch.com: What are the main findings of the study? Dr. Alexander:

There have been large shifts in the types of treatments used to treat Type 2 diabetes during the past decade in the United States.
We document large declines in the use of glitazones and sulfonylureas and important increases in the use of the newer DPP-4 inhibitors and GLP-1 agonists.
We also found large shifts in the types of insulins used, with substantial reductions in the use of regular and intermediate insulins, and large increases in the use of long-acting and ultra short-acting therapies.
Costs have increased significantly over the past 5 years, driven primarily by insulin and DPP-4 inhibitors
All of these changes notwithstanding, biguanides continue to remain a mainstay of therapy.

21 Nov Metabolically healthy obese still at increased risk of diabetes, heart disease

Posted at 18:43h in Author Interviews, Diabetes, Heart Disease, JCEM, Weight Research

MedicalResearch.com Interview with: Carlos Lorenzo, MD Department of Medicine, University of Texas Health Science Center 7703 Floyd Curl Drive San Antonio, Texas 78229 MedicalResearch.com: What are the main findings of the study? Dr. Lorenzo: Metabolically healthy obese individuals are at increased risk of developing of diabetes and cardiovascular disease. These findings were demonstrated in men and women and in Mexican Americans and non-Hispanic whites. Management of excess weight and any metabolic abnormality appears to be important for all individuals. Our study is also in agreement with previous studies that indicate that metabolically unhealthy normal weight individuals are at increased risk of developing of diabetes and cardiovascular disease.

21 Nov Hospital Readmissions: Best US Hospitals Reduce Globally

Posted at 14:16h in Author Interviews, BMJ, Hospital Readmissions

MedicalResearch.com Interview with: Kumar Dharmarajan MD MBA Fellow in Cardiovascular Medicine Columbia University Medical Center MedicalResearch.com: What were the main findings of the study Dr. Dharmarajan: In the United States, 1 in 5 older patients is readmitted to the hospital within 30 days of hospital discharge. However, there is great variation in rates of 30-day readmission across hospitals, and we do not know why some hospitals are able to achieve much lower readmission rates than others. We therefore wondered whether top performing hospitals with low 30-day readmission rates are systematically better at preventing readmissions from particular conditions or time periods after discharge. For example, are hospitals with low 30-day readmission rates after hospitalization for heart failure especially good at preventing readmissions due to recurrent heart failure or possible complications of treatment? Similarly, are top performing hospitals especially good at preventing readmissions that occur very soon after discharge, which may signify poor transitional care as the patient moves form the hospital back home?

21 Nov Pulmonary Fibrosis: Strongly Associated with a Herpes Virus

Posted at 13:09h in Author Interviews, Herpes Viruses, Infections, Nature, Pulmonary Disease

MedicalResearch.com Interview with: Gerard Nuovo MD Professor College of Medicine, The Ohio State University Satellite Laboratory, Ohio State Univ Comprehensive Cancer Center Phylogeny Inc, Powell, Ohio MedicalResearch.com: What are the main findings of the study? Dr. Nuovo: The main finding of the study was that idiopathic pulmonary fibrosis was strongly associated with an infection by a herpesvirus. The data that supported this main finding included:

1) detection of the viral DNA by in situ hybridization in each case of idiopathic pulmonary fibrosis (IPF) and in none of the controls;
2) the localization of the viral DNA to the nucleus of the cell that orchestrates IPF, the regenerating epithelial cell (herpes viruses localize to the nucleus of the target cell);
3) the demonstration that the viral DNA co-localized with "pirated proteins" that the virus makes during productive infection (these were IL-17. cyclin D, dihydrofolate reductase, and thymidylate synthase); this combination of proteins are rarely if ever co-expressed in lung disease and their co-expression per se was highly suggestive of a viral infection;
4) the demonstration by RTPCR that the cyclin D RNA in IPF comes from the virus and not the human cells;
5) the recognition that this family of herpesviruses (called gammaherpesvirus) causes IPF in other animals including horses, mice, and donkeys;
6) the cloning of part of the gene of the virus from a clinical IPF sample that showed 100% homology to the published sequence of the likely viral pathogen - herpesvirus saimiri.

21 Nov Atrial Fibrillation: Effects of Weight Reduction

Posted at 12:44h in Author Interviews, Heart Disease, JAMA, Weight Research

MedicalResearch.com Interview with: Prof. Prashanthan Sanders Director, Centre for Heart Rhythm Disorders University of Adelaide | Royal Adelaide Hospital | SAHMRI NHMRC Practitioner Fellow Centre for Heart Rhythm Disorders Department of Cardiology | Royal Adelaide Hospital Adelaide 5000 | Australia MedicalResearch.com: What are the main findings of the study? Answer: Aggressive treatment of risk factors and weight reduced the symptom burden associated with atrial fibrillation. It is therefore important that in a similar manner to how we treat coronary artery disease, in atrial fibrillation there should be management directed at the reasons why these individuals got AF in the first place.

19 Nov Childhood Asthma: Novel Susceptibility Gene Identified

Posted at 01:43h in Asthma, Author Interviews, Nature, Pediatrics

MedicalResearch.com Interview Invitation Klaus Bønnelykke  MD, PhD   The Faculty of Health Sciences  University of Copenhagen The Danish Pediatric Asthma Center Copenhagen University Hospital Gentofte Ledreborg Alle 34 DK-2820 Copenhagen Denmark MedicalResearch.com: What are the main findings of the study?  Answer: First, we identified CDHR3 as a novel susceptibility gene. This is likely to represent a yet unknown mechanism of childhood...

18 Nov Colon Cancer: Racial Disparities in Metastatic Disease

Posted at 20:35h in Author Interviews, Colon Cancer, Nature, Race/Ethnic Diversity, Stanford

MedicalResearch.com Interview with: James Murphy, M.D. Assistant Professor, Department of Radiation Medicine and Applied Sciences, Center for Advanced Radiotherapy Technologies ,UC San Diego Moores Cancer Center La Jolla, CA 92093 MedicalResearch.com: What are the main findings of the study? Dr. Murphy: This study evaluated racial disparity in metastatic colorectal cancer. In a large population-based cohort we found of over 11,000 patients we found that black patients were less likely to be seen in consultation by a cancer specialist, and were less likely to receive treatment with chemotherapy, surgery, or radiation. Furthermore, we found that this disparity in treatment accounted for a substantial portion of the race-based differences between black and white patients.

18 Nov Sleep Disorders: Accuracy of Portable Sleep Tests

Posted at 14:30h in Author Interviews, CMAJ, Sleep Disorders

MedicalResearch.com Interview with: Mohamed El Shayeb MD, MSc Health Technology and Policy Unit University of Alberta 3025 Research Transition Facility Edmonton, Alberta, Canada T6G2V2 MedicalResearch.com: What are the main findings of the study? Dr. El Shayeb: Our study shows that limited channel level-3 portable devices, used at home, are of good diagnostic value compared to the comprehensive reference-standard level-1 sleep tests conducted in lab in the diagnosis of obstructive sleep apnea (the most common subtype of sleep disordered breathing.)  Were any of the findings unexpected? None of the findings were unexpected. Level-3 portable devices are commonly used in clinical practice; however, this technology has been widely disseminated, without solid evidence about their diagnostic performance or the subpopulation of sleep disordered breathing patients who are most appropriately diagnosed with them. Our research provides a high level of evidence on the diagnostic performance of these devices, and most importantly, defines the subgroup of patients who are eligible for this test (patients with simple obstructive sleep apnea, and without significant comorbidities.)

18 Nov Thyroid Dysfunction and Hyperlipidemia

Posted at 14:20h in Author Interviews, JAMA, Lipids, Thyroid Disease

MedicalResearch.com Interview with: Angela M. Leung, MD, MSc Clinical Assistant Professor of Medicine Division of Endocrinology, Department of Medicine University of California Los Angeles MedicalResearch.com: What are the main findings of the study? Dr. Leung: Despite current guidelines to screen for thyroid dysfunction as a secondary cause of newly-diagnosed hyperlipidemia, this was performed only about 50% of the time by primary care providers in over 8,700 patients at a large, urban Boston academic medical center. Approximately 5% of patients who had thyroid function checked were found to have hypothyroidism. The majority of hypothyroid patients who received treatment with levothyroxine had successful correction of the initial hyperlipidemia within one year.

16 Nov Food Addiction and Obesity

Posted at 12:03h in Author Interviews, PLoS, Weight Research

MedicalResearch.com Interview with: Guang Sun MD, PhD Professor, Discipline of medicine Faculty of medicine, Memorial University Canada MedicalResearch.com: What are the main findings of the study? Dr. Sun: Plenty of anecdotal reports on how ‘Food Addiction’ may be a potential culprit of the rising prevalence of obesity. However to date no scientific study, based on a comprehensive criterion of the diagnosis of Food Addiction, has been performed at the population level. The main findings are in the following fours aspects: 1) Food Addiction is indeed an important contributing factor in the development of obesity. 2) The prevalence of Food Addition was 5.4% and increased concomitantly with obesity status defined by either body mass index (BMI) or body fat percentage (%BF). In another word, there is one food addict in every twenty adults (Newfoundland Province, Canada) 3) Clinical Symptom Count(s) of Food Addiction is strongly associated with the severity of obesity. 4) Women are twice as likely to be diagnosed with “Food Addiction” than men.

14 Nov Acute Cystitis in Premenopausal Women: How Valuable is Midstream Urine Culture?

Posted at 18:25h in Author Interviews, NEJM, Urinary Tract Infections

MedicalResearch.com Interview with: Thomas M. Hooton M.D. Professor of Medicine and Vice Chair for VA Affairs, University of Miami Miller School of Medicine Associate Chief of Staff, Medical Service, Miami VA Healthcare System Clinical Director, Division of Infectious Diseases MedicalResearch.com: What are the main findings of the study? Dr. Hooten: The main findings from this study are: · Voided urine colony counts of E. coli as low as 101 to 102 cfu/mL are highly sensitive and specific for their presence in bladder urine in symptomatic women (growth of bacteria in bladder urine is the gold standard for the etiology of UTI). Moreover, even when E. coli is found along with other mixed flora in voided urine, it should not be considered a contaminant since it likely represents true bladder infection. · On the other hand, enterococci and Group B streptococci, which are frequently isolated from voided urine, are rarely isolated from paired catheter specimens, suggesting that these organisms only rarely cause acute uncomplicated cystitis. In our study, E. coli frequently grew from the urines of these women and is the likely cause for UTI symptoms in such episodes. · Organisms usually considered contaminants, such as lactobacilli, occasionally grow from catheter urines, but they are rarely found alone with pyuria, suggesting that these bacteria rarely cause acute uncomplicated cystitis. · The etiology of a quarter of acute uncomplicated cystitis episodes is unknown. It is possible that some of these women have E. coli urethritis, which has been documented in some women with UTI symptoms, but we did not do further studies to evaluate this. It is possible also that enterococci and Group B streptococci may also cause urethritis, but there is no published evidence of this in young women with UTI symptoms. · Although voided urine cultures growing mixed flora are common in women with acute cystitis, true polymicrobic cystitis, as determined by sampling bladder urine, appears to be rare in this population.

12 Nov High Chocolate Intake and Lower Body Fat

Posted at 21:54h in Author Interviews, Chocolate, Nature, Nutrition, Pediatrics, Weight Research

MedicalResearch.com Interview with: Magdalena Cuenca García, PhD University of Granada Department of Physiology, School of Medicine Avd. Madrid 12; 18012 Granada (Spain) MedicalResearch.com: What are the main findings of the study? Answer: In conclusion, the results of the present study showed that a higher chocolate consumption was associated with lower levels of central and total fatness in European adolescents. Of note is that the observed association was independent of total energy intake and saturated fat intake as well as objectively measured physical activity. In addition, results remained unchanged after adjusting for foods with high catechins concentration as fruit, vegetables and tea; as well as other products such as coffee that could influence the observed association between chocolate consumption and markers of total and central body fat.

12 Nov Traumatic Brain Injury: PET Scanning to Detect Amyloid Deposition, Possible Dementia Risk

Posted at 11:46h in Author Interviews, Brain Injury, Cognitive Issues, Lancet

MedicalResearch.com Interview with: Prof David K Menon MD PhD FRCP FRCA FFICM FMedSci Head, Division of Anaesthesia, University of Cambridge  Consultant, Neurosciences Critical Care Unit  BOC Professor, Royal College of Anaesthetists Professorial Fellow, Queens' College, Cambridge Senior Investigator, National Institute for Health Research Box 93, Addenbrooke's Hospital,  Cambridge CB2 2QQ, UK MedicalResearch.com: What is the background for your study? Dr. Menon: We have known for some time that a history of traumatic brain injury (TBI) results in a significant (between 2 and 10 fold) increase in the likelihood of getting dementia in later life. On possible mechanistic explanation for this comes from the finding that about a third of individuals who died of TBI, regardless of age, are found at autopsy to have deposits of β-amyloid in the brain, often Aβ₄₂, which is the same variant of amyloid seen in the brain of patients who have Alzheimer’s Disease. However, such detection after death has made it impossible to examine the linkage of such early amyloid deposition to late dementia. More recently, imaging with positron emission tomography (PET) and Pittsburgh compound B (PIB) has been used to image amyloid deposits in Alzheimer’s Disease. However, the technique had not been validated in traumatic brain injury.

12 Nov Nutrition: Diet, Physical Activity and Socioeconomics

Posted at 10:46h in General Medicine, PLoS

MedicalResearch.com Interview with: Jonas D. Finger and Dr. Gert B.M. Mensink Jonas Finger, MPhil (Epidemiology) MA (Sports Sc) MA (Political Sc) Robert Koch-Institute - Department of Epidemiology and Health MonitoringDivision 24 - Interview surveys and European collaboration General-Pape-Straße 62-66, 12101 Berlin Germany MedicalResearch.com: What are the main findings of the study? Answer: People with a low level of education consume energy dense foods (sugar- and fat-rich foods) more frequently and low energy foods (fruit and vegetables) and alcohol less frequently compared to people with a high level of education. A new study aspect is that the role of physical activity level for the link between education and high energy food intake was also investigated. People with a low level of education have more frequently physically-demanding jobs leading to a higher level of total energy expenditure compared to sedentary office workers (mainly high educated). The latter are more active in their leisure time. The study provides some evidence to support the hypothesis that the low educated consumed more energy dense foods than the high educated because they expend more energy due to the physical work they do.

11 Nov Breast Cancer: Intraoperative vs Whole Breast Radiotherapy

Posted at 23:13h in Author Interviews, Breast Cancer, Lancet, Radiation Therapy

MedicalResearch.com Interview with: Prof Jayant S Vaidya PhD Clinical Trials Group, Division of Surgery and Interventional Science University College London, London, UK MedicalResearch.com: What are the main findings of the study? Dr. Vaidya: The main findings are

a) these are longer term results that have confirmed our original publication in 201
(b) We found that when TARGIT intraoperative radiotherapy is given at the time of lumpectomy for breast cancer, the local control and survival from breast cancer is similar to several weeks of whole breast radiotherapy
c) we also found that with TARGIT there are significantly fewer deaths from other causes - i.e., fewer deaths from cardiovascular causes and other cancers

07 Nov After Stroke & TIA: Medical Management vs Angioplasty and Stenting

Posted at 03:38h in AHA Journals, Author Interviews, Lancet, Stroke

MedicalResearch.com Interview with: Dr. Colin Derdeyn Mallinckrodt Institute of Radiology and the Departments of Neurology and Neurosurgery Washington University School of Medicine, St Louis, MO, USA MedicalResearch.com: What are the main findings of the study? Dr. Derdeyn: The primary results indicate that medical management, consisting of dual antiplatelets for 3 months after a transient ischemic attack (TIA) or stroke, and rapid, effective control of blood pressure (systolic BP less than 140 mm Hg and 130 mm Hg if diabetic) and LDL-cholesterol (less than 70 mg/dl), in addition to management of other risk factors, is superior to angioplasty and stenting in addition to the same medical regimen for reducing the risk of future stroke in patients with severe atherosclerotic stenosis (>70%) of a major intracranial artery. In addition, while there were subgroups at higher risk for stroke on medical treatment (older age, female gender, prior stroke in the territory), none of these subgroups appeared to have a benefit from stenting (i.e. stroke rates in the stenting groups in these subgroups was higher too).

07 Nov Depression: Usefulness of Patient Engagement Programs

Posted at 03:28h in Author Interviews, Depression, JAMA

MedicalResearch.com Interview with: Richard L. Kravitz, MD, MSPH Professor and Co-vice Chair (Research) Interim Director, UC Center Sacramento Co-Editor in Chief, Journal of General Internal Medicine MedicalResearch.com: What is the background for your study? Dr. Kravitz: Depression in the United States is both undertreated and overtreated. As the de facto mental health care system for many, primary care is at the nexus of this problem. Up to 30% of patients with major depression in primary care go undiagnosed. At the same time, partly as a result of marketing, lots of patients who don’t need meds are started on antidepressants. So we were interested in finding ways to get more truly depressed patients into treatment without overtreating patients who don’t need it.

07 Nov Thyroid Disease: Mortality in Elderly Hospitalized Patients

Posted at 03:19h in Author Interviews, Endocrinology, JCEM, Thyroid Disease

MedicalResearch.com Interview with: Pedro Iglesias, MD Department of Endocrinology and Nutrition Hospital Ramón y Cajal, Madrid Spain MedicalResearch.com What are the main findings of the study? Dr. Iglesias: The main findings of our study are that alterations in TFT results are related to mortality in aged patients hospitalized for acute illness not only during hospitalization...

07 Nov Bariatric Surgery: Adolescents and Perioperative Course

Posted at 02:59h in Author Interviews, JAMA, Pediatrics, Weight Research

MedicalResearch.com Interview with: Thomas H. Inge, MD, PhD, FACS, FAAP Surgical Director, Surgical Weight Loss Program for Teens Director, Center for Bariatric Research and Innovation Attending Surgeon, Cincinnati Children’s Hospital Medical Center Professor, UC Department of Surgery Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio MedicalResearch.com: What are the main findings of the study? Dr. Inge: The mean age of the 242 participants of this observational study was 17.1±1.6 years and the median BMI was 50.5 kg/m². Fifty-one percent demonstrated four or more major co-morbid conditions. Laparoscopic Roux-en-Y gastric bypass, vertical sleeve gastrectomy, and adjustable gastric banding were performed in 66%, 28%, and 6% of subjects, respectively. There were no deaths during the initial hospitalization or within 30 days of surgery; major complications were seen in 19 subjects (8%). Minor complications were noted in 36 subjects (15%). All re-operations and 85% of re-admissions were related to WLS.

06 Nov Mediterranean Diet May Be Helpful in Midlife and Beyond

Posted at 01:06h in Annals Internal Medicine, Author Interviews, General Medicine, Mediterranean Diet, Nutrition

MedicalResearch.com Interview with Cécilia Samieri, PhD Institut pour la Santé Publique et le Développement, Case 11, Université Bordeaux Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France MedicalResearch.com: What are the main findings of the study? Dr. Samieri: That women with healthier dietary patterns at midlife were 40% more likely to survive age 70 or over free of major chronic diseases and with no impairment in physical function, cognition or mental health.

05 Nov Bariatric Surgery: Self-Reported Weight Loss Fairly Accurate

Posted at 12:52h in JAMA, Weight Research

MedicalResearch.com Interview with: Nicholas J. Christian, PhD Graduate School of Public Health University of Pittsburgh MedicalResearch.com: What are the main findings of the study? Dr. Christian: We found that the differences between measured and self-reported weights following bariatric surgery were small and did not systematically differ by measured body mass index or degree of postoperative weight change. The average degree of underreporting by self-report was 0.7 kg for women and 1.0 kg for men.

05 Nov PCOS – Polycystic Ovary Syndrome: Should it be Renamed?

Posted at 12:27h in Author Interviews, Endocrinology, JCEM, Metabolic Syndrome, OBGYNE

MedicalResearch.com Interview with: Professor Helena Teede MBBS, PhD, FRACP Director Monash Centre for Health Research and Implementation -- MCHRI, And Head Womens Public Health Research, School Public Health and Preventive Medicine Monash University, in partnership with Monash Health Head Diabetes and Vascular Medicine, Monash Health President Elect- Endocrine Society of Australia NHMRC Practitioner Fellow 43-51 Kanooka Grove,...