Author Interviews, Dermatology, NEJM / 10.07.2015
New Generation Biologic Markedly Improved Psoriasis
MedicalResearch.com Interview with:
Prof. Dr. med. Kristian Reich
DERMATOLOGIKUM HAMBURG
Hamburg
Medical Research: What is the background for this study? What are the main findings?
Prof. Reich: The Phase 2b X-PLORE study compared a new generation biologic therapy, guselkumab - an inhibitor of IL–23, with the anti–tumor necrosis factor (TNF)–alpha agent adalimumab (Humira®) and placebo in the treatment of moderate-to-severe plaque-type psoriasis. It showed that up to 86 percent of patients treated with guselkumab achieved a Physician’s Global Assessment (PGA) score of cleared psoriasis or minimal psoriasis at week 16, the study’s primary endpoint. Interestingly, levels of efficacy were higher for several guselkumab doses through week 16 when compared to adalimumab. Improvements with guselkumab continued through week 40 with every eight- or twelve-week maintenance treatment. (more…)