Pediatrics

13 Apr

Posted at 21:43h in Author Interviews, JAMA, Mental Health Research, Pediatrics, Social Issues
MedicalResearch.com Interview with: Regina Triplett, M.D., M.S. Developmental Neuroscience Post-Doctoral Research Scholar Department of Neurology Washington University in St. Louis, MO  MedicalResearch.com:  What is the background for this study?  What are the main findings?  Response: This is an ongoing, longitudinal, prospective study of 399 pairs of mothers studied throughout pregnancy and their infants, designed to investigate exposure to early life adversity (prenatal poverty and stress) on infant brain development and behavior in early childhood. We examined measures of maternal socioeconomic status including neighborhood factors and stress/mental health during pregnancy in relation to data from infant brain MRI scans conducted in the first weeks after birth. We found that poverty during pregnancy is associated with reduced size and folding of infant brains. We found these associations across the whole brain and not specific to one region.

27 Mar

Posted at 19:41h in Abuse and Neglect, Author Interviews, Dermatology, JAMA, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58947" align="alignleft" width="150"]Aaron M. Drucker Dr. Drucker[/caption] Aaron Drucker MD, ScM, FRCPC Division of Dermatology, Department of Medicine, Women’s College Hospital Scientist, Women’s College Research Institute Assistant Professor, Department of Medicin and Institute of Health Policy, Management and Evaluation University of Toronto Adjunct Scientist, ICES  MedicalResearch.com:  What is the background for this study?  What are the main findings?   Response: Because atopic dermatitis is a chronic condition that is common in children, parents and physicians often wonder if it will affect overall child well-being, including their growth parameters. Previous studies were mostly cross-sectional, so we conducted a longitudinal study to follow children over time. We found that although young children with atopic dermatitis were somewhat shorter with higher BMI than children without atopic dermatitis, these differences were small and attenuated as children grew older.

07 Mar

Posted at 20:42h in Author Interviews, Environmental Risks, Pediatrics, Toxin Research
MedicalResearch.com Interview with: [caption id="attachment_58840" align="alignleft" width="150"]Jeanette Stingone PhD Assistant Professor, Epidemiology Mailman School of Public Health Columbia University Dr. Stingone[/caption] Jeanette Stingone PhD Assistant Professor, Epidemiology Mailman School of Public Health Columbia University MedicalResearch.com:  What is the background for this study?  What are the main findings? Response: Lead is a well-established neurotoxin, particularly when exposure occurs early in life and in childhood. Associations between elevated blood lead levels and lower scores on tests of neurodevelopment and cognition are seen consistently across studies, even when examining lower levels of exposure. While reducing exposure to lead is the primary intervention to prevent these adverse outcomes, there aren’t many interventions designed to support the neurodevelopment of children who have been exposed to lead. Some municipalities consider elevated blood lead levels as a criteria for inclusion in Early Intervention programs. Early Intervention programs are mandated under the Individuals with Disabilities Education Act and provide services for children younger than 3 years old with disabilities or developmental delays. The objective of this study was to compare 3rd grade standardized test scores among children who had elevated blood lead levels early in life to see if children who had received Early Intervention services performed better on these tests than those who did not receive services. Using matching methods and an existing administrative data linkage of children who were born and attended public school in New York City, we observed that children exposed to lead who received Early Intervention services scored higher on standardized tests in both math and English Language arts than children exposed to lead who did not receive services. 

17 Feb

Posted at 19:27h in Author Interviews, Insomnia, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58809" align="alignleft" width="153"]Julio Fernandez-Mendoza, PhD, CBSM, DBSM Associate Professor of Psychiatry & Behavioral Health Sleep Research & Treatment Center Director, Behavioral Sleep Medicine Program Penn State Health Milton S. Hershey Medical Cente Dr. Fernandez-Mendoza[/caption] Julio Fernandez-Mendoza, PhD, CBSM, DBSM Associate Professor of Psychiatry & Behavioral Health Sleep Research & Treatment Center Director, Behavioral Sleep Medicine Program Penn State Health Milton S. Hershey Medical Center MedicalResearch.com:  What is the background for this study?  Is insomnia familial? Response: Consistent research has shown that about 25% of school-age children have insomnia symptoms consisting of difficulties initiating or maintaining sleep. However, what has remained unknown is to what extent those insomnia symptoms persist all the way into adulthood, or whether they developmentally remit (go away with age) as the child grows into adolescence or young adulthood. This is the question that our study focused on.

16 Feb

Posted at 17:38h in Author Interviews, JAMA, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58751" align="alignleft" width="200"]Izzuddin M Aris, PhD Assistant Professor Department of Population Medicine, Harvard Medical School Division of Chronic Disease Research Across the Lifecourse, Harvard Pilgrim Health Care Institute Boston, MA Dr. Aris[/caption] Izzuddin M Aris, PhD Assistant Professor Department of Population Medicine, Harvard Medical School Division of Chronic Disease Research Across the Lifecourse Harvard Pilgrim Health Care Institute Boston, MA MedicalResearch.com:  What is the background for this study?  Response: Puberty is a key stage during child development. Previous research indicates that children in the United States are entering puberty at younger ages. These children may be in danger of developing certain diseases, such as type 2 diabetes, later in life. A better understanding of how early life factors affect puberty development is important for combating earlier puberty onset. .

04 Feb

Posted at 17:36h in Author Interviews, Environmental Risks, JAMA, OBGYNE, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58736" align="alignleft" width="200"]Anders Hviid M.Sc.,Dr.Med.Sci. Head of Department (acting), Professor of Pharmacoepidemiology, Department of Epidemiology Research Statens Serum Institut Dr. Hviid[/caption] Anders Hviid M.Sc.,Dr.Med.Sci. Head of Department (acting), Professor of Pharmacoepidemiology, Department of Epidemiology Research Statens Serum Institut MedicalResearch.com:  What is the background for this study?  Response: An unusually low number of extremely preterm births have been observed in some countries during the initial covid-19 lockdowns. We speculated that this could be because of fewer infections, reduced activity levels, less stress etc. These are also factors that change with the seasons, and we hypothesized that extremely preterm birth might be associated with seasonality.

03 Feb

Posted at 10:45h in Author Interviews, COVID -19 Coronavirus, JAMA, Pediatrics, Respiratory, Yale
MedicalResearch.com Interview with: [caption id="attachment_58724" align="alignleft" width="200"]Thomas Murray MD PhD Associate Professor, Yale School of Medicine Department of Pediatrics, Infectious Disease and Global Health Associate Medical Director, Infection Prevention Yale New Haven Children's Hospital Dr. Murray[/caption] Thomas Murray MD PhD Associate Professor, Yale School of Medicine Department of Pediatrics, Infectious Disease and Global Health Associate Medical Director, Infection Prevention Yale New Haven Children's Hospital MedicalResearch.com:  What is the background for this study?  Response: This study was performed by Yale- CARES (Children and Adults Research in Early Education Study Team) a multidisciplinary group of researchers that are interested in learning how the COVID-19 pandemic has impacted early child care programs in the US including the effects on both the children and those who care for them in this setting. This is important because when child care programs close it becomes very difficult for working families to find safe, affordable alternative care. We surveyed over 6000 child care workers from across the US in May/June 2020 with a follow up survey in May/June 2021. This includes both center based and home based child care programs. One question we were interested in was what things they were doing in their programs to reduce the risk of COVID-19. We then asked whether their program closed at any time in that year because of COVID-19.

20 Jan

Posted at 17:07h in Author Interviews, Diabetes, NEJM, Pediatrics, Technology
MedicalResearch.com Interview with: [caption id="attachment_58667" align="alignleft" width="200"]Dr Julia Ware (née Fuchs) Clinical Research Associate Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories  and Medical Research Council Metabolic Diseases Unit, University of Cambridge Addenbrooke’s Hospital, Cambridge  Dr. Ware[/caption] Dr Julia Ware (née Fuchs) Clinical Research Associate Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories and Medical Research Council Metabolic Diseases Unit, University of Cambridge Addenbrooke’s Hospital, Cambridge MedicalResearch.com: What is the background for this study? Response: Management of type 1 diabetes is challenging in very young children, due to their high variability of insulin requirements and unpredictable eating and activity patterns. As a result, many young children do not meet the recommended glycemic targets, or only maintain recommended glycemic control with extensive caregiver input. This in turn leads to high management burden and reduced quality of life for the whole family. While the increasing use of continuous glucose-monitoring devices and insulin-pump therapy has led to reductions in the incidence of severe hypoglycaemia and diabetic ketoacidosis, and has been accompanied by modest improvements in glycemic control, the burden of management has remained high. Hybrid closed-loop systems (also called an artificial pancreas), in which an algorithm automatically adjusts insulin delivery on the basis of real-time sensor glucose levels, may address ongoing challenges in this age group. However, to date hybrid closed-loop studies involving very young children have been small and of short duration and the efficacy and safety of longer term use of a closed-loop system, as compared with standard therapy, was unclear.   To address this knowledge gap, we compared 16-week use of the Cambridge closed-loop algorithm with sensor-augmented pump therapy in children aged 1 to 7 years with type 1 diabetes in a multi-national randomised crossover study.

18 Jan

Posted at 21:57h in Author Interviews, Critical Care - Intensive Care - ICUs, JAMA, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58650" align="alignleft" width="150"]Edward Bell, MD Professor of Pediatrics-Neonatology Vice Chair for Faculty Development, Stead Family Department of Pediatrics Roy J. and Lucille A. Carver College of Medicine University of Iowa Dr. Bell[/caption] Edward Bell, MD Professor of Pediatrics-Neonatology Vice Chair for Faculty Development, Stead Family Department of Pediatrics Roy J. and Lucille A. Carver College of Medicine University of Iowa MedicalResearch.com: What is the background for this study? Response: The National Institute of Child Health and Human Development, a branch of the National Institutes of Health (NIH), has supported the Neonatal Research Network (NRN) since 1986. The NRN, a group of US academic centers, is tasked with conducting research to improve the treatment and health outcomes of premature and critically-ill babies in US neonatal intensive care units (NICUs). Every few years, the NRN publishes reports on the survival rates and outcomes of surviving extremely premature babies, those born before 28 weeks of gestation. These reports help us to judge progress in the care and outcomes of these infants. This paper is the 9th in this series of reports but the first that includes not only survival and in-hospital outcomes but also outcomes at 2 years of age. 

11 Jan

Posted at 16:04h in Author Interviews, COVID -19 Coronavirus, JAMA, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58626" align="alignleft" width="150"]Stephen Freedman MDCM, MSc Professor of Pediatrics and Emergency Medicine Alberta Children’s Hospital Foundation Professor in Child Health and Wellness Alberta Children’s Hospital Research Institute, Cumming School of Medicine University of Calgary Dr. Freedman[/caption] Stephen Freedman MDCM, MSc Professor of Pediatrics and Emergency Medicine Alberta Children’s Hospital Foundation Professor in Child Health and Wellness Alberta Children’s Hospital Research Institute, Cumming School of Medicine University of Calgary MedicalResearch.com: What is the background for this study? Response: During the early stages of the global 2019 coronavirus disease (COVID-19) pandemic, children represented fewer than 5% of reported cases.  However, children now represent a significant percent of all new COVID-19 cases.  Similarly, pediatric hospitalizations due to COVID-19, are now at an all-time high.  Although COVID-19 is generally mild in children, severe outcomes and death do occur.  The risk of severe outcomes among SARS-CoV-2 infected children is poorly understood with estimates varying considerably between study designs, settings, and regions.  Studies generally include large administrative databases (i.e. community based), hospitalized populations, and children admitted to the intensive care unit (ICU). Identified risk factors for severe COVID-19 in children have included young (i.e. 1-3 months) or old (15-18 years) pediatric age group, male sex, and pre-existing medical condition.  However, data from large prospective cohort studies which include children with early or mild stages of disease seeking emergency department (ED) care are lacking. To address this knowledge gap we sought to quantify the frequency of and risk factors for severe outcomes in SARS-CoV-2 infected children enrolled in a prospective ED-based cohort study. 

07 Jan

Posted at 16:43h in Author Interviews, Cannabis, JAMA, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58615" align="alignleft" width="150"]Daniel Myran, MD, MPH, CCFP, FRCPC Family and Public Health and Preventive Medicine Physician  CIHR Fellow, Ottawa Hospital Research Institute  Department of Family Medicine Innovation Fellow University of Ottawa  Dr. Myran[/caption] Daniel Myran, MD, MPH, CCFP, FRCPC Family and Public Health and Preventive Medicine Physician CIHR Fellow, Ottawa Hospital Research Institute Department of Family Medicine Innovation Fellow University of Ottawa MedicalResearch.com: What is the background for this study? Response: Canada legalized recreational, or non-medical, cannabis in October 2018. Canada took phased approach to legalization initially only allowing flower-based cannabis products and oils and after one year permitting the sale of commercial cannabis edibles (e.g. THC containing candies, baked goods, and drinks). In this study we took advantage of this phased roll out of legal cannabis to understand the impact of legalization on cannabis exposures or poisonings in children aged 0-9 years and the contribution of different types of cannabis products to these events.

06 Jan

Posted at 23:52h in Author Interviews, Columbia, COVID -19 Coronavirus, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58598" align="alignleft" width="200"]Dani Dumitriu, MD, PhD Assistant Professor of Pediatrics (in Psychiatry) The Sackler Institute for Developmental Psychobiology Columbia University, New York Dr. Dumitriu[/caption] Dani Dumitriu, MD, PhD Assistant Professor of Pediatrics (in Psychiatry) The Sackler Institute for Developmental Psychobiology Columbia University, New York MedicalResearch.com: What is the background for this study? What are the main findings?  Response: A lot of research has focused on the effects of COVID-19 in various vulnerable populations, such as elderly individuals, immunocompromised patients, and individuals with severe comorbidities. However, one vulnerable population that has remained relatively understudied are the infants exposed to maternal COVID-19 disease during pregnancy. While early on in the pandemic we and other groups showed reassuring data on low risk of vertical transmission, meaning the passing of the virus from mother-to-infant is rare, this does not necessarily mean that these infants wouldn't experience long-term consequences related to the maternal infection through other means. We know from other viral illness that maternal illness, most commonly through the activation of her immune system, can lead to a cascade of events that affect fetal development. This is why a large number of physicians and researchers at Columbia University spearheaded the COVID-19 Mother Baby Outcomes (COMBO) Initiative -- to look at potential long-term health effects on both infants and mothers.

31 Dec

Posted at 14:57h in Author Interviews, Eating Disorders, Exercise - Fitness, JAMA, Pediatrics
MedicalResearch.com Interview with: Sean C. Rose, MD Child Neurology Nationwide Children’s Hospital The Ohio State University, Columbus MedicalResearch.com: What is the background for this study? What are the main findings?  Response: There is conflicting evidence regarding the association between repetitive head impacts during youth contact sports and worse neurocognitive outcomes.   Most research has been conducted in older adults, while the research in children is mostly limited to 1-2 sports seasons.

15 Dec

Posted at 10:25h in Author Interviews, Cannabis, Neurology, Pediatrics
MedicalResearch.com Interview with: Rayyan Raja Zafar BSc. MSc. MRSB. Medical Research Council Doctoral Training Partnership (MRC DTP) PhD Candidate Centre for Psychedelic research & Neuropsychopharmacology Division of Psychiatry Department of Brain Sciences, Faculty of Medicine Professor David Nutt DM, FRCP, FRCPsych, FSB, FMedSci Faculty of Medicine, Department of Brain Sciences The Edmond J Safra Chair in Neuropsychopharmacology Imperial College London MedicalResearch.com: What is the background for this study? Response: Since 2018 medical cannabis prescription has become legal in the UK for patients to access. In spite of this legal change less than 3 NHS prescriptions have been made available and access to whole-plant medical cannabis products has been restricted largely to private prescriptions with very few clinicians prescribing such products. There has been a lot of anecdotal and real world evidence of the value of whole-plant medical cannabis in children suffering with treatment resistant epilepsy.

10 Dec

Posted at 18:10h in Author Interviews, Dental Research, JAMA, Pediatrics, USPSTF
MedicalResearch.com Interview with: [caption id="attachment_58505" align="alignleft" width="150"]Michael Cabana, M.D., M.A., M.P.H professor of pediatrics at the Albert Einstein College of Medicine. He is also physician-in-chief at the Children's Hospital at Montefiore and the chair of the Department of Pediatrics at the Albert Einstein College of Medicine U.S. Preventive Services Task Force Dr. Cabana[/caption] Michael Cabana, M.D., M.A., M.P.H Professor of Pediatrics Albert Einstein College of Medicine. Physician-in-chief , Children's Hospital at Montefiore Chair of the Department of Pediatrics Albert Einstein College of Medicine Member, U.S. Preventive Services Task Force  MedicalResearch.com: What is the background for this study and recommendation statement?  Response: Dental caries, also known as cavities or tooth decay, is the most common chronic disease in children in the United States and can develop in any child whose teeth have come in. Many young children under five years old do not visit a dentist, so the Task Force reviewed the latest evidence on how primary care clinicians can help prevent tooth decay in young children. The Task Force’s research led to two important findings: all young children whose teeth have come in should have fluoride varnish applied by their clinician, and all children six months and older whose water supply doesn’t contain enough fluoride should receive fluoride supplements. Both approaches can help prevent cavities in kids. The Task Force also determined that there is not enough evidence to recommend for or against screening for tooth decay in the primary care setting for children under five. This is consistent with the Task Force’s 2014 recommendation on dental caries.

08 Dec

Posted at 22:07h in Asthma, Author Interviews, NEJM, Pediatrics, Pulmonary Disease, Vanderbilt
MedicalResearch.com Interview with: [caption id="attachment_58461" align="alignleft" width="200"]Leonard B. Bacharier, MD Janie Robinson and John Moore Lee Chair in Pediatrics Professor of Pediatrics Director - Center for Pediatric Asthma Research Scientific Director - Center for Clinical and Translational Research Section Chief - Pediatric Allergy and Immunology Division of Allergy, Immunology and Pulmonary Medicine Dr. Bacharier[/caption] Leonard B. Bacharier, MD Janie Robinson and John Moore Lee Chair in Pediatrics Professor of Pediatrics Director - Center for Pediatric Asthma Research Scientific Director - Center for Clinical and Translational Research Section Chief - Pediatric Allergy and Immunology Division of Allergy, Immunology and Pulmonary Medicine Monroe Carell Jr. Children’s Hospital at Vanderbilt University Medical Center  MedicalResearch.com: What is the background for this study?  Is Dupilumab used for other atopic conditions, ie eczema/atopic dermatitis?   Response: Many children with moderate-severe asthma continue to experience asthma exacerbations and poor asthma control despite use of controller therapies.  Dupilumab has been shown to reduce asthma exacerbations in adolescents and adults, as well as to improve atopic dermatitis in children and adults.

25 Oct

Posted at 16:44h in Author Interviews, Cannabis, JAMA, Pediatrics
MedicalResearch.com Interview with: Carmen Lim BSc(Hons), MSc, CStat PhD Candidate National Centre for Youth Substance Use Research Faculty of Health and Behavioural Sciences The University of Queensland Brisbane Australia MedicalResearch.com: What is the background for this study? What are the main findings? Response: This review has systematically summarized the trends and products used for cannabis vaping using 17 studies published globally between Jan 1, 2003 and August 19, 2020. The pooled prevalence has increased for lifetime use (6.1% in 2013 to 13.6% in 2020), past-year use (7.2% in 2017 to 13.2% in 2020) and past-month use (1.6% in 2013 to 8.4% in 2020). Adolescents' preference for cannabis products may be shifting from less potent products (e.g., herbal cannabis) to highly potent vape oil and concentrates.

28 Sep

Posted at 00:41h in Author Interviews, COVID -19 Coronavirus, Pediatrics, Vaccine Studies
MedicalResearch.com Interview with: [caption id="attachment_57633" align="alignleft" width="200"]Dr. Baktari Dr. Baktari[/caption] Jonathan Baktari, MD CEO of e7health.com Dr. Baktari, CEO discusses Pfizer’s recent announcement that their vaccine trial for children ages 5-11 has been safe and effective, marking a major milestone in the fight against COVID-19.   MedicalResearch.com: What risks should parents weigh? Response: Pfizer has already said that based on their studies the lower dose two shot COVID vaccine for children is safe, meaning that their data shows minimal side effects. If that data is correct, then we should expect the same minor symptoms we see with teenagers to the COVID vaccine 

27 Sep

Posted at 21:46h in Author Interviews, CMAJ, COVID -19 Coronavirus, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58162" align="alignleft" width="200"]Shaun K. Morris MD, MPH, FRCPC, FAAP, DTM&H Divisions of General Pediatrics Clinician-Scientist, Division of Infectious Diseases Division of Infectious Diseases at the Hospital for Sick Children (SickKids)  for the Canadian Paediatric Surveillance Program COVID-19 Study Team Dr. Morris[/caption] Shaun K. Morris MD, MPH, FRCPC, FAAP, DTM&H Divisions of General Pediatrics Clinician-Scientist, Division of Infectious Diseases Division of Infectious Diseases at the Hospital for Sick Children (SickKids) for the Canadian Paediatric Surveillance Program COVID-19 Study Team MedicalResearch.com: What is the background for this study? Response: The SARS-CoV-2 virus can cause the disease we now call COVID-19. In early 2020, when the SARS-CoV-2 virus first spread outside of China, it quickly became apparent that cases may be seen in Canada. It was not known at the time how infection with the virus would affect children and youth. Because more severe disease from other respiratory viruses often disproportionally affect the very young, we expected that a similar pattern may be seen with SARS-CoV-2. We also did not know if children and youth with certain underlying medical conditions may be at higher risk for more severe disease. Ultimately, this study was designed to get a better understanding of how often children and youth in Canada are hospitalized with SARS-CoV-2 infection, how often severe disease happens, and which children or youth may be at higher risk for severe disease.     

17 Sep

Posted at 21:12h in Author Interviews, Columbia, Emergency Care, JAMA, Pediatrics, Race/Ethnic Diversity, Yale
MedicalResearch.com Interview with: [caption id="attachment_58134" align="alignleft" width="201"]Destiny Tolliver, MD National Clinician Scholars Program Yale University School of Medicine New Haven, CT 06510-8088 Dr. Tolliver[/caption] Destiny Tolliver, MD National Clinician Scholars Program Yale University School of Medicine New Haven, CT 06510-8088 Katherine Nash MD, MHS Assistant Professor of Pediatrics Columbia University Irving Medical Center MedicalResearch.com: What is the background for this study? Response: This study was motivated by work from our colleagues in the adult Emergency Medicine world. Earlier this year Dr. Ambrose Wong and colleagues published work describing racial disparities in the physical restraint of adults in the ED. This prompted our group to consider whether these disparities were also present for children.

28 Aug

Posted at 11:55h in Author Interviews, Brigham & Women's - Harvard, JAMA, OBGYNE, Pediatrics, Weight Research
MedicalResearch.com Interview with: [caption id="attachment_57981" align="alignleft" width="200"]Emily Oken MD MPH Professor, Harvard Medical School Professor in the Department of Population Medicine Associate Director and Advisor, Oliver Wendell Holmes Society. Professor, Department of Nutrition, Harvard School of Public Health Dr. Oken[/caption] Emily Oken MD MPH Professor, Harvard Medical School Professor in the Department of Population Medicine Associate Director and Advisor, Oliver Wendell Holmes Society. Professor, Department of Nutrition, Harvard School of Public Health MedicalResearch.com: What is the background for this study? What are the main findings? Response: In this study of over 11,000 mothers and children, we found that a mothers with higher weight in late pregnancy had children with poorer performance on tests of cognition and behavior in childhood and adolescence. The findings are consistent with results from studies in other populations around the world, as well as animal experiments.  This research suggests that maternal nutrition is important for child health over the long-term, and specifically provides support for mothers to try to achieve healthy weight and nutritional status during pregnancy.

28 Aug

Posted at 11:40h in Accidents & Violence, Author Interviews, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_49551" align="alignleft" width="144"]Dr-Gary A. Smith Dr. Gary Smith[/caption] Gary A. Smith, MD, DrPH Director, Center for Injury Research and Policy Nationwide Children’s Hospital Columbus, OH MedicalResearch.com: What is the background for this study? Response: Furniture and TV tip-overs are an important source of injury, especially for children younger than 6 years old. Our study found that an estimated 560,200 children younger than 18 years old were treated in U.S. emergency departments for furniture or TV tip-over injuries from 1990 through 2019. In 2019, there were 11,521 injured children, which is an average of one child every 46 minutes.

09 Jul

Posted at 17:35h in Author Interviews, Brigham & Women's - Harvard, Electronic Records, JAMA, Pediatrics, Primary Care
MedicalResearch.com Interview with: [caption id="attachment_57766" align="alignleft" width="200"]Lisa Rotenstein, MD, MBA Assistant Medical Director Population Health and Faculty Wellbeing Department of Medicine Brigham and Women's Hospital Dr. Rotenstein[/caption] Lisa Rotenstein, MD, MBA Assistant Medical Director Population Health and Faculty Wellbeing Department of Medicine Brigham and Women's Hospital MedicalResearch.com: What is the background for this study? Response: Our previous work in JAMA Internal Medicine demonstrated significant differences in time spent on the electronic health record (EHR) by specialty, and specifically showed that primary care clinicians spent significantly more total and after-hours time on the EHR than surgical and medical specialty counterparts. Primary care clinicians spent twice as long as surgical colleagues on notes, and received more than twice as many messages from team-mates, five times as many patient messages, and fifteen times as many prescription messages each day. Given these findings, the heavy administrative burden placed on primary care clinicians, and previous data about burnout among primary care clinicians, we wanted to better understand differences in time spent on the EHR among the different types of primary care clinicians.

19 Jun

Posted at 01:05h in Author Interviews, Education, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_57664" align="alignleft" width="200"]Lisa Forbes, Ph.D, LPC, NCC Clinical Assistant Professor Counseling Program University of Colorado Denver Dr. Forbes[/caption] Lisa Forbes, Ph.D, LPC, NCC Clinical Assistant Professor Counseling Program University of Colorado Denver MedicalResearch.com: What is the background for this study? What are the main findings?  Response: The most common mode of learning in tertiary education is lecture-based learning despite the knowledge that more active, engaged, and flexible approaches to teaching may better support the learning process. This study aimed to understand graduate students’ experiences with a playful pedagogy as an alternative approach to learning.

11 Jun

Posted at 00:51h in Author Interviews, CDC, COVID -19 Coronavirus, JAMA, Pediatrics
MedicalResearch.com Interview with: Angela P. Campbell, MD, MPH Medical Officer Epidemiology and Prevention Branch in the Influenza Division MIS-C Incidence Authorship Group CDC MedicalResearch.com: What is the background for this study?
  • Response: Multisystem inflammatory syndrome in children (MIS-C) is a serious condition associated with COVID-19 where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, and gastrointestinal organs. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, or feeling extra tired. Not all children with MIS-C have the same symptoms.
  • It is still not known exactly how MIS-C may be linked to prior COVID-19 infection. However, 99% of cases in the CDC national surveillance system tested positive for COVID-19. The remaining 1% were around someone with COVID-19.
  • MIS-C incidence might vary by certain patient characteristics, such as such as race, ethnicity, age, sex and geographic location.
  • In this study we estimated the rate of MIS-C cases overall in the general population as well as the rate of MIS-C cases among those with COVID-19.

28 May

Posted at 17:12h in Author Interviews, Autism, Cannabis, JAMA, Pediatrics
MedicalResearch.com Interview with: Daimei Sasayama, M.D., Ph.D. Department of Psychiatry Shinshu University MedicalResearch.com: What is the background for this study? Response: The diagnosis of autism spectrum disorder (ASD) is increasing worldwide. A 2016 US survey reported a prevalence of 1.85% in 8-year-olds, and a birth cohort study in Denmark reported that the future cumulative incidence of ASD could exceed 2.8%. Our recent regional cohort study in Japan reported an even higher cumulative incidence of 3.1%. So we examined whether the cumulative incidence in our regional cohort represents the nationwide incidence in Japan. 

13 May

Posted at 10:26h in Author Interviews, ENT, Pediatrics, University of Pittsburgh
MedicalResearch.com Interview with: [caption id="attachment_57406" align="alignleft" width="200"]Alejandro Hoberman, Dr. Hoberman[/caption] Alejandro Hoberman, M.D. Vice Chair of Clinical Research, Division Director, General Academic Pediatrics, and Professor of Pediatrics and Clinical and Translational Science Jack L. Paradise, MD Endowed Professor of Pediatric Research, UPMC Children's Hospital of PittsburghPresident, UPMC Children's Community Pediatrics MedicalResearch.com: What is the background for this study? Response: Acute otitis media (AOM) is the most frequently diagnosed illness in children in the United States for which antibiotics are prescribed. Recurrent AOM is the principal indication for tympanostomy-tube placement, the most frequently performed operation in children after the newborn period. Supporting the performance of tympanostomy-tube placement for recurrent acute otitis media has been the commonplace observation, after surgery, of acute otitis media–free periods of varying duration. Counterbalancing this view have been the cost of tympanostomy-tube placement; risks and possible late sequelae of anesthesia in young children; the possible occurrence of refractory tube otorrhea, tube blockage, premature extrusion, or dislocation of the tube into the middle-ear cavity; various structural tympanic membrane sequelae; and the possible development of mild conductive hearing loss. Tempering support for surgery is the progressive reduction in the incidence of acute otitis media that usually accompanies a child’s increasing age. Previous trials of tympanostomy-tube placement for recurrent acute otitis media, all conducted before the introduction of pneumococcal conjugate vaccine, have given mixed results and were limited, variously, by small sample size, uncertain validity of diagnoses of acute otitis media determining trial eligibility, short periods of follow-up, and substantial attrition of participants. Official recommendations regarding tympanostomy-tube placement for children with recurrent acute otitis media differ — an otolaryngologic guideline recommends the procedure for children with recurrent acute otitis media, provided that middle-ear effusion is present in at least one ear; a contemporaneous pediatric guideline discusses tympanostomy-tube placement as an “option [that] clinicians may offer.” Given these uncertainties, we undertook the present trial involving children 6 to 35 months of age who had a history of recurrent acute otitis media to determine whether tympanostomy-tube placement, as compared with medical management (comprising episodic antimicrobial treatment, with the option of tympanostomy-tube placement in the event of treatment failure), would result in a greater reduction in the children’s rate of recurrence of acute otitis media during the ensuing 2-year period.

13 May

Posted at 10:21h in Author Interviews, Mental Health Research, Pediatrics
MedicalResearch.com Interview with: Kristina Aspvall | Psychologist, PhD Eva Serlachius MD PhD Adjunct professor Professor David Mataix-Cols, PhD Karolinska Institutet Department of Clinical Neuroscience Child and Adolescent Psychiatry Research Center Stockholm MedicalResearch.com: What is the background for this study? Response: The problem we were trying to solve is the shortage of specialist Cognitive Behavioral Therapy (CBT) for children and adolescents with Obsessive-Compulsive Disorder (OCD). CBT is the first line treatment for children and adolescents with OCD but is a highly specialist treatment rarely available outside large medical centres, typically located in big cities. Previous work by our group and others had shown that it is possible to deliver CBT via the internet in the form of a self-help programme with minimal support from a clinician. The clinician can be located anywhere and provide asynchronous support via a built-in messaging system. Parental support is a key component of the treatment. In essence, the parents take over as the child’s main therapist, under the guidance of the expert clinician. 

09 May

Posted at 11:22h in Author Interviews, Dermatology, JAMA, OBGYNE, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_57303" align="alignleft" width="150"]Niklas Worm Andersson, MD Department of Epidemiology Research Statens Serum Institut, Copenhagen Denmark Dr. Andersson[/caption] Niklas Worm Andersson, MD Department of Epidemiology Research Statens Serum Institut, Copenhagen Denmark  MedicalResearch.com: What is the background for this study? Response: "Findings from some previous fetal safety studies on topical corticosteroid use in pregnancy have raised concerns for an increased risk of newborns being small for gestational age or having low birth weight, in particular among pregnancies where larger amounts of potent to very potent agents have been used."

23 Apr

Posted at 10:23h in Author Interviews, COVID -19 Coronavirus, JAMA, OBGYNE, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_57214" align="alignleft" width="200"]Prof. Papageorghiou Prof. Papageorghiou[/caption] Aris Papageorghiou MBChB, MRCOG Professor of Fetal Medicine and the Clinical Research Director Oxford Maternal and Perinatal Health Institute University of Oxford MedicalResearch.com: What is the background for this study? Response: Our study was really guided by a key question: does Covid-19 in pregnancy increase the risk of adverse maternal and neonatal outcomes as compared with pregnant women who do not have the infection? The question is highly relevant because of the known deleterious effects of other coronavirus infections in pregnancy, e.g. SARS (severe acute respiratory syndrome) and MERS-CoV (Middle East respiratory syndrome coronavirus). In order to answer this question we undertook this multinational cohort study.