MedicalResearch.com Interview with:
Purvesh Khatri, Ph.D.
Stanford Institute for Immunity, Transplantation and Infection (ITI)
Stanford Center for Biomedical Informatics Research (BMIR)
Department of Medicine
Stanford, CA 94305
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: We have previously described a 3-gene signature for distinguishing patients with active tuberculosis (ATB) from those with other diseases, latent mycobacterium tuberculosis (LTB) infection, and healthy controls (Sweeney et al. Lancet Respir Med 2016).
The current study in JAMA Network Open is a follow up study to validate the 3-gene signature in 3 additional independent cohorts that were prospectively collected.
Using these 3 cohorts we have now showed that the 3-gene signature
(1) can identify patients with LTB that will progress to ATB about 6 months prior to diagnosis of active tuberculosis.
(2) can identify patients with ATB in active screening, and
(3) can identify patients with ATB at diagnosis that have higher likelihood of persistent lung inflammation due to subclinical ATB at the end of treatment. Continue reading