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14 Jan Separate Roles For Protein Kinases in Embryo Development and Cancer
More on Protein Kinases on MedicalResearch.com MedicalResearch.com Interview with: Dr Angus Cameron Kinase Biology Laboratory Barts Cancer Institute at Queen Mary University of London and Professor Peter Parker Protein Phosphorylation Laboratory The Francis Crick Institute Medical Research: What is the background for this study? What are the main findings? Response:...25 Nov Obesity: Protein Kinase II and Hepatic Insulin Signaling
MedicalResearch.com Interview with: Ira Tabas, M.D., Ph.D. Richard J. Stock Professor and Vice-Chair of Research Department of Medicine Professor of Anatomy & Cell Biology (in Physiology and Cellular Biophysics) Columbia University New York, NY 10032 MedicalResearch.com: What are the main findings of the study? Dr. Tabas: We discovered a new...28 Jun Two Kinases That Keep Heart Beating May Be Targets For Heart Failure Therapy
MedicalResearch.com Interview with: Dr. Audrey Chang, PhD Kamm-Stull Lab UT Southwestern Medical Center AudreyN.Chang@UTSouthwestern.edu MedicalResearch.com: What is the background for this study? What are the main findings? Response: The heart is a singular kind of muscle that contracts and relaxes continuously over a lifetime to pump blood to the body’s...19 Mar Bypass Pathways Allow Some Cancers To Resist Kinase Inhibitor Drugs
MedicalResearch.com Interview with: Douglas.A. Lauffenburger PhD Ford Professor of Biological Engineering, Chemical Engineering, and Biology Head, Department of Biological Engineering Massachusetts Institute of Technology Cambridge, MA 02139 MedicalResearch.com: What is the background for this study? What are the main findings? Dr. Lauffenburger: We aimed to advance understanding concerning causes of...15 Dec Discovering A Protein That Blocks Cells From Becoming Fat Cells
MedicalResearch.com Interview with: Dr. Richard Phipps PhD Department of Environmental Medicine and Flaum Eye Institute, School of Medicine and Dentistry, University of Rochester, Rochester, New York Medical Research: What is the background for this study? What are the main findings? Response: Obesity has risen dramatically over the past 30 years...27 Jun Kidney Cancer: Nervous System Protein May Provide New Therapeutic Target
MedicalResearch.com Interview with: Dr. John A. Copland, PhD Associate Professor of Biochemistry/Molecular Biology Professor of Cancer Biology Cancer Basic Science Mayo Clinic, Jacksonville, Florida MedicalResearch: What are the main findings of the study? Dr. Copland: In our study we identified a pro-cancerous role for a novel protein- neuronal pentraxin 2...17 Sep Melanoma: PDK1 Kinase Required for Development and Metastasis
MedicalResearch.com Interview with: Ze’ev Ronai, Ph.D. Professor and scientific director of Sanford-Burnham Medical Research Institute La Jolla San Diego, Calif. MedicalResearch.com: What are the main findings of the study? Answer: This study provides the first direct evidence of the importance of the PDK1 enzyme in the development of melanoma and...06 Oct Tyk2 protein potential new Breast Cancer Therapy Target
New Rochelle, NY, October 5, 2011 — A possible new target for breast cancer therapy comes from the discovery that the Tyk2 protein helps suppress the growth and metastasis of breast tumors, as reported in Journal of Interferon & Cytokine Research, a peer-reviewed journal published by Mary Ann Liebert, Inc....
31 Jul Artificial Antibody Knocks Out Kidney Inflammation
Protein kinase C inhibition may be a potential strategy to alter the course of glomerulonephritis.
27 Jul How Small Molecules Accelerate Drug Discovery in Biomedical Research
Posted at 20:13h
in Laboratories
Small molecules under 900 Daltons drive modern drug discovery — from target identification and HTS screening through cAMP pathway probes and PEG300 formulation — and AI is now accelerating what once took years.
11 Jun Berberine in the Age of Ozempic: Discussing What the RCT Evidence Shows
Explore what RCTs reveal about berberine's effects on blood sugar, weight loss, and cholesterol, and how it compares with Ozempic.
11 Feb STIVARGA (Regorafenib) For Patients with Unresectable Hepatocellular Carcinoma
This is a real-life observational study of patients with unresectable hepatocellular carcinoma for whom physicians decided to treat with regorafenib.
05 Jun Accumulation of Metabolite M-2 Predicts Overall Survival of Chemorefractory Metastatic Colorectal Cancer Patients Treated with Regorafenib (Stivarga®)
The study brought valuable insights into how the body handles regorafenib and its active metabolites.14 Dec Tapeworm Drug May Be Repurposed To Fight Parkinson’s Disease
MedicalResearch.com Interview with: Dr. Youcef Mehellou PhD Lecturer in Medicinal Chemistry Cardiff School of Pharmacy and Pharmaceutical Sciences Cardiff University MedicalResearch.com: What is the background for this study? Response: Over the last decade or two, there has been many reports linking genetic mutations to the pathogenesis of Parkinson’s disease (PD). Among...14 Sep Targeted Immunotherapy Can Prevent Some Melanomas From Spreading
MedicalResearch.com Interview with: Dr Alexander Menzies BSc(Med) MBBS (Hons) FRACP PhD Medical Oncologist and Senior Research Fellow at Melanoma Institute Australia The University of Sydney and Royal North Shore and Mater Hospital MedicalResearch.com: What is the background for this study? Response: For early-stage melanoma, surgical resection is the standard treatment...06 Apr Model of RAF Inhibitor Action Provides Roadmap For Resistant Colon and Thyroid Cancer Treatment
MedicalResearch.com Interview with: Poulikos I. Poulikakos, PhD Assistant Professor Department of Oncological Sciences Department of Dermatology The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? Response: Mutations in the oncoprotein kinase BRAF are found in about 8% of human tumors,...18 Aug Circulating TMAO Levels Correlate with Coronary Plaque Vulnerability and Rupture
MedicalResearch.com Interview with: Lemin Zheng, Ph.D. Professor, Lab Director, and Principal Investigator The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Health Science Center Beijing China MedicalResearch.com: What is the background for this study? Response: Optical coherence tomography (OCT) has been considered as an ideal tool to characterize...24 Apr Fructose Metabolism Offers Potential New Target for Hepatocellular Cancer Diagnosis and Treatment
MedicalResearch.com Interview with: Zhimin (James) Lu, M. D., Ph. D Ruby E. Rutherford Distinguished Professor Department of Neuro-Oncology MD Anderson Cancer Center Houston, TX 77030 MedicalResearch.com: What is the background for this study? Dr. Lu: Among primary liver cancers, hepatocellular carcinoma (HCC) is the most common histological subtype, accounting for...09 Apr Autism Pathways Linked To Multisystem Involvement and To Other Disease States
MedicalResearch.com Interview with: Ya Wen PhD TRANSCEND Research, Neurology Department Massachusetts General Hospital, Charlestown, Massachusetts, Harvard Medical School, Harvard University, Boston, Massachusetts Higher Synthesis Foundation, Cambridge, Massachusetts MedicalResearch.com: What is the background for this study? Dr. Ya Wen: At the time of this study (December 2014), the SFARI (Simons Foundation...04 Feb Single Gene Rearrangement Uses Three Paths To Cause Rare Brain Tumor
Posted at 18:52h
in Author Interviews, Brain Cancer - Brain Tumors, Genetic Research, Pediatrics, University of Pennsylvania
MedicalResearch.com Interview with: Dr. Adam C. Resnick, Ph.D Assistant Professor of Neurosurgery Faculty, Abramson Cancer Center Director of Children’s Brain Tumor Tissue Consortium Division of Neurosurgery Director, CHOP/PENN Department of Neurosurgery Brain Tumor Tissue BiorepositoryDirector for Neurosurgical Translational Research, Division of Neurosurgery Children’s Hospital of Philadelphia Payal Jain, PhD Candidate...
31 Jul Cancer Drug Can Activate HIV Reservoirs To Target For Eradication
MedicalResearch.com Interview with: Dr. Satya Dandekar PhD Professor and Chair Department of Medical Microbiology and Immunology UC Davis Medical Research: What is the background for this study? What are the main findings? Dr. Dandekar: Current anti-retroviral therapy is effective in suppressing HIV replication and enhancing immune functions in HIV infected...21 Jun Resveratrol May Help Convert Bad Fat to Good
MedicalResearch.com Interview with: Dr. Min Du Ph.D Department of Animal Sciences Washington Center for Muscle Biology Washington State University Pullman, WA Medical Research: What is the background for this study? What are the main findings? Response: The beige fat is only recently identified and is highly inducible. we observed that...19 Mar Melanoma: Targeting Macrophages Increases BRAF Inhibitors’ Effectiveness
MedicalResearch.com Interview with: Russel E. Kaufman, MD President Emeritus Professor, Molecular and Cellular Oncogenesis Program Molecular and Cellular Oncogenesis Program The Wistar Institute Medical Research: What is the background for this study? What are the main findings? Response: Targeted therapies in cancer were hailed as a “magic bullet” because of...24 Feb Signaling Pathways That Lead Pancreatic Cancer Identified
MedicalResearch.com Interview with: Peter Storz, Ph.D. Associate Professor & Consultant Department of Cancer Biology Mayo Clinic Jacksonville, FL 32224 Medical Research: What is the background for this study? What are the main findings? Dr. Storz: Our study focuses on cellular signaling mechanisms that lead to the initiation of...30 Oct Study Identifies Potential Target In Huntington’s Disease Pathway
MedicalResearch.com Interview with: Srinivasa Subramaniam, Ph.D., Assistant Professor Department of Neuroscience The Scripps Research Institute Jupiter, Florida 33458 Medical Research: What is the background for this study? What are the main findings? Dr. Subramaniam: Huntington’s disease (HD) is a genetic disorder occurs due to a mutation in a protein...16 Jul Study Probes Hormonal Pathway in Skin That Influences Melanoma Risk
MedicalResearch.com Interview with: John D’Orazio, M.D., Ph.D. Drury Pediatric Research Endowed Chair Associate Professor, Univ. KY College of Medicine Pediatric Hematology-Oncology The Markey Cancer Center Lexington, KY 40536-0096 Medical Research: What is the background for this study? Dr. D’Orazio: Malignant melanoma is the deadliest of skin cancers, and it’s incidence...09 Feb Obesity and Colon Polyp Risk
Posted at 14:27h
in Author Interviews, Colon Cancer, General Medicine, PLoS, University of Michigan, Weight Research
MedicalResearch.com Interview with: Jenifer I Fenton Assistant Professor Department of Food Science and Human Nutrition Michigan State University East Lansing, MI 48824 MedicalResearch.com: What are the main findings of the study? Dr. Fenton: This was a cross-sectional study, and thus, a snapshot in time. Although it cannot infer cause or...
29 Apr Hebrew University Researchers Identify RNA Dicing as Key Driver of JAK1 Oncogenic Activity in Endometrial Cancer
Dr. Yuval Malka and Dr. William Faller discuss RNA dicing, a newly described mechanism that generates multiple protein isoforms from a single mRNA, and its implications for JAK1 biology, endometrial cancer, and targeted therapy.