Author Interviews, Ophthalmology, Technology / 16.01.2025

MedicalResearch.com Interview with: Prof Alfonso Savastano Ospedale Generale Regionale “F. Miulli” - Acquaviva delle Fonti (BA) and Libera Università Mediterranea Degennaro (L.U.M.)- Casamassima (BA)  MedicalResearch.com: What is the background for this study? Response: The SING IMT® (Smaller-Incision New-Generation Implantable Miniature Telescope) is a novel, intraocular device for people blinded in the central vision by late-stage, age-related macular degeneration (AMD), the leading cause of unpreventable blindness. It is approved for use in CE referenced countries and under investigation in the United States. Our study evaluated the intermediate-term visual and safety outcomes of the SING IMT in patients (n=35) 55 years and older at 6 months post-surgery and found that SING IMT implantation improved distance and near vision, with an expected impact on the corneal endothelium cell density and manageable safety outcomes. Key findings include:
  • At six months post-surgery, at least 1-, 2-, and 3-line gains in best-corrected distance (BCDVA) were achieved in 97.1 percent, 68.6 percent and 51.4 percent of operated eyes, respectively
  • The percentage of patients able to read at near distance increased from 28.6 percent at baseline to 97.1 percent at six months.
  • The study also found that corrected near visual acuity was also significantly improved by ⁓3 lines at 6 months post-surgery.
  • The mean (SD) change from baseline in corneal endothelial cell density (ECD) at six months in operated eyes was -280.7 (315.9) cells/mm2 (-11.4 %). This is a result similar to that seen with standard cataract surgery.
  • The most frequent adverse event was corneal edema, and all cases were resolved with topical medications.
(more…)
Author Interviews, Psychological Science / 16.01.2025

MedicalResearch.com Interview with: Xinyang Yu, PhD Candidate Institute of Psychiatry Psychology & Neuroscience King’s College London MedicalResearch.com: What is the background for this study? Response: This study explores how genetics, brain development, and mental health work together to influence eating behaviours in young people. By analysing data from nearly 1,000 adolescents, we investigated the relationships between eating behaviours, genetic predispositions for high BMI, and changes in brain structure and mental health from ages 14 to 23. The aim was to understand why disordered eating behaviours, such as restrictive dieting or emotional overeating, often emerge alongside mental health issues during adolescence—a time when eating disorders are increasingly common. (more…)
Author Interviews, Cannabis / 15.01.2025

MedicalResearch.com Interview with: Vishal A Shetty, MS, PhD Candidate Center for Pharmacy and Innovation Outcomes, Geisinger University of Massachusetts AmherstVishal A Shetty, MS, PhD Candidate Center for Pharmacy and Innovation Outcomes, Geisinger University of Massachusetts Amherst MedicalResearch.com: What is the background for this study? Response: With more U.S. states moving toward the legalization of medical and recreational cannabis, recent studies have explored electronic health record (EHR) documentation to understand the nature of cannabis use among patient populations. However, these efforts have not been extended to patient portal messaging, which allows patients to describe health-related behaviors in ways that may not be sufficiently captured in standard EHR documentation. The primary objective of this study was to identify patient and provider secure messages that discussed cannabis and contextualize these discussions over periods prior to and after its legalization for medical purposes in Pennsylvania. (more…)
Infections, Vaccine Studies / 14.01.2025

MedicalResearch.com Interview with: Professor Ooi Eng Eong Emerging Infectious Diseases Programme Duke-NUS Medical School and Shirin Kalimuddin Assistant Professor  and Senior Consultant Department of Infectious Diseases Singapore General Hospital and a faculty member of the Emerging Infectious Diseases Programme at Duke-NUS Medical School   MedicalResearch.com: What is the background for this study? Response: The recent pandemic taught us the importance of T cells to protect against COVID-19, especially severe disease. Indeed, where SARS-CoV-2 antibody titres have been too low to neutralise new variants of concern, there is now sizeable evidence that T cells can serve as the correlate of protection against symptomatic infection. However, most working on developing or applying vaccines to prevent diseases such as dengue, continue to focus on measuring antibodies. The goal of this study was thus to determine the extent to which T cells, in the absence of neutralising antibodies, can control infection and hence disease. We thus took advantage of two other viruses that are genetically related to dengue virus, with licensed vaccines that allow us to probe the effectiveness of T cells in controlling infection. The two vaccines are the live attenuated yellow fever vaccine and the Japanese encephalitis/yellow fever chimeric vaccine. The latter vaccine was constructed using the yellow fever vaccine as the genetic backbone but bearing the genes that encode the Japanese encephalitis viral membrane and envelope proteins. As neutralising antibodies target the envelope protein, vaccination with one vaccine would produce antibodies that would not neutralise the second vaccine. However, the T cell response, which mostly target the other proteins that remain common in both vaccine strains, would be identical.  (more…)
Neurology / 14.01.2025

MedicalResearch.com Interview with: Brian C. Callaghan, MD, Ph.D, FAAN, Chair of the American Academy of Neurology’s Health Services Research Subcommittee University of Michigan Health in Ann Arbor, Michigan MedicalResearch.com: What is the background for this study? Response: Access to neurologists can be a challenge, but few studies have attempted to quantify wait times to see neurologists and the factors that affect how long a patient must wait. MedicalResearch.com: What are the main findings? Response:  Patients on Medicare wait an average of 34 days to see a neurologist after being referred by another physician with almost one in five waiting more than 90 days. (more…)
Education, Nursing, Technology / 10.01.2025

Key Takeaways

  • Online healthcare education offers flexibility for students to balance work and studies.
  • Technological advancements are enhancing virtual learning experiences.
  • Accreditation is crucial in choosing a reputable online program.
  • Affordability and financial aid can significantly impact student decisions.
  • There are challenges in maintaining practical hands-on training in virtual scenarios.

The Rise of Online Healthcare Education

The landscape of education has radically transformed with the advent of online learning platforms. In many fields, particularly healthcare, the demand for qualified professionals continues to grow, prompting numerous educational institutions to offer online nursing programs. These programs are meticulously designed to offer the same quality and depth of education as their traditional counterparts while providing students with the flexibility to learn at their convenience. Geographic barriers are dissolving as students can now attend lectures from the other side of the world, fostering a global educational community. This democratization of education ensures that learners from diverse backgrounds can access top-quality instruction, irrespective of their location. With the pandemic further accelerating the adoption of online education, it is clear that this modality is not just a temporary trend but a permanent shift in the educational paradigm. (more…)
Alzheimer's - Dementia, Author Interviews, Herpes Viruses / 08.01.2025

MedicalResearch.com Interview with: Dr. Or Shemesh PhD The Harvey M. Krueger Family Center for Center for Nanoscience and Nanotechnology School of Pharmacy - Institute for Drug Research The Hebrew University of Jerusalem MedicalResearch.com: What is the background for this study? Response: Our study investigated the connection between herpes simplex virus 1 (HSV-1) and Alzheimer's disease (AD) pathologies. We explored how HSV-1 proteins are present in the brains of individuals with AD and examined their interactions with tau, a key protein in AD pathology. MedicalResearch.com: What are the main findings? Response:  The main finding is that tau, traditionally seen as detrimental, might initially act as a protective response to HSV-1 by reducing neuronal death through an antiviral innate immunity pathway called cGAS-STING . Over time, this (initially beneficial) antiviral response of tau can manifest as the well established tau toxicity in Alzheimer's disease. (more…)
Author Interviews, Nutrition, Prostate Cancer / 29.12.2024

By Dr. Dan Sperling M.D., D.A.B.R. Medical Director and Chief of Interventional Uroradiology at the Sperling Prostate Center in Florida Medical Director of its parent practice, the Sperling Medical Group If the name Dr. Dean Ornish rings a bell, it’s probably because over 30 years ago he became the poster boy for preventing heart disease through diet and exercise. His 1990 book, “Dr. Dean Ornish's Program for Reversing Heart Disease,” made the NYTimes best seller list. To this day, when we think of Dr. Ornish, we think of a long and heart-healthy life. Although we don’t link Dr. Ornish with prostate health, there’s good reason to do so—but most men don’t know it. In 2008, the National Academy of Sciences published research  by Dr. Ornish and his team in an article titled “Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention.” They broke new ground in our understanding of preventing prostate cancer (PCa). Dr. Ornish and his team showed that a comprehensive lifestyle program they designed actually caused changes in gene regulation. They designed an experimental lifestyle protocol and tested is on 30 PCa patients; all 30 had been diagnosed with low-risk PCa and were on Active Surveillance (no other treatment). At the start of the 3-month study, each patient’s biopsy samples were used to profile his PCa gene activity. Then all participants adhered faithfully to the following protocol:
  • A vegan (plant-based) diet (with 10% of calories from fat
  • Physical activity (walking 30 minutes a day for 6 days a week)
  • Stress reduction (yoga, progressive relaxation, breathing, meditation)
  • Dietary supplements (vitamins C and E, soy, fish oil, selenium)
  • A weekly support group to provide advice and sustain adherence to the program.
(more…)
Author Interviews, Cancer Research, Lymphoma, Nutrition, University of Pennsylvania / 24.12.2024

MedicalResearch.com Interview with: Shan Liu, PhD, Postdoctoral fellow Perelman School of Medicine University of Pennsylvania MedicalResearch.com: What is the background for this study? Response: Our study provides evidence that the efficacy of CAR T cell immunotherapies can be influenced by an important lifestyle factor: diet.   MedicalResearch.com: What are the main findings? Response:  Our study found that a ketogenic diet can enhance CAR T cell function through its metabolite, β-Hydroxybutyrate (BHB). Importantly, instead of altering the diet, providing BHB via oral supplementation in our preclinical model is sufficient to improve the anti-tumor function of CAR T cells. However, it's important to note that we’re still in the early stages, and we’re not yet recommending any dietary changes or supplements for patients. (more…)
Alzheimer's - Dementia, Infections / 19.12.2024

MedicalResearch.com Interview with: Benjamin Readhead PhD Research Associate Professor Banner Neurodegenerative Disease Research Center Biodesign Institute Arizona State University MedicalResearch.com: What is the background for this study? Response: Our study describes a surprising link between an intestinal infection with a common virus, human cytomegalovirus (HCMV), and the development of Alzheimer’s in a subset of people with the disease. In a study published earlier this year in the journal Nature Communications, we found that research participants with Alzheimer’s disease were more likely than those without it to harbor a particular immune cell type (“CD83(+) microglia”) in their brains. While trying to uncover what might be driving the presence of these CD83(+) microglia, we discovered an antibody (IgG4) in the intestine of these same subjects that were suggestive of the possibility that some kind of infection might contribute to this form of the disease. (more…)
Author Interviews, Clots - Coagulation, Environmental Risks / 17.12.2024

MedicalResearch.com Interview with: Pamela L Lutsey PhD, MPH Professor, Division of Epidemiology & Community Health University of Minnesota Minneapolis, Minnesota MedicalResearch.com: What is the background for this study? Response: Air pollution is ubiquitous. In order to understand the impact of exposure on health, it is necessary to look across diverse health conditions. Associations with lung disease and atherosclerotic cardiovascular disease are more established. Less is known about the role of air pollution exposure on coagulation and venous thromboembolism (VTE). MedicalResearch.com: Are individuals less ambulatory in heavily polluted areas? The study did not address this question directly. The association did persist across a wide range of subgroups of the sample, including those who were not smokers and who had no evidence of lung disease. (more…)
Hydration / 16.12.2024

Editor's note:  Don't overdo it with hydration.  Over consumption of water has it's own risks and side effects.   Similarly, IV hydration has potential risks. Please consult your personal health care provider regarding your water intake and any possible IV hydration therapy. Water is the essence of life, making up about 60% of the human body and a staggering 75% of the brain. Adequate hydration is essential not only for physical health but also for maintaining optimal cognitive function. The relationship between hydration and brain performance has garnered significant attention in recent years. Numerous studies have highlighted how even mild dehydration can impair mental capabilities, affecting everything from memory to mood. This article delves into the intricate connection between hydration and cognitive function, exploring the science behind it, the effects of dehydration, and strategies to maintain optimal hydration for peak mental performance. The Science of Hydration and the Brain Water's Role in Brain Function Water is integral to various physiological processes in the brain:
  • Neuronal Communication: Water facilitates the transmission of electrical signals between brain cells, or neurons. Proper hydration ensures that these signals are sent efficiently, supporting processes like thinking, learning, and memory.
  • Neurotransmitter Production: Adequate hydration aids in the synthesis of neurotransmitters, chemicals that transmit signals across synapses. This affects mood regulation, focus, and overall brain function.
  • Removal of Toxins: Water helps flush out toxins and metabolic waste products from brain cells, maintaining a clean environment for optimal function.
(more…)
Author Interviews, Cancer Research, Exercise - Fitness, Hematology / 16.12.2024

MedicalResearch.com Interview with: Janine Joseph, MS, MBA Senior Research Specialist Cancer Prevention & Control Roswell Park Comprehensive Cancer Center Buffalo, NY MedicalResearch.com: What is the background for this study? Response: Due to improvements in treatments, patients with multiple myeloma (MM) are experiencing longer lifespans and seeking ways to enhance their quality-of-life.  Fatigue, pain and negative psychological states such as anxiety and depression are common in cancer patients, including patients with MM.  Pain is particularly relevant, as MM can cause painful osteolytic (bone) lesions. The trials we discussed at ASH were aimed at evaluating the effect of exercise, specifically supervised resistance training and unsupervised walking exercise, on these and other states, including physical function and immune profile. (more…)
Education / 16.12.2024

A basic ingredient in healthcare is like medication or treatment: communication plays the same role. Indeed, patient education about their ailments, treatments, or precautions empowers them to make effective choices for further trust between patients and those administering the care. Presenting complex medical information, though, to people little involved with medicine can be complex enough. The art and science, empathy, clarity, and storytelling power all come to the fore. Healthcare storytelling, particularly when complemented by modern tools like educational video makers, has revolutionized how patients receive and retain information. Let’s explore how to simplify complex medical information for patients and leverage storytelling for effective educational content. (more…)
Alzheimer's - Dementia, Author Interviews, Biomarkers / 11.12.2024

MedicalResearch.com Interview with: Alberto J. Espay, MD, MSc, FAAN Professor of Neurology Director and Endowed Chair Gardner Family Center for Parkinson's disease and Movement Disorders University of Cincinnati Academic Health Center MedicalResearch.com: What is the background for this study? What are the main findings Response:  Because aducanumab, lecanemab, and donanemab were only in a minority of anti-amyloid treatments showing a benefit, I was interested in finding out what makes them special. It turns out that they not only clean the brain from amyloid, like other monoclonal anti-Aβ antibodies, but they also increase Aβ42 in the spinal fluid, which is a measure of the normal protein in the brain. Everyone with Alzheimer’s has low Aβ42 levels because this protein clumps into amyloid plaques. I tested the hypothesis that increasing Aβ42 could explain the cognitive outcomes at least as well as decreasing amyloid, and that’s exactly what we found. This suggests that restoring the normal protein levels, Aβ42, may explain why some anti-amyloid treatments (presumably those that increased those levels the most) come with benefits. (more…)
Electronic Records / 11.12.2024

MedicalResearch.com Interview with: Prof. Adam J. Rose Shuli Brammli-Greenberg and Adam J. Rose share senior authorship. Faculty of Medicine, Hebrew University of Jerusalem Beit-Horon, Jerusalem, 9093500, Israel MedicalResearch.com: What is the background for this study? Would you briefly explain what is meant by the Elixhauser Comorbidity Model? Response: Patients admitted to the hospital can have very different levels of illness severity. In addition, different hospitals may admit different numbers of very sick patients. Therefore, comparing two hospitals regarding something like length of stay or in-hospital mortality is not valid unless one adjusts for the illness burden of the population of patients at each hospital. Risk adjustment is the name for the process of building a model to predict the risk of each patient for a particular outcome, such as mortality or readmission, based on what is known about them and their illness burden. By summing all the risks of patients at a hospital, one gets an aggregate sense of the illness burden at the hospital, and different hospitals can be compared. The Elixhauser Comorbidity Model is a widely-used risk adjustment model which performs well in the sense that it is very predictive of outcomes like mortality. It also has the advantage of being calculated from diagnosis codes, which are widely available data for hospitalized patients. (more…)
Exercise - Fitness, Rheumatology / 10.12.2024

  Arthritis is a common condition that can cause pain, stiffness, and swelling in the joints, affecting mobility and quality of life. Engaging in regular physical activity is one of the effective ways to manage and potentially prevent the onset of arthritis. Including specific activities in your routine can improve joint health and reduce the risk of developing arthritis. Exercise not only strengthens the muscles around the joints but also promotes flexibility and balance, which are critical factors in minimizing arthritis symptoms. This article explores a variety of physical activities that can be beneficial for joint health, offering an accessible approach to arthritis prevention for individuals of all fitness levels. (more…)
Author Interviews, Medical Imaging / 05.12.2024

MedicalResearch.com Interview with: Miriam A. Bredella, MD, MBA Bernard and Irene Schwartz Professor of Radiology & Vice Chair for Strategy Associate Dean for Translational Science Director, Clinical and Translational Science Institute NYU Grossman School of Medicine NYU Langone Health Translational Research Building 743 New York, NY 10016   MedicalResearch.com: What is the background for this study? Response: We perform >80 million CTs every year in the US, and there is a lot of information on these CTs that is not used and “thrown away.” Opportunistic imaging or opportunistic screening with the help of AI takes advantage of this information and automatically detects and quantifies vascular calcification, bone mineral density, abdominal fat or muscle mass. In our study, we wanted to detect whether calcification of the abdominal aorta, quantified using AI, could predict coronary artery calcification and major cardiovascular events (e.g. myocardial infarction, cardiac revascularization, stroke, or death). (more…)
Author Interviews, Cancer Research, NEJM, NIH, OBGYNE / 05.12.2024

MedicalResearch.com Interview with: Diana W. Bianchi, M.D. Senior Investigator Center for Precision Health Research Director, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health MedicalResearch.com: What is the background for this study? Response: The ability of prenatal cell-free DNA (cfDNA) sequencing to incidentally detect maternal cancers has been demonstrated by several retrospective studies from commercial or national laboratories. However, there are no standardized approaches to the identification and medical management of prenatal screening results that might indicate a maternal cancer. We sought to prospectively identify DNA sequencing patterns and other biomarkers that could distinguish which women with nonreportable or unusual cfDNA sequencing results had cancer and to determine the best approach for diagnostic work-up of pregnant people who receive these results. (more…)
Supplements, Vitamin C, Vitamin D, Vitamin E, Vitamin K / 04.12.2024

Be sure to discuss your specific use of vitamins and supplements with your health care provider.  Vitamins and supplements may have side effects and/or interfere with other medications. Vitamins and supplements may also be toxic in higher doses. Over-the-counter vitamins and supplements may not be FDA approved or contain inaccurate labeling information. Every cell, every organ and every function in our bodies depends on nutrients. From supporting the immune system to keeping bones strong, stabilising energy levels and even enhancing mental clarity, vitamins and minerals are essential for us to function properly. But even with a balanced diet, ensuring we get all the nutrients we need can be a challenge. The rise of processed foods, long storage times and agricultural practices, leave gaps in what we eat. The ideal multivitamin formula can vary significantly by gender and age, as different groups have unique nutritional needs. The best multivitamin for men will typically include ingredients that provide additional support for heart health and muscle function, such as supplements with higher levels of vitamin E and magnesium. Ingredients such as coenzyme Q10, which is known to support cardiovascular health, and lycopene, which benefits prostate health, are also found in some products. Particularly important for women are nutrients such as folate and biotin that are important for reproductive health and for hair, skin and nails. The best multivitamin for women may also include iron, especially for those who may have higher needs due to menstruation. For the elderly, the focus is on nutrients that compensate for the natural decline in absorption and physiological changes. For example, what is the best multivitamin for a 70-year-old woman? Probably one with higher levels of vitamin B12 and vitamin D. Formulas for older people are also often gentle on the stomach and designed for better absorption, making them suitable for sensitive digestive systems. (more…)
Author Interviews, OBGYNE / 04.12.2024

MedicalResearch.com Interview with: John W. AyersJohn W. Ayers, PhD, MA Altman Clinical Translational Research Institute University of California San Diego, La Jolla MedicalResearch.com: What is the background for this study? Response: Crisis pregnancy centers (CPCs) are frequently at the center of news and policy debates, yet little data exists about where they operate or what they actually do. To address this gap, we developed ChoiceWatch.org, a tool that systematically collected and analyzed over 470,000 webpages from CPC websites. In our study published in JAMA Internal Medicine, we used ChoiceWatch.org, to answer fundamental questions, such as how many crisis pregnancy centers operate in the U.S., where they are located, and what services they advertise. (more…)
Author Interviews, COVID -19 Coronavirus, Mental Health Research, Pulmonary Disease / 30.11.2024

MedicalResearch.com Interview with: Sean B. Fain, Ph.D. Professor and Vice Chair for Research Department of Radiology Affiliate Appointments BME and ECE University of Iowa Iowa City, IA MedicalResearch.com: What is the background for this study? Response: This study uses MRI to investigate connections between lung and brain function. We employ an advanced MRI technique that uses hyperpolarized xenon gas as a contrast agent. This approach allows us to image which parts of the lung are effectively inhaling xenon gas and which parts are not (i.e. ventilation). Additionally, xenon provides insights into lung gas exchange (i.e. oxygen transfer into and out of the blood), as it freely diffuses into alveolar tissue and binds to red blood cells. Using this technology, we hypothesized that the severity of lung injury in individuals with Long COVID would correlate with the degree of cognitive dysfunction and brain imaging. (more…)
Cognitive Issues, Supplements / 28.11.2024

Editor's note: Most Nootropics are not FDA tested or approved. Supplements, including those sold as cognitive enhancers, may have side effects. Please do not take nootropic medications or supplements without discussing with your health care provider first. Have you ever wished for a way to sharpen your focus, improve your memory, or simply stay mentally clear throughout the day? Nootropics, often referred to as "cognitive enhancers," might be the solution you've been curious about. These supplements are gaining popularity among students, professionals, and anyone looking for that extra edge in mental performance. But how exactly do they work, and are they right for you? What Are Nootropics? Nootropics are substances—either natural or synthetic—that are designed to enhance cognitive functions like memory, creativity, and focus. Some of these might be things you’re already familiar with, like caffeine, while others are lesser-known compounds or herbal extracts. A defining feature of nootropics from the likes of Simply Nootropics is that they are thought to support brain function without causing significant side effects. They’re not about forcing your brain into overdrive but rather optimising its natural processes. (more…)
Mental Health Research / 25.11.2024

 If you have experienced suicidal thoughts or have lost someone to suicide and want to seek help, you can contact the Crisis Text Line by texting "START" to 741-741 or call the Suicide Prevention Lifeline at 800-273-8255. Handling High Patient Demands   Mental health practices are seeing more new patients than ever before. Growing awareness of mental health issues has encouraged more people to seek help, but this increase has created challenges for providers. Many practices are now dealing with long waitlists and overworked staff, which can affect the quality of care and overall patient satisfaction.   To manage these issues, mental health professionals need clear strategies. These approaches must ensure that new patients get the help they need while practices run smoothly. Read on!

Why Patient Demand Is Rising

The demand for mental health services has grown for several reasons. More people now recognize the importance of mental health, and the stigma around seeking help has decreased. At the same time, global challenges and daily stress have caused more individuals to face anxiety and depression.   In smaller communities, a lack of an available health professional adds to the problem. For example, a single counselor in a town may receive far more appointment requests than they can handle. This creates delays for patients and stress for providers. Understanding the reasons behind this increased demand is key to finding solutions. (more…)
Author Interviews, Cannabis, JAMA, Mental Health Research / 22.11.2024

MedicalResearch.com Interview with: Belén Blasco PhD Student in Neuroscience - MD Psychiatry Clinical and Translational Sciences (CaTS) Lab Integrated Program in Neuroscience McGill University | Douglas Research Centre Montreal, Canada MedicalResearch.com: What is the background for this study? Response: Our research is centered on uncovering the early brain changes that might contribute to psychosis development. Using innovative brain imaging techniques, we aimed to measure synapsis in individuals with early psychotic symptoms or who are considered at high clinical risk. Synapses are the crucial points of connection between neurons, allowing communication across the brain. A key aspect of our study was to understand how lifestyle factors, like cannabis use, might impact these brain changes, particularly since cannabis consumption has been associated with an increased risk of developing psychosis in young people. (more…)
Author Interviews, Genetic Research, Leukemia, Personalized Medicine / 12.11.2024

MedicalResearch.com Interview with: Professor Ong Sin Tiong Cancer & Stem Cell Biology Signature Research Programme Duke-NUS Medical School, Singapore Dr Yu Mengge Research Fellow, Cancer & Stem Cell Biology Signature Research Programme Duke-NUS Medical School MedicalResearch.com: What is the background for this study? Response: The background of this study is rooted in the observation that certain genetic variations among East Asian populations, notably the BIM deletion polymorphism (BDP), impact treatment outcomes in chronic myeloid leukaemia (CML). Patients with the BDP show resistance to conventional treatments, specifically tyrosine kinase inhibitors like imatinib. This resistance stems from the variant's role in promoting cancer cell survival, which leads to more aggressive disease progression. (more…)