Author Interviews, Critical Care - Intensive Care - ICUs, Yale / 09.11.2013

MedicalResearch.com Interview with: John Ney, MD, MPH Clinical Assistant Professor, Department of Neurology, University of Washington [email protected] MedicalResearch.com: What are the main findings of the study? Dr. Ney: My colleagues and I used a large, publicly available dataset to examine the usage and effectiveness of electroencephalography (EEG) in adult intensive care units (ICUs) in the United States over a five year period.  We compared routine EEG, which consists of a portable machine hooked up to the patient to record brainwaves for a short duration, usually 20-40 minutes, with continuous EEG monitoring, where a patient’s brainwaves are recorded continuously for 24 hours or more and examined, ideally in real-time.  Because most patients in the ICU are comatose, we have generally poor and crude indicators of their brain function.  ICU patients are particularly at risk for non-convulsive seizures, where the brain is seizing, but there are few outward signs of a seizure.  EEG is the only means of detecting non-convulsive seizures, and is useful in determining the brain’s reactions to drugs, monitoring for stroke and other abnormal activity. Our main finding is that ICU patients receiving continuous EEG monitoring was associated with increased survival relative to those who received routine EEG only.    In our sample, 39% of ICU patients who received routine EEG died compared to only 25% of those with continuous EEG monitoring. This finding was both substantial and statistically significant, even after adjustment for age and other demographics, clinical disease comorbidity severity measures, and hospital factors.  Although continuous EEG monitoring was more expensive, the increase in hospital charges were not significant after adjustment. (more…)
Author Interviews, Cancer Research, OBGYNE, Pediatrics / 09.11.2013

Alastair Sutcliffe M.D., Ph.D. From the Institute of Child Health University College LondonMedicalResearch.com  Interview with: Alastair Sutcliffe M.D., Ph.D. From the Institute of Child Health University College London   MedicalResearch.com: What are the main findings of the study?   Dr. Sutcliffe: Good NEWS for couples who need assisted conception. All the births (106,000) from Great Britain over 18 years were linked to the National Childhood Cancer Registry from the Human Fertilisation and Embryology Authority (which has recorded all births sine 1991 by law.)Those children who showed up on both registries, had IVF conception and childhood cancer. We predicted the number we would expect from the known national childhood cancer rates. We found ALMOST IDENTICAL rates 108 in our group and 109 predicted. NO INCREASED RISK OF CANCER AFTER IVF CONCEPTION IN OFFSPRING. (more…)
AHA Journals, Author Interviews, Lancet, Stroke / 07.11.2013

Dr. Colin Derdeyn Mallinckrodt Institute of Radiology and the Departments of Neurology and Neurosurgery Washington University School of Medicine, St Louis, MO, USAMedicalResearch.com Interview with: Dr. Colin Derdeyn Mallinckrodt Institute of Radiology and the Departments of Neurology and Neurosurgery Washington University School of Medicine, St Louis, MO, USA MedicalResearch.com: What are the main findings of the study?  Dr. Derdeyn: The primary results indicate that medical management, consisting of dual antiplatelets for 3 months after a transient ischemic attack (TIA) or stroke, and rapid, effective control of blood pressure (systolic BP less than 140 mm Hg and 130 mm Hg if diabetic) and LDL-cholesterol (less than 70 mg/dl), in addition to management of other risk factors, is superior to angioplasty and stenting in addition to the same medical regimen for reducing the risk of future stroke in patients with severe atherosclerotic stenosis (>70%) of a major intracranial artery.    In addition, while there were subgroups at higher risk for stroke on medical treatment (older age, female gender, prior stroke in the territory),  none of these subgroups appeared to have a benefit from stenting (i.e. stroke rates in the stenting groups in these subgroups was higher too). (more…)
Author Interviews, Depression, JAMA / 07.11.2013

Richard L. Kravitz, MD, MSPH Professor and Co-vice Chair (Research) Interim Director, UC Center Sacramento Co-Editor in Chief, Journal of General Internal MedicineMedicalResearch.com Interview with: Richard L. Kravitz, MD, MSPH Professor and Co-vice Chair (Research) Interim Director, UC Center Sacramento Co-Editor in Chief, Journal of General Internal Medicine MedicalResearch.com: What is the background for your study? Dr. Kravitz: Depression in the United States is both undertreated and overtreated.  As the de facto mental health care system for many, primary care is at the nexus of this problem.  Up to 30% of patients with major depression in primary care go undiagnosed.  At the same time, partly as a result of marketing, lots of patients who don’t need meds are started on antidepressants.   So we were interested in finding ways to get more truly depressed patients into treatment without overtreating patients who don’t need it. (more…)
Author Interviews, Exercise - Fitness, Pediatrics / 07.11.2013

MedicalResearch.com Interview with: Chris Fritz BSs PEZZ Center for Pediatric Endocrinology Zurich, Zurich, Switzerland MedicalResearch.com: What are the main findings of the study? Answer: Targeted strength training significantly increases daily spontaneous physical activity (PA) behaviour in boys. The less active children showed the greatest increase. 102 healthy school children were randomly placed in two groups. The control group continued three PE classes per week, whereas the intervention group had two out of three PE classes replaced by an individualised strength training program. At baseline there was no difference in anthropometry, body composition and PAEE between the groups. At the end of the training intervention, we found a significant increase of upper and lower body strength in the intervention group in boys and in girls. Boys significantly increased their PA by 10%. Without taking into account the energy expenditure during the strength training, the 10% PAEE increase corresponds to a weekly bike ride of 28 miles for a child of 40 kg body weight. Or in other words, an individualised school based strength training program increases energy expenditure outside the intervention by an equivalent of about 7kg of body fat corresponding to 10kg of chocolate per year. (more…)
Author Interviews, Breast Cancer / 07.11.2013

Mila Donker, MD Resident in Radiation Oncology Study monitor EORTC 10981-22023 AMAROS trialMedicalResearch.com Interview with: Mila Donker, MD Resident in Radiation Oncology Study monitor EORTC 10981-22023 AMAROS trial The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands MedicalResearch.com: What are the main findings of the study?  Dr. Donker: Results of EORTC trial 10853 which were recently published in the Journal of Clinical Oncology showed that breast conserving treatment combined with radiotherapy reduces the risk of local recurrence in women with ductal carcinoma in situ (DCIS). Between 1986 and 1996, this phase III EORTC trial 10853 randomized 1010 women with complete local excision of DCIS to no further treatment (503 patients) or radiotherapy (507 patients). The risk of any local recurrence was found to be reduced by 48% in the patients who also received radiotherapy. The 15-year local recurrence-free rate was 69% for the group of patients receiving breast conserving surgery alone, but this increased to 82% for the group of patients who also received radiotherapy, and the 15-year invasive local recurrence-free rate was 84% versus 90%, respectively. (more…)
Author Interviews, JAMA, Pediatrics, Weight Research / 07.11.2013

Thomas H. Inge, M.D., Ph.D. Professor of Surgery and Pediatrics Director of the Surgical Weight Loss Program for Teens Director for the Center for Bariatric Research and Innovation Cincinnati Children’s Hospital Medical CenterMedicalResearch.com Interview with: Thomas H. Inge, MD, PhD, FACS, FAAP Surgical Director, Surgical Weight Loss Program for Teens Director, Center for Bariatric Research and Innovation Attending Surgeon, Cincinnati Children’s Hospital Medical Center Professor, UC Department of Surgery Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio MedicalResearch.com: What are the main findings of the study? Dr. Inge: The mean age of the 242 participants of this observational study was 17.1±1.6 years and the median BMI was 50.5 kg/m2.  Fifty-one percent demonstrated four or more major co-morbid conditions.  Laparoscopic Roux-en-Y gastric bypass, vertical sleeve gastrectomy, and adjustable gastric banding were performed in 66%, 28%, and 6% of subjects, respectively.  There were no deaths during the initial hospitalization or within 30 days of surgery; major complications were seen in 19 subjects (8%). Minor complications were noted in 36 subjects (15%).  All re-operations and 85% of re-admissions were related to WLS. (more…)
Author Interviews, Cost of Health Care, Emergency Care / 06.11.2013

MedicalResearch.com Interview with: Jessica E. Galarraga, MD, MPH Resident Physician Department of Emergency Medicine George Washington University Hospital 2120 L. St. N.W. Suite 475 Washington D.C. Jessica E. Galarraga, MD, MPH Resident Physician Department of Emergency Medicine George Washington University Hospital 2120 L. St. N.W. Suite 475 Washington D.C.   MedicalResearch.com: What are the main findings of the study? Dr. Galarraga: This study examined how emergency department (ED) reimbursements for outpatient visits may be impacted by the insurance coverage expansion of the Patient Protection and Affordable Care Act as newly eligible patients gain coverage either through the Medicaid expansion or through health insurance exchanges. We conducted our analyses using the Medical Expenditure Panel Survey, a nationally representative survey managed by the Agency for Healthcare Research and Quality. We found that ED reimbursements for outpatient encounters by the previously uninsured who gain Medicaid insurance may increase by  17 percent and moving Medicaid-expansion ineligible patients to the private insurance market through insurance exchanges may increase reimbursements as high as 39 percent after the act is implemented. (more…)
Annals Internal Medicine, Author Interviews, General Medicine, Mediterranean Diet, Nutrition / 06.11.2013

Cécilia Samieri, PhD Institut pour la Santé Publique et le Développement, Case 11, Université Bordeaux Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, FranceMedicalResearch.com Interview with Cécilia Samieri, PhD Institut pour la Santé Publique et le Développement, Case 11, Université Bordeaux Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France MedicalResearch.com: What are the main findings of the study? Dr. Samieri: That women with healthier dietary patterns at midlife were 40% more likely to survive age 70 or over free of major chronic diseases and with no impairment in physical function, cognition or mental health. (more…)
Author Interviews, Cancer Research, Chemotherapy / 06.11.2013

MedicalResearch.com Interview with: Dr. Shuichi Hironaka, MD Clinical Trial Promotion Department, Chiba Cancer Center 666-2 Nitona-cho Chuo-ku Chiba-shi Chiba, 260-8717 Japan MedicalResearch.com: What are the main findings of the study? Dr. Hironaka: This is the first randomized phase III trial comparing paclitaxel and irinotecan in second-line chemotherapy for advanced gastric cancer. This study showed that no statistically significant difference was observed between paclitaxel and irinotecan for overall survival. However, both are reasonable second-line treatment options for advanced gastric cancer. (more…)
Author Interviews, Diabetes, NYU, Weight Research / 06.11.2013

Manish Parikh MD Associate Professor of Surgery, NYU School of Medicine Director of Bariatric Surgery, Bellevue Hospital Center 550 First Ave NBV 15 South 7 New York, NY 10010MedicalResearch.com Interview with: Manish Parikh MD Associate Professor of Surgery, NYU School of Medicine Director of Bariatric Surgery, Bellevue Hospital Center 550 First Ave NBV 15 South 7 New York, NY 10010 MedicalResearch.com: What are the main findings of the study? Dr. Parikh: The main findings of this study is that surgery is safe and effective in patients with type 2 diabetes and BMI under 35.  The overall estimated rate of diabetes remission was 55% at 12 months, ranging from 33% for the adjustable gastric banding, 49% for the “mini” gastric bypass, 54% for the sleeve gastrectomy, 64% for the gastric bypass, 71% for the biliopancreatic diversion, and 81% for ileal transposition. (more…)
Author Interviews, Blood Pressure - Hypertension, University of Michigan / 05.11.2013

Jeremy Sussman, MD, MS Division of General Internal Medicine University of Michigan Staff Scientist, Center for Clinical Management Research Ann Arbor Veterans Affairs Healthcare SystemMedicalResearch.com Interview with: Jeremy Sussman, MD, MS Division of General Internal Medicine University of Michigan Staff Scientist, Center for Clinical Management Research Ann Arbor Veterans Affairs Healthcare System MedicalResearch.com: What are the main findings of the study? Dr. Sussman: We could prevent up to 180,000 more heart attacks and strokes in America every year using less medication overall. (more…)
Aging, General Medicine, McGill / 05.11.2013

Dr. Laurent Azoulay Project Leader, Lady Davis Institute Assistant Professor, Department of Oncology, McGill UniversityMedicalResearch.com Interview with: Dr. Laurent Azoulay Project Leader, Lady Davis Institute Assistant Professor, Department of Oncology, McGill University MedicalResearch.com: What are the main findings of the study? Dr. Azoulay: Using large population-based databases from the UK, we assembled a cohort of men newly-diagnosed with non-metastatic prostate cancer. Within this group of men, the use of statins after prostate cancer diagnosis was associated with a 24% decreased risk in cancer-related mortality. We observed duration- as well as a dose-response relationships. Furthermore, in a secondary analysis, we observed that the benefits were greater among men who used also used statins before their diagnosis, with more modest yet significant benefits among men who initiated the treatment after their diagnosis. The latter result is one of the novelties of this study, as it provides an estimate of the potential benefits of statins, if used in the adjuvant setting. (more…)
JAMA, Weight Research / 05.11.2013

MedicalResearch.com Interview with: Nicholas J. Christian, PhD Graduate School of Public Health University of Pittsburgh MedicalResearch.com:  What are the main findings of the study? Dr. Christian: We found that the differences between measured and self-reported weights following bariatric surgery were small and did not systematically differ by measured body mass index or degree of postoperative weight change. The average degree of underreporting by self-report was 0.7 kg for women and 1.0 kg for men. (more…)
Allergies, Author Interviews / 05.11.2013

Dr. Eric Macy, MD MS Southern California Permanente Medical Group Department of Allergy San Diego Medical Center, San Diego, CalifMedicalResearch.com Interview with: Dr. Eric Macy, MD MS Southern California Permanente Medical Group Department of Allergy San Diego Medical Center, San Diego, Calif   MedicalResearch.com: What are the main findings of the study? Dr. Macy: Admission to hospital with a history of penicillin allergy, though often inaccurate, is associated with significantly higher total hospital utilization along with significantly higher rates of MRSA, VRE, and Clostridium difficile infections. (more…)
Author Interviews, Pediatrics, Sleep Disorders, Weight Research / 05.11.2013

Chantelle Hart, Ph.D. Associate Professor of Public Health Center for Obesity Research & Education Department of Public Health 3223 N. Broad Street Philadelphia, PA 19140MedicalResearch.com Interview with: Chantelle Hart, Ph.D. Associate Professor of Public Health Center for Obesity Research & Education Department of Public Health Philadelphia, PA 19140   MedicalResearch.com: What are the main findings of the study? Dr. Hart: Following one week of sleeping their typical amount, children 8-11 years old were asked to decrease and increase their time in bed by 1.5 hours/night for one week each in random order.  Compared to when children decreased their sleep, when they increased their sleep, they reported consuming 134 kcal/day fewer, had lower fasting levels of leptin, a hunger-regulating hormone that is also highly correlated with the amount of adipose tissue, and weighed approximately 0.5 lbs less.  Reported decreases in food intake were most pronounced later in the day. (more…)
Author Interviews, Heart Disease, JAMA, Wake Forest / 05.11.2013

Elsayed Z Soliman MD, MSc, MS, FAHA, FACC Director, Epidemiological Cardiology Research Center (EPICARE) Wake Forest School of Medicine Medical Center Blvs, Winston Salem, NC 27157MedicalResearch.com Interview with: Elsayed Z Soliman MD, MSc, MS, FAHA, FACC Director, Epidemiological Cardiology Research Center (EPICARE) Wake Forest School of Medicine Medical Center Blvs, Winston Salem, NC 27157 Atrial Fibrillation and the Risk of Myocardial Infarction MedicalResearch.com: What are the main findings of the study? Dr. Soliman: Using data from the REGARDS study, one of the largest US cohorts, we examined the risk of incident myocardial infarction (MI) associated with atrial fibrillation (AF). Overall, AF was associated with almost double the risk of MI. When we adjusted for common cardiovascular risk factors and potential confounders, the risk remained significantly high; about 70% increased risk. When we looked at women, men, blacks, and whites separately,  we found significant differences between races and sex.  AF in women and blacks was associated with more than double the risk of MI. This compares to less than 50% increased risk of heart attack associated with AF in men and whites . So AF is basically bad for all, but the risk of MI associated with AF is more pronounced in women and blacks. (more…)
Author Interviews, Orthopedics / 05.11.2013

Dr. Geoffrey S. Marecek, MD Department of Orthopaedic Surgery University of Southern California Keck School of Medicine Los Angeles, CAMedicalResearch.com Interview with: Dr. Geoffrey S. Marecek, MD Department of Orthopaedic Surgery University of Southern California Keck School of Medicine Los Angeles, CA MedicalResearch.com: What are the main findings of the study? Dr. Marecek: There were several main findings: 1. It is not safe to drive while wearing a sling or splint on the upper extremities 2. It is not safe to drive while wearing a brace, cast, or boot on the lower extremities 3. Braking function does not return to normal for at least 4 weeks after knee arthroscopy, total knee arthroplasty (TKA) and total hip arthroplasty (THA), for 9 weeks after ankle fracture repair, and for 6 weeks after weight bearing begins for a fracture (up to 18 weeks for articular fractures). (more…)
Author Interviews, BMJ / 04.11.2013

MedicalResearch.com Interview with: r. Christopher Jones MD Attending Physician Department of Emergency Medicine, Cooper Medical School of Rowan University One Cooper Plaza, Camden, NJ 08103, USADr. Christopher Jones MD Attending Physician Department of Emergency Medicine, Cooper Medical School of Rowan University One Cooper Plaza, Camden, NJ 08103, USA MedicalResearch.com: What are the main findings of the study? Dr. Jones: We identified a group of 585 clinical trials with at least 500 participants which had been prospectively registered with ClinicalTrials.gov and completed prior to 2009. Following an extensive search of the medical literature, we were unable to identify published manuscripts for 171 (29%) of these studies. For these unpublished studies we also determined whether results were available in the ClinicalTrials.gov results database, and we found that 133 studies had no results available either in the published literature or on ClinicalTrials.gov. (more…)
Anesthesiology, Author Interviews, Menopause / 04.11.2013

MedicalResearch.com Interview with: David Walega, MD Chief of the Division of Pain Medicine Northwestern Memorial Hospital and Northwestern University Feinberg School of Medicine.David Walega, MD Chief of the Division of Pain Medicine Northwestern Memorial Hospital and Northwestern University Feinberg School of Medicine. MedicalResearch.com: What are the main findings of the study? Dr. Walega: Patients who underwent a single stellate ganglion injection with a local anesthetic had a 50% decrease in moderate -to- very severe hot flashes and this effect appeared to last thru the 6 month duration of the study; the placebo or "sham control" group had injections of saline and they did not demonstrate long-term improvements in hot flash symptoms (more…)
Author Interviews, BMJ, Sugar, Weight Research / 02.11.2013

MedicalResearch.com Interview with: Adam D M Briggs Academic Clinical Fellow British Heart Foundation Health Promotion Research Group, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK MedicalResearch.com: What are the main findings of the study? Answer: For the first time this study estimates the impact of a sugary drinks tax in the UK on obesity. We estimate the tax would reduce the number of adults with obesity by around 180,000 or just over 1% of all adults who are obese, and the number of adults who are either overweight or obese by 285,000. The greatest reductions are seen in young adults. We also estimate that the effects of the tax will be similar across all income groups. (more…)
Author Interviews, Rheumatology / 02.11.2013

Dr. Laura Coates Division of Rheumatic and Musculoskeletal Disease Chapel Allerton Hospital Chapeltown Road Leeds NIHR Clinical Lecturer at the University of LeedsMedicalResearch.com Interview with: Dr. Laura Coates Division of Rheumatic and Musculoskeletal Disease Chapel Allerton Hospital Chapeltown Road Leeds NIHR Clinical Lecturer at the University of Leeds
MedicalResearch.com: What are the main findings of the study? Answer: The TICOPA study showed that treating patients with early psoriatic arthritis to an objective target with regular review improved patient's clinical outcome both in terms of arthritis and skin psoriasis.  There was an increase in adverse events in the tight control arm but only 4 serious infections seen in the tight control arm that were thought to be related to treatment (2 cases of cellulitis, 2 cases of chest infection). (more…)
Author Interviews, Lancet, Vaccine Studies / 01.11.2013

Dr Belén Pedrique Epidemiologist Drugs for Neglected Diseases initiative DNDi, 15 Chemin Louis Dunant 1202 Geneva, Switzerland MedicalResearch.com Interview with : Dr Belén Pedrique Epidemiologist Drugs for Neglected Diseases initiative DNDi, 15 Chemin Louis Dunant 1202 Geneva, Switzerland MedicalResearch.com : What are the main findings of the study? Dr. Pedrique: Of the 850 new drugs and vaccines approved for all diseases in 2000-2011, 4% (37) were for neglected diseases, defined broadly as those prevalent primarily in poor countries: malaria, tuberculosis, 17 neglected tropical diseases (NTDs) as defined by the World Health Organization (WHO), 11 diarrheal diseases, and 19 other diseases of poverty, excluding HIV/AIDS. Globally these neglected diseases represent an 11% health burden, based on a recent assessment of 2010 disability-adjusted life-years (DALYs). Most newly developed therapeutic products were repurposed versions of existing drugs. Of the 336 brand-new drugs (new chemical entities, or NCEs) approved for all diseases in 2000-2011, only four, or 1%, were for neglected diseases; three were for malaria, and one for diarrheal disease. None were for any of the 17 WHO-listed NTDs Of 148,445 phase I-III clinical trials registered as of Dec 31, 2011, only 1% (2,016) were for neglected diseases. (more…)
Cancer Research, MD Anderson, Radiation Therapy / 01.11.2013

Steven J. Frank, M.D., associate professor of Radiation Oncology at The University of Texas MD Anderson Proton Therapy CenterMedicalResearch.com Interview with: Steven J. Frank, M.D., associate professor of Radiation Oncology at The University of Texas MD Anderson Proton Therapy Center discusses the findings of his latest study, “Gastrostomy Tubes Decrease by Over 50% with Intensity Modulated Proton Therapy during the Treatment of Oropharyngeal Cancer Patients.” MedicalResearch.com: What are the main findings of the study? Dr. Frank: The study found that the use of feeding tubes in oropharyngeal carcinoma (OPC) cancer patients treated with intensity modulated proton therapy (IMPT) decreased by more than 50% percent compared to patients treated with intensity modulated radiation therapy (IMRT). This suggests that proton therapy may offer vital quality of life benefits for patients with tumors occurring at the back of the throat. Of the 50 OPC patients enrolled in the study:
  • Twenty-five patients were treated with IMPT and 25 received IMRT.
  • Five patients treated with IMPT required the use of feeding tubes (20%) compared to 12 patients treated with IMRT (48%).
  • IMPT patients were spared from serious side effects, usually a result of IMRT, such as loss of taste, vomiting, nausea, pain, mouth and tongue ulcers, dry mouth, fatigue, and swallowing difficulty.
  • IMPT patients could better sustain their nutrition and hydration levels, often leading to faster recovery during and after treatment.
IMPT is an advanced form of proton radiation therapy and a treatment currently only offered in North America at The University of Texas MD Anderson Proton Therapy Center. It delivers protons to the most complicated tumors by focusing a narrow proton beam and essentially “painting” the radiation dose onto the tumor layer by layer. Unlike IMRT, which destroys both cancerous and healthy cells, IMPT has the ability to destroy cancer cells while sparing surrounding healthy tissue from damage. Therefore, important quality of life outcomes such as neurocognitive function, vision, swallowing, hearing, taste and speech can be preserved in head and neck patients. (more…)
Author Interviews, Prostate Cancer, Weight Research / 01.11.2013

MedicalResearch.com Interview with: Reina Haque, PhD, MPH Research scientist, Kaiser Permanente Department of Research & Evaluation MedicalResearch.com: What are the main findings of the study? Answer: The main study findings are that men who are overweight or obese when they are diagnosed with prostate cancer are more likely to die from the disease than men who are of healthy weight. In patients with more aggressive forms of prostate cancer, the researchers also found an even stronger correlation between obesity and mortality. The study was restricted to patients undergoing surgical treatment for prostate cancer, rather than other treatments such as radiation or hormone therapy. (more…)
Antioxidants, Author Interviews, Diabetes, Nutrition / 01.11.2013

Kumar Sharma, M.D. Professor of Medicine Director, Institute of Metabolomic Medicine Director, Center for Renal Translational Medicine University of California, San Diego La Jolla, CA 92093-0711MedicalResearch.com Interview with: Kumar Sharma, M.D. Professor of Medicine Director, Institute of Metabolomic Medicine Director, Center for Renal Translational Medicine University of California, San Diego La Jolla, CA 92093-0711 MedicalResearch.com: What are the main findings of the study? Dr. Sharma: Main findings are that diabetes is associated with reduced superoxide production in the kidney and heart and that stimulation of superoxide production with AMPK led to improvement in organ function. (more…)
Author Interviews, Diabetes, Nutrition / 01.11.2013

Diewertje Sluik, DrPH Postdoctoral fellow | Division of Human Nutrition | Section Epidemiology & Pubic Health | Wageningen University Postal address: PO Box 8129 | NL-6700 EV Wageningen| The Netherlands Visiting address: Agrotechnion, Building 309, Room 1019 | Bomenweg 4 | 6703 HD WageningenMedicalResearch.com Interview with: Diewertje Sluik, DrPH Postdoctoral fellow | Division of Human Nutrition | Section Epidemiology & Pubic Health | Wageningen University Postal address: PO Box 8129 | NL-6700 EV Wageningen| The Netherlands Visiting address: Agrotechnion, Building 309, Room 1019 | Bomenweg 4 | 6703 HD Wageningen MedicalResearch.com: What are the main findings of the study? Response: The main finding of the study is that lifestyle advice with respect to mortality for patients with diabetes should not differ from recommendations for the general population. Diabetes status did not substantially influence the associations between lifestyle and mortality risk. People with diabetes may benefit more from a healthy diet, but the directions of association were similar. These results highlight that the difficulties in recognizing and diagnosing diabetes and its different stages are of minor importance with respect to healthy diet and lifestyle recommendations, because no difference in recommendations depending on the stage of the disease seems necessary. (more…)