Author Interviews, Breast Cancer / 26.01.2014

MedicalResearch.com Interview with: Deirdre McLaughlin PhD MAPS Associate Professor, Principal Research Fellow Centre for Longitudinal and Lifecourse Research and Janni Leung, BHS School of Population Health University of Queensland MedicalResearch.com: What are the main findings of the study? Answer: Breast cancer patients living in rural areas were diagnosed later than breast cancer patients living in urban areas. Evidence from Australia, Egypt, Italy, Canada, Poland, South Africa, Denmark, and parts of the United States indicated that patients residing in rural areas were more likely to be diagnosed with more advanced breast cancer. Our meta-analysis showed that rural breast cancer patients had 1.19 higher odds (95% confidence interval= 1.12-1.27) of diagnosis of a late stage breast cancer compared to urban breast cancer patients.
Author Interviews, BMJ, Hip Fractures, Hormone Therapy, Orthopedics / 25.01.2014

Professor Nigel Arden Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences Botnar Research Centre Windmill Road Oxford OX3 7LDMedicalResearch.com Interview with: Professor Nigel Arden Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences Botnar Research Centre Oxford  OX3 7LD MedicalResearch.com: What are the main findings of the study? Professor Arden: We found that in a cohort of women who had used hormone replacement therapy (HRT) and underwent knee or hip replacement their risk of implant revision was reduced by about 40% compared to non-users of HRT.
Author Interviews, Vitamin D / 24.01.2014

MedicalResearch.com Interview with: Professor Mark Bolland Senior Research Fellow in the Department of Medicine University of Auckland, New Zealand MedicalResearch.com: What are the main findings of the study? Prof. Bolland: We pooled data from randomised controlled trials of vitamin D supplements in traditional meta-analyses and trial sequential analyses to assess the effect on important health outcomes. We found that vitamin D supplements (with or without calcium) had no effect on myocardial infarction, stroke, total cancer, or total fracture, and further similar trials are unlikely to alter these conclusions. For hip fracture, the results were more complicated. There was uncertainty as to whether vitamin D by itself increased the risk of hip fracture or had no effect, whereas the combination of vitamin D with calcium had no effect on hip fracture in people living in the community, but reduced hip fracture risk in two trials of elderly women living in residential care.
Author Interviews, FDA, JAMA, Yale / 23.01.2014

MedicalResearch.com Interview with: Nicholas S. Downing, AB Yale University School of Medicine New Haven, Connecticut MedicalResearch.com: What are the main findings of the study? Answer: In our systematic review of all new drugs approved by the FDA over an 8 year period, we found that there was real variability in the quality and quantity of clinical trial evidence used as the basis of the agency’s approval decisions. Some drugs were studied in multiple randomized, double-blinded, controlled clinical trials that provide very helpful information for patients and physicians. However, other drugs were studied in clinical trials that did not produce as much information about their safety and effectiveness.
Author Interviews, BMJ, General Medicine, Mental Health Research, Pediatrics / 22.01.2014

MedicalResearch.com Interview with: Prof. Kathryn M Abel Professor of Psychiatry & Honorary Consultant Psychiatrist University of Manchester and Honorary Senior Lecturer at the Institute of Psychiatry, London. MedicalResearch.com: What are the main findings of the study? Answer: The main study findings were that exposure of a mother to a severe psychological stress of losing a close family member up to either 6 months before conception or at any time during pregnancy did not increase risk of subsequent psychotic illness in the offspring. Secondly, we found during childhood, if a close family member died then, especially a sibling of the child or one of their parents, these children were at slightly increased risk of developing a psychotic illness later in life. This was most likely to happen following a sudden death especially suicide and in particular following suicide a psychotic mood disorder was more likely than other kinds of psychosis such as schizophrenia (although the risk of schizophrenia was also increased following suicide). This effect was not accounted for by having  a family history of a psychotic illness or suicide.
Author Interviews, Brain Injury, JAMA / 22.01.2014

John W. O'Kane M.D. Associate Professor Family Medicine and Orthopaedics and Sports Medicine Medical Coordinator, U.W. Intercollegiate Athletics University of Washington Sports Medicine Clinic, SeattleMedicalResearch.com Interview with: John W. O'Kane M.D. Associate Professor Family Medicine and Orthopaedics and Sports Medicine Medical Coordinator, U.W. Intercollegiate Athletics University of Washington Sports Medicine Clinic, Seattle MedicalResearch.com: What are the main findings of the study? Dr. O’Kane:  In 11 to 14 year old female elite soccer players the concussion incidence was 13% with a rate of 1.2 per 1000 athletic exposures.   Symptoms lasted a median of 4 days and players with light or noise sensitivity, emotional lability, memory loss, nausea, and concentration problems took significantly longer to recover.  Heading the ball accounted for 30.5% of concussions and the vast majority of concussions (86%) occurred in games.  The majority of players (58.6%) reported playing with symptoms and less than half (44.1%) sought medical attention for their symptoms.  Those seeking medical attention were symptomatic longer and were less likely to play with symptoms.
Annals Internal Medicine, Author Interviews, Cost of Health Care, Health Care Systems, University of Pittsburgh / 22.01.2014

Janel Hanmer, MD, PhD University of Pittsburgh Medical Center Montefiore Hospital Pittsburgh, PA 15213MedicalResearch.com Interview with: Janel Hanmer, MD, PhD University of Pittsburgh Medical Center Montefiore Hospital Pittsburgh, PA 15213 MedicalResearch.com: What are the main findings of the study? Dr. Hanmer: We used the National Inpatient Sample - a sample of about 20% of US community hospitals with all discharges from those hospitals - to examine if insurance status is associated with transfer from one hospital to another. We were looking at patients who were already admitted to the hospital, not the patients who presented to the Emergency Department. We selected the five most common general medicine admissions for adults aged 18 to 64. We found that uninsured patients were less likely to be transferred than privately insured patients in four of the five conditions (about 20-40% less likely). We also found that women were less likely than men to be transferred in five of the conditions (about 35 to 40% less likely).
Author Interviews, Breast Cancer, Psychological Science, Radiation Therapy / 22.01.2014

Guy H. Montgomery, Ph.D. Director, Integrative Behavioral Medicine Program Cancer Prevention and Control Department of Oncological Sciences, Box 1130 Icahn School of Medicine at Mount Sinai New York, NY 10029-6574MedicalResearch.com Interview with: Guy H. Montgomery, Ph.D. Director, Integrative Behavioral Medicine Program Cancer Prevention and Control Department of Oncological Sciences Icahn School of Medicine at Mount Sinai New York, NY 10029-6574 MedicalResearch.com: What are the main findings of the study? Dr. Montgomery: A brief psychological intervention comprised of cognitive behavioral techniques and hypnosis (CBTH) reduced fatigue during, and for up to six months after, radiotherapy in breast cancer patients.
Author Interviews, Genetic Research, Psychological Science / 21.01.2014

Eric Lacourse, Ph.D. Professeur agrégé Département de sociologie Université de Montréal Groupe de Recherche sur l'Inadaptation Psychosociale chez l'enfant (GRIP) Centre de Recherche de l'Hôpîtal Ste-JustineMedicalResearch.com Interview with: Eric Lacourse, Ph.D.  Professeur agrégé Département de sociologie Université de Montréal Groupe de Recherche sur l'Inadaptation Psychosociale chez l'enfant  Centre de Recherche de l'Hôpîtal Ste-Justine MedicalResearch.com: What are the main findings of the study? Dr. Lacourse: The gene-environment analyses revealed that early genetic factors were pervasive in accounting for developmental trends, explaining most of the stability and change in physical aggression, ” Lacourse said. “However, it should be emphasized that these genetic associations do not imply that the early trajectories of physical aggression are set and unchangeable. Genetic factors can always interact with other factors from the environment in the causal chain explaining any behaviour.”
Antioxidants, Author Interviews, Diabetes, Nutrition / 21.01.2014

MedicalResearch.com Interview with: Prof Aedin Cassidy University of East Anglia, Norwich Research Park, Norwich MedicalResearch.com: What are the main findings of the study? Answer: We know fruits and vegetables seem to be particularly important for prevention of  heart disease and diabetes but what constituent may responsible for these benefits is unclear. These foods contain powerful bioactive compounds called flavonoids and in lab and animal experiments we know that flavonoids can reduce inflammation, improve BP, keep our arteries healthy and flexible, improve blood flow and reduce cholesterol levels. Our previous work had shown that a higher level of one class of flavonoids, the anthocyanins, responsible for the brilliant red/blue colours in fruits and other plant foods/products, could reduce the risk of developing type 2 diabetes and of having a heart attack. This study builds on this and now we have evidence in humans that following intake of one portion of berries per day we can see these heart health benefits, and benefits on how we control our insulin and glucose levels.
Aging, Author Interviews / 21.01.2014

Paula A. Rochon MD, MPH, FRCPC Vice President, Research, Women's College Hospital Senior Scientist, Women's College Research Institute Professor, Department of Medicine University of Toronto Toronto, Ontario CanadaMedicalResearch.com Interview with Paula A. Rochon MD, MPH, FRCPC Vice President, Research, Women's College Hospital Senior Scientist, Women's College Research Institute Professor, Department of Medicine University of Toronto, Ontario Canada MedicalResearch.com: What are the main findings of the study? Dr. Rochon: Our main findings are that there are now more than 1800 centenarians in Ontario. Among those over 100 years of age, 60 per cent are 101 years of age or older. In addition, most centenarians are women (85 per cent), and this percentage increases to 90 per cent among those who are 105 years of age and older.
Aging, CMAJ / 21.01.2014

Professor Andrew Steptoe, MA, DPhil, DSc, FMedSci Director, Institute of Epidemiology and Health Care University College London British Heart Foundation Professor of Psychology Department of Epidemiology and Public Health London WC1E 6BTMedicalResearch.com Interview with: Professor Andrew Steptoe, MA, DPhil, DSc, FMedSci Director, Institute of Epidemiology and Health Care University College London British Heart Foundation Professor of Psychology Department of Epidemiology and Public Health London WC1E 6BT MedicalResearch.com: What are the main findings of the study? Dr. Steptoe: We are trying to understand whether positive well-being has beneficial effects as far as health and physical function is concerned.  The main findings are that the risk of developing impairments in activities of daily living (things life being able to bath or shower without help) over the next few years among older people is lower in people who enjoy life more. In addition, enjoyment of life predicted less decrease in walking speed over our 8 year study period in this sample of older men and women. Of course, these associations could be due to many things: the people with greater enjoyment of life could be more affluent, have less physical illness or disability to start with, or have healthier lifestyles at the outset, and these factors could predict the changes in physical function over time. But what we found is that baseline health, economic circumstances, and lifestyle explain only part of the association between enjoyment of life and deterioration in function. So the research suggests that enjoyment of life contributes to healthier and more active old age.
Addiction, Author Interviews, Cannabis / 21.01.2014

David J. Allsop, PhD National Cannabis Prevention and Information Centre, National Drug and Alcohol Research Centre, Faculty of Medicine Now with the School of Psychology, University of Sydney, Sydney, AustraliaMedicalResearch.com Interview with: David J. Allsop, PhD National Cannabis Prevention and Information Centre, National Drug and Alcohol Research Centre, Faculty of Medicine Now with the School of Psychology, University of Sydney, Sydney, Australia MedicalResearch.com: What are the main findings of the study? Dr. Allsop: We found that administering a botanical preparation of the cannabinoids Tetrahydrocannabidiol (THC - the main psychoactive ingredient in cannabis) and Cannabidiol (a lesser known component of the cannabis plant that counteracts the psychotogenic effects of THC with anxiolytic properties) to dependent cannabis smokers during initial abstinence from cannabis substantially dampened their withdrawal experience. In essence this is akin to Nicotine Replacement Therapy (NRT) but for cannabis users. It might seem obvious - sure you give cannabis users a cannabis preparation and they find it easier to quit - but this is important because it has never been done before - and we currently have no consensus evidence based medicines to offer cannabis users who ask for help.
Antioxidants, Author Interviews, Macular Degeneration, Ophthalmology / 20.01.2014

Jie Jin Wang MMed (Clin Epi) MAppStat PhD Professor Australian NHMRC Senior Research Fellow (Level B) Centre for Vision Research Westmead Millennium Institute University of Sydney C24 Westmead Hospital, NSW 2145 AustraliaMedicalResearch.com Interview with: Jie Jin Wang MMed (Clin Epi) MAppStat PhD Professor Australian NHMRC Senior Research Fellow (Level B) Centre for Vision Research Westmead Millennium Institute University of Sydney C24 Westmead Hospital, NSW 2145 Australia MedicalResearch.com: What are the main findings of the study? Answer: We documented a consistent association between high dietary intake of lutein/zeaxanthin (LZ) and a reduced long-term risk of early age-related macular degeneration (AMD) in persons who carry ≥2 risk alleles of either or both the complement factor H (CFH-rs1061170) and/or the age-related maculopathy susceptibility gene 2 (ARMS2-rs10490924) in two older population-based cohorts.
Author Interviews, Critical Care - Intensive Care - ICUs, Infections, Outcomes & Safety / 20.01.2014

Allan J. Walkey, M.D., M.Sc Boston University School of Medicine Pulmonary Center Boston, MassachusettsMedicalResearch.com Interview with: Allan J. Walkey, M.D., M.Sc Boston University School of Medicine Pulmonary Center Boston, Massachusetts MedicalResearch.com: What are the main findings of the study? Dr. Walkey: Thank you for the interest in our study.  Current evidence-based treatments for severe sepsis (ie, infection+systemic inflammatory response+ end organ dysfunction) include specific processes of care rather specific therapeutics.  These processes include early administration of antibiotics, early fluid resuscitation, and lung protective ventilation strategies.  We hypothesized that hospitals with more ‘practice’ at treating patients with severe sepsis may have more effective care processes leading to improved patient outcomes.  We examined more than 15,000 severe sepsis admissions from 124 US academic medical centers. Our findings supported our hypothesis. After adjustment for patient severity of illness and hospital characteristics, mortality in the highest quartile severe sepsis case volume hospitals was 22% and  mortality in lowest severe sepsis case volume hospitals was 29%.  The 7% absolute mortality difference would result in an estimated number needed to treat in high severe sepsis volume hospitals to prevent one death in low case volume hospitals of 14 (though we advise caution in interpretation of a number needed to treat in an observational study). Costs and length of stay were not different across levels of severe sepsis case volume.  Results were robust to multiple subgroup and sensitivity analyses.
Author Interviews, Baylor College of Medicine Houston, JAMA, Outcomes & Safety, Surgical Research / 17.01.2014

MedicalResearch.com Interview with: Daniel A. Anaya, MD, FACS Associate Professor of Surgery - Surgical Oncology Michael E. DeBakey Department of Surgery Baylor College of Medicine Chief, General Surgery & Surgical Oncology SectionDirector, Liver Tumor Program Michael E. DeBakey VA Medical Center Houston, TX 77030 and Dr. Courtney J. Balentine, MD First author and surgical resident at Baylor College of Medicine MedicalResearch.com: What are the main findings of the study? Dr. Anaya:  That a good proportion of patients having colorectal operations will need additional assistance to recover during the postoperative period, resulting in being discharged to other facilities (nursing facilities, skilled care, etc) after surgery, and that hospitals where a higher-volume of colorectal operations are performed are more likely to discharge patients back to home after surgery.
Author Interviews, Breast Cancer, Surgical Research / 17.01.2014

MedicalResearch.com Interview with: Dr. R.A. Badwe, MS Director,  Tata Memorial Centre E. Borges Marg, Parel Mumbai 400 012 MedicalResearch.com: What are the main findings of the study? Answer: The trial was a randomized control study involving 350 women with per primum metastatic breast cancer. These women were divided into two groups from February 2005 to May 2013. One group underwent surgery and radiotherapy (LRT) (n=173) while another group of 177 women were spared these (no LRT). Both groups had undergone six successful rounds of chemotherapy before their recruitment into the trial. Women who underwent surgery had the primary breast tumour and lymph nodes removed, followed by locoregional radiation therapy. The primary endpoint of the study was overall survival (OS). At a median follow-up of 17 months, no difference was observed in OS between the groups; the OS rates were 19.2% and 20.5%, respectively, (HR = 1.04; 95%CI, 0.80-1.34; P = 0.79).  The lack of a survival benefit is due to a trade-off between local control and distant disease progression. The results indicated that women who underwent surgery and had improved locoregional control and significantly worse distant progression-free survival compared with women who did not undergo surgery (HR = 1.41; 95% CI, 1.08-1.85; P = .01). Progression of distant disease was 42% more likely (P = .01) in the LRT arm whereas the risk of local progression was 84% lower with LRT.
Author Interviews, Exercise - Fitness / 17.01.2014

Rebecca Seguin, PhD, CSCS Cornell University, Division of Nutritional Sciences Ithaca NY 14853MedicalResearch.com Interview with: Rebecca Seguin, PhD, CSCS Cornell University, Division of Nutritional Sciences Ithaca NY 14853 MedicalResearch.com: What are the main findings of the study? Answer: The main findings of the study are that regardless of demographic factors and physical activity levels, women who spent the most time engaged in sedentary behaviors had higher risk of death and women who spent the least amount of time engaged in sedentary behaviors.
Author Interviews, Exercise - Fitness / 17.01.2014

MedicalResearch.com Interview with: Maike Neuhaus, MPsych Australian Postgraduate Award PhD Candidate Cancer Prevention Research Centre School of Population Health The University of Queensland Herston, QLD 4006 Australia MedicalResearch.com: What are the main findings of the study? Answer: Substantial epidemiological evidence shows that high volumes of sedentary behaviour – simply put  too much sitting- are linked to detrimental health outcomes such as overweight and obesity, type 2 diabetes, some cancers, and all-cause mortality. Desk-based office workers typically spend around 75% of their work hours sitting at their desks or in meetings. Furthermore, they are unlikely to compensate for these high volumes of sitting time at work with less sedentary activities outside of work. Office workers are thus a high-risk group and an important target for intervention. The Stand Up UQ study examined best-practice approaches to reduce excessive sitting in office workers. Three separate groups of administrative office workers from The University of Queensland in Brisbane, Australia, participated in this study: One group received height-adjustable workstations only; another group received the same height-adjustable workstations plus additional individual (e.g. face-to-face coaching) and organisational strategies (e.g. management consultation, staff information session) to reduce workplace sitting; the third group served as control group and maintained their usual work-practice. Results showed that relative to the control group, the group receiving height-adjustable workstations and additional strategies had a three-fold greater reduction in sitting time than the group receiving height-adjustable workstations only. These findings have important practical and financial implications for workplaces targeting sitting time reductions.
Alcohol, Author Interviews, General Medicine, Karolinski Institute / 17.01.2014

Andrea Bellavia MSc Institute of Environmental Medicine, Karolinska Institutet Stockholm, SwedenMedicalResearch.com Interview with: Andrea Bellavia MSc Institute of Environmental Medicine, Karolinska Institutet Stockholm, Sweden Dr. Montgomery: What are the main findings of the study? Answer: We evaluated for 15 years a cohort of Swedish men and women and observed, after taking into account various socio-demographic, dietary, and lifestyle factors, that a low daily consumption of alcoholic beverages is tied with longer survival.
Allergies, Author Interviews / 17.01.2014

MedicalResearch.com Interview with: Katja M Hakkarainen, M.Sc.Pharm. Doctoral researcher Nordic School of Public Health NHV Guest teacher, Doctoral studentSection for Social Medicine Department of Public Health and Community Medicine, Institute of Medicine Sahlgrenska Academy, University of Gothenburg Gothenburg, SwedenKatja M Hakkarainen, M.Sc.Pharm. Doctoral researcher Nordic School of Public Health NHV Guest teacher, Doctoral studentSection for Social Medicine Department of Public Health and Community Medicine, Institute of Medicine Sahlgrenska Academy, University of Gothenburg Gothenburg, Sweden MedicalResearch.com: What are the main findings of the study? Answer: In total 12% of the adult general public was found to experience harm from medicines, i.e. adverse drug events (ADEs), when we scrutinised the medical and dispensing records of 4970 adults in Sweden during three months, including 29 inpatient care departments in three hospitals, 110 specialised outpatient clinics, and 51 primary care units. Most ADEs were adverse drug reactions (also called side effects) and sub-therapeutic effects. Commonly used drugs caused most ADEs, with a high frequency of adverse drug reactions from antidepressants and cardiovascular drugs as well as sub-therapeutic effects of analgesics and cardiovascular drugs. Of all ADEs, 39% were potentially preventable, because the drug therapy or use was judged suboptimal.
Author Interviews, Brigham & Women's - Harvard, Health Care Systems, JAMA, Medical Research Centers, Outcomes & Safety / 17.01.2014

Elliot Wakeam MD Center for Surgery and Public Health Brigham and Women's Hospital Boston MA 02115MedicalResearch.com Interview with Elliot Wakeam MD Center for Surgery and Public Health Brigham and Women's Hospital Boston MA 02115 MedicalResearch.com: What are the main findings of the study? Dr. Wakeam: Our study examined failure to rescue (FTR), or death after postoperative complications, in safety net hospitals. Prior work has shown that hospital clinical resources can improve rescue rates, however, despite having higher levels of technology and other clinical resources that should lead to better rates of patient rescue, safety net hospitals still had greater rates of death after major complications.
Author Interviews, Pediatrics / 17.01.2014

Dr. Daniel S. Budnitz MD MPH CAPT, USPHS Division of Healthcare Quality Promotion Director of the Centers for Disease Control and Prevention’s Medication Safety Program Atlanta, GeorgiaMedicalResearch.com Interview with: Dr. Daniel S.  Budnitz MD MPH CAPT, USPHS Division of Healthcare Quality Promotion Director of the Centers for Disease Control and Prevention’s Medication Safety Program Atlanta, Georgia MedicalResearch.com: What are the main findings of the study? Dr. Budnitz: To reduce dosing errors when administering orally ingested over-the-counter (OTC) liquid medications, especially among children, the US Food and Drug Administration (FDA) released and the Consumer Healthcare Products Association (CHPA) released recommendations for how to display dosing directions and markings on dosing devices. This study assessed recommendation adherence for national brand name orally ingested OTC liquid pediatric analgesics/antipyretics and cough, cold, and allergy products available after the FDA guidance was finalized in 2011.  To identify and prioritize specific areas for improvement, recommendations were categorized as ‘top tier’ (potential to address ≥3-fold errors) or ‘low tier’ (intended to improve clarity and consistency). Of 68 products, 91% of dosing directions and 62% of dosing devices adhered to all top tier recommendations; 57% of products adhered to every top tier recommendation, and 93% adhered to all or all but one. A dosing device was included with all products (e.g., oral syringe, dosing cup). No dosing directions used atypical volumetric units (e.g., drams), and no devices used volumetric units that did not appear in dosing directions. Six products used trailing zeros or failed to use leading zeros with decimal doses; eight did not use small font for fractions.  Appropriate use of zeros and decimals is important to avoid 10-fold overdoses; using small font for fractions (½ vs. 1/2) helps avoid potential  4-fold errors if 1/2 interpreted as 1 or 2.  Product adherence to low tier recommendations ranged from 26% to 91%.
Alcohol / 16.01.2014

MedicalResearch.com Interview with: Séverine Sabia, PhD Epidemiology & Public Health, Div of Population Health University College London - Gower Street - London MedicalResearch.com: What are the main findings of the study? Dr. Sabia: The present study shows a detrimental effect of heavy alcohol consumption on cognitive ageing, and the effects are seen as early as 55 years old.
Author Interviews, BMJ, OBGYNE, Pediatrics / 16.01.2014

Sophie Grigoriadis, MD, MA, PhD, FRCPC Head, Women's Mood and Anxiety Clinic: Reproductive Transitions, Fellowship Director, Sunnybrook Health Sciences Centre, Scientist, Sunnybrook Research Institute Adjunct Scientist, Women's College Research Institute, Associate Professor, Faculty of Medicine, University of TorontoMedicalResearch.com Interview with: Sophie Grigoriadis, MD, MA, PhD, FRCPC Head, Women's Mood and Anxiety Clinic:  Reproductive Transitions, Fellowship Director, Sunnybrook Health Sciences Centre, Scientist, Sunnybrook Research Institute Adjunct Scientist, Women's College Research Institute, Associate Professor, Faculty of Medicine, University of Toronto MedicalResearch.com: What are the main findings of the study? Dr. Grigoriadis: Infants of women exposed to selective serotonin reuptake inhibitors (SSRIs) during late pregnancy (but not early) are at risk for developing persistent pulmonary hypertension of the newborn (PPHN). PPHN is a condition in which blood pressure remains high in the lungs following birth and which results in breathing difficulties.  The symptoms can range from mild to severe, but the condition can be managed successfully typically after SSRI exposure. It is important to note that the baseline risk for PPHN in the general population is low (about 2 per 1,000 live births), and so the increase in risk with SSRIs still represents a low overall risk for developing PPHN following SSRI exposure in late pregnancy (increasing to approximately 5 per 1,000 live births). This increased risk means that 286 to 351 women would have to be treated with an SSRI during late pregnancy in order to result in 1 additional case of PPHN.
Author Interviews, BMJ, Outcomes & Safety / 16.01.2014

Sunita Vohra MD MSc FRCPC FCAHS Director, CARE Program Director, PedCAM Network, AIHS Health Scholar Professor, Dept of Pediatrics Faculty of Medicine & Dentistry University of Alberta Edmonton Continuing Care Centre, Edmonton, Alberta CanadaMedicalResearch.com Interview with: Sunita Vohra MD MSc FRCPC FCAHS Director, CARE Program Director, PedCAM Network, AIHS Health Scholar Professor, Dept of Pediatrics Faculty of Medicine & Dentistry University of Alberta Edmonton Continuing Care Centre, Edmonton, Alberta Canada MedicalResearch.com: What are the main findings of the study? Dr. Vohra: Our main findings were: (i) relative to how often systematic reviews evaluate the effectiveness of health interventions, the systematic review of harms is quite neglected; and (ii) even when systematic reviews do aim to evaluate harms, there is considerable room for improvement in reporting.
Alcohol, Author Interviews / 16.01.2014

Professor Karen Hughes Professor in Behavioural Epidemiology Centre for Public Health Liverpool John Moores University Liverpool L3 2ETMedicalResearch.com Interview with: Professor Karen Hughes Professor in Behavioural Epidemiology Centre for Public Health Liverpool John Moores University Liverpool L3 2ET MedicalResearch.com: What are the main findings of the study? Answer: We used trained actors to test whether servers in pubs, bars and nightclubs would sell alcohol to people showing signs of extreme intoxication, despite this being illegal in the UK. In over four fifths (83.6%) of purchase attempts, bar servers sold alcohol to the pseudo-drunk actors – even though many clearly identified the actors as being drunk. We also collected data on bar environments, looking specifically at ten factors that have been associated with alcohol-related harm in previous studies: low levels of seating, loud noise, crowding, poor lighting, dirtiness, cheap drink promotions, young bar staff, young customers, rowdiness, and customer drunkenness. We found that the more of these characteristics bars had, the more likely they were to sell alcohol to drunks, with 100% of bars with 8 or more of these characteristics serving the pseudo-drunk actors. However, even in bars with none of these characteristics, two thirds of purchase attempts resulted in an alcohol sale. Having security staff managing entrance to the premises was also associated with alcohol service; possibly suggesting that bar servers in premises with door staff believe responsibility for vetting customers lies with such staff.
General Medicine / 16.01.2014

MedicalResearch.com Interview with: Weiya Zhang, BPH, MEpi, PhD Associate Professor & Reader Division of Rheumatology, Orthopaedics and Dermatology The University of Nottingham Clinical Sciences Building City Hospital Nottingham NG5 1PB MedicalResearch.com: What are the main findings of the study? Dr. Zhang: We found the prevalence and incidence of gout keep rising from 1997 to 2012, but the management (percentage of patients treated with the recommended effective drugs) remains poor.
Allergies, Asthma, Author Interviews, Lancet / 15.01.2014

Mariona Pinart, PhD CREAL-Centre for Research in Environmental Epidemiology ISGlobal alliance Parc de Recerca Biomèdica de Barcelona Doctor Aiguader, 88 | 08003 BarcelonaMedicalResearch.com Interveiw with: Mariona Pinart, PhD CREAL-Centre for Research in Environmental Epidemiology ISGlobal alliance Doctor Aiguader, 88 | 08003 Barcelona MedicalResearch.com: What are the main findings of the study? Answer: The study examined 23.434 children at 4 and 8 years from 12 ongoing European population-based birth cohort studies that recorded information on current eczema, rhinitis, and asthma from questionnaires and serum-specific IgE to six allergens. We wanted to assess how often eczema, rhinitis and asthma coexist in the same children (comorbidity) and whether the occurrence of comorbidities was due to causality or casualty and finally we wanted to examine whether the occurrence of comorbidity was modified by IgE sensitization. We found that comorbidity affects about 4% of children aged 4–8 years and that about 50% of this comorbidity is due to causality, suggesting that these diseases share common pathophysiological mechanisms. In addition, we found that children comorbidity at age 4 are 30 to 60 times more likely to have comorbidity at age 8 years, suggesting that the presence of comorbidity at age 4 years is a strong determinant of comorbidity at age 8 years. Even children with one single disease are also at high risk of developing comorbidity by age 8 years. Interestingly, we found that not only comorbidity is present in children both sensitized and not sensitized to IgE but also that only 38% of incident comorbidity at age 8 years is explained by the presence of IgE sensitization at age 4 years.