Some Emergency Departments See Drop in Heroin Overdoses
Monitoring overdose fatalities is difficult as a result of time lags in reporting...
Monitoring overdose fatalities is difficult as a result of time lags in reporting...
Recent-onset symptomatic atrial fibrillation usually terminates spontaneously and therefore an acute cardioversion is not always necessary, as a wait-and-see approach...
MedicalResearch.com Interview with:Daniel J. Lane PhD
Institute of Health Policy, Management and Evaluation
Dalla Lana School of Public Health, University of Toronto
Rescu, Li Ka Shing Knowledge Institute, St Michael’s Hospital
Toronto, Ontario, Canada
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Early resuscitation and early antibiotics have become the mainstay treatment for patients with sepsis. The time to initiation of these treatments is thought to be an important factor in patients surviving their disease; however, the independent benefits or harms of intravenous fluid resuscitation, in particular a more aggressive versus more conservative approach to this therapy, remains difficult to evaluate given the concurrent use of these therapies in hospital.
To gain a better understanding of this treatment independent of antibiotic use, we assessed intravenous fluid resuscitation by paramedics on the in-hospital mortality of patients with sepsis. By accounting for the interaction between initial systolic blood pressure and the treatment, we found that earlier resuscitation by paramedics was associated with decreased mortality in patients with low initial blood pressures but not associated with mortality for patients with normal or higher initial blood pressures.