Author Interviews, Diabetes, Heart Disease / 13.01.2017
Even with Cardiac Risk Factors, Non-CV Deaths More Common In Patients With Impaired Fasting Glucose
MedicalResearch.com Interview with:
Dr. Abhinav Sharma MD
Duke Clinical Research Institute, Duke University, Durham, NC
Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
Renato D. Lopes, MD, PhD, MHS
Duke Clinical Research Institute
Durham, NC
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Impaired fasting glucose (IFG) has been demonstrated to be a risk factor for cardiovascular death; however, there is growing research suggesting that IFG also increases the risk of non-cardiovascular deaths such as cancer.
The data on the distribution of causes of death among patients with impaired fasting glucose and cardiovascular risk factors have not been described. Our analysis used data from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial. We identified that while myocardial death is the most common adjudicated cause of death, overall, non-cardiovascular deaths were more common that cardiovascular deaths.
Among non-cardiovascular, cancer deaths were the most common cause of death. Furthermore, the burden of non-cardiovascular deaths increases relative to cardiovascular death over time.
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