Author Interviews, JAMA, Pediatrics, Weight Research / 28.07.2022

MedicalResearch.com Interview with: Amanda Staiano, PhD Associate Professor Director, Pediatric Obesity and Health Behavior Laboratory Pennington Biomedical Research Center Baton Rouge, LA MedicalResearch.com:  What are the main findings? Response: The U.S. government funds the National Health and Nutrition Examination Survey (NHANES), which is an ongoing surveillance study on the health and nutritional status of people living in the U.S. What is special about NHANES is it’s designed to be nationally representative and it uses objective measurements, so we’re more confident that this accurately reflects the health of the country. For this paper, we looked at the most recently released data to see how many children in the U.S. have obesity, meaning they’re above the 95th percentile for height and weight based on their age and sex. We extracted data from 2011 to 2020, which includes nearly 15,000 children and adolescents and is the most recently available data prior to the March 2020 COVID-19 shutdown when NHANES paused. (more…)
Author Interviews, Breast Cancer, JACC, Weight Research / 18.05.2022

MedicalResearch.com Interview with: Dr. Amy Kirkham, PhD Assistant Professor of Clinical Cardiovascular Health Faculty of Kinesiology & Physical Education University of Toronto Affiliate Scientist at Toronto Rehabilitation Institute MedicalResearch.com:  What is the background for this study?  Response: Women who have had a breast cancer diagnosis are at least two-fold and often higher risk of cardiovascular or heart disease compared to women without a history of breast cancer. Older age, higher body mass index, and receipt of chemotherapy treatment that can injure the heart are risk factors for cardiovascular death after a breast cancer diagnosis. Time-restricted eating is a type of intermittent fasting that appears to be easy to follow and to improve some measures of metabolic health but has not been studied in populations with a cancer history. Time-restricted eating simply involves consuming all calorie intake within a specific time window, commonly 8 hours, like between 12 and 8 pm, and then only consuming water or black coffee outside of those hours. We enrolled breast cancer survivors who were aged 60 or older, had an overweight or obese mass index, and were finished chemotherapy treatment in a single-arm trial of time-restricted eating for 8 weeks. We asked participants to restrict their calorie intake between 12 and 8 pm from Monday to Friday with no restrictions on weekend and no further instructions on what to eat. (more…)
Author Interviews, Cleveland Clinic, Diabetes, JACC, Surgical Research, Weight Research / 14.04.2022

MedicalResearch.com Interview with: Amgad Mentias, MD MS FACC FESC Assistant Professor, CCLCM Section of Clinical Cardiology, Heart and Vascular Institute. Cleveland, OH 44195Amgad Mentias, MD MS FACC FESC Assistant Professor, CCLCM Section of Clinical Cardiology, Heart and Vascular Institute. Cleveland, OH 44195  MedicalResearch.com:  What is the background for this study?    Response:  There is evidence that bariatric or weight loss surgery can decrease the risk of heart attack, stroke, and death in young and middle age patients with obesity and diabetes. However, the evidence is less clear for older patients and patients without diabetes. There is also no long-term data on outcomes of bariatric surgery in the Medicare beneficiaries. So, in our study, we aimed to report long-term outcomes of bariatric surgery from a contemporary nationwide cohort from the US, while also looking into outcomes in patients older than 65 years, and patients without type 2 diabetes specifically. (more…)
Author Interviews, Nature, Weight Research / 07.04.2022

MedicalResearch.com Interview with: Lee Roberts PhD Professor and Chair of Molecular Physiology and Metabolism Department of Discovery and Translational Science Leeds Institute of Cardiovascular & Metabolic Medicine School of Medicine University of Leeds MedicalResearch.com:  What is the background for this study?  What are the main findings?  Response: Obesity rates have nearly tripled worldwide since 1975. In 2016, there were more than 650 million adults aged 18 and above with obesity. Obesity can lead to increased fat in the blood which damages tissues and organs, contributing to the development of cardiovascular and metabolic diseases including type 2 diabetes. This elevated blood fat can damage the cellular organelle responsible for making protein, the endoplasmic reticulum, causing the cell to come under stress and potentially resulting in the cell dying. When this occurs in skeletal muscle it can contribute to features of the metabolic syndrome including metabolic dysfunction and insulin resistance. (more…)
Author Interviews, JAMA, Mental Health Research, USPSTF, Weight Research / 23.03.2022

MedicalResearch.com Interview with: Lori Pbert, Ph.D Professor, Department of Population and Quantitative Health Sciences Associate chief of the Division of Preventive and Behavioral Medicine Founder and Director of the Center for Tobacco Treatment Research and Training University of Massachusetts Medical School Dr. Pbert joined the U.S. Preventive Services Task Force in January 2019 MedicalResearch.com:  What is the background for this study?  Response: This is the first time that the Task Force has looked at the evidence around screening for eating disorders. It was important to address this topic because of the serious harm that these conditions can cause to people’s physical and mental health, and the tremendous toll eating disorders have on individuals and families. MedicalResearch.com:  What are the main findings? Response: After reviewing the limited available research, we determined there is not enough evidence to recommend for or against screening teens and adults for eating disorders in adolescents and adults who do not have signs or symptoms of an eating disorder or concerns about their eating. It’s important to note that this recommendation is not for people who are showing signs or symptoms of eating disorders, like rapid weight loss or gain, slow heart rate, delayed puberty, or a disruption of menstruation, or for those expressing concern about their eating. (more…)
Author Interviews, Endocrinology, Nutrition, Testosterone, Weight Research / 11.03.2022

MedicalResearch.com Interview with: Joe Whittaker, MSc Nutritionist MedicalResearch.com:  What is the background for this study?  Response: There are several studies showing a generational decline in men's testosterone levels, beginning in the 1970s. This is due to a variety of factors such as poorer diets, lack of physical activity, and increasing toxin exposure. Therefore, there is intense research interest in ways we can optimise testosterone levels, to combat this generational decline. Some well-known studies have found low-carbohydrate diets boost testosterone levels, but others have show the reverse effect. So, to settle the controversy we gathered and reanalysed all known studies on the topic. There was also the question of high protein diets and their effects on testosterone, which are currently disputed. (more…)
Author Interviews, Brigham & Women's - Harvard, Circadian Rhythm, Diabetes, Occupational Health, Science, Weight Research / 06.12.2021

MedicalResearch.com Interview with: Sarah L. Chellappa, MD PhD Medical Chronobiology Program Division of Sleep and Circadian Disorders Departments of Medicine and Neurology Brigham and Women’s Hospital Division of Sleep Medicine, Harvard Medical School Boston, MA Department of Nuclear Medicine Faculty of Medicine and University Hospital Cologne University of Cologne, Cologne, Germany. Frank A.J.L. Scheer, M.Sc., Ph.D. Professor of Medicine. Medical Chronobiology Program Division of Sleep and Circadian Disorders Departments of Medicine and Neurology Brigham and Women’s Hospital Division of Sleep Medicine, Harvard Medical School Boston, MA MedicalResearch.com: What is the background for this study? Would you explain the difference between the central circadian ‘clock’ and endogenous circadian glucose rhythms?  Response: Night work increases diabetes risk. This increased risk is not fully explained by differences in lifestyle, family history, and/or socioeconomic status, thus other mechanisms are likely involved. Laboratory studies in humans have shown glucose intolerance in both non-shift workers and shift workers exposed to simulated night work. Animal experimental data suggests that this may be in part due to a misalignment between central and peripheral rhythms. Central circadian rhythms (e.g., body temperature) are primarily modulated by the central circadian “clock”, which is located in the brain’s suprachiasmatic nucleus and is responsible for synchronizing our physiology and behavior with the 24-hour cycle. Peripheral rhythms, including endogenous circadian glucose rhythms, are likely modulated by peripheral “clocks” across the body that play an integral role in modulating the circadian expression of physiology, including metabolic functions. These central and peripheral clocks share a common molecular mechanism underlying their circadian rhythm generating capacity, including transcription-translation feedback loops of circadian “clock” genes.  (more…)
Author Interviews, JAMA, Johns Hopkins, Weight Research / 25.11.2021

MedicalResearch.com Interview with: Alejandra Ellison-Barnes, MD MPH General Internal Medicine Johns Hopkins Medicine MedicalResearch.com: What is the background for this study? What are the main findings?  Response: Emerging adulthood is a unique period of development that ultimately leads to the formation of adult identity, but how this stage contributes to obesity is relatively understudied. The prevalence of obesity has been increasing in the United States population as a whole, and we wanted to know how mean body mass index and the prevalence of obesity have changed over the past several decades specifically among emerging adults. We found that among emerging adults aged 18 through 25, mean BMI has increased from 23.1 kg/m2 in 1976-1980 to 27.7 kg/m2 in 2017-2018. In the same period, the prevalence of obesity increased from 6.2% to 32.7%. (more…)
Author Interviews, Weight Research / 07.11.2021

MedicalResearch.com Interview with: Neha Agrawal PhD Department of Physiology Development and Neuroscience University of Cambridge MedicalResearch.com: What is the background for this study? Response: Obesity levels are rising rapidly around the world and are a major risk factor for diseases such as Type 2 diabetes, cancers and recently, COVID-19. New strategies to understand obesity are thus needed to prevent and treat obesity and associated disease. Genetic studies in humans have shown that 40-70% of variation in body weight depends on our genes. Therefore, identifying genes linked to obesity and understanding their function can be a useful way to both understand how we gain weight and identify potential targets for weight loss therapy. However, human genetic obesity studies face significant limitations in identifying causal obesity genes and understanding their relationship to weight gain in human patients. The model system Drosophila melanogaster (Fruit flies) has provided vital insights into fundamental biology and human diseases for over a century. It is a powerful genetic model with well conserved metabolic pathways. Fruit flies also gain weight when fed a high-sugar or high-fat diet and develop heart disease and diabetes. We therefore decided to use fruit flies to identify novel obesity genes and their site of action in the body. (more…)
Author Interviews, JAMA, Race/Ethnic Diversity, Surgical Research, Weight Research / 18.10.2021

MedicalResearch.com Interview with: Amresh D. Hanchate, PhD Professor, Department of Social Sciences and Health Policy Director, Program in Health Services Research Division of Public Health Sciences Wake Forest School of Medicine Medical Center Boulevard Winston-Salem, NC  27157-1063 MedicalResearch.com: What is the background for this study? Response: There is strong evidence of increase in access to outpatient physicians among low income individuals who gained Medicaid following changes initiated with the Affordable Care Act. But there is little evidence of whether Medicaid expansion has similarly resulted in increased use of elective inpatient procedures. Bariatric surgery is a particularly important service to study, as the number of adults with severe obesity continues to grow in the United States, and this is the most effective available treatment. Additionally, bariatric procedures are primarily performed among the age group targeted by Affordable Care Act expansions (18-64), and there is a lot of evidence that only a small fraction of eligible uninsured patients are having surgery.  (more…)
Author Interviews, Brigham & Women's - Harvard, JAMA, OBGYNE, Pediatrics, Weight Research / 28.08.2021

MedicalResearch.com Interview with: Emily Oken MD MPH Professor, Harvard Medical School Professor in the Department of Population Medicine Associate Director and Advisor, Oliver Wendell Holmes Society. Professor, Department of Nutrition, Harvard School of Public Health MedicalResearch.com: What is the background for this study? What are the main findings? Response: In this study of over 11,000 mothers and children, we found that a mothers with higher weight in late pregnancy had children with poorer performance on tests of cognition and behavior in childhood and adolescence. The findings are consistent with results from studies in other populations around the world, as well as animal experiments.  This research suggests that maternal nutrition is important for child health over the long-term, and specifically provides support for mothers to try to achieve healthy weight and nutritional status during pregnancy. (more…)
Author Interviews, COVID -19 Coronavirus, Occupational Health, Weight Research / 01.08.2021

MedicalResearch.com Interview with: https://www.newtopia.com/Jeff Ruby, JD, MBA, Founder and Chief Executive Officer Leonard Fensterheim, MPH Vice President of Analytics MedicalResearch.com: What is the background for this study? What are common weight-change findings during the pandemic?  Obesity has been linked to increased risk of serious complications and the need for costly medical utilization – all of which has been exacerbated by the COVID-19 pandemic. There has been an increase of imposed restrictions that impact healthy lifestyles – the closing of gyms as an example – leading to additional stress and the complete disruption of daily lives. It’s no surprise that many people have gained weight since the beginning of the pandemic. According to the Centers for Disease Control and Prevention (CDC), before the pandemic, about 40% of Americans had obesity in the United States. This was already an alarming figure, but given that the American Psychological Association found that 42% of U.S. adults report undesired weight gain, with an average gain of 29 lbs. since the start of the pandemic, we expect that percentage has continued to grow. Against this backdrop, Newtopia sought to evaluate the impact of a guided habit change program on weight loss for 12 months during the COVID-19 pandemic. Method:
  • This was a retrospective study that looked at 1436 participants who began participating in the Newtopia experience in early 2020.
  • This analysis focused on weight change and was restricted to those participants with a body mass index >
  • 52% of participants were female, and the average age of the total study population was 46.5 years old (±10.6).
  • The percentage of participants with a 4.3% weight reduction after 12 months was assessed. This has been shown to be associated with meaningful reduction in healthcare costs.
  • The average weight loss and the percentage BMI decrease was also assessed.
  Outcomes:
  • 77% of participants lost weight.
  • 44% of participants had a weight loss of >3%.
  • Average weight loss was 4.2% (p<.0001).
  • 22% of obese participants dropped a BMI category.
Despite the challenges of the Covid-19 pandemic, individuals participating in the Newtopia habit change experience still achieved impactful weight loss. (more…)
Author Interviews, Brigham & Women's - Harvard, Chocolate, Weight Research / 24.06.2021

MedicalResearch.com Interview with: Frank A. J. L. Scheer, PhD, MSc, Neuroscientist and Marta Garaulet, PhD, Visiting Scientist Division of Sleep and Circadian Disorders Departments of Medicine and Neurology, Brigham and Women's Hospital. MedicalResearch.com: What is the background for this study? Response: We and others have shown that not only “what” but also “when” we eat relates to obesity and weight loss
  • Meal timing can influence circadian rhythms and eating a high energy and high sugar food, such as chocolate, either at night or in the morning may have a different effect on the circadian system, and consequently on body weight and metabolism.
  • Milk chocolate has a name for contributing to weight gain due to its high fat, sugar and caloric content. Chocolate eating habit has been associated with long-term weight gain especially in postmenopausal females who are particularly vulnerable to weight gain.
(more…)
Author Interviews, Brigham & Women's - Harvard, Primary Care, Surgical Research, Weight Research / 10.06.2021

MedicalResearch.com Interview with: Alexander Turchin, MD, MS Director of Informatics Research Division of Endocrinology, Diabetes and Hypertension Associate Professor of Medicine, Harvard Medical School Brigham and Women's Hospital MedicalResearch.com: What is the background for this study? Response: There is an epidemic of obesity in the U.S.: over 40% of adults are obese. Obesity causes numerous complications, ranging from heart attacks to cancer. Bariatric surgery is one of the most effective ways to treat obesity, but very few patients utilize it; it is unclear why.  (more…)
Author Interviews, JAMA, OBGYNE, USPSTF, Weight Research / 03.06.2021

MedicalResearch.com Interview with: Chien-Wen Tseng, M.D., M.P.H., M.S.E.E. The Hawaii Medical Service Association Endowed Chair Health Services and Quality Research Professor, and Associate Research Director Department of Family Medicine and Community Health University of Hawaii John A. Burns School of Medicine MedicalResearch.com: What is the background for this study? What are the main findings? Response: Gaining weight during pregnancy is natural but gaining too little or too much weight can be harmful for pregnant people and their babies. For the first time, the Task Force reviewed the evidence and found that counseling pregnant people on healthy weight gain during pregnancy can lower their risk for diabetes during pregnancy, emergency cesarean deliveries, and babies born with a birth weight that is too high. Pregnant people may not know what amount of weight gain is healthy during pregnancy, or how weight gain can affect their pregnancy and baby. We recommend that clinicians offer all pregnant people counseling on healthy weight gain throughout their pregnancy for healthier, safer pregnancies. (more…)
Author Interviews, Diabetes, Gastrointestinal Disease, Weight Research / 16.05.2021

MedicalResearch.com Interview with: Anna Carolina Hoff, MD Lead researcher on the study Founder and Clinical Director Angioskope Brazil São José dos Campos  MedicalResearch.com: What is the background for this study? Response: Obesity is a chronic disease that has become a global pandemic, and its prevalence continues to increase. Overweight (Body Mass Index (BMI) ≥ 27 kg/m2) and obesity (BMI ≥ 30kg/m2) lead to numerous clinical comorbidities, including metabolic, cardiovascular, oncologic, and mental health disorders. It is challenging to achieve significant and sustained weight loss with diet and lifestyle modification alone. Additionally, a reversal of obesity-related co-morbidities and improvement in quality of life entails a percent total body weight loss (%TBWL) of between 5-10%, which is rarely achieved with medications alone. The Endoscopic Sleeve Gastroplasty (ESG) results in a %TBWL between 14.6%-19.7% at 18-24 months,  and improvements in systolic blood pressure (SBP), HbA1c, and dyslipidemia at 12 months. (more…)
Author Interviews, Gastrointestinal Disease, Imperial College, Probiotics, Pulmonary Disease, Weight Research / 16.05.2021

MedicalResearch.com Interview with: Benjamin Mullish PhD NIHR Academic Clinical Lecturer Department of Metabolism Digestion and Reproduction Imperial College MedicalResearch.com: What is the background for this study? Which probiotic did you use and why?  Response: We recently reported the results of a randomized, double-blind placebo-controlled trial in which participants who were overweight or with obesity (aged between 30-65 years of age) were randomized to receive probiotics or placebo for six months.  The primary focus was on weight loss and metabolism.  The probiotic used was Lab4P, containing three different strains of Bifidobacteria and two of Lactobacilli, which have shown to be safe and efficacious for use in rodent models and earlier clinical studies. Of note, probiotics have also been shown to have other beneficial effects upon human health.  Previous studies have suggested that they may have a role in preventing upper respiratory tract infections (URTIs) in healthy people and children; however, this has not been explored in older people or overweight/ people with obesity, even though such groups have higher rates of URTIs. We looked back at our trial, and reviewed symptom diaries completed by participants daily during the study.  We were looking at recorded symptoms most consistent with upper respiratory tract symptoms (including cough, wheezing and headache), and explored if rates of these were different between those participants taking probiotics compared to placebo over the six month course of the study.   (more…)
Author Interviews, Exercise - Fitness, Weight Research / 10.04.2021

MedicalResearch.com Interview with: Prof. Dr. Karsten Koehler Department of Sport and Health Sciences Technical University of Munich MedicalResearch.com: What is the background for this study? Response: The primary background is the phenomenon that most people fail to loose (meaningful) weight through exercise alone, which is related to what we call compensatory eating – an increase in food intake to compensate for the increased energy expenditure of exercise. This is been described in a number of studies and is considered a key weight loss barrier – yet few have come up with solutions to overcome this problem. Therefore, we wanted to see if the timing of food choices has an impact on how much and what we want to eat in the context of exercise. (more…)
Author Interviews, Brigham & Women's - Harvard, Endocrinology, Insomnia, Menopause, Sleep Disorders, Weight Research / 23.03.2021

MedicalResearch.com Interview with: Leilah K. Grant, PhD Postdoctoral Research Fellow in Medicine Brigham and Women’s Hospital Harvard Medical School  MedicalResearch.com: What is the background for this study? Response: The prevalence of obesity increases in women around the age of menopause which increases the risk of diseases like diabetes and heart disease. Changes in hormones, like estrogen, are thought to contribute to weight gain during menopause, but other common symptoms of menopause such as sleep interruption may also play a role. While short sleep is known to adversely affect metabolism, little is known about the metabolic consequences of the type of sleep disruption most common in menopausal women – increased nighttime awakenings (i.e., sleep interruption) caused by hot flashes, but no change in overall sleep duration. We therefore did this study to see how an experimental model menopause-related sleep interruption would affect metabolic outcomes that may contribute to weight gain.  (more…)
Author Interviews, Environmental Risks, Pediatrics, Toxin Research, Weight Research / 08.03.2021

MedicalResearch.com Interview with: Alison P. Sanders, PhD Pronouns:  She/Her Assistant Professor Icahn School of Medicine at Mount Sinai Department of Environmental Medicine and Public Health Department of Pediatrics Director, Interdisciplinary Environmental Health Postdoctoral Fellowship MedicalResearch.com: What is the background for this study? Response: My research group is dedicated to understanding environmental and early life risk factors that contribute to kidney function decline. While some of the pathobiology leading to chronic kidney disease remains unclear, we understand that the process is complex and, like many chronic diseases, begins long before clinical diagnosis. My research investigates how the environment and mixtures of environmental chemicals/toxicants interact with traditional risk factors such as obesity, preterm birth, and nutritional status to hasten or prevent chronic kidney disease. (more…)
Author Interviews, Heart Disease, MD Anderson, Menopause, University of Pittsburgh, Weight Research / 04.03.2021

MedicalResearch.com Interview with: Samar El Khoudary, PhD, MPH, BPharm, FAHA Associate Professor of Epidemiology University of Pittsburgh Graduate School of Public Health MedicalResearch.com: What is the background for this study? Response: Research increasingly shows that it isn’t so important how much fat a woman is carrying, which doctors typically measure using weight and BMI, as it is where she is carrying that fat. To investigate this, we looked at 25 years of data on 362 women from Pittsburgh and Chicago who participated in the Study of Women’s Health Across the Nation (SWAN) Heart study. The women, who were an average age of 51, had their visceral adipose tissue—fat surrounding the abdominal organs—measured by CT scan and the thickness of the internal carotid artery lining in their neck measured by ultrasound, at a few points during the study. Carotid artery thickness is an early indicator of heart disease. (more…)
Author Interviews, Diabetes, Sugar, Weight Research / 24.02.2021

MedicalResearch.com Interview with: Eric Crosbie, PhD, MA Assistant Professor School of Community Health Sciences Ozmen Institute for Global Studies University of Nevada Reno MedicalResearch.com: What is the background for this study? Response: My colleague Dr. Laura Schmidt and I established a framework for studying preemption (when a higher level of government limits the authority of lower levels to enact laws) by studying the history of state preemption of local tobacco control policies in the U.S., which we published last year (2020) in AJPH. We noticed the same strategies that the tobacco industry employed were now being used by the beverage industry to suppress local taxation policies on sugar sweetened beverages (e.g. soda, coffee drinks, energy drinks, etc). We used this preemption framework to publish a new study this year in AJPH that analyzed state preemption of local sugar sweetened beverage taxes in the U.S.  (more…)
Author Interviews, Race/Ethnic Diversity, Weight Research / 26.01.2021

MedicalResearch.com Interview with: Raveena Chara Loma Linda University Loma Linda, CA MedicalResearch.com: What is the background for this study? latin food fried food obesityResponse: In a country struggling with an epidemic of obesity, Hispanics are one of the fastest growing population groups in the U.S. and have the highest prevalence of obesity. They are also least likely to enroll in weight reduction programs, complete them, and successfully lose weight (though reasons for this remain elusive). Obesity- a leading predisposing factor for many chronic diseases - is a complex biophysical phenomenon shaped by many factors, including a person’s social environment, health and culture. Culture permeates many aspects of one’s life including how a person views weight and behaviors associated with eating and physical activity. Indeed, for many values and norms about what is culturally acceptable and views on “body weight” vary culturally and affect their decisions about weight and weight loss. This too is the case within the Hispanic population in the US. Given the rising human and financial impact of obesity, preventing and reducing obesity, diabetes and other weight related medical conditions is a growing priority, especially for low income Hispanics.  (more…)
Author Interviews, Diabetes, JAMA, Weight Research / 14.01.2021

MedicalResearch.com Interview with: Dr. Steven Heymsfield, MD Professor, Pennington Biomedical Research Center Baton Rouge, LA MedicalResearch.com: What is the background for this study? Response: Bimagurmab is a monoclonal antibody that blocks the activin type 2 receptor. This receptor is found mainly on skeletal muscles and when blocked acts to stimulate muscle growth. Bimagrumab was developed as a potential treatment for skeletal muscle disorders. However, the first-in-man studies revealed an unexpected response to the drug: not only did skeletal muscle mass increase, but marked lowering in body fat and improved insulin sensitivity were observed. The current study was launched to follow up on these initial observations.  (more…)
Author Interviews, Microbiome, Nature, Weight Research / 21.12.2020

MedicalResearch.com Interview with: Harriët Schellekens MSc PhD Lecturer Department of Anatomy & Neuroscience, and APC Microbiome Ireland SFI Research Centre University College Cork, Cork, IRELAND.  MedicalResearch.com: What is the background for this study? Response: There has been an increased emphasis on gut microbiota-targeted therapeutics for the amelioration of obesity. Recent studies have identified several probiotic strains with different anti-obesity effects, including members of the genus Bifidobacterium, but the exact mechanisms of action are still lacking. Moreover, positive effects in animal studies often do not translate in human studies. The APC Microbiome Ireland has set up a “culture-to-product” platform, a well catalogued and quality controlled collection of bacteria with potential biofunctional activities. In my laboratory, I have developed a state-of the art “bug-to-drug” screening approach, using high-throughput biochemical and cellular assays, to fully characterize bacteria and identify the most promising bacterial strains with specific desirable probiotic and functional properties. This careful in vitro screening of APC’s strains (or customer strains) is designed to identify the most potent candidates that can impact on host physiology and overall gut-brain axis function, e.g. by producing microbial metabolites or neuroactives, altering gut-barrier function, reducing inflammation, or modifying G-protein coupled receptors. This comprehensive screening approach facilitates the precise selection and prediction of the best strains that are likely to yield a specific positive health effects in subsequent animal and human studies, based on their in vitro probiotic and functional properties.  (more…)
Author Interviews, Weight Research / 18.12.2020

MedicalResearch.com Interview with: Dr. Louis Aronne, MD, FACP Chief Medical Officer, Intellihealth Medical Director, Comprehensive Weight Control Center Weill Cornell Medicine MedicalResearch.com: What is the background for the study “Effect of an Online Weight Management Program Integrated With Population Health Management on Weight Change: A Randomized Clinical Trial”? Response: More than 70% of U.S. adults have overweight or obesity. Online programs promoting lifestyle change have had some success in helping people achieve and maintain weight loss, but study results have been variable, and these programs have not been widely implemented in primary care. We studied the effectiveness of an online program we have developed (Intellihealth, formerly known as BMIQ) in routine primary care practices, both alone and integrated with population health management (with participants receiving additional support and outreach from nonclinical staff). The study’s objective was to determine whether a combined intervention integrating online weight management with population health management would increase weight loss at 12 months among primary care patients compared with the online program only and usual care. (more…)
Author Interviews, Weight Research / 03.12.2020

MedicalResearch.com Interview with: Gurmukh Singh, MD, PhD, MBA Department of Pathology, Section of Clinical Pathology Walter Shepeard Professor of Pathology Section Chief, Clinical Pathology. Associate Medical Director, Clinical Laboratory GRMC and Children's Hospital of Georgia MedicalResearch.com: What is the background for this study? Would you briefly explain what is meant by the obesity paradox? Response: Obese people tend to get more diseases, such as hypertension, diabetes, cancer etc. However, when they get seriously ill, e.g., sick enough to require admission to intensive care treatment unit (ICU), obese people tend to have better outcomes than normal weight people. (more…)
Author Interviews, Orthopedics, Radiology, Rheumatology, UCSF, Weight Research / 18.11.2020

MedicalResearch.com Interview with: Silvia Schirò MD Department of Radiology and Biomedical Imaging University of California, San Francisco MedicalResearch.com: What is the background for this study?  Response: Knee osteoarthritis (OA) is worldwide the second most frequent cause of lower extremity disability, and it has a global incidence of 199 cases per 100.000, including over 14 million people with symptomatic knee OA in the US. Overweight and obese individuals have a higher incidence of knee OA due to excessive knee joint load. The association between physical activity and knee OA, has not been systematically addressed in overweight and/or obese subjects and its association seems to be controversial. On the one hand, mild to non-weight-bearing physical activities have been found to be beneficial in the management knee homeostasis, the physiologic knee joint load providing an optimized environment for the joint tissues. On the other hand, excessive fast-paced physical activity with high load-joint torsion such as racquet sports, ball sports and running have been found to have an increased incidence of knee injury compared to mild-moderate exercise such as swimming, bicycling and low-impact aerobics independent of body weight. (more…)