Author: Marie Benz MD FAAD
31 Oct IV Melatonin Did Not Reduce Surgical Pain
MedicalResearch.com Interview with:
Lars Peter Holst Andersen MD., Ph.d. Fellow / Læge, Ph.d. studerende
Department of Surgery Herlev Hospital
Gastroenheden, Herlev Hospital
Medical Research: What is the background for this study?
Dr. Andersen: The sleep hormone, melatonin is diverse molecule. Several experimental animal studies have documented significant antinociceptive effects in a wide range of pain models. In perioperative medicine, administration of melatonin has demonstrated anxiolytic, analgesic and anti-oxidant effects. Optimization of the analgesic treatment in surgical patients is required due to documented inadequate analgesia and the risk of adverse effects and complications caused by commonly used NSAIDs and opioids. Our goal was to investigate if melatonin was able to reduce pain scores or analgesic use in patients undergoing laparoscopic cholecystectomy.
31 Oct Higher Intake of Linoleic Acid Leads To Lower Coronary Heart Disease Risk
MedicalResearch.com Interview with
Frank B. Hu, MD, PhD
Professor of Nutrition and Epidemiology
Harvard School of Public Health
Professor of Medicine Harvard Medical School
Boston, MA 02115
Medical Research: What is the background for this study? What are the main findings?
Dr. Hu: There has been much confusion and sensational headlines about the role of different types of fat in coronary heart disease. A recent meta-analysis suggested that higher saturated fat intake was not associated with coronary heart disease (CHD), but people don't consume saturated fat in isolation from other components of diet. Typically people swap for one type of fat for another. Therefore it is important to look at replacement nutrient when we talk about health effects of saturated fat. Randomized clinical trials have shown that replacing saturated fat with polyunsaturated fat reduces total and LDL cholesterol. Thus it is important to examine whether such replacement confers long-term beneficial effects on heart disease prevention. We performed a systematic review and meta-analysis of prospective cohort studies to summarize the evidence regarding the link between dietary intake of linoleic acid (the predominant type of polyunsaturated fat) and heart disease risk in generally healthy people. We identified 13 published and unpublished cohort studies with a total of 310,602 individuals and 12,479 total coronary heart disease events including 5,882 CHD deaths. We found that dietary linoleic acid intake is inversely associated with coronary heart disease risk in a dose-response manner—meaning, higher intake of linoleic acid resulted in a lower risk of CHD. Comparing the highest to the lowest level of consumption, dietary linoleic acid was associated with a 15% lower risk of coronary heart disease events and a 21% lower risk of CHD deaths. These results were independent of common coronary heart disease risk factors such as smoking and other dietary factors such as fiber consumption.
31 Oct Sales Receipts May Lead to High Levels of BPA Absorption
MedicalResarch.com Interview with:
Julia A. Taylor, Ph.D.
Assistant Research Professor
Division of Biological Sciences
University of Missouri Columbia, MO 65211
Medical Research: What is the background for this study? What are the main findings?
Dr. Taylor: Bisphenol A (BPA) is an industrial chemical present in a large number of consumer products, including polycarbonate plastics, food can linings, resins and thermal paper. A 2008 study of BPA levels in human urine concluded that over 90% of the U.S. population is exposed to BPA. BPA is an endocrine disrupter; its estrogenic properties were first described long before its commercial use, but today it is known that it not only acts like an estrogen but also interferes with thyroid hormone, androgen and insulin action. In population-based studies, higher urinary levels of BPA have been linked to a number of human health issues. For example, higher BPA concentrations have been associated with obesity and aggressive and hyperactive behaviors in children, and with cardiovascular disease and diabetes, altered liver and kidney function, and immune and reproductive disorders in adults.
It was at one time thought that almost all human exposure occurs via food and drink, but calculations of exposure from these sources do not adequately account for the sometimes high amounts measured in urine, and the fact that BPA concentrations in population-based studies are not lower with increasing fasting time suggests that some other form of ongoing exposure. Our interest here was in thermal paper. BPA has been used as a color developer in thermal paper for many years and can be present in milligram amounts in the paper coating. Because thermal printing is widely used for items such as sales and ATM receipts, airline tickets and luggage labels, thermal paper may represent an important high-concentration source of exposure.
We screened thermal paper receipts from 50 in-state vendors and found that 44% used BPA as the color developer, but 52% used another chemical called BPS (bisphenol S) which was present in similar quantities to BPA. Two receipts contained neither BPA nor BPS, and so presumably used an alternative (unidentified) chemical.
In preliminary work we measured the transfer of BPA from thermal paper to the hands, and found much higher transfer to hands that were pre-wet using hand sanitizer. We also determined that BPA transferred to hands could then be transferred to food. In our study we asked men and women to first wet their hands with sanitizer before holding the receipts for a few minutes, and then with the same hands pick up french fries and hold them briefly before eating them. We then cleaned one hand but allowed the other to remain “contaminated”. We took blood samples over the next 90 minutes, either from the arm linked to the clean hand or the arm linked to the dirty hand, and collected a urine sample at the end.
30 Oct Ebola: Infectiousness Greatly Increases With Disease Progression
MedicalResearch.com Interview with:
Dan Yamin PhD
Postdoctoral Associate
Yale School of Public Health
New Haven, CT 06520
Medical Research: What is the background for this study?
Dr. Yamin: With limited resources, West Africa is currently overwhelmed by the most devastating Ebola epidemic known to date. In our research, we seek to address two questions:
- 1) who is mostly responsible for transmission? and 2) what intervention programs should be applied to contain the current Ebola outbreak?
30 Oct Meditation May Improve Creative Thinking and Problem Solving
MedicalResearch.com Interview with: Dr. Lorenza S. Colzato, Assistant Professor and Dominque Lippelt, Research Master Student Cognitive Neuroscience ResearchProgram Leiden, The Netherlands Medical Research: What is the background for this study? What are the main findings? Response: Our study aimed to investigate whether prior meditation experience could modulate the effect of two types of meditation on two aspects of creative thought. Creativity can be thought of as consisting of two main ingredients: Convergent thinking (finding one solution to a defined problem) and divergent thinking (finding many possible solutions to a problem). In a previous study we found that Open Monitoring meditation and Focused Attention meditaton (FAM) have distinguishable effects on creativity. OMM induces a control state that promotes divergent thinking while Focused Attention meditaton does not improve convergent thinking. Our results confirm and extend these findings. Open Monitoring meditation improved performance on a divergent thinking task, while Focused Attention meditaton did not, and these effects were present in both experienced and novice practitioners, suggesting that one does not have to have many years of meditation experience to benefit from its effects. However, while solving convergent thinking problems experienced practitioners tended to solve more problems through insight as opposed to using an analytical strategy, a way of problem solving that bears similarities to divergent thinking.30 Oct Pregestational Diabetes Mellitus: Preconception Care May Improve Outcomes and Save Billions
MedicalResearch.com: Interview with:
Dr. Cora Peterson PhD
Health Economist at Centers for Disease Control
Medical Research: What is the background for this study? What are the main findings?
Dr. Peterson: Women with pregestational diabetes mellitus (PGDM) have increased risk for adverse birth outcomes. Preconception care for women with pregestational diabetes mellitus reduces the frequency of such outcomes, most likely by improving glycemic control before and during the critical first weeks of pregnancy.
Preconception care for women with pregestational diabetes mellitus includes the following activities:
- medical or dietary blood sugar control, blood sugar monitoring, screening and treatment of complications due to diabetes,
- counseling and education about the risks of diabetes in pregnancy, and
- using effective birth control or contraceptives until appropriate levels of blood sugar are achieved.
30 Oct Prostate Cancer: Androgen Deprivation Therapy May Be Harmful For Some Men
MedicalResearch.com Interview with:
David R. Ziehr B.S., MD Candidate
Harvard Medical School
Medical Research: What is the background for this study? What are the main findings?
Response: Androgen deprivation therapy (ADT), commonly achieved with gonadotropin-releasing hormone agonists or antagonists, is a mainstay of prostate cancer therapy. While randomized controlled trials demonstrate that ADT improves survival among men with unfavorable risk prostate cancer, retrospective studies have suggested that some men with comorbid illnesses such as heart disease may not derive a benefit from—or may even be harmed by—ADT. However, the nature of this harm has not been characterized. We studied over 5000 men with prostate cancer who were treated with brachytherapy (implanted radioactive seeds) with or without ADT. We analyzed the men based on pre-treatment cardiac comorbidity and examined the association between ADT and death from cardiac causes. We found that among men with congestive heart failure or a past myocardial infarction (MI), Androgen deprivation therapy was associated with a three-times greater risk of death from heart disease. However, Androgen deprivation therapy was not associated with greater risk of cardiac mortality in men without heart disease or with a risk factor for heart disease, such as diabetes, hypertension or hyperlipidemia.
30 Oct Screening Chemotherapies for Effectiveness On Cultures Of Breast Cancer Biopsy Cells
MedicalResearch Interview with:
Melissa Skala, Ph.D.
Assistant Professor of Biomedical Engineering
Assistant Professor of Cancer Biology
Vanderbilt University Nashville, TN 37235
Medical Research: What is the background for this study? What are the main findings?
Dr. Skala: We developed a new metabolic imaging technique that is highly sensitive to tumor cell response to anti-cancer drug treatment. We coupled this imaging technique with new, three-dimensional cultures that can be grown from breast tumor biopsies. Together, our data indicate that this approach could be used to perform rapid, low-cost, and accurate drug screens for individualized treatment of cancer patients.
30 Oct Study Identifies Potential Target In Huntington’s Disease Pathway
MedicalResearch.com Interview with:
Srinivasa Subramaniam, Ph.D., Assistant Professor
Department of Neuroscience
The Scripps Research Institute Jupiter, Florida 33458
Medical Research: What is the background for this study? What are the main findings?
Dr. Subramaniam: Huntington’s disease (HD) is a genetic disorder occurs due to a mutation in a protein called huntingtin (mHtt), which affects 5-10 people per 100000 populations worldwide. Our research revolves around the question— why mutant huntingtin despite its ubiquitous expression through out the body selectively affects brain regions such as striatum, a region that regulates voluntary movement. We now found that mHtt activates a protein kinase complex, mammalian target of rapamycin complex 1 (mTORC1), which is required for normal functions such as translation of genes into proteins and also organelle recycling. We found the mTORC1 activation is so robust and sustained in the striatum that lead to the severe motor disabilities and premature death of HD mice. Our study indicates a functional relationship between huntingtin and mTOR the developmentally important genes with implication in Huntington’s disease pathogenesis.
30 Oct Is Pretreatment With Platelet Inhibitors Beneficial or Harmful For Acute Coronary Syndrome?
MedicalResearch.com Interview with: Anne Bellemain-Appaix Service de Cardiologie-La Fontonne Hospital, Antibes, France and Gilles Montalescot Professor of Cardiology Institut de CardiologiePitié-Salpêtrière Hospital Université Paris 6, France ACTION Study Group, Paris, France Medical Research: What is the background for this study? Response: Pretreatment with P2Y12 inhibitors for Non-ST-Elevation Acute Coronary Syndrome (NSTE-ACS) patients, although advised in current guidelines, has been recently questioned in term of benefit/risk ratio (no ischemic benefit and increase in major bleeding). We wanted to answer this question by giving enough power to results in a complete meta-analysis of studies comparing P2Y12 inhibitors pretreatment (defined as its administration before the coronary angiogram) to no pretreatment in NSTE-ACS.29 Oct Does Milk Increase Bone Fractures?
MedicalResearch.com Interview with:
Professor Karl Michaëlsson
Professor in Medical Epidemiology, Senior Consultant in Orthopaedic Surgery
Uppsala Clinical Research Institute
Medical Research: What are the main findings of the study?
Prof. Michaëlsson: A high milk intake is recommended for the prevention of osteoporotic fractures but milk is also the major dietary source of galactose intake. The addition of galactose by injection or in the diet is an established animal model of aging by induction of oxidative stress and inflammation. Previous research results regarding the importance of milk intake for the prevention of fractures and the influence on mortality rates are conflicting. High milk intake was in our study associated with higher mortality in one cohort of women and in another cohort of men, and with higher fracture incidence in women. In subsamples of two additional cohorts, one in males and one in females, a positive association was seen between milk intake and both urine 8-iso-PGF2α (a biomarker of oxidative stress) and serum interleukin 6 (a main inflammatory biomarker).
29 Oct Reliability of East German Pharmaceutical Investigations Questioned
MedicalResearch.com Interview with:
Dr. med. Rainer Erices
Institut für Geschichte und Ethik der Medizin
Medical Research: What are the main findings of the study?
Dr. Erices: The study presents the results of a first systematic investigation of clinical drug trials carried out by Western pharmaceutical firms in Eastern Germany in the 1980s. The scientific investigation of the East German Health system has only just started. The study shows that in that period of time, around 220 clinical trials were carried out. We now know how many patients took part and what remuneration the GDR received. It continues to be difficult to evaluate these tests. Despite intensive research efforts in different archives, we have been unable to find documentation on how detailed (and systematically) patients were informed about the trial they were taking part in. The responsible institutions repeatedly advised testers to stick to the law during the clinical trials. The law required that these trials should only be carried out on patients which had given their informed consent and had decided to participate voluntarily. However, so far there is no convincing proof that these legal requests were met.
29 Oct Community Interventions Improved Blood Pressure Control In Diverse Populations
Posted at 12:57h
in AHA Journals, Author Interviews, Blood Pressure - Hypertension, Duke, Race/Ethnic Diversity
MedicalResearch.com Interview with:
Kevin L Thomas, MD
Assistant Professor of Medicine
Division of Clinical Cardiac Electrophysiology
Duke Clinical Research Institute
Medical Research: What are the main findings of the study?
Dr. Thomas: The number of participants with controlled blood pressure (readings of less than 140/90) increased by 12 percent in the six months between the first and last readings. Mean systolic blood pressure for the population decrease by 4.7mmHg. The number of participants who had high blood pressure in the range of 140-149/90-99 decreased systolic blood pressure by a mean of 8.8mmHg and those with readings in the higher range of 150/100 or above decreased systolic blood pressure by 23.7percent. The study concluded that a program that followed this type of approach was associated with improved blood pressures across a diverse high-risk community.”
29 Oct Gut Bacteria Linked To Heart Failure and Mortality Risk
MedicalResearch.com Interview with:
W. H. Wilson Tang, MD FACC FAHA
Professor of Medicine,
Cleveland Clinic Lerner College of Medicine at CWRU
Director, Cardiomyopathy Program, Kaufman Center for Heart Failure
Research Director, Section of Heart Failure and Cardiac Transplantation Medicine
Heart and Vascular Institute, Cleveland Clinic Cleveland, OH 44195
Medical Research: What are the main findings of the study?
Dr. Tang: A chemical byproduct of gut bacteria-dependent digestion, TMAO (trimethylamine N-oxide), was previously shown to contribute to heart disease development. In this study, blood levels of TMAO for the first time are linked to heart failure development and mortality risk.
29 Oct Leftover US Hospital Supplies Can Have Lifesaving Impact Overseas
MedicalResearch.com Interview with: Eric Wan BS and Miceile Barrett BS Johns Hopkins University School of Medicine Baltimore, MD Medical Research: What is the background for this study? What are the main findings? Answer: Access to surgery is limited in resource-poor settings and low-and-middle income countries (LMICs) due to a lack of human and material resources. In contrast, academic hospitals in high-income countries often generate significant amounts of unused and clean medical supplies that cannot be re-used in the operating rooms of high-income countries. Programs such as Supporting Hospitals Abroad with Resources and Equipment (SHARE) provide an avenue for recovery of these supplies and donation to resource-poor hospitals in LMICs. From data collected from SHARE supplies donated by Johns Hopkins, we found that the nationwide impact for these programs to be $15.4 million among US academic hospitals, which accounts for only 19 categories of commonly recovered supplies. When we tracked our donated supplies to hospitals in Ecuador serving the poor, we found that the cost-effectiveness of these donations was US $2.14 per disability-adjusted life-year prevented.29 Oct Snoring During Twenties May Be Predictive of Sleep Apnea in Forties
Posted at 12:17h
in Obstructive Sleep Apnea
MedicalResearch.com Interview with: Dr. Swati Gulati, MD Internal Medicine John H. Stroger Hospital of Cook County Chicago, IL Medical Research: What are the main findings of the study? Dr. Gulati: We conducted an observational study by providing questionnaire about the onset and progression of sleep apnea symptoms to patients seen in our sleep...
29 Oct “Bad Cholesterol” LDL-C Linked to Aortic Valve Disease
MedicalResearch.com Interview with: George Thanassoulis, MD MSc FRCP(C) Director, Preventive and Genomic Cardiology FRQ-S Clinician-Scientist/Chercheur-Boursier Clinicien Assistant Professor of Medicine, McGill University McGill University Health Center Montreal, QC Medical Research: What is the background for this study? What are the main findings? Dr. Thanassoulis: Although LDL-C (i.e. bad cholesterol) has been linked with aortic valve disease in several prior reports, randomized trials to lower cholesterol in aortic valve disease were not effective suggesting that cholesterol may not be important in valve disease. To address this, we performed a Mendelian randomization study, that showed that a genetic predisposition to LDL-C, was associated with both calcium deposits on the aortic valve and aortic stenosis (I.e. Valve narrowing). These results can be viewed as the effect of a life-long increase in LDL-C on the incidence of aortic valve disease and suggest that increases in LDL-C cause aortic stenosis.29 Oct Men With Sleep Disorders Have Greater Risk of Alzheimer’s Disease
MedicalResearch.com Interview with:
Christian Benedict PhD
Associate Professor of Neuroscience
Uppsala University Dept. of Neuroscience
Medical Research: What is the background for this study?
Answer: Our study involved ~1500 men who were followed from 1970 to 2010. All participants were 50 years old at the start of study.
Medical Research: What are the main findings?
Answer: Men with reports of sleep disturbances had a 50%-higher risk to develop Alzheimer's disease during the 40-year follow-up period, than men without reports of sleep disturbances.
28 Oct How To Quickly Disseminate Best Practices To Doctors
MedicalResearch.com Interview with:
Luís A. Nunes Amaral PhD
HHMI Early Career Scientist
Professor of Chemical & Biological Eng.
Professor of Medicine
Howard Hughes Medical Institute
Northwestern University, Evanston, Illinois
Medical Research: What is the background for this study? What are the main findings?
Dr. Amaral: There is a well known difficulty in promoting the rapid adoption of best practices by physicians. Because of their work load and because of the inability to figure out when some result is a true advance or just hype, doctors tend to stick to what they believe works. Unfortunately, as a 15 year old Institute of Medicine study shows, this lack of adoption of best practices costs society hundreds of thousands of lives a year in the US alone.
The typical process for informing doctors of what best practices are (such as continual medical education and other broadcasting approaches) do not work well. We believe that a weakness of typical approaches is that they have a one talking to the many style, and they are out of a medical practice context. Our hypothesis was that by seeding a few doctors with desired knowledge, one could have spread of the adoption through one-on-one contacts between physicians in the context of treating patients. We found that this approach has the potential to be very effective.
28 Oct Age-Related Macular Degeneration: If One Eye Has It, The Other Eye More Likely To Develop It As Well
MedicalResearch.com Interview with:
Ronald Klein, MD, MPH, Professor
Department of Ophthalmology and Visual Sciences
University of Wisconsin School of Medicine and Public Health
Madison WI
Medical Research: What are the main findings of the study?
Dr. Klein: We found that more severe age-related macular degeneration (AMD) in 1 eye was associated with increased incidence of age-related macular degeneration [levels 1-2: hazard ratio [HR], 4.90 [95%CI, 4.26-5.63] and accelerated progression [levels 2-3: HR, 2.09 [95%CI, 1.42-3.06]; levels 3-4: HR, 2.38 [95%CI, 1.74-3.25] and incidence of late age-related macular degeneration [levels 4-5: HR, 2.46 [95%CI, 1.65-3.66] in its fellow eye. Less severe AMD in 1 eye was associated with less progression of AMD in its fellow eye. We estimated that 51% of participants who develop any age-related macular degeneration maintained age-related macular degeneration severity states within 1 step of each other between eyes and 90% of participants stay within 2 steps.
28 Oct Cocoa Flavenols May Improve Age-Related Memory Decline
MedicalResearch.com Interview with:
Scott A. Small, MD
Boris and Rose Katz Professor of Neurology
Division of Aging and Dementia
Director, Alzheimer's Disease Research Center
Taub Institute for Research on Alzheimer's Disease and the Aging Brain Department of Neurology, Columbia University New York, NY
Medical Research: What is the background for this study?
Dr. Small: Previous work, including from my lab, had shown that changes in a specific part of the brain—the dentate gyrus—are associated with age-related memory decline. Until now, however, the evidence in humans showed only a correlational link, not a causal one. To see if the dentate gyrus is the source of age-related memory decline in humans, we tested whether compounds called cocoa flavanols can improve the function of this brain region and improve memory. Flavanols extracted from cocoa beans had previously been found to improve neuronal connections in the dentate gyrus of mice.
28 Oct International Societies Urge Expedited Ebola Vaccine Development
MedicalResearch.com Interview with:
Prof. Clive Maurice Gray
Division of Immunology, Institute of Infectious Diseases and Molecular Medicine,National Health Laboratory Services
University of Cape Town, Cape Town, South Africa
Medical Research: What is the background for this report? What are the main findings?
Prof. Gray: This report is a response on behalf to the International Union of Immunology Societies (IUIS) and is designed to focus a message from the global immunology community to those who are making vaccines and therapies implementing clinical trials and very importantly on Governments and funding bodies. Time is not our side and that vaccine efforts need to be expedited and that production of therapeutics needs to be ramped up. Due to the fact that many people in West Africa are dying, we wish to convey a strong message that to curb this outbreak, therapies and especially vaccines must be rolled out as soon as possible.
28 Oct Does Long Term Viagra Improve Heart Disease?
MedicalResearch.com Interview with:
Dr. Andrea M. Isidori, MD, PhD
Consultant - Assistant Professor of Endocrinology
Department of Experimental Medicine
Medical Pathophysiology
Sapienza University of Rome
Medical Research: What is the background for this study? What are the main findings?
Dr. Isidori : Our meta-analytic research originated to clarify some controversies emerging from the available human studies. We wanted to analyze if chronic PDE5i administration was cardioprotective and safe, and, if so, where the benefits were mainly seen: cardiac muscle, peripheral vessels, or both. In the last sixteen years pre-clinical and clinical research into the extra-urological effects of PDE5i has expanded dramatically, revealing previously unsuspected indications for these drugs. Several animal studies have shown that PDE5i attenuates cardiac remodeling, with an anti-hypertrophic and anti-fibrotic effect, and protects the heart against different types of injury. Some small clinical trials have demonstrated that chronic PDE5 inhibition improves cardiac performance and geometry in various clinical conditions, including heart failure, myocardial infarction and diabetic cardiomyopathy.
We showed that continuous administration of Viagra improves cardiac performance (increase of ejection fraction and cardiac index) and has an anti-remodeling effect (decrease of left ventricular mass and increase of end diastolic volume) without a major impact on vascular parameters (blood pressure and vascular resistance) suggesting that it does indeed have a direct effect on the heart. The novelty of this meta-analysis is the identification of subgroups of patients that may benefit more from PDE5i: patients with cardiac hypertrophy and heart failure. Our study is the first to show in a large patient cohort that chronic PDE5i administration improves cardiac output and decreases heart rate. This could result in longer survival, increased exercise tolerance and a better quality of life. Surprisingly, the magnitude of effects was similar to that seen with the drugs currently used to treat these clinical conditions, and was obtained in a relatively brief period (3 to 12 months). Most strikingly, we found that PDE5is are among the very few drugs that are able to improve diastolic relaxation, thus helping the correct refilling of the ventricle after each contraction, a nearly unique feature in drugs used in cardiology, and with incredible potential for future development in the prevention of heart failure. We also demonstrated their high tolerability and safety in a population that included elderly patients with various stages of cardiac disease and numerous comorbidities who were taking multiple pharmacological treatments. This setting resembles what we normally see in real life, supporting that daily administration is safe and involves no increase in the risk of adverse events compared to on-demand use.
28 Oct Simple Nucleic Acid Biomarker May Enhance Bedside Diagnosis
MedicalResearch.com Interview with:
Dr. Adam Woolley PhD
Department of Chemistry and Biochemistry
Brigham Young University
Medical Research: What is the background for this study? What are the main findings?
Dr. Woolley: High-performance biomarker analysis methods are usually complex and expensive. In contrast, simple and inexpensive biomarker detection methods
typically have low performance.
Our study demonstrates a simple nucleic acid measurement system that
requires no detection instrumentation. Nucleic acid mimics of microRNA were
quantified with sequence specificity down to 10 pg/mL levels.
27 Oct Powerpoint of This Week’s Exclusive Medical Research Interviews
Posted at 23:54h
in Author Interviews
27 Oct Traumatic Brain Injury Raises Dementia Risk in Elderly
MedicalResearch.com Interview with:
Raquel C. Gardner, MD, Research Fellow
San Francisco VA Medical Center
Clinical Instructor
Memory and Aging Center, Department of Neurology
University of California, San Francisco
Medical Research: What are the main findings of the study?
Dr. Gardner: We found that people who experience a traumatic brain injury (TBI )when they are 55 or older have a 26% higher chance of getting dementia over the next 5 to 7 years compared to people who experience bodily trauma.
27 Oct Agave Offers Placebo Effect For Cough In Young Children
MedicalResearch.com Interview with: Ian M. Paul, M.D., M.Sc. Professor of Pediatrics and Public Health Sciences Chief, Division of Academic General Pediatrics Associate Vice Chair for Research, Department of Pediatrics Penn State College of Medicine Hershey, PA 17033-0850 Medical Research: What are the main findings of the study? Dr. Paul: This study highlights that a significant placebo effect exists in the treatment of young children with cough due to colds because agave nectar and placebo both resulted in improvement of child symptoms by parents compared with no treatment.27 Oct Who Relapses After Emergency Room Visit For Asthma?
Posted at 19:49h
in Author Interviews
MedicalResearch.com Interview with:
Brian H. Rowe, MD, MSc, CCFP(EM), FCCP
Tier I Canada Research Chair in Evidence-based Emergency Medicine
Scientific Director, Emergency Strategic Clinical Network
Professor, Department of Emergency Medicine
University of Alberta
Medical Research: What is the background for this study? What are the main findings?
Dr. Rowe: The study was designed to evaluate non-pharmacological issues associated with relapse following discharge from the emergency department with acute asthma. Many years of high-quality research have shown that systemic and inhaled corticosteroids (ICS) in combination are required to reduce relapse. In this study all patients received systemic corticosteroids and the majority received inhaled corticosteroids (either as mono-therapy or in combination with long-acting beta-agonists {LABA}).
This study design permitted us to evaluate other factors associated with relapse as a guide for clinicians to use in planning discharge.
The main findings include identifying the key factors independently associated with relapse: female sex (OR = 1.9; 95% confidence interval [CI]: 1.2, 3.0), symptom duration of > 24 hours prior to emergency department visit (OR = 1.7; 95% CI: 1.3, 2.3), ever using oral corticosteroids (OR = 1.5; 95% CI: 1.1, 2.0), current use of an ICS/LABA combination product (OR = 1.9; 95% CI: 1.1, 3.2), and owning a spacer device (OR = 1.6; 95% CI: 1.3, 1.9).
27 Oct Is Depression Related To Hormone Levels in Premenopausal Women?
MedicalResearch.com Interview with:
Dr. Sunni Mumford PhD
Earl Stadtman Investigator in the DESPR Epidemiology Branch
Eunice Kennedy Shriver National Institute of Health and Human Development
Medical Research: What are the main findings of the study?
Dr. Mumford: Depressive symptoms in healthy women who don’t have diagnosed clinical depression isn’t related to reproductive hormone levels, like estrogen, or impaired ovulation.
Medical Research: What was most surprising about the results?
Dr. Mumford: Earlier research indicates that changes in estrogen may be associated with depression, for instance during the menopausal transition. Our study identified significant associations between estrogen and depressive symptoms in models that didn’t account for confounding factors, but this relationship was completed eliminated when adjustments were made for common confounding factors like age, race, BMI, and also stress level in these premenopausal women. Another interesting finding was that a score describing mood-related menstrual symptoms indicated that such symptoms are highest in the premenstrual phase, but remain lower throughout the rest of women’s cycles. This tells us that altered mood symptoms are most frequent prior to menstruation.