Author: Marie Benz MD FAAD
07 Oct Neurotic Symptoms In Midlife May Presage Alzheimer’s Dementia
MedicalResearch.com Interview with:
Lena Johansson, PhD, MSc, RN
Institute of Neuroscience and Physiology
Department of Psychiatry and Neurochemistry
Sahlgrenska Academy at Gothenburg University
Medical Research: What are the main findings of the study?
Dr. Johansson: We found that a higher degree of neuroticism in midlife was associated with increased risk of Alzheimer’s disease over 38 years. On the 24 point scale, the risk increased with 4% per each step. Women who score high on the neuroticism scale were more likely to experience feelings such as anxiety, nervousness, worry, and irritability, and they were more moodiness and stress-prone.
The association between neuroticism and Alzheimer’s disease diminished after adjusting for longstanding perceived distress symptoms, which suggest that the associations was at least partly depended on long-standing distress symptoms.
When the two personality dimensions were combined, women with high neuroticism/low extraversion had a double risk of Alzheimer’s disease compared to those with low neuroticism/high extraversion.
07 Oct TIAs, Strokes Decline Over Last Decade
MedicalResearch.com Interview with:
Vijaya Sundararajan, MD, MPH, FACP
Associate Professor
Head, Health Outcomes Group, Head, Biostatistics Hub
Research Advisor, Centre for Palliative Care
Department of Medicine Eastern Hill Academic Centre
Melbourne Medical School
Faculty of Medicine, Dentistry and Health Sciences University of Melbourne
Medical Research: What are the main findings of this study?
Dr. Sundararajan: The main findings of the study are that over the last 10 years, there has been a measurable decline in people having a stroke 3 months after a new mini stroke (TIA); a mini stroke is also known as a ‘warning sign for stroke’. There has also been an overall decline in of the proportion of people having these mini strokes in the Australian State of Victoria (population 5.6million). These trends probably reflect improved primary and secondary prevention efforts for the last decade. These improvements are likely to include increased use of preventive medications and surgery for carotid artery narrowing in people identified as being at high risk of having a stroke, as well as improved behaviors (e.g. reducing smoking, improving diets, uptake of physical activity, among others).
The most important aspect of our results is many fewer strokes occur when people with a TIA are managed in a hospital with a stroke unit (up to 6%). Even when the patient’s TIA is managed in an Emergency Department and the patient released without admission, if the hospital has a stroke unit, these patients appear to have better outcomes. This likely reflects the cohesion and organization of the stroke unit in implementing the necessary tests and treatments promptly, and setting up the infrastructure to follow patients up.
07 Oct Sexting Teens More Likely Sexually Active
MedicalResearch.com Interview with:
Jeff R. Temple, PhD
Associate Professor and Psychologist
Director, Behavioral Health and Research
Department of Ob/Gyn
UTMB Health Galveston, TX 77555-0587
Medical Research: What are the main findings of the study?
Dr. Temple: Through previous research, we know that teen sexting is related to actual sexual behaviors, but we did not have any information on the temporal link between these two behaviors.
In short, we found that teens who sexted had 32% higher odds of being sexually active over the next year relative to youth who did not sext – this was even after controlling for history of prior sexual behavior, ethnicity, gender, and age. We also found that active sexting (actually sending a naked picture to another teen) mediated the relationship between passive sexting (asking for or being asked for a sext) and sexual behaviors. In other words, while sending a sext was predictive of subsequent sexual behavior, asking for/being asked for a sext was only associated with sexual behavior through its relationship with active sexting.
06 Oct Cafffeine Intake Associated With Reduced Kidney Stone Risk
MedicalResearch.com Interview with:
Pietro Manuel Ferraro, MD PhD Candidate
Division of Nephrology
Catholic University of the Sacred Heart
Rome Italy
Medical Research: What are the main findings of the study?
Dr. Ferraro: We analyzed the association between caffeine intake and the risk of developing kidney stones in three large cohorts of U.S. health professionals. The 217,883 participants included did not have any history of kidney stones when follow-up began. During 20 years of follow-up, 4,982 of them developed a kidney stone. In all three cohorts, participants with higher intakes of caffeine had a reduced risk of developing kidney stones. Intake of caffeine from sources other than coffee was also associated with reduced risk of kidney stones. Among 6,033 participants with 24-hour urine data, intake of caffeine was associated with higher excretion of calcium but also higher urine volume and lower likelihood of calcium and uric acid stone formation.
06 Oct Oxygen Sensors In Skin Dressings Can Enhance Wound Repair
MedicalResearch.com Interview with:
Conor L. Evans, PhD
Assistant Professor Harvard Medical School
Wellman Center for Photomedicine
Massachusetts General Hospital
Affiliate Faculty, Harvard University Biophysics Program
Charlestown, MA
Medical Research: What are the main findings of the study?
Dr. Evans: The main finding of this research is that topically applied rapid-drying wound dressings containing optical sensors for oxygen can be used to quantify skin oxygenation status in a way that reflects the viability of the underlying tissue, and therefore has the potential to aid in the clinical care for patients with burns, grafts and various other skin conditions.
06 Oct As Tanning Became More Fashionable, Melanoma Became More Common
MedicalResearch.com Interview with:
David Polsky, MD, PhD
Alfred W. Kopf, MD, professor of Dermatologic Oncology
Ronald O. Perelman Department of Dermatology
NYU Langone Medical Center
Medical Research: What are the main findings of the study?
Dr. Polsky: We utilized a multi-disciplinary approach including an analysis of socioeconomic factors to elucidate the evolution of attitudes and behaviors maximizing personal ultraviolet light exposure during the 20th century in the United States. We then compared melanoma incidence rates from national cancer registries to estimated skin exposure and found that they rose in parallel. Though causation cannot be made in an analysis such as this one, this paper describes a historical context for the changing attitudes promoting increased UV exposure, and the rising incidence of melanoma throughout the past century. It also provides a framework in which to consider public health and education measures that may ultimately help reverse melanoma incidence trends.
04 Oct Long Term Physical Activity May Decrease Cataract Risk
MedicalResearch.com Interview with: Jinjin Zheng Selin, MSc Unit of Nutritional Epidemiology Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden Medical Research: What are the main findings of the study? Response: Our results suggest that higher levels of total physical activity, especially in the long-term, as well as specific types of physical activity including walking/bicycling and work/occupational activity, may be associated with decreased risk of age-related cataract among middle-aged and elderly women and men. On the other side, high levels of leisure time inactivity may be associated with increased risk of cataract.04 Oct Alcohol Consumption Linked To Poor Semen Quality
MedicalResearch.com: Interview with:
Professor Tina Kold Jensen MD
Professor, Department of Environmental Medicine
Research leader, Odense Child Cohort
Medical Research: What are the main findings of the study?
Prof. Jensen: Our study suggests that even modest habitual alcohol consumption of more than 5 units per week had adverse effects on semen quality although most pronounced effects were seen in men who consumed more than 25 units per week. Alcohol consumption was also linked to changes in testosterone and SHBG levels.
03 Oct Deaths From Skin Diseases Differ Between Developed and Developing Countries
MedicalResearch.com: Interview Invitation Robert Dellavalle, MD, PhD, MSPH Chief, Dermatology Service Denver VA Medical Center Denver, CO 80220 Co-Authors: Lindsay Boyers and Chante Karimkhani Medical Research: What are the main findings of the study? Answer: This cross-sectional study of Global Burden of Disease 2010 results, investigated the rates of death from ten conditions with skin manifestations. There were statistically significant mortality differences in developed countries compared to developing countries. Developing countries had greater rates of death for all conditions except melanoma and basal and squamous cell carcinomas. The greatest death rates in developing countries were due to measles, syphilis, and varicella. Conversely, developed countries had greater rates of death of melanoma and basal and squamous cell carcinomas.03 Oct Marijuana May Be Protective Against Traumatic Brain Injury
MedicalResearch.com Interview with:
David Plurad, MD
Los Angeles Biomedical Research Institute.
Medical Research: What are the main findings of the study?
Based on a survey of patients with traumatic brain injuries, a group of Los
Angeles Biomedical Research Institute researchers found those who tested
positive for tetrahydrocannabinol (THC), the active ingredient in marijuana, were more likely to survive than those who tested negative for the illicit substance.
We surveyed 446 patients who were admitted to a major urban hospital with
traumatic brain injuries between Jan. 1, 2010, and Dec. 31, 2012, who were
also tested for the presence of THC in their urine. We found 82 of the
patients had THC in their system. Of those, 2.4% died. Of the remaining
patients who didn't have THC in their system, 11.5% died.
While most - but not all - the deaths in the study can be attributed to the
traumatic brain injury itself, it appears that both groups were similarly
injured. The similarities in the injuries between the two groups led to the
conclusion that testing positive for THC in the system is associated with a
decreased mortality in adult patients who have sustained traumatic brain
injuries.
03 Oct Bariatric Surgery Effective For Both Weight Loss and Diabetes Remission
Posted at 02:54h
in Author Interviews, JAMA, Surgical Research, University of Pittsburgh, Weight Research
MedicalResearch.com Interview with:
Anita P. Courcoulas M.D., M.P.H., F.A.C.S
Professor of Surgery
Director, Minimally Invasive Bariatric & General Surgery
University of Pittsburgh Medical Center
Medical Research: What are the main findings of the study?
Dr. Courcoulas: This paper was not a study but a summary of findings from a multidisciplinary workshop (and not a consensus panel) convened in May 2013 by the National Institute of Diabetes and Digestive and Kidney Diseases and the National Heart, Lung, and Blood Institute. The goal of the workshop was to summarize the current state of knowledge of bariatric surgery, review research findings on the long-term outcomes of bariatric surgery, and establish priorities for future research.
03 Oct Free Long-Acting Contraception Lowered Unwanted Pregnancy and Abortion Rates
MedicalResearch.com Interview with:
Dr. Jeff Peipert MD, PhD
Institute for Public Health
Robert J. Terry Professor, Department of Obstetrics & Gynecology, School of Medicine
Washington University in St. Louis
Medical Research: What are the main findings of this study?
Dr. Peipert: In the Contraceptive CHOICE Project, over 70% of teenage girls and women who were provided no-cost contraception and were educated about the effectiveness and benefits of long-acting reversible contraceptive (LARC) methods selected the intrauterine device (IUD) or contraceptive implant. This group of over 1400 young women aged 15-19 years had rates of pregnancy, birth, and abortion that were far below national rates for sexually experienced teens.
03 Oct Increased Alcohol Use Linked To Greater Risk of HPV Infection
MedicalResearch.com: Interview with:
Matthew B. Schabath, Ph.D
Assistant Member, Department of Cancer Epidemiology
Moffitt Cancer Center Tampa, Florida
Medical Research: What are the main findings of the study?
Dr. Schabath: Overall, the results from these analyses demonstrated that men who consumed the highest amounts of alcohol were associated with an increased risk for genital human papillomavirus (HPV) infections.
03 Oct Fast Growth After Preterm Birth Linked To Persistent Neurocognitive Ability
MedicalResearch.com Interview,
Sara Sammallahti, MA
Institute of Behavioral Sciences
University of Helsinki, Finland.
Medical Research: What are the main findings of the study?
Answer: Not only did we find that faster growth right after preterm birth is
associated with better neurocognitive abilities - we also showed that
these effects persist into adulthood, that they are seen across a wide
spectrum of abilities, and that head growth very early on seems
especially relevant in predicting long-term outcomes. These
associations were found when we examined 103 young adults who were
born prematurely and with very low birth weight (under 1500 grams).
03 Oct Vitamin D: No Causal Link With Type 2 Diabetes
MedicalResearch.com Interview with:
Dr Nita Forouhi, MRCP, PhD, FFPHM
Lead Scientist and Programme Leader
MRC Programme Leader and Consultant Public Health Physician
MRC Epidemiology Unit
University of Cambridge School of Clinical Medicine
Cambridge Biomedical Campus Cambridge, UK
Medical Research: What are the main findings of the study?
Dr. Forouhi: This large study found that low blood concentrations of 25-hydroxyvitamin D [25(OH)D], a clinical indicator of vitamin D status, were associated with an increased risk of type 2 diabetes, but this did not appear to be a cause-effect relationship. To investigate these associations, we did two things. We first did a systematic review and meta-analysis across 22 published studies and confirmed that there was a strong inverse relation between vitamin D levels and the risk of future new-onset type 2 diabetes among people who did not initially have diabetes. We then used a genetic approach, called Mendelian randomisation, which allows us to test a cause-effect relationship, and found that genetically lower vitamin D levels were not related to risk of type 2 diabetes. This means that we were able to distinguish between association and causation, and concluded that the vitamin D levels did not have a causal link with type 2 diabetes.
03 Oct Fish Oil Found Not Effective in Atrial Fibrillation Prevention
MedicalResearch.com Interview with:
Dr. Anil Nigam MD MSc FRCPC
Director, Research Program in Preventive Cardiology at ÉPIC Centre
Montreal Heart Institute
Associate Professor, Department of Medicine at Université de Montréal
Medical Research: What are the main findings of the study?
Dr. Nigam: The main finding is that high-dose fish oil rich in marine omega-3 fatty acids did not reduce recurrence of atrial fibrillation in individuals with paroxysmal or persistent atrial fibrillation not receiving conventional anti-arrhythmic therapy.
03 Oct TIA Increases Risk of PTSD
Posted at 00:11h
in General Medicine
MedicalResearch.com Interview with:
Kathrin S. Utz, PhD
Department of Neurology
University of Erlangen-Nuremberg
Erlangen, German
Medical Research: What are the main findings of the study?
Dr. Utz: A transient ischemic attack is caused when there is a temporary disruption in the blood supply to a person’s brain. It causes the person to experience symptoms, similar to those of a stroke, such as speech and visual disturbance and numbness or weakness in the arms and legs. A transient ischemic attack is only temporary and people make a full physical recovery from it. We found, however, that a TIA is not without cost. Specifically, we found that such persons are at a greater risk of going on to develop the psychiatric condition known as posttraumatic stress disorder (PTSD). We found 1 in 3 patients develop it. PTSD, which is perhaps better known as a problem found in survivors of war zones and natural, can develop when a person experiences a frightening event that poses a serious threat. It leads the person to experience symptoms such as worry, nightmares, flashbacks and social isolation. We found that TIA patients who develop PTSD are also more likely to suffer from depression and anxiety symptoms. Taken together these symptoms pose a significant psychological burden for the affected patients and it therefore comes as no surprise that we also found TIA patients with PTSD have a measurably lower sense of quality of life than TIA patients who do not develop PTSD. We could also identify some potential risk-factors for the development of PTSD following a TIA. Younger patients and patients who overestimate their future stroke risk are more likely to develop PTSD. Also important in this context are the strategies that patients typically adopt to deal with stressful situations. Those patients who use certain types of coping strategies, such as denying the problem, blaming themselves for any difficulties or turning to drugs for comfort, face a greater risk of developing PTSD after TIA.
02 Oct Evolocumab For Resistant Familial Hypercholesterolemia
MedicalResearch.com Interview with: Dr. Raul Santos Unidade Clínica de Lipides InCor-HCFMUSP Sao Paulo, Brazil. Medical Research: What are the main findings of the study? Dr. Santos: Evolocumab 420 mg injected subcutaneously every 4 weeks reduced LDL-C by 31% on average, in relation to placebo, in Homozygous familial hypercholesterolemia patients that were using maximally tolerated lipid lowering therapy but not on lipid apheresis regimen. Patients were separated according to the type of LDL receptor mutation, those with at least one allele codifyng a defective mutation on the LDL receptor (residual receptor activity 2-25%) had on average a 41% reduction on LDL-cholesterol. The 2 patients homozygotes with alleles that codify a null mutation )receptor activity < 2%), did not respond to treatment. This was expected since PCSK9 inhibitors need a functional LDL receptor do work. Basically they increase the expression of the receptor that facilitates the clearance from plasma of circulating LDL particles. In those patients with defective LDL receptor mutations there was 24% reduction of lipoprotein(a) concentrations, an extra risk factor for cardiovascular disease in familial hypercholesterolemia patients.02 Oct ACL Injury Risk Factors Different For Men than Women
MedicalResearch.com Interview with:
Dr. Bruce Beynnon
McClure Professor of Musculoskeletal Research
Dept Orthopedics and Rehabilitation
University of Vermont College of Medicine
Burlington, VT 05405-0084
Medical Research: What are the main findings of the study?
Dr. Beynnon: The anterior cruciate ligament (ACL) is an important stabilizer of the joint, and the study investigated how geometry of this ligament and surrounding bone is related to non-contact injury of this ligament. Specifically, the study focused on MRI-based measurements of the size of the ACL, measured as its volume, and the size of the femoral intercondylar notch, or the small space located in the center of the femur in which the ACL resides. Our study revealed that a decrease in the volume of the ACL and a decrease in the size of the intercondylar notch were associated with an increased risk of suffering a non-contact ACL injury in athletes.
This finding may be explained by the fact that a smaller ligament is associated with a decrease in its biomechanical properties, such as a smaller ultimate failure load. An alternative explanation is that a decreased femoral intercondylar notch size could result in a greater tendency for the ACL to impinge against the walls of the femoral notch during high demand activities, and increase the risk of injury.
The investigation was a longitudinal study with a nested case-control analysis of young, healthy high school and college athletes. The investigation was rigorously designed to control for age, sex, and participation on the same sports team. This enabled us to determine which combination of geometric parameters of the ACL and adjacent bony structures influence risk of suffering a first time non-contact ACL injury.
02 Oct Evolocumab Markedly Reduced LDL in Hypercholesterolemia
MedicalResearch.com Interview with:
Professor F. J. Raal
FRCP, FRCPC, FCP(SA), Cert Endo, MMED, PhD
Director, Carbohydrate & Lipid Metabolism Research Unit
Professor & Head, Division of Endocrinology & Metabolism
Faculty of Health Sciences, University of the Witwatersrand
Johannesburg Hospital Johannesburg South Africa
Medical Research: What are the main findings of the study?
Dr. Raal: Heterozygous familial hypercholesterolaemia (HeFH) is one of the most common inherited disorder in man affects between 1:250 to 1:300 persons worldwide. Thus, there are likely more than 3 million patients with heterozygous familial hypercholesterolaemia in the United States and Europe alone. The RUTHERFORD-2 study was a large world-wide multinational study of the use of the PCSK9-inhibitor, evolocumab, in over 300 patients with heterozygous familial hypercholesterolaemia (HeFH). Evolocumab administered either 140 mg biweekly or 420 mg monthly as a subcutaneous injection, much like an insulin injection, was well tolerated with minimal side effects, and markedly reduced levels of LDL cholesterol or “bad cholesterol” by over 60% compared to placebo.
02 Oct Prior Cancer Excludes Many Patients From Lung Cancer Trials
MedicalResearch.com Interview with:
Dr. David Gerber MD
Associate Professor of Internal Medicine
Division of Hematology and Oncology
Harold C. Simmons Cancer Center at UT Southwestern Medical Center
Medical Research: What are the main findings of the study?
Dr. Gerber: Fewer than 3% of adult cancer patients in the United States are enrolled in clinical trials. Increasingly numerous and stringent eligibility criteria are a major factor limiting participation in clinical trials. We examined the longstanding and widespread practice of excluding patients with prior cancer from oncology clinical trials. This policy presumably reflects concerns that a prior cancer would interfere with the conduct, outcomes, or interpretation of a clinical trial, although there is no clear evidence supporting that assumption.
We examined more than 50 National Cancer Institute (NCI)-sponsored lung cancer clinical trials. We found that 80% excluded patients with prior cancers. This exclusion criterion was applied broadly, including to more than two-thirds of trials with non-survival endpoints. We then examined national Surveillance Epidemiology and End Results (SEER)-Medicare linked data to estimate the proportion of patients who would be excluded from these trials due to prior cancer. We found that up to 18% of potential patients are excluded for this reason alone. In large phase 3 clinical trials, that corresponds to more than 200 patients.
02 Oct Foods With Polyunsaturated Fat May Decrease Risk of Coronary Heart Disease
For MedicalResearch.com
Jyrki Virtanen, PhD
Adjunct Professor of Nutritional Epidemiology
University of Eastern Finland
Kuopio, Finland
Medical Research: What are the main findings of the study?
Dr. Virtanen: The main finding was that saturated fat intake was not an independent risk factor for Coronary Heart Disease even in a population with relatively high average saturated fat intake, like in this population with middle-aged and older men from Eastern Finland. In other words, intake of carbohydrates in place of saturated fat was not associated with lower risk, not even when the quality of carbohydrates was taken into account. Only when polyunsaturated fat replaced saturated fat in the diet, was the risk of Coronary Heart Disease, especially Coronary Heart Disease mortality, lower. In fact, also replacing trans fat or carbohydrates with polyunsaturated fat was associated with lower risk. The associations were similar with both n-6 and n-3 polyunsaturated fatty acids.
Trans fat intake was not associated with the Coronary Heart Disease risk, but that is most likely explained by the low intake of trans fat in Finland already in mid-1980s.
We also investigated the associations of the fatty acid intake with carotid artery atherosclerosis, and the results were generally similar to the findings with incident Coronary Heart Disease events.
02 Oct FDG PET/CT May Improve Staging In Young Breast Cancer Patients
MedicalResearch.com Interview with:
Gary Ulaner, MD, PhD
Assistant Attending Radiologist
Memorial Sloan Kettering Cancer Center
Assistant Professor of Radiology, Weill Cornell Medical School
Chair, Radiology Research Committee
Medical Research: What are the main findings of the study?
Dr. Ulaner: FDG PET/CT revealed distant metastases in 17% of asymptomatic stage IIB breast cancer patients below 40 years of age. Although NCCN guidelines recommend against systemic staging in patients with stage II disease, our data suggests that PET/CT might be valuable in younger patients at earlier stages of disease than previously expected.
01 Oct Sildenafil May Cause Visual Problems in Genetically Predisposed
MedicalResearch.com Interview with:
Dr. Michael Kalloniatis
School of Optometry and Vision Science, UNSW Australia, Sydney, New South Wales, Australia; Centre for Eye Health, Sydney, New South Wales, Australia;
Medical Research: What are the main findings of the study? What was most surprising about the results?
Dr. Kalloniatis: Normal mice given a single sildenafil treatment had a transient loss of visual function which recovered in two days. Carrier mice (mice which carry a single copy of a mutation that commonly causes recessive Retintis Pigmentosa) showed a supernormal visual response (a response much larger than the norm) to sildenafil which took two weeks to recover to normal. Carrier mice also showed an increase in an early marker for apoptosis (a protein which suggest cells may be preparing to die) suggesting sildenafil may cause retinal degeneration in these mice.
01 Oct Benzodiazepines May Adversely Affect ICU Patients On Ventilators
MedicalResearch.com Interview with:
Nick Lonardo, PharmD
Pharmacy, Clinical Coordinator
Department of Pharmacy Services
Salt Lake City, Utah 84132
Medical Research: What are the main findings of the study?
Dr. Lonardo: To our knowledge, this is the first, large, multicenter, retrospective cohort study to show that continuous infusion benzodiazepines are independently associated with increased mortality in mechanically ventilated ICU patients. In addition, benzodiazepines were associated with an increased time of mechanical ventilation and ICU length of stay.
01 Oct Bioprosthetic vs Mechanical Aortic Valves: Similar Safety, Different Complications
MedicalResearch.com Interview with: Joanna Chikwe MD Associate Professor Department of Cardiovascular Surgery Mount Sinai Medical Center and Natalia N. Egorova, PhD Department of Health Evidence and Policy, Icahn School of Medicine at Mount Sinai New York, New York Medical Research: What are the main findings of the study? Answer: This is one of the largest studies to date on the long-term outcomes of patients after aortic valve replacement. We found that bioprosthetic valves are as safe as mechanical valves in younger patients (age 50-69) - specifically, long-term death rates and stroke risk were very similar in patients who had either valve type. The main differences lay in the risk of other long-term complications: patients who had bioprosthetic valves were more likely to need repeat surgery in the long-term, whereas patients who had mechanical valves were more likely to experience a major bleeding event.01 Oct New HPV Vaccine Has Potential To Prevent Nearly All Cervical Pre-Cancers
MedicalResearch.com Interview with:
Elmar A. Joura, MD
Department of Gynaecology and Obstetrics
Medical University of Vienna, Comprehensive Cancer Center
Vienna, Austria
Medical Research: What are the main findings of the study?
Dr. Joura: The upcoming ninevalent vaccine has the potential to prevent 85% of the cervical precancers and surgeries such as LEEP (conization)
01 Oct NSAIDS May Increase Risk of Venous Thromboembolism
MedicalResearch.com Interview with:
Patompong Ungprasert, MD
Division of Rheumatology
Mayo Clinic, MN
Medical Research: What are the main findings of the study?
Dr. Ungprasert: We find a statistically significant association between NSAIDs (non-steroidal anti-inflammatory drugs) use and VTE (venous thromboembolism).
01 Oct Physical Activity Less Helpful In Preventing Diabetes For Those At Greatest Genetic Risk
MedicalResearch.com Interview Invitation with:
Dr. Yann C Klimentidis, PhD
Assistant professor of Epidemiology and Biostatistics
Mel and Enid Zuckerman College of Public Health
University of Arizona Medical Center
Medical Research: What are the main findings of the study?
Dr. Klimentidis: The main finding is that the association of physical activity with type-2 diabetes risk is weakest among those who are at high genetic risk for type-2 diabetes. Furthermore, we find that this trend is stronger among women as compared to men, and that it appears to be driven mainly by genetic risk to insulin resistance, as opposed to genetic risk for reduced beta-cell function.