Author Interviews, BMJ, Endocrinology, General Medicine / 14.02.2014

Simon D. Brandt, PhD Reader in Bioactive Drug Chemistry School of Pharmacy & Biomolecular Sciences Liverpool John Moores University Liverpool, L3 3AF, UK Associate Editor "Drug Testing and Analysis" (Wiley)MedicalResearch.com Interview with: Simon D. Brandt, PhD Reader in Bioactive Drug Chemistry School of Pharmacy & Biomolecular Sciences Liverpool John Moores University Associate Editor "Drug Testing and Analysis" (Wiley)Author's background comment:This type of work represents one of our areas of activity related to multi-disciplinary approaches to harm reduction which combines public health work with research on various properties of bioactive substances.MedicalResearch.com: What are the main findings of the study?Answer: As part of our work related to so-called lifestyle and image-enhancing drugs and legal highs/bath salts, we became interested in a particular "food/dietary supplement" called "Esto Suppress" because it was discussed on some Internet forums dedicated to the topic of bodybuilding. Some forum members were speculating that tamoxifen might be present in this particular product. The reason for this speculation came from the chemical name that was written on the label which pointed in that direction. This particular product was also widely available from a number of online retailers and while some indications existed that the same chemical name was mentioned, others were seen to list a modified version of that name which did not always make much chemical sense. We test purchased four "Esto Suppress" samples in a local fitness store and confirmed that three of them contained the breast cancer drug tamoxifen. (more…)
Author Interviews, BMJ, Exercise - Fitness / 14.02.2014

Medical Research.com Interview with: James Woodcock Senior Research Associate UK CRC Centre for Diet and Activity Research MRC Epidemiology Unit, University of CambridgeMedicalResearch.com: What are the main findings of the study?Dr. Woodcock: The cycle hire scheme in London has benefited health through increasing physical activity. This reduces risk from a range of diseases including heart disease, type 2 diabetes, and depression. These benefits were at a population level bigger than the harms the cyclists faced from injury risk or air pollution exposure. Looking at the harms air pollution did not make much difference. The injury risk for users of the hire bikes appears to not be higher and may be lower than that for general cycling in the same area. However, the injury risks for general cycling in the cycle hire zone were quite high and benefits for cyclists would be greater if these risks were reduced. When we broke results for general cycling in the area down by age & gender we found two interesting findings. Firstly, that the risks faced by women were higher than for men and so benefits were less clear. Secondly, when we looked at results by age group the trade-off improved very considerably as people got older and for younger people (under 30) there may actually be harms. (more…)
Author Interviews, Flu - Influenza, Pediatrics / 14.02.2014

Philip M. Polgreen, MD, MPH. Associate Professor of Internal Medicine - Infectious Diseases University of Iowa Carver College of MedicineMedicalResearch.com Interview with:Philip M. Polgreen, MD, MPH. Associate Professor of Internal Medicine - Infectious Diseases University of Iowa Carver College of MedicineMedicalResearch.com: What are the main findings of the study?Dr. Polgreen:In this paper, to determine if well-child visits are associated with increased risk for subsequent influenza-like-illness visits, we used a large database that tracks healthcare expenditures of families over time. Controlling for other factors such as the presence of other children, insurance and demographics, we found that well-child visits were a risk factor for subsequent influenza-like-illness within the next two weeks for a patient or for a family member. The estimated probability of a subsequent influenza-like illness visit was increased by 3.2 percentage points for those with well-child visit. We estimated that this additional risk translates to over 700,000 cases of influenza-like-illness per year in the United States. Total costs (lost wages, medical costs, etc.) for these infections could amount to $500 million annually. (more…)
Author Interviews, Dental Research, Diabetes, Diabetes Care / 14.02.2014

ayse_basak_cinarMedicalResearch.com Interview with: Ayse Basak Cinar, Assistant Professor The Department of Odontology The Faculty of Medical and Health Resources 2200 Copenhagen N DenmarkMedicalResearch.com: What are some of the unique or enlightening findings of this study that haven’t been published before?Answer: To our knowledge, this is the first randomized controlled intervention study comparing the impact of individualized Health Coaching (HC) to formal Health Education (HE); applying HC as a holistic intervention for management of more than one specific type of chronic disease, namely oral health and diabetes management.The present study has two phases [the Turkish Phase, Turkey (2010-2012) and the Danish Phase, Denmark (2012- ...)]. The unique/enlightening figures from the Turkish phase as follows:The HC group compared to the HE group had significantly higher improvement at;HbA1c* (reduction: 0, 8% vs. 0%), and Periodontal Attachment Loss (PAL) (56% vs. 26%), (p≤0.01)Tooth Brushing Self-Efficacy (TBSE) (increase: 61% vs.25%) and stress (reduction: 16% vs. 1%), (p≤0.01). (more…)
Author Interviews, Heart Disease, Vitamin D / 14.02.2014

Eirik Magnus Meek Degerud Department of Clincal Medicine University of BergenMedicalResearch.com Interview with: Eirik Magnus Meek Degerud Department of Clincal Medicine University of Bergen MedicalResearch.com: What are the main findings of the study?Answer: That among patients with established coronary artery disease there was no observable relationship between the amount of vitamin D circulating in their blood and the extent of disease progression during the following year.(more…)
Author Interviews, BMJ, Primary Care, Pulmonary Disease / 13.02.2014

Professor Chris van Weel Emeritus Professor of Family Medicine/General Practice Radboud University Nijmegen, The Netherlands Professor of Primary Health Care Research, Australian National University, Canberra Past President of WoncaMedicalResearch.com: Interview with: Professor Chris van Weel Emeritus Professor of Family Medicine/General Practice Radboud University Nijmegen, The Netherlands Professor of Primary Health Care Research, Australian National University, CanberraBackground from Professor Chris van WeelThank you for the opportunity to respond to your questions. My paper was a commentary to the study of Jones and colleagues, Opportunities to diagnose chronic obstructive pulmonary disease in routine care in the UK: a retrospective study of a clinical cohort looking at the implications of the study findings.MedicalResearch.com: What are the main findings of the study?Answer: Jones and colleagues reported that in the UK, there are many missed opportunities to diagnose COPD. My comments are that this is not a unique UK problem, but a universal one: under-diagnosis or late diagnosis of COPD is a universal problem in most if not all countries in the world.To understand it, it is important to analyse more in-depth the diagnostic challenge in primary care, for general practitioners(GP)/family physicians (FP). The paper of Jones highlights this diagnostic problem - symptoms of COPD are initially insidious and may fluctuate over time. And from my earlier research it is also clear that patients 'adept' their daily activities (less physical activities) and therefore may underplay or even become unaware of, their symptoms.At the same time, this is a problem for the physician, when encountering these symptoms. As I highlighted in my commentary, GPs/FPs have to pay attention to other possible diseases that might cause these symptoms: pneumonia, heart failure, lung cancer. The 'low key symptoms' and the need of applying a broad diagnostic scope together cause what Jones and his colleagues called the 'missed opportunities' to diagnose COPD. (more…)
Author Interviews, HPV, Outcomes & Safety / 13.02.2014

Craig Meyers, Ph.D. Distinguished Professor Department of Microbiology and Immunology H107 The Penn State College of Medicine Hershey, PA 17033MedicalResearch.com Interview with: Craig Meyers, Ph.D. Distinguished Professor Department of Microbiology and Immunology H107 The Penn State College of Medicine Hershey, PA 17033MedicalResearch.com: What are the main findings of the study?Dr. Meyers: The human papillomavirus type 16 (HPV16) is the most common HPV type associated with human cancer. It has always been assumed that HPV16 was susceptible to commonly used disinfectants. However, this has never been tested. We developed the only reproducible method to grow authentic HPV in the laboratory. Our studies show that highly resistant virus; more so than other non-enveloped viruses previously tested. Simply stated that any materials in a healthcare facility that rely on disinfectants (those presently used by healthcare facilities) do absolutely nothing to HPV. This suggests the possibility of risk of infection from inanimate objects, particularly those use in healthcare and dental clinics that depend on disinfectant treatment. Additionally it has been reported that at any one time 20% of individuals with anogenital HPV infections have the virus on their fingertips and the common hand sanitizers do nothing to inactivate the virus. (more…)
Author Interviews, BMJ, Breast Cancer, Mammograms / 13.02.2014

Anthony Miller, MD Director, Canadian National Breast Screening Study Professor Emeritus, Dalla Lana School of Public Health University of TorontoMedicalResearch.com Interview with:Anthony Miller, MD Director, Canadian National Breast Screening Study Professor Emeritus, Dalla Lana School of Public Health University of TorontoMedicalResearch.com: What are the main findings of the study?Prof. Miller: The study involved 89,835 women aged 40 to 59. All underwent an annual physical breast examination, while half were randomly assigned to undergo annual mammograms for five years, beginning in 1980.During the five-year screening period, 666 invasive breast cancers were diagnosed in the mammography arm and 524 in the controls. Over the 25 year follow-up 180 women in the mammography arm and 171 women in the control arm died of breast cancer. The overall hazard ratio for death from breast cancer diagnosed during the screening period associated with mammography was 1.05 (95% CI: 0.85 – 1.30). The findings for women aged 40-49 and aged 50-59 were almost identical.After 15 years of follow-up an excess of 106 cancers was observed in the mammography arm, attributable to over-diagnosis, i.e. 22% of screen-detected invasive breast cancers, half of those detected by mammography alone. This represents one over-diagnosed breast cancer for every 424 women screened by mammography.By 2005, 3,250 of the 44,925 women in the mammography arm of the study were diagnosed with breast cancer, and 500 had died of it. The control group of 44,910 women had 3,133 breast cancer diagnoses and 505 breast cancer deaths.We conclude that annual mammography in women aged 40-59 does not reduce mortality from breast cancer beyond that of physical examination or usual care when adjuvant therapy for breast cancer is freely available.(more…)
Author Interviews, Dermatology, JAMA, University of Pennsylvania / 13.02.2014

Dr. Misha A. Rosenbach Assistant Professor of Dermatology Hospital of the University of Pennsylvania Section Editor, JAMA Dermatology Patient PageMedicalResearch.com Interview with:Dr. Misha A. Rosenbach Assistant Professor of Dermatology Hospital of the University of Pennsylvania Section Editor, JAMA Dermatology Patient PageMedicalResearch.com: What are the main findings of the study?Dr. Rosenbach: There is strong agreement between teledermatologists and in-person dermatologists when evaluating inpatients at a tertiary care academic hospital. The primary aim of this study was to assess telederm as a triage tool. Many dermatologists are not full-time hospitalists, but work in private practice or clinics which may be remote from affiliated hospitals. The goal was to evaluate whether teledermatology could help those providers assess the acuity of inpatient consults. There was strong concordance. (more…)
Author Interviews, Johns Hopkins, NEJM / 13.02.2014

MedicalResearch.com Interview with:Dr. Richard P. Allen Department of Neurology Johns Hopkins University Baltimore, MD 21224,MedicalResearch.com: What are the main findings of the study?Dr. Allen: This study should serve to change medical practice by reducing use of pramipexole and ropinirole to avoid the insidious worsening of restless legs syndrome that occurs for many on these drugs.Pramipexole (Mirapex) a medication that mimics dopamine in the brain in usual therapeutic doses for treatment of restless legs syndrome (RLS) works at first but over time one year makes the disease worse for up to 9% of the patients on 0.5 mg a day.Pregabalin (Lyrica) an anti-convulsant and pain drug that works on a calcium channel in the brain in therapeutic dose for RLS (300 mg a day) does not make the disease worse (There is some natural progression of the disease shown to occur fro 1 - 2% or patients over a year.. seen in this study).Pregabalin is in the short run as effective as pramipexole (over 12 weeks) and in the long run over 52 weeks more effective.These results confirm what had been expected that the dopamine drug pramipexole makes worse Restless Legs Syndrome while a drug not directly acting on the dopamine system does NOT make restless legs syndrome worse.(more…)
Author Interviews, BMJ, Cost of Health Care, Electronic Records / 13.02.2014

Dr Sarah Slight, School of Medicine Pharmacy and Health, Wolfson Research Institute University of Durham, United Kingdom.MedicalResearch.com Interview with; Dr Sarah Slight, School of Medicine Pharmacy and Health, Wolfson Research Institute University of Durham, United Kingdom. MedicalResearch.com: What are the main findings of the study?Dr. Slight: Our study identified four main cost categories associated with the implementation of EHR systems, namely: infrastructure (e.g., hardware and software), personnel (e.g., project management and training teams), estates / facilities (e.g., furniture and fittings), and other (e.g., consumables and training materials). Many factors were felt to impact on these costs, with different hospitals choosing varying amounts and types of infrastructure, diverse training approaches for staff, and different software applications to integrate with the new system. (more…)
Addiction, BMJ, Tobacco Research / 13.02.2014

dr_jenny_hatchardMedicalResearch.com Interview with:Dr Jenny L Hatchard University of Bath and UK Centre for Tobacco and Alcohol Studies MedicalResearch.com: What are the main findings of the study?Dr. Hatchard: Our study found that global tobacco companies’ claims that standardised packaging ‘won’t work’ should be viewed sceptically.The aim of standardised packaging, with no logos, brand imagery, symbols, or promotional text, is to restrict the already limited opportunities that tobacco companies have to market their products, and deter people from starting smoking. It was introduced in Australia in 2012 and the UK Government is currently considering following suit.We analysed the evidence cited by four global tobacco companies in their lengthy responses (1521 pages in total) to a recent UK Government consultation on standardised packaging for cigarettes. (more…)
Author Interviews, BMJ, Outcomes & Safety / 13.02.2014

Professor Yi Min Xie, FTSE, FIEAust Director, Centre for Innovative Structures and Materials Deputy Head of School, Research & InnovationMedicalResearch.com Interview with:Professor Yi Min Xie, FTSE, FIEAust Director, Centre for Innovative Structures and Materials Deputy Head of School, Research & Innovation School of Civil, Environmental and Chemical Engineering Royal Melbourne Institute of Technology (RMIT University) Melbourne 3001, Victoria AustraliaMedicalResearch.com: What are the main findings of the study?Professor Yi Min Xie: This study examined acupuncture needles of two of the most popular brands in the world. Significant surface irregularities and defects at needle tips were found, especially of needles from one of the two brands. The main conclusion of the study was that acupuncture needle manufacturers, including the well established ones, should review and improve their quality control procedures for the fabrication of acupuncture needles. (more…)
Author Interviews, Pulmonary Disease / 13.02.2014

MedicalResearch.com Interview with:Erika J. Sims, PhD Senior Researcher Research in Real Life Ltd Cambridge, CB24 3BARupert C M Jones MD Plymouth University Peninsula School of Medicine and Dentistry, Plymouth, UKProf David Price MD Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UKMedicalResearch.com: What are the main findings of the study?Authors: The main findings are that the majority of patients with COPD identified in our study, had visited their doctor with respiratory symptoms prior to the diagnosis being made, but that the underlying cause of their symptoms - COPD - wasn't diagnosed. Indeed, in the 5 years before being diagnosed with COPD, 85% of patients had visited their doctors with respiratory problems without the diagnosis being made. Furthermore, some patients repeatedly attended and received treatment and multiple chest X-rays before they had the diagnosis made. We also identified a large increase in the proportion of patients with comorbidity over the duration of the study, and that patients with comorbidity appear to be being diagnosed with COPD at any earlier stage. As this study includes data on 38,000 people with a diagnosis of COPD identified from two large general practice databases in the UK - Optimum Patient Care Research Database and Clinical Practice Research Datalink, we believe our findings are generalisable to UK and international primary and secondary care. (more…)
Author Interviews, Hospital Acquired / 12.02.2014

Patricia W. Stone, PhD, FAAN Columbia University School of Nursing New York, NY 10032.MedicalResearch.com Interview with:Patricia W. Stone, PhD, FAAN Columbia University School of Nursing New York, NY 10032. MedicalResearch.com: What are the main findings of the study?Dr. Stone: Our study found variation in the presence of infection control policies directed at central-line bloodstream infections, ventilator-associated pneumonia and catheter-associated urinary tract infections. Even when present, the policies were adhered to only about half of the time. (more…)
Author Interviews, HPV, JAMA, Karolinski Institute, Vaccine Studies / 12.02.2014

Lisen Arnheim Dahlström Associate Professor (Docent) Institutionen för medicinsk epidemiologi och biostatistik Department of Medical Epidemiology and Biostatistics Karolinska Institutet SwedenMedicalResearch.com Interview with: Lisen Arnheim Dahlström Associate Professor (Docent) Institutionen för medicinsk epidemiologi och biostatistik Department of Medical Epidemiology and Biostatistics Karolinska Institutet SwedenMedicalResearch.com: What are the main findings of the study?Answer: The main finding, when studying HPV vaccine effectiveness against condyloma by dose level is that 3 doses offered the maximum protection, although 2 doses also offered a substantial protection. (more…)
Author Interviews, Breast Cancer, Journal Clinical Oncology, Radiation Therapy, Sloan Kettering, Surgical Research / 12.02.2014

dr_monica_morrow MedicalResearch.com Interview Invitation with:Monica Morrow MD Anne Burnett Windfohr Chair of Clinical Oncology Chief Breast Service memorial Sloan Kettering Cancer Center MedicalResearch.com: What are the main findings of the study?Dr. Morrow:The study is the report of a Consensus panel examining the question of whether more widely clear lumpectomy margins than no ink on tumor decrease local recurrence. A metaanalysis of published literature was used as the primary evidence base for the conclusion. (more…)
Author Interviews, Exercise - Fitness, Sleep Disorders / 12.02.2014

MedicalResearch.com Interview with:Matthew Buman PhD School of Nutrition and Health Promotion, Arizona State University Arizona State University, School of Nutrition and Health Promotion Phoenix, AZMatthew BumanPhD School of Nutrition and Health Promotion, Arizona State University Arizona State University, School of Nutrition and Health Promotion Phoenix, AZMedicalResearch.com: What are the main findings of the study?Dr. Buman: We found that that exercise at night (within 4 hours of bedtime) was not associated with poor sleep compared with individuals that did not exercise before bed. However, we also found that morning exercise appears to be associated with optimal sleep quality. (more…)
Author Interviews, Breast Cancer, Cancer, Smoking / 12.02.2014

MedicalResearch.com Interview with: Masaaki Kawai MD, PhD Division of Public Health Sciences, Fred Hutchinson Cancer Research Center Seattle, WashingtonMedicalResearch.com: What are the main findings of the study?Answer: Ever-smokers had a 1.3-fold increased risk of breast cancer. They also had a 1.4-fold increased risk of ER-positive breast cancer. Current/recent smokers with a 10 pack-year history of smoking had a 1.6-fold increased risk of ER-positive breast cancer. (more…)
Author Interviews, Diabetes, Lancet, Nutrition / 12.02.2014

MedicalResearch.com Interview with: Kirstie Bell Diabetes Dietitian, CDE & PhD Candidate Human Nutrition Unit The University of SydneyMedicalResearch.com: What are the main findings of the study?Answer: Overall, the evidence to support carbohydrate counting is limited, with current data showing a non-significant improvement in HbA1c. Pooled results from 7 quality randomised control trials studies showed carbohydrate counting had no significant effect on glycemic control (-0.35%, p = 0.096). There was a significant improvement in HbA1c of 0.64% points in studies in adults that were conducted in a parallel design.This is the first meta-analysis of carbohydrate counting in type 1 diabetes. Up until now, it has not been known what improvement in glycemic control can be expected. Current international guidelines for diabetes management have been based merely on gradings of the available evidence. However, assessing the overall effectiveness of carbohydrate counting is critical in clinical practice to guide medical and dietary management decisions. (more…)
Author Interviews, JAMA, Menopause, Sexual Health, University of Pittsburgh / 11.02.2014

MedicalResearch.com Interview with: Holly Thomas, MD General Internal Medicine Fellow, Women's Health and Clinical Research University of Pittsburgh Pittsburgh, PA 15213MedicalResearch.com: What are the main findings of the study?Dr. Thomas: We found that, despite popular perception, the majority of women (85%) who are sexually active at midlife will remain sexually active four years later. We also found that the majority of women score low on a measure of sexual function. However, low sexual function scores did not mean women stopped having sex. In fact, the score on the sexual function measure did not predict whether women maintained sexual activity. Finally, we found that importance of sex was a strong predictor of whether women remained sexually active. Women who felt sex was moderately to extremely important in their lives were 3 times more likely to maintain sexual activity. (more…)
Author Interviews, Critical Care - Intensive Care - ICUs, Duke, Flu - Influenza, Vaccine Studies / 11.02.2014

Dr Cameron Wolfe MBBS(Hons), MPH Assistant Professor of Medicine Clinical / Transplant Infectious Diseases Duke University Medical CenterMedicalResearch.com Interview with:Dr Cameron Wolfe MBBS(Hons), MPH Assistant Professor of Medicine Clinical / Transplant Infectious Diseases Duke University Medical Center MedicalResearch.com: What are the main findings of the study?Dr. Wolfe: The major findings of the study were that at least in our center, there was a significant burden of critical illness due to H1N1 influenza infection. The average age of the patients admitted to the hospital was just 28yrs, consistent with the younger patient age in 2009 when H1N1 emerged. Most critically, we also observed a significantly lower rate of influenza vaccine uptake in patients admitted to the Intensive Care Units at our center. (more…)
Author Interviews, Gastrointestinal Disease, Pediatrics / 11.02.2014

Jim Tsung, MD, MPH Department of Emergency Medicine Mount Sinai School of Medicine Guggenheim Pavilion 1 Gustave Levy Place Box 1149 New York, NY 10029MedicalResearch.com Interview with: Jim Tsung, MD, MPH Department of Emergency Medicine Mount Sinai School of Medicine Guggenheim Pavilion New York, NY 10029MedicalResearch.com: What are the main findings of the study? Dr. Tsung:1. Point-of-care ultrasound performed by clinicians was as accurate as ultrasound performed in the radiology department for evaluating appendicitis in children.2. This led to significant reductions in emergency department stays when point-of-care ultrasound was able to contribute to the decision to send the patient to the operating room or to discharge home without further imaging studies. On average, a 2 hour (46%) reduction in ED LOS for patients only requiring radiology ultrasound and a 6 hour (68%) reduction in ED LOS for patients that needed CT scan.3. Point-of-care ultrasound can also reduce the rate of CT scans obtained when used as a front-line test, 44% to 27%. (more…)
Author Interviews, C. difficile, Gastrointestinal Disease / 10.02.2014

Stephanie Angione PhD Candidate Brown University School of Engineering Center for Biomedical EngineeringMedicalResearch.com Interview with: Stephanie Angione PhD Candidate Brown University School of Engineering Center for Biomedical EngineeringMedicalResearch.com: What are the main findings of the study?Answer: This study demonstrates the application of a novel nucleic acid detection platform to detect Clostridium difficile (C. difficile)in subjects presenting with acute diarrheal symptoms. This method amplifies three genes associated with C. difficile infection as well as genes associated with virulence attributed to the NAP1/027/BI strain. The novel PCR assay allows for simple and rapid detection of three C. difficile genes: tcdB, cdtB, and tcdC, which code for C. difficile toxin B, C. difficile binary toxin, and a protein suspected to regulate toxin production, which includes the NAP1/027/BI tcdC variant. Amplification of DNA from the tcdB, tcdC and cdtB genes can be carried out using a droplet sandwich platform that performs real-time polymerase chain reaction (PCR) in microliter droplets for the detection and identification of amplified fragments of DNA. Our technique of multiplex gene amplification provides a unique method that is both sensitive and specific to rapidly detect C. difficile in patient stool samples that can be adapted to point-of-care testing. (more…)
Alcohol, Author Interviews, Lancet / 10.02.2014

Dr John Holmes PhD, MA, BA (Hons) (York) Section of Public Health, ScHARR, University of Sheffield, Sheffield S1 4DA, UKMedicalResearch.com with:Dr John Holmes PhD, MA, BA (Hons) (York) Section of Public Health, ScHARR, University of Sheffield, Sheffield S1 4DA, UK MedicalResearch.com: What are the main findings of the study?Dr. Holmes:The study aimed to examine which groups in society would be affected by a 45p minimum unit price for alcohol. This was in response to concerns expressed by, among others, the UK Government that the policy may not tackle harmful drinking and may penalise responsible drinkers.We found no support for these concerns. As the policy targets the cheap alcohol which is disproportionately purchased by those drinking at harmful levels, the effects are mainly felt by those at greatest risk of suffering harm from their drinking. On the other hand, moderate drinkers, including those on low incomes, buy very little of this cheap alcohol so are relatively unaffected. (more…)
Author Interviews, CMAJ, OBGYNE / 10.02.2014

MedicalResearch.com Interview with:Dr. Sharon Daniel MD, MPH Physician, Intern in pediatrics at Soroka Medical Center, Beer-Sheva, Israel PhD Candidate and Prof. Amalia Levy (MPH, PhD Epidemiologist, Head of the Department of Public Health Principle Investigator. Ben-Gurion University of the Negev in Beer-Sheva, Israel,MedicalResearch.com: What are the main findings of the study?Answer: We tested the risk for miscarriage following the use of NSAIDs (ibuprofen, diclofenac, naproxen, indomethacin, etodolac) on the first trimester of pregnancy. We did not find increased risk among women who took those drugs during the first trimester of pregnancy, although we did find increased risk after the use of indomethacin. We found higher risk after the use of specific NSAIDs (Celecoxib, Rofecoxib, Etoricoxib) which are usually used to treat inflammatory diseases, only the exposure group was very small. (more…)
Author Interviews, CHEST, Pediatrics, Sleep Disorders / 10.02.2014

David Gozal, MD The Herbert T. Abelson Professor and Chair Department of Pediatrics Physician-in-Chief, Comer Children's Hospital The University of Chicago Chicago, IL 60637MedicalResearch.com Interview with:David Gozal, MD The Herbert T. Abelson Professor and Chair Department of Pediatrics Physician-in-Chief, Comer Children's Hospital The University of Chicago Chicago, IL 60637MedicalResearch.com: What are the main findings of the study?Dr. Gozal: Our study shows that in children with mild obstructive apnea, treatment with an anti-inflammatory combination of 2 medications, namely nasal corticosteroid and oral montelukast is associated with favorable outcomes in the vast majority of the children. Thus, rather than pursue treatment with adenotonsillectomy as is currently the case in most places, this study paves the way for non-surgical alternative therapies in pediatric OSA. (more…)
Author Interviews, Heart Disease / 10.02.2014

Bríain ó Hartaigh, Ph.D. Assistant Research Professor of Epidemiology Dalio Institute of Cardiovascular Imaging Weill Cornell Medical CollegeMedicalResearch.com Interview with: Bríain ó Hartaigh, Ph.D. Assistant Research Professor of Epidemiology Dalio Institute of Cardiovascular Imaging Weill Cornell Medical College MedicalResearch.com: What are the main findings of the study?Answer: Sustained elevations in resting heart rate measured longitudinally over the course of 6 years were strongly and independently associated with a greater risk of death from all causes in adults aged 65 years or older. (more…)
Accidents & Violence, Author Interviews, Johns Hopkins / 10.02.2014

MedicalResearch.com Interview with study leaders:Shalini Selvarajah MD, MPHPostdoctoral Research Fellow Center for Surgical Trials and Outcomes Research Department of Surgery Johns Hopkins University School of Medicine Baltimore, MD 21287 andEdward R. Hammond, MD, PhD, MPHResearchAssociate International Center for Spinal Cord Injury Hugo W. Moser Research Institute at Kennedy Krieger Institute Baltimore, MD 21205.MedicalResearch.com: What are the main findings of the study?Researchers:· Between 2007 and 2010, the number of serious traumatic spinal cord injuries (TSCI) in the United States (U.S.) increased, doing so more rapidly among older adults (age ≥65 years) compared to younger adults (age <65 years). Injuries from falls have overtaken motor vehicle crashes as the main cause of adult TSCI.· Older adults are more likely to experience worse outcomes compared to younger adults even after taking into account severity and mechanism of injury, as well as other co-morbid conditions. Older adults are 4 times more likely to die in the emergency room, and if admitted to inpatient care, they are 6 times more likely to die as inpatients compared to younger adults.· Emergency room charges for treatment of acute TSCI among adults increased 20% from $3,342 per encounter in 2007 to $4,024 per encounter in 2010 even after accounting for the cost of inflation.(more…)
General Medicine, Vanderbilt / 10.02.2014

Dr. Scott L. Zuckerman, MD Department of Neurological Surgery Vanderbilt Sports Concussion CenterMedicalResearch.com Interview with:Dr. Scott L. Zuckerman, MD Department of Neurological Surgery Vanderbilt Sports Concussion Center MedicalResearch.com: What are the main findings of the study?Dr. Zuckerman: Our study evaluated 244 athletes who suffered sports-related concussion (SRC), 122 males and 122 females, and assessed for gender differences in number, severity, and resolution of post-concussive symptoms using reliable change index (RCI) methodology applied to days to return to symptom baseline. Both groups were matched on number of prior concussions, age, and days to first post-concussion assessment, which consisted of the 22 symptom Post Concussion Symptom Checklist from the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) evaluation tool. (more…)