Bipolar Disorder, Cocaine / 16.05.2025
What Is the Relationship Between Bipolar Disorder and Cocaine Addiction?
Introduction
In recent years, sound therapy has stepped into the limelight not only as an age-old spiritual activity but also as a complementary healing asset backed by emerging medical research. Among the most interesting tools applied in this area are singing bowls which have quite pleasing vibrations and a strong feel. Coming from the Himalayan area, these carefully made metal bowls are now used all over the globe in wellness centers, yoga studios, and even some clinical places. This paper will look into how sound therapy with singing bowls is important for medicine and ways it can help people stay healthy both physically and mentally.What Are Singing Bowls?
Singing bowls are metal tools normally made of a mix of seven metals. When hit or rubbed with a stick, they make deep, musical sounds that form a soothing and engaging sound space. They are often used for:- Meditation
- Pain relief
- Stress and anxiety reduction
- Sleep support
- Chakra balancing
Dental Research / 16.05.2025
7 Pros and Cons of Ceramic Veneers
[caption id="attachment_68544" align="aligncenter" width="500"] Photo By: Kaboompics.com:[/caption]
If you go to the dentist and request a veneer, they will normally give you two options. You can either get a ceramic or a porcelain one. They are both viable choices, but some dentists will recommend one over the other.
The argument over ceramic vs porcelain veneers is one that is ongoing in the dental profession, with certain individuals advocating for one, and some the other. While which one is better in the long run is a matter of opinion to some degree, there is no denying that both choices have their pros and cons.
In this article, we will discuss some of the most notable drawbacks and advantages of ceramic veneers. This list might help you make up your mind if you are facing this decision anytime soon.
Photo By: Kaboompics.com:[/caption]
If you go to the dentist and request a veneer, they will normally give you two options. You can either get a ceramic or a porcelain one. They are both viable choices, but some dentists will recommend one over the other.
The argument over ceramic vs porcelain veneers is one that is ongoing in the dental profession, with certain individuals advocating for one, and some the other. While which one is better in the long run is a matter of opinion to some degree, there is no denying that both choices have their pros and cons.
In this article, we will discuss some of the most notable drawbacks and advantages of ceramic veneers. This list might help you make up your mind if you are facing this decision anytime soon.
Ophthalmology / 16.05.2025
Eye Care Services That Come to You
[caption id="attachment_68539" align="aligncenter" width="500"] Photo by Ksenia Chernaya[/caption]
Vision care is a key part of staying healthy and independent, especially as we age. For those with mobility issues or busy schedules, traveling to an optician’s clinic can be difficult or inconvenient. The option of in-home services is becoming more popular as people seek comfort and accessibility in all aspects of their healthcare. This flexible approach brings qualified professionals and advanced equipment directly to the home, offering the same quality of care found in a traditional clinic. Whether for regular check-ups, new prescriptions, or glasses fittings, mobile eye care can adapt to individual needs. It’s a solution that combines personal attention with practical service. If you've ever delayed an eye test due to travel concerns, this may be the change you've been waiting for.
Photo by Ksenia Chernaya[/caption]
Vision care is a key part of staying healthy and independent, especially as we age. For those with mobility issues or busy schedules, traveling to an optician’s clinic can be difficult or inconvenient. The option of in-home services is becoming more popular as people seek comfort and accessibility in all aspects of their healthcare. This flexible approach brings qualified professionals and advanced equipment directly to the home, offering the same quality of care found in a traditional clinic. Whether for regular check-ups, new prescriptions, or glasses fittings, mobile eye care can adapt to individual needs. It’s a solution that combines personal attention with practical service. If you've ever delayed an eye test due to travel concerns, this may be the change you've been waiting for.
Struggling with lower back pain is common, as most of you who are working office jobs and for more than 8 hours per day can probably relate, I’ve come to understand just how important it is to take proactive steps to protect your spine.
Sitting for prolonged periods without proper support or movement can slowly wreak havoc on your posture, muscle balance, and overall comfort.
This guide walks you through five practical and effective steps you can implement right now to help prevent back pain while sitting at your desk, whether you’re working from home or in a traditional office setting.
Get a Better Office Chair
When choosing an office chair for back pain, look for one that encourages good posture, offers solid lumbar support, and is fully adjustable to fit your body. A well-designed ergonomic chair supports the natural curve of your lower back, helping to prevent slouching and reduce pressure on your spine. The seat should be deep enough to support your thighs without cutting off circulation, while the armrests should let your arms rest comfortably, easing tension in your shoulders and neck. If you're unsure where to start there are plenty of helpful resources online that explain what to look for in an ergonomic chair.
[caption id="attachment_68527" align="aligncenter" width="500"] Source: Freepik.com[/caption]
In industries like construction, warehousing, telecommunications, and maintenance, working at heights is often part of the job. But it’s also one of the most dangerous parts, requiring strict procedures, clear safety protocols, and, most importantly, proper training.
Height safety training courses are designed to give workers the knowledge and skills to handle elevated work environments safely. These courses cover a wide range of areas – let’s explore the most common ones and why they matter so much.
Source: Freepik.com[/caption]
In industries like construction, warehousing, telecommunications, and maintenance, working at heights is often part of the job. But it’s also one of the most dangerous parts, requiring strict procedures, clear safety protocols, and, most importantly, proper training.
Height safety training courses are designed to give workers the knowledge and skills to handle elevated work environments safely. These courses cover a wide range of areas – let’s explore the most common ones and why they matter so much.
Legal Responsibilities and Risk
One of the first topics that is usually covered in any height safety training course is the legal framework surrounding work at heights. You learn about workplace health and safety (WHS) laws, employer and employee responsibilities, and the potential consequences of not complying. Understanding the legal side helps workers take accountability and play their role in creating a safe environment. You can also get a Certificate IV in Work Health and Safety to explore WHS laws in more depth.
Author Interviews, Pain Research / 14.05.2025
Declines and regional variation in use of the atypical opioid tapentadol in the US
MedicalResearch.com Interview with:
[caption id="attachment_61470" align="alignleft" width="149"]
Dr. Piper[/caption]
Brian J. Piper, PhD
Department of Medical Education
Center for Pharmacy Innovation & Outcomes
Geisinger College of Health Sciences
Scranton, PA 18509
MedicalResearch.com: What is the background for this study?
Dr. Piper: Tapentadol has an unusual mechanism of action. This opioid is similar to morphine in that it activates mu, the main opiate receptor which is important for pain. This drug also acts similar to an antidepressant like duloxetine (Cymbalta) with equal ability to block both the norepinephrine and the serotonin transporters (Figure 1). The combination of opioid and monoaminergic activity may influence both therapeutic and side effect profiles.
[caption id="attachment_68512" align="aligncenter" width="192"]
Figure 1. Biological mechanism of action of the atypical opioid tapentadol involves binding to the mu opiate receptor, blocking the norepinephrine transporter (NET), and blocking the serotonin transporter (SERT) [1].[/caption]Tapentadol is approved in the US for moderate to severe acute pain, moderate to severe chronic pain, and neuropathic pain associated with diabetic peripheral neuropathy. However, tapentadol is not generally considered first-line for any of these indications. Although this agent has a high potential for abuse and is classified as a Schedule II substance, a manufacturer of extended release tapentadol (Grunenthal) has conducted a misinformation campaign claiming tapentadol has a “minimum potential of abuse”, does not cause respiratory depression (a well-known opioid effect), does not cause any euphoric feelings, has no street value, and is not an opioid [2]. Prior pharmacoepidemiological studies have examined the use patterns of other prescription opioids that can be misused like oxycodone [3], fentanyl [4], meperidine [5] and methadone [6] but there is limited national information about the use of tapentadol.
Dr. Piper[/caption]
Brian J. Piper, PhD
Department of Medical Education
Center for Pharmacy Innovation & Outcomes
Geisinger College of Health Sciences
Scranton, PA 18509
MedicalResearch.com: What is the background for this study?
Dr. Piper: Tapentadol has an unusual mechanism of action. This opioid is similar to morphine in that it activates mu, the main opiate receptor which is important for pain. This drug also acts similar to an antidepressant like duloxetine (Cymbalta) with equal ability to block both the norepinephrine and the serotonin transporters (Figure 1). The combination of opioid and monoaminergic activity may influence both therapeutic and side effect profiles.
[caption id="attachment_68512" align="aligncenter" width="192"] Figure 1. Biological mechanism of action of the atypical opioid tapentadol involves binding to the mu opiate receptor, blocking the norepinephrine transporter (NET), and blocking the serotonin transporter (SERT) [1].[/caption]Tapentadol is approved in the US for moderate to severe acute pain, moderate to severe chronic pain, and neuropathic pain associated with diabetic peripheral neuropathy. However, tapentadol is not generally considered first-line for any of these indications. Although this agent has a high potential for abuse and is classified as a Schedule II substance, a manufacturer of extended release tapentadol (Grunenthal) has conducted a misinformation campaign claiming tapentadol has a “minimum potential of abuse”, does not cause respiratory depression (a well-known opioid effect), does not cause any euphoric feelings, has no street value, and is not an opioid [2]. Prior pharmacoepidemiological studies have examined the use patterns of other prescription opioids that can be misused like oxycodone [3], fentanyl [4], meperidine [5] and methadone [6] but there is limited national information about the use of tapentadol.
Accidents & Violence, Addiction, addiction-treatment / 13.05.2025
Acadia Healthcare Treatment Addresses Connection Between Trauma and Addiction
The relationship between trauma and addiction is complex but well established. Studies show traumatic experiences, including abuse, neglect, and violence, lead to a higher likelihood of developing substance use disorders. Acadia Healthcare’s network of affiliated behavioral health facilities, offers treatment programs for those who have suffered a trauma and for patients who suffer from co-occurring conditions across behavioral health and addiction concerns.
Unfortunately, one of the common issues for many who experience trauma is the use of substances to self-medicate or manage overwhelming emotions. That’s just one of many possibly harmful outcomes of untreated trauma.
On its website, Acadia Healthcare points out PTSD can have long-lasting impacts on the lives of children, adolescents, adults, and seniors. Left untreated, post-traumatic stress disorder and other trauma-related disorders, such as acute stress disorder or adjustment disorder, can worsen.
For younger children, this can cause developmental delays, particularly in brain, speech, and language development. Without timely intervention, children and teens may experience challenges in school, forming friendships, and maintaining jobs. Some may turn to substance use. Untreated trauma in adults contributes to significant life struggles, which could include relationship breakdowns, financial instability, and addiction.
“While the effects of PTSD and other trauma-related concerns might sound overwhelming, getting professional treatment can make an individual’s symptoms manageable,” Acadia shared on its web page about PTSD treatment.
[caption id="attachment_68499" align="aligncenter" width="500"] Photo by Valeria Boltneva[/caption]
When you experience a new or sudden symptom, especially concerning the eyes, it can be quite worrying. The problem is that modern life is very fast-paced, and many people struggle to fit appointments into their day. However, your health is the most important thing of them all, and ignoring symptoms can lead to worsening problems down the road.
If you experience any of the following eye-related symptoms, book an appointment as soon as you can.
Photo by Valeria Boltneva[/caption]
When you experience a new or sudden symptom, especially concerning the eyes, it can be quite worrying. The problem is that modern life is very fast-paced, and many people struggle to fit appointments into their day. However, your health is the most important thing of them all, and ignoring symptoms can lead to worsening problems down the road.
If you experience any of the following eye-related symptoms, book an appointment as soon as you can.
Sudden Blurry Vision
Many people in the world experience blurry vision. In fact, sometimes, the solution is as simple as getting a pair of mens reading glasses. However, sudden blurry vision can be a sign of something more serious, including:- Macular Edema
- A Detached Retina
- Glaucoma
- Cataracts
Author Interviews, Gastrointestinal Disease, Hepatitis - Liver Disease / 13.05.2025
Role of Genetic Research in Advancing PSC Treatment
MedicalResearch.com discussion with:
Dr. Bertus Eksteen PhD, MBChB, FRCP
Founder of the Calgary PSC Clinic
Member of the Calgary Liver Unit and the Southern Alberta Liver Transplant Clinic
Aspen Woods Clinic
Calgary, Canada
[caption id="attachment_68489" align="aligncenter" width="500"] Dr. Bertus Eksteen[/caption]
Primary sclerosing cholangitis (PSC) is a liver disease characterized by progressive inflammation and scarring of the bile ducts. PSC still has no known cause or cure and often leads to liver failure or cancer. For patients and clinicians, the lack of answers is deeply frustrating. But that's beginning to change.
Thanks to genetic research, we’re uncovering clues about PSC’s origins—and why it behaves differently from patient to patient. By learning more about the genomic underpinnings of PSC, researchers can create new treatment targets, devise risk profiles for early diagnosis, and even develop better clinical tools for detecting the disease in its earliest stages.
And that path forward doesn’t just start with new treatments — it begins in the lab.
Dr. Bertus Eksteen[/caption]
Primary sclerosing cholangitis (PSC) is a liver disease characterized by progressive inflammation and scarring of the bile ducts. PSC still has no known cause or cure and often leads to liver failure or cancer. For patients and clinicians, the lack of answers is deeply frustrating. But that's beginning to change.
Thanks to genetic research, we’re uncovering clues about PSC’s origins—and why it behaves differently from patient to patient. By learning more about the genomic underpinnings of PSC, researchers can create new treatment targets, devise risk profiles for early diagnosis, and even develop better clinical tools for detecting the disease in its earliest stages.
And that path forward doesn’t just start with new treatments — it begins in the lab.
Genetic Clues to PSC Onset
PSC isn't directly inherited, but genetics likely play a significant role in determining who develops the disease. Several immune-related gene variations, particularly those related to the human leukocyte antigen (HLA) complex, have increased the risks of developing PSC. These variations don’t cause PSC on their own— researchers believe they interact with intestinal bacteria and other environmental factors, prompting the immune system to launch an attack on the bile ducts. Understanding these genetic foundations provides a roadmap for following this disease very early. Instead of reacting to symptoms, we can start asking why specific people are predisposed in the first place. That insight is key to prevention and long-term disease management.
In the evolving field of orthodontics, staying at the forefront of technology is essential for achieving the best patient outcomes. Recent advancements in orthodontic techniques are revolutionizing how treatments are planned and executed. From AI-driven tools to innovative materials, these developments are reshaping patient care.
As you delve into the world of modern orthodontics, it's clear that local professionals, such as an orthodontist rochester, are instrumental in integrating these advancements into daily practice, enhancing the overall patient experience. Orthodontic care has undergone significant transformations with the advent of new technologies and materials. These changes are enhancing treatment precision and improving patient satisfaction. With AI-driven treatment planning, orthodontists can predict treatment outcomes with greater accuracy, allowing for more personalized and efficient care plans. This technological evolution represents a shift towards more data-driven approaches, ensuring that each patient receives tailored treatments suited to their unique needs.
Choosing the right senior care solution is an important decision that impacts the well-being of your loved one. By considering...
Dental Research, Sleep Disorders / 09.05.2025
The Connection Between Orthodontics and Better Sleep Quality
Dental misalignment is significantly connected to temporomandibular joint (TMJ) discomfort, affecting numerous individuals. Understanding this link is essential for developing effective treatment strategies. This article explores orthodontic interventions and collaborations with physical therapy to manage TMJ-related issues effectively.
Many people experience discomfort due to malocclusion, which is a misalignment of the teeth that can lead to TMJ issues. These problems often manifest as jaw pain, headaches, and difficulty in chewing. The role of an orthodontist Houston TX becomes pivotal in addressing these concerns by providing tailored treatments that consider the unique needs of each patient. As you explore solutions for TMJ discomfort, it is essential to understand the potential impacts of orthodontic care on your overall well-being.
Have you ever wondered how memory care for seniors keeps getting better each year?
New research is helping caregivers find better ways to support older adults with memory problems. These fresh ideas bring hope and comfort to families and those they love. By using new findings, care centers can offer more help where it matters most.
Keep reading to see how these changes are making a real difference every day.
How Aging Affects Memory
As people get older, their brains may not work the same as before. It can take longer to think or find the right words to say. Some might forget names or mix up details now and then. This can feel scary, especially when it happens more often. The brain changes with age, and that's a normal part of life. It helps to stay calm and gives the person time to think. With kindness and care, you can help them feel safe and supported each day.Research-Backed Care Strategies
Helping seniors with memory loss takes patience, care, and the right support each day. Some ways work better than others, and new research helps us see what works most. People need time, clear steps, and caring voices to feel safe and calm. That's why many care homes now use specialized memory programs to guide their daily work. These programs give older adults a chance to stay active and feel more at ease. With steady care and support, many seniors can still enjoy their days in simple, meaningful ways.
Emergency Care, Health Care Workers / 09.05.2025
Top 6 Challenges Faced by NEMT Services and How They Overcome Them
[caption id="attachment_68441" align="aligncenter" width="500"] Image source[/caption]
Non-emergency medical transportation (NEMT) services are an essential part of the healthcare system. They address the transportation needs of individuals who require assistance when traveling to medical appointments, treatments, or other healthcare facilities. These services cater to a wide range of patients, including those with disabilities, chronic illnesses, or mobility challenges, as well as individuals who lack access to personal or public transportation.
However, since NEMT services operate in a complex and dynamic environment, they often require juggling multiple demands simultaneously. They must also manage vehicle fleets, comply with strict healthcare and transportation regulations, and ensure patient safety and satisfaction. On top of these challenges, rising costs and the need for modern technology can further complicate operations. Fortunately, there are numerous ways to overcome these obstacles.
In this article, we’ll delve into the challenges that NEMT providers face daily and highlight the innovative strategies they employ to overcome these obstacles.
Image source[/caption]
Non-emergency medical transportation (NEMT) services are an essential part of the healthcare system. They address the transportation needs of individuals who require assistance when traveling to medical appointments, treatments, or other healthcare facilities. These services cater to a wide range of patients, including those with disabilities, chronic illnesses, or mobility challenges, as well as individuals who lack access to personal or public transportation.
However, since NEMT services operate in a complex and dynamic environment, they often require juggling multiple demands simultaneously. They must also manage vehicle fleets, comply with strict healthcare and transportation regulations, and ensure patient safety and satisfaction. On top of these challenges, rising costs and the need for modern technology can further complicate operations. Fortunately, there are numerous ways to overcome these obstacles.
In this article, we’ll delve into the challenges that NEMT providers face daily and highlight the innovative strategies they employ to overcome these obstacles.
- System Responsiveness and Efficiency
Accidents & Violence, Author Interviews / 09.05.2025
Teens Should Drive Newer Cars with Most Safety Features to Decrease Fatal Accidents
MedicalResearch.com Interview with:
Jingzhen Ginger Yang, PhD, MPH
Principal Investigator at the Center for Injury Research and Policy
Abigail Wexner Research Institute at Nationwide Children’s Hospital
Professor of Pediatrics at The Ohio State University College of Medicine
with a courtesy appointment in the Department of Epidemiolog
in The Ohio State University College of Public Health
MedicalResearch.com: What is the background for this study?
Response: Motor vehicle crashes are the leading cause of death for U.S. teens. Newer vehicles and driver assistance technologies show promise in reducing crashes and injury severities.
Our study found that driving vehicles 6-15 years old had a 19% greater risk of driver death in fatal crashes, and driving vehicles older than 15 years had a 31% greater risk, both compared to driving vehicles 5 years old or newer, regardless of driver age. Additionally, each driver assistance technology already present in vehicles was associated with a 6% reduction in the risk of driver death in fatal crashes.
Jingzhen Ginger Yang, PhD, MPH
Principal Investigator at the Center for Injury Research and Policy
Abigail Wexner Research Institute at Nationwide Children’s Hospital
Professor of Pediatrics at The Ohio State University College of Medicine
with a courtesy appointment in the Department of Epidemiolog
in The Ohio State University College of Public Health
MedicalResearch.com: What is the background for this study?
Response: Motor vehicle crashes are the leading cause of death for U.S. teens. Newer vehicles and driver assistance technologies show promise in reducing crashes and injury severities.
Our study found that driving vehicles 6-15 years old had a 19% greater risk of driver death in fatal crashes, and driving vehicles older than 15 years had a 31% greater risk, both compared to driving vehicles 5 years old or newer, regardless of driver age. Additionally, each driver assistance technology already present in vehicles was associated with a 6% reduction in the risk of driver death in fatal crashes.
AACR, Author Interviews, Cancer Research / 08.05.2025
AACR25: Novel strategy for p53 mutant cancers leveraging their DNA damage response liabilities
MedicalResearch.com Interview with:
[caption id="attachment_68425" align="alignleft" width="150"] Dr. Andrei Bakin[/caption]
Andrei Bakin, PhD, Associate Professor of Oncology, Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center – first author of “A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response” and senior author of “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities”
Christos Fountzilas, MD, FACP, Associate Professor of Oncology, Department of Medicine, Roswell Park Comprehensive Cancer Center - and senior author of “A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response”
Mohammed Alruwaili, MS, PhD, newly graduated doctoral candidate in Cancer Genetics & Genomics at Roswell Park Comprehensive Cancer Center, first author of “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities”
Dr. Andrei Bakin[/caption]
Andrei Bakin, PhD, Associate Professor of Oncology, Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center – first author of “A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response” and senior author of “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities”
Christos Fountzilas, MD, FACP, Associate Professor of Oncology, Department of Medicine, Roswell Park Comprehensive Cancer Center - and senior author of “A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response”
Mohammed Alruwaili, MS, PhD, newly graduated doctoral candidate in Cancer Genetics & Genomics at Roswell Park Comprehensive Cancer Center, first author of “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities”
AACR, Author Interviews, Breast Cancer, Cancer Research / 08.05.2025
AACR25: New therapeutic strategy against triple negative breast cancer: Synergistic effect of tamoxifen and doxorubicin on a novel estrogen receptor
MedicalResearch.com Interview responses from:
[caption id="attachment_68422" align="alignleft" width="150"] Dr. Gokul Das[/caption]
First author Gokul Das, PhD, Professor of Oncology and Co-Director of the Breast Translational Group, Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center
Chetan Oturkar, PhD, Research Assistant Professor in the Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, first author on the study
MedicalResearch.com: What is the background for this study?
Dr. Gokul Das: Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer for which effective targeted therapies are not available, and which rapidly becomes resistant to chemotherapy. TNBC tumors are negative for estrogen receptor α (ERα), progesterone receptor (PR), and HER-2/neu receptor. Endocrine therapy or HER2-targeted therapies are not effective against TNBC. Currently available options including immunotherapy benefit only some patients. They are cost-prohibitive and have severe adverse effects. Therefore, there is an unmet need for rationally designed therapies for TNBC. Although ERα is absent in TNBC, majority of these tumors express estrogen receptor beta (ERβ), a structurally related but functionally distinct isoform of the estrogen receptor coded by a different gene. Tumor suppressor protein p53 is mutated in the majority (80%) of TNBC. p53, when mutated, loses its tumor suppression capabilities, and instead gains oncogenic or tumor-driving functions. One of the major oncogenic functions of mutant p53 is to bind and inactivate another tumor suppressor named p73. The Das laboratory has been focusing on the mechanisms underlying the estrogen receptor β-p53-p73 axis for discovering rational and effective therapeutic strategies against TNBC.
Dr. Gokul Das[/caption]
First author Gokul Das, PhD, Professor of Oncology and Co-Director of the Breast Translational Group, Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center
Chetan Oturkar, PhD, Research Assistant Professor in the Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, first author on the study
MedicalResearch.com: What is the background for this study?
Dr. Gokul Das: Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer for which effective targeted therapies are not available, and which rapidly becomes resistant to chemotherapy. TNBC tumors are negative for estrogen receptor α (ERα), progesterone receptor (PR), and HER-2/neu receptor. Endocrine therapy or HER2-targeted therapies are not effective against TNBC. Currently available options including immunotherapy benefit only some patients. They are cost-prohibitive and have severe adverse effects. Therefore, there is an unmet need for rationally designed therapies for TNBC. Although ERα is absent in TNBC, majority of these tumors express estrogen receptor beta (ERβ), a structurally related but functionally distinct isoform of the estrogen receptor coded by a different gene. Tumor suppressor protein p53 is mutated in the majority (80%) of TNBC. p53, when mutated, loses its tumor suppression capabilities, and instead gains oncogenic or tumor-driving functions. One of the major oncogenic functions of mutant p53 is to bind and inactivate another tumor suppressor named p73. The Das laboratory has been focusing on the mechanisms underlying the estrogen receptor β-p53-p73 axis for discovering rational and effective therapeutic strategies against TNBC.
Exercise - Fitness / 08.05.2025
Enhancing Longevity Through Active Ageing: Five Practical Strategies
Tune Into Your Body's Signals Your body knows best. Don't ignore signs of fatigue or discomfort—they're cues for rest or...
Author Interviews, Cancer Research, Gastrointestinal Disease / 07.05.2025
DDW25: Cleveland Clinic Reports Progress Made in Early Diagnosis of Gastric Cancer
MedicalResearch.com Interview with:
[caption id="attachment_68401" align="alignleft" width="150"] Dr. Siddiqui[/caption]
Mohamed Tausif Siddiqui, MD
The study’s lead author and a Gastroenterology fellow
Cleveland Clinic.
MedicalResearch.com: What is the background for this study?
Response: Our study looked at how the stage of gastric cancer diagnosis has changed over the past two decades in the U.S., using national SEER data. Gastric cancer has long been a challenge because it’s often diagnosed late, when treatment options are limited and survival rates are poor.
But with advancements in endoscopic technology—like high-definition imaging, narrow-band imaging, and endoscopic ultrasound—we wanted to see if these tools were making a difference in catching cancers earlier.
Dr. Siddiqui[/caption]
Mohamed Tausif Siddiqui, MD
The study’s lead author and a Gastroenterology fellow
Cleveland Clinic.
MedicalResearch.com: What is the background for this study?
Response: Our study looked at how the stage of gastric cancer diagnosis has changed over the past two decades in the U.S., using national SEER data. Gastric cancer has long been a challenge because it’s often diagnosed late, when treatment options are limited and survival rates are poor.
But with advancements in endoscopic technology—like high-definition imaging, narrow-band imaging, and endoscopic ultrasound—we wanted to see if these tools were making a difference in catching cancers earlier.
Author Interviews, Cancer Research, Colon Cancer, Gastrointestinal Disease, HPV / 07.05.2025
DDW25: More Older White and Hispanic Women Developing Anal Cancer
MedicalResearch.com Interview with:
[caption id="attachment_68399" align="alignleft" width="150"] Dr. Robinson[/caption]
Ashley Robinson, MD, lead author
Second-year internal medicine resident
Advocate Lutheran General Hospital
MedicalResearch.com: What is the background for this study?
Response: Briefly, anal cancer makes up around 1% of gastrointestinal cancers and more than 90% of all anal cancers are caused by chronic human papillomavirus or HPV infections.
In previous research, it has been noted that women over the age of 65 have rates that were increasing more than other groups and myself along with my colleagues and the principal investigator of this project, Dr. Eli Ehrenpreis, wanted to further characterize these findings, looking into more specific details of these previously noted trends. Using data from a public database ran by the National Cancer Institute called the Surveillance, Epidemiology and End Results program, also known as SEER, and their statistical analysis software, SEER*Stat, we analyzed anal cancer incidence trends, looking at differences between sex, age, and ethnicity in order to further identify specific groups that have more rapidly increasing rates than others.
Dr. Robinson[/caption]
Ashley Robinson, MD, lead author
Second-year internal medicine resident
Advocate Lutheran General Hospital
MedicalResearch.com: What is the background for this study?
Response: Briefly, anal cancer makes up around 1% of gastrointestinal cancers and more than 90% of all anal cancers are caused by chronic human papillomavirus or HPV infections.
In previous research, it has been noted that women over the age of 65 have rates that were increasing more than other groups and myself along with my colleagues and the principal investigator of this project, Dr. Eli Ehrenpreis, wanted to further characterize these findings, looking into more specific details of these previously noted trends. Using data from a public database ran by the National Cancer Institute called the Surveillance, Epidemiology and End Results program, also known as SEER, and their statistical analysis software, SEER*Stat, we analyzed anal cancer incidence trends, looking at differences between sex, age, and ethnicity in order to further identify specific groups that have more rapidly increasing rates than others.
Addiction, addiction-treatment / 07.05.2025
Beyond Recovery: How Addiction Treatment Programs Foster Personal Empowerment
The journey through addiction treatment is a transformative process that offers more than just sobriety; it provides an opportunity for individuals to reclaim their lives and find strength in personal empowerment. Successful recovery programs recognize that overcoming dependency is not solely about abstaining from substances but also about building a resilient and autonomous self who can navigate life's challenges. Personal empowerment becomes a cornerstone in this healing process, enabling those in recovery to make positive life changes and establish a sense of control over their destiny. Below, we explore the myriad ways in which addiction treatment programs contribute to this empowering experience.
Author Interviews, Surgical Research / 07.05.2025
The Surgeon-Scientist Crisis: Insights on Navigating Challenges in Modern Medicine
[caption id="attachment_68380" align="aligncenter" width="500"] Image source: Unsplash[/caption]
Surgeon-scientists represent a critical intersection between clinical practice and scientific innovations. Their unique dual roles allow them to identify pressing clinical challenges and pursue evidence-based solutions through research. However, external pressures in academic medicine have introduced additional obstacles, from institutional shifts in priorities to dwindling time for research.
Dr. Melina Kibbe MD notes how these challenges are compounded by mounting clinical demands, financial pressures, and insufficient support structures, all of which threaten the sustainability of this vital career pathway. Dr. Kibbe is Dean, UVA School of Medicine; Chief Health Affairs Officer, UVA Health; Editor-in-Chief, JAMA Surgery. As academic centers reassess their values, there's growing recognition of the need to better support these professionals.
Image source: Unsplash[/caption]
Surgeon-scientists represent a critical intersection between clinical practice and scientific innovations. Their unique dual roles allow them to identify pressing clinical challenges and pursue evidence-based solutions through research. However, external pressures in academic medicine have introduced additional obstacles, from institutional shifts in priorities to dwindling time for research.
Dr. Melina Kibbe MD notes how these challenges are compounded by mounting clinical demands, financial pressures, and insufficient support structures, all of which threaten the sustainability of this vital career pathway. Dr. Kibbe is Dean, UVA School of Medicine; Chief Health Affairs Officer, UVA Health; Editor-in-Chief, JAMA Surgery. As academic centers reassess their values, there's growing recognition of the need to better support these professionals.
Author Interviews, Laboratories, Pets / 07.05.2025
Development and Diagnostic Value of an ELISA-Based Method for Detecting Dirofilaria repens Infection in Dogs
Author: Iuliia Dakhno, PhD in Veterinary Medicine
Affiliation: Independent Researcher, USA
Correspondence: juliadakhno@gmail.com | +1 (347) 778-1295
Abstract:
This article presents a methodologically validated ELISA approach for detecting Dirofilaria repens infection in dogs. Given the emerging risk of parasite introduction to the United States, especially through imported animals and climate-related changes in vector distribution, the proposed diagnostic tool has important applications in both veterinary and public health contexts.
[caption id="attachment_68377" align="aligncenter" width="874"] Dirofilaria repens[/caption]
Introduction
Dirofilaria repens is a filarial nematode responsible for subcutaneous dirofilariasis in domestic and wild canids, felids, and humans. Unlike Dirofilaria immitis, which causes cardiopulmonary disease and is endemic to North America, D. repens tends to reside in subcutaneous tissues, where it forms nodules or migratory swellings. D. immitis is widely studied and routinely screened, while D. repens remains underdiagnosed due to its subtle presentation and emerging zoonotic recognition (Genchi & Kramer, 2017; Capelli et al., 2018).
Dirofilaria repens[/caption]
Introduction
Dirofilaria repens is a filarial nematode responsible for subcutaneous dirofilariasis in domestic and wild canids, felids, and humans. Unlike Dirofilaria immitis, which causes cardiopulmonary disease and is endemic to North America, D. repens tends to reside in subcutaneous tissues, where it forms nodules or migratory swellings. D. immitis is widely studied and routinely screened, while D. repens remains underdiagnosed due to its subtle presentation and emerging zoonotic recognition (Genchi & Kramer, 2017; Capelli et al., 2018).
Author Interviews, Gastrointestinal Disease, Hepatitis - Liver Disease, Weight Research / 07.05.2025
DDW25: GLP-1 Receptor Agonists May Result in Better Liver Outcomes than Bariatric Surgery in Obese Patients
[caption id="attachment_68344" align="alignleft" width="200"] Dr. Gernhard[/caption]
MedicalResearch.com Interview with:
Dr. Katilyn Gernhard DO
Internal Medicine Resident
Allegheny Health Network Pittsburgh
MedicalResearch.com: What is the background for this study?
Response: The background for this study is the steadily rising prevalence of obesity in the United States, which has been accompanied by an increase in related comorbid conditions, including Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD). Bariatric surgery and GLP-1 receptor agonists are two commonly used treatment options to address obesity and its associated complications.
While both have demonstrated benefits in weight loss and metabolic improvement, there has been limited direct comparison of their effectiveness specifically in patients with MASLD. Our study aimed to address this gap by comparing clinical outcomes in patients with MASLD treated with GLP-1 receptor agonists versus those treated with bariatric surgery.
Dr. Gernhard[/caption]
MedicalResearch.com Interview with:
Dr. Katilyn Gernhard DO
Internal Medicine Resident
Allegheny Health Network Pittsburgh
MedicalResearch.com: What is the background for this study?
Response: The background for this study is the steadily rising prevalence of obesity in the United States, which has been accompanied by an increase in related comorbid conditions, including Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD). Bariatric surgery and GLP-1 receptor agonists are two commonly used treatment options to address obesity and its associated complications.
While both have demonstrated benefits in weight loss and metabolic improvement, there has been limited direct comparison of their effectiveness specifically in patients with MASLD. Our study aimed to address this gap by comparing clinical outcomes in patients with MASLD treated with GLP-1 receptor agonists versus those treated with bariatric surgery.
Author Interviews, Gastrointestinal Disease / 07.05.2025
DDW25: Study Finds Adding Dried Fruit to Diet Reduces Constipation
MedicalResearch.com Interview with:
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Dr. Steenson[/caption]
Dr. Simon Steenson PhD
Postdoctoral Research Associate
Department of Nutritional Sciences
King’s College London
MedicalResearch.com: What is the background for this study?
Response: Chronic constipation is something that can be embarrassing, but it affects 1 in 10 people globally. It has a big impact on people’s quality of life and treating constipation has substantial costs for the healthcare system. Dried fruits are recommended for managing constipation, but there are very few studies that have actually tested whether following this advice is helpful. To fill this gap in our knowledge, we completed the largest clinical trial to date to see whether dried fruits and fruit juices could benefit constipation symptoms.
Dr. Steenson[/caption]
Dr. Simon Steenson PhD
Postdoctoral Research Associate
Department of Nutritional Sciences
King’s College London
MedicalResearch.com: What is the background for this study?
Response: Chronic constipation is something that can be embarrassing, but it affects 1 in 10 people globally. It has a big impact on people’s quality of life and treating constipation has substantial costs for the healthcare system. Dried fruits are recommended for managing constipation, but there are very few studies that have actually tested whether following this advice is helpful. To fill this gap in our knowledge, we completed the largest clinical trial to date to see whether dried fruits and fruit juices could benefit constipation symptoms. 
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Source[/caption]
Source[/caption]
Key Takeaways
- Thorough preparation, including consultations and following pre-operative guidelines, is essential for a successful LASIK experience.
- Managing contact lens use, nutrition, hydration, and mental readiness can significantly impact both the procedure's outcome and recovery.
- Thoughtful planning—such as packing appropriately and arranging post-surgery support—helps ensure a smoother and more comfortable LASIK journey.
Introduction to LASIK
Deciding to undergo LASIK eye surgery can be life-changing. The promise of clearer vision and the potential to abandon glasses or contact lenses are compelling reasons for many. However, to fully capitalize on the expertise found at places like LASIK Orlando, it's essential to understand the importance of thorough preparation. The steps you take before your LASIK appointment can substantially impact the outcome and success of the procedure. From consultations to post-operative care, each phase plays a critical role in attaining a smooth and effective experience. LASIK is a popular vision correction procedure that uses advanced laser technology to reshape the cornea and improve eyesight. Many clinics offer customized treatments performed by experienced ophthalmologists. Patients often choose Orlando for LASIK due to its reputable providers and competitive pricing.
Author Interviews, Colon Cancer, Gastrointestinal Disease, Race/Ethnic Diversity / 04.05.2025
DDW25: Kaiser Program Reduced Racial Differences in Colorectal Cancer Screening and Outcomes Through Outreach Program
MedicalResearch.com Interview with:
[caption id="attachment_68341" align="alignleft" width="125"]
Dr. Corley[/caption]
Douglas Corley, MD, PhD
Chief Research Officer, The Permanente Medical Group
Kaiser Permanente, Northern California
MedicalResearch.com: What is the background for this study?
Response: Kaiser Permanente Northern California (KPNC) is an integrated health care system that designs and implements population-based programs that support cancer prevention and early detection. In 2006, KPNC began to implement a comprehensive colorectal cancer screening program with the goal of increasing member screening rates, preventing colorectal cancer through polyp removal, and reducing cancer mortality. The initiative identifies whether screening-eligible KPNC members are up to date with their colorectal cancer screening test by either a colonoscopy or by stool-based tests, such as a fecal immunochemical testing (FIT) kit. If they are not up to date with screening, it mails them a FIT kit for at-home testing. Members can also choose other options for colorectal cancer screening, such as a colonoscopy, through their physician.
Dr. Corley[/caption]
Douglas Corley, MD, PhD
Chief Research Officer, The Permanente Medical Group
Kaiser Permanente, Northern California
MedicalResearch.com: What is the background for this study?
Response: Kaiser Permanente Northern California (KPNC) is an integrated health care system that designs and implements population-based programs that support cancer prevention and early detection. In 2006, KPNC began to implement a comprehensive colorectal cancer screening program with the goal of increasing member screening rates, preventing colorectal cancer through polyp removal, and reducing cancer mortality. The initiative identifies whether screening-eligible KPNC members are up to date with their colorectal cancer screening test by either a colonoscopy or by stool-based tests, such as a fecal immunochemical testing (FIT) kit. If they are not up to date with screening, it mails them a FIT kit for at-home testing. Members can also choose other options for colorectal cancer screening, such as a colonoscopy, through their physician.