MedicalResearch.com Interview with:
Prof Guangwei Li MD
Department of Endocrinology
China-Japan Friendship Hospital
Center of Endocrinology and Cardiovascular Disease, National Center of Cardiology & Fuwai Hospital, Beijing, China
MedicalResearch.com: What are the main findings of the study?
Answer: Our study first shows that a six-year period of lifestyle intervention in Chinese people with IGT reduced the incidence of diabetes over a protracted time period and was ultimately associated with a significant reduction in total and cardio-vascular disease mortality. This reduction in mortality appears to be mediated in part by the delay in onset of diabetes resulting from the lifestyle interventions.
MedicalResearch.com Interview with:
Shanthi Srinivasan, M.D.
Associate Professor of Medicine
Division of Digestive Diseases Department of Medicine
Emory University Atlanta, GA 30322
MedicalResearch.com: What are the main findings of the study?
Dr. Srinivasan: The main findings of this study are that the neurotrophic factor GDNF is was able to protect against the weight gain induced by mice on a high fat diet. The mice that had overexpression of GDNF showed less weight gain while eating the same high fat diet as the control mice. GDNF seems to have effects on the genes regulating fat metabolism and energy expenditure and this could be the mechanism of prevention of weight gain.
MedicalResearch.com Interview with
James D. Sargent, MD, Professor of Pediatrics
Professor of Community and Family Medicine
Professor of The Dartmouth Institute
Co-Director, Cancer Control Research Program
Norris Cotton Cancer Center Norris Cotton Cancer Center,
Department of Pediatrics
Geisel School of Medicine at Dartmouth
Lebanon, New Hampshire
MedicalResearch.com: What are the main findings of the study?
Dr. Sargent: We showed children aged 3-7 years depictions of healthy foods in McDonald’s and Burger King television advertisements that aired in 2010-11. Children were asked what they saw in the images and not prompted to respond specifically to any aspect of the images. All images contained the two healthy foods—apples and milk—the companies purported to be advertising through the Children’s Food and Beverage Advertising Initiative. Only 52% and 70% of children correctly identified McDonald’s and Burger King images of milk. Whereas 80% correctly identified McDonald’s image of apples, only 10% identified the Burger King apples as apples. Instead, 81% mistook them as french fries.
Please see the video of children responding to the BK apples depiction at
http://cancer.dartmouth.edu/about_us/newsdetail/66129/
MedicalResearch.com Interview with:
Chung-Jung Chiu DDS PhD
Scientist II, JM USDA Human Nutrition Research Center on Aging
Assistant Professor, School of Medicine
Tufts University Boston MA 02111
MedicalResearch.com: What are the main findings of the study?
Answer: In this study, we found that advanced age-related macular
degeneration (AMD) is predictable by using clinically readily available
information. We devised a simple algorithm to summarize the clinical
predictors and showed the validity of our prediction model in both
clinic-based and community-based cohorts. We also develop an
application (App) for the iPhone and iPad as a practical tool for our
prediction model.
MedicalResearch.com Interview with:
Dr Tobias Teichert
Assistant Professor of Psychiatry
University of Pittsburgh
Pittsburgh, PA 15261
MedicalResearch.com: What are the main findings of the study?
Dr. Teichert:
"Our study provided three main findings:
First, we measured how long it takes subjects to allocate attention to a relevant target and how effectively they can block out the distractors. We found that after 120 msec selective attention is fully engaged and completely blocks out the distractor. Based on this finding, we predicted that subjects should be able to improve decision accuracy by delaying decision onset, and that this should be more effective than simply prolonging the whole decision process.
Most importantly, we found that subjects indeed use this more effective way of improving decision onset: On average, subjects delayed decision onset by about 50 msec when we asked them be as accurate as possible. The good news is that people seem to use this more optimal mechanism automatically, without being told to do so and without being aware of what they do. The bad news is that we don’t seem to be using this skill quite as effectively as we could. In our case, subjects could have improved accuracy even further by delaying decision onset by an additional 50 ms. However, taken together, our findings show that decision onset is to some degree under cognitive control, and that we might be able to devise training strategies to harness its full potential”
MedicalResearch.com Interview with:
Karen Yeung
Professor of Law
Centre for Technology, Ethics Law & Society
King's College London
London WC2R 2LS
MedicalResearch.com: What are the main findings of the study?
Professor Yeung: This study found a gap in existing legal regulation of healthcare quality in the UK. While patients receiving treatment under mental health legislation are protected by the criminal law against wilful neglect or ill treatment, other patients are not subject to the same level of protection, although many such patients are just as vulnerable as those who are mentally incapacitated. Hence we argue that a new criminal offence of 'wilful neglect or ill treatment' of patients in the healthcare sector is needed.
MedicalResearch.com Interview with:
Dr. David Hanauer, MD
Associate Professor, University of Michigan Medical School
1500 East Medical Center Drive
Ann Arbor, MI 48109-5940
MedicalResearch.com: What are the main findings of the study
Dr. Hanauer: From my perspective, the primary findings were that 65% of the general public is now aware of physician rating web sites and among those who are aware, about 36% had used them in the prior year. Awareness and usage seems to be rapidly increasing compared to what has been reported in prior studies from just a few years ago. We also found that patients consider word of mouth recommendations (from family/friends) to be almost twice as important as ratings sites are.
MedicalResearch.com Interview with:
Simon D. Brandt, PhD
Reader in Bioactive Drug Chemistry
School of Pharmacy & Biomolecular Sciences
Liverpool John Moores University
Associate Editor "Drug Testing and Analysis" (Wiley)
Author's background comment:
This type of work represents one of our areas of activity related to multi-disciplinary approaches to harm reduction which combines public health work with research on various properties of bioactive substances.
MedicalResearch.com: What are the main findings of the study?
Answer: As part of our work related to so-called lifestyle and image-enhancing drugs and legal highs/bath salts, we became interested in a particular "food/dietary supplement" called "Esto Suppress" because it was discussed on some Internet forums dedicated to the topic of bodybuilding. Some forum members were speculating that might be present in this particular product. The reason for this speculation came from the chemical name that was written on the label which pointed in that direction. This particular product was also widely available from a number of online retailers and while some indications existed that the same chemical name was mentioned, others were seen to list a modified version of that name which did not always make much chemical sense. We test purchased four "Esto Suppress" samples in a local fitness store and confirmed that three of them contained the breast cancer drug tamoxifen.
MedicalResearch.com Interview with:
Dr. Scott L. Zuckerman, MD
Department of Neurological Surgery
Vanderbilt Sports Concussion Center
MedicalResearch.com: What are the main findings of the study?
Dr. Zuckerman: Our study evaluated 244 athletes who suffered sports-related concussion (SRC), 122 males and 122 females, and assessed for gender differences in number, severity, and resolution of post-concussive symptoms using reliable change index (RCI) methodology applied to days to return to symptom baseline. Both groups were matched on number of prior concussions, age, and days to first post-concussion assessment, which consisted of the 22 symptom Post Concussion Symptom Checklist from the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) evaluation tool.
MedicalResearch.com Interview with:
Jenifer I Fenton
Assistant Professor
Department of Food Science and Human Nutrition
Michigan State University
East Lansing, MI 48824
MedicalResearch.com: What are the main findings of the study?
Dr. Fenton: This was a cross-sectional study, and thus, a snapshot in time. Although it cannot infer cause or temporality of obesity and colon polyp risk in men, it does show that obese men were more likely to have a polyp than their lean counterpart. In addition, there were serum biomarkers also associated with this risk. This could eventually lead to future blood tests to identify individuals at greater risk for polyps and inform screening recommendations.
MedicalResearch.com Interview with:
Andrea Bellavia MSc
Institute of Environmental Medicine, Karolinska Institutet
Stockholm, Sweden
Dr. Montgomery: What are the main findings of the study?
Answer: We evaluated for 15 years a cohort of Swedish men and women and observed, after taking into account various socio-demographic, dietary, and lifestyle factors, that a low daily consumption of alcoholic beverages is tied with longer survival.
MedicalResearch.com Interview with:
Caroline Landelle, PharmD, PhD
Infection Control Unit, Centre Hospitalier Universitaire (CHU) Albert Chenevier–Henri Mondor, Assistance Publique–Hôpitaux de Paris, Université Paris–Est Créteil, France
MedicalResearch.com: What are the main findings of the study?
Dr. Landelle: The main findings point to the fact that nearly one in four healthcare workers’ hands are contaminated with Clostridium difficile spores after routine care of patients infected with the bacteria, before performing hand hygiene. This is the first study focusing upon the carriage of viable C. difficile spores on healthcare workers’ hands. C. difficile exist in 2 possible forms: vegetative and spore. Vegetative forms of C. difficile are killed when exposed to air, whereas their spores are resistant to oxygen, desiccation, and most disinfectants, and may persist in the hospital environment for long periods of time; thus, bacterial spores could be the principal form of transmission. Furthermore, contamination of exposed healthcare workers’ hands is statistically associated with direct exposure to fecal soiling and contact without the use of gloves.
MedicalResearch.com Interview with:
Aisha T. Langford, PhD, MPH
Postdoctoral Fellow
VA Health Services Research and Development Service & U-M Center for Bioethics and Social Sciences in Medicine
Ann Arbor, MI 48109
MedicalResearch.com: What are the main findings of the study?
Dr. Langford: The main and perhaps most interesting finding was that there were no racial/ethnic differences in cancer clinical trial enrollment, refusal rates, or "no desire to participate in research" as the reason given for clinical trial refusal; however, patients over the age of 65 had lower odds of being enrolled in a clinical trial. Additionally, higher odds of having physical/medical conditions were associated with older age, males, and non-Hispanic blacks.
Medical Research.com Interview with:
Dr. Beate Wieseler
Head of Department Dept. Drug Assessment
Institute for Quality and Efficiency
in Health Care (IQWiG)
Im Mediapark
Köln Germany
MedicalResearch.com: What are the main findings of the study?
Dr. Wieseler: Our study shows that unpublished clinical study reports, i.e. reports submitted to regulatory authorities during the approval procedure for a drug, provide substantially more information on patient-relevant outcomes than publicly available sources, i.e. articles published in medical journals and reports published in online clinical trial registries. (A “patient-relevant outcome” is an outcome describing morbidity, mortality or health-related quality of life.)
MedicalResearch.com Interview with:
Dr. Lianne Jeffs
PhD
Nurse and researcher at St. Michael's Hospital
University of Toronto
MedicalResearch.com: What are the main findings of the study?
Dr. Jeffs: The main findings of the study include:
1. Patients described the bedside nursing handover as engaging, personal and informative. The bedside nursing handover created a a space to connect with their nurses in a more personal manner (e.g., provided an introduction between patient and nurse at the beginning of the shift)
2. Patients found the experience increased their engagement in their own care, and kept them informed about their health status and care plan. It also gave the patient an opportunity to identify important needs to the nurse (e.g., daily activities)
3. Not all patients wanted to participate in the bedside nursing handover. This was typically exemplified by long-term-stay patients.
MedicalResearch.com Interview with
Deanna Kepka, PhD, MPH
Assistant Professor
College of Nursing & Huntsman Cancer Institute
University of Utah
MedicalResearch.com: What are the main findings of the study?
Dr. Kepka: Nearly two-thirds, 64.8% (95% CI: 62.2% - 67.3%) of women reporting a hysterectomy also reported a recent Pap test since their hysterectomy and more than half, 58.4% (95% CI: 55.3% - 61.4%) of women age 65 years and older without a hysterectomy reported a Pap test in the past three years. Together, this represents approximately 14 million in the United States.
MedicalResearch.com Interview with:
Alize J. Ferrari
University of Queensland
School of Population Health
Herston, Queensland, Australia
MedicalResearch.com: What are the main findings of the study?
Answer: In our paper recently published in PloS Medicine, we report findings from the Global Burden of Disease Study 2010 for depression. We found that depression (defined as major depressive disorder and dysthymia) accounted fr 8% of the non fatal burden in 2010, making it the second leading cause of disability worldwide. Burden due to depression increased by 35% between 1990 and 2010, although this increase was entirely driven by population growth and ageing. Burden occurred across the entire lifespan, was higher in females compared to males, and there were differences between world regions.When depression was considered a risk factor for other health outcomes it explained 46% of the burden allocated to suicide and 3% of the burden allocated ischemic heart disease.
MedicalResearch.com Interview with
Cécilia Samieri, PhD
Institut pour la Santé Publique et le Développement, Case 11, Université Bordeaux Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
MedicalResearch.com: What are the main findings of the study?
Dr. Samieri: That women with healthier dietary patterns at midlife were 40% more likely to survive age 70 or over free of major chronic diseases and with no impairment in physical function, cognition or mental health.
MedicalResearch.com Interview with:
Dr. Laurent Azoulay
Project Leader, Lady Davis Institute
Assistant Professor, Department of Oncology, McGill University
MedicalResearch.com: What are the main findings of the study?
Dr. Azoulay: Using large population-based databases from the UK, we assembled a cohort of men newly-diagnosed with non-metastatic prostate cancer. Within this group of men, the use of statins after prostate cancer diagnosis was associated with a 24% decreased risk in cancer-related mortality. We observed duration- as well as a dose-response relationships. Furthermore, in a secondary analysis, we observed that the benefits were greater among men who used also used statins before their diagnosis, with more modest yet significant benefits among men who initiated the treatment after their diagnosis. The latter result is one of the novelties of this study, as it provides an estimate of the potential benefits of statins, if used in the adjuvant setting.
MedicalResearch.com Interview with:
Mark W. Ketterer, PhD, ABPP
Senior Bioscientific Staff
Henry Ford Hospital/A2
Detroit, MI 48202
Clinical Professor of Psychiatry & Behavioral Neurosciences
Department of Psychiatry Wayne State University
MedicalResearch.com: What are the main findings of the study:
Dr. Ketterer: A survey of 84 patients admitted to Henry Ford Hospital found 54% to have Moderate-Severe Cognitive Impairment (CI).
MEDICALRESEARCH.COM: INTERVIEW WITH:
Qi Sun, MD ScD
Assistant Professor of Medicine
Channing Division of Network Medicine
Brigham and Women's Hospital and Harvard Medical School, Assistant Professor
Department of Nutrition, Harvard School of Public Health
665 Huntington Avenue, Boston, MA 02115
MEDICALRESEARCH.COM: What are the main findings of the study?
Response: We have three major findings.