Annals Internal Medicine, Author Interviews, Cognitive Issues, Heart Disease, Stroke / 28.08.2019
Small and Large Brain Infarctions Associated with Cognitive Decline
MedicalResearch.com Interview with:
Gwen Windham, MD MHS
Professor of Medicine
Memory Impairment & Neurodegenerative Dementia (MIND) Center
University of Mississippi Medical Center
MedicalResearch.com: What is the background for this study?
Response: Silent infarctions are a primary cause of strokes in the brain, but they are also common in people without a history of a stroke. Infarctions are generally only reported if they are larger (at least 3mm) and are ignored clinically if they are smaller (less than 3mm).
We examined 20 years of cognitive decline among stroke free, middle-aged people with and without smaller, and larger infarctions. The comparison groups included participants as follows: those with
(1) no infarctions, the reference group;
(2) only smaller infarctions;
(3) only larger infarctions
4) both smaller and larger infarctions
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