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04 Feb Single Gene Rearrangement Uses Three Paths To Cause Rare Brain Tumor

Posted at 18:52h in Author Interviews, Brain Cancer - Brain Tumors, Genetic Research, Pediatrics, University of Pennsylvania

MedicalResearch.com Interview with: Dr. Adam C. Resnick, Ph.D Assistant Professor of Neurosurgery Faculty, Abramson Cancer Center Director of Children’s Brain Tumor Tissue Consortium Division of Neurosurgery Director, CHOP/PENN Department of Neurosurgery Brain Tumor Tissue BiorepositoryDirector for Neurosurgical Translational Research, Division of Neurosurgery Children’s Hospital of Philadelphia Payal Jain, PhD Candidate...

04 Feb Immunotherapy Shows Promise For Severe Sinusitis With Nasal Polyps

Posted at 12:00h in Allergies, Asthma, Author Interviews, JAMA

MedicalResearch.com Interview with: Prof Dr. Dr. h.c. Claus Bachert Head Upper Airways Research Laboratory (URL) Chief of Clinics ENT-Department University Hospital Ghent Ghent, Belgium Medical Research: What is the background for this study? What are the main findings? Prof. Bachert: Chronic sinusitis with nasal polyposis represents mucosal inflammation, and polyps in...

02 Feb Proton Radiation Therapy: Treats Pediatric Brain Tumor With Fewer Long Term Side Effects

Posted at 01:08h in Author Interviews, Brigham & Women's - Harvard, Cancer Research, Lancet, Pediatrics, Radiation Therapy

MedicalResearch.com Interview with: Dr. Torunn Yock, MD Director, Pediatric Radiation Oncology Associate Professor, Harvard Medical School Radiation Oncology Quality Assurance Massachusetts General Hospital, Proton Center Boston, MA Medical Research: What is the background for this study? Dr. Yock: Proton radiotherapy is a highly targeted form of radiation therapy that can...

25 Jan Genetic Markers Help Individually Identify Melanoma Patients At Risk For Metastases

Posted at 16:17h in AACR, Author Interviews, Melanoma, NYU/NYMC, Personalized Medicine

MedicalResearch.com Interview with: Tomas Kirchhoff, PhD Assistant Professor, Departments of Population Health and Environmental Medicine NYU Langone Medical Center Member, Laura and Isaac Perlmutter Cancer Center NYU Langone Medical Research: What is the background for this study? Dr. Kirchhoff: Melanoma is the deadliest form of skin cancer, and the cause...

18 Jan CRISPR Editing May Lead To Genetic Treatment of Retinitis Pigmentosa

Posted at 18:59h in Author Interviews, Genetic Research, Ophthalmology

More on Gene Therapy on MedicalResearch.com MedicalResearch.com Interview with: Benjamin Bakondi, Ph.D. Postdoctoral Scientist Laboratory of: Shaomei Wang, M.D., Ph.D. Institute Director: Clive N. Svendsen, Ph.D. Board of Governors Regenerative Medicine Institute Cedars-Sinai Medical Center; Dept. of Biomedical Sciences Los Angeles, CA 90048 Medical Research: What is the background for...

16 Jan Functional Genomics Identifies Genes Essential To Breast Cancer Cell Survival

Posted at 23:23h in Author Interviews, Breast Cancer, Genetic Research, NYU/NYMC

More on Breast Cancer Research on MedicalResearch.com MedicalResearch.com Interview with: Dr. Benjamin Neel MD PhD Professor, Department of Medicine Director Perlmutter Cancer Center NYU Langone Medical Center Medical Research: What is the background for this study? What are the main findings? Dr. Neel: Over the past 10 years, there have...

15 Jan Researchers Developing Nano Bubbles To Deliver Chemotherapy To Tumors

Posted at 23:48h in Author Interviews, Cancer Research, Technology

More on Cancer Research on MedicalResearch.com MedicalResearch.com Interview with: Elena V. Batrakova, Ph.D. Associate Professor Center for Nanotechnology in Drug Delivery Division of Molecular Pharmaceutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill, NC Medical Research: What is the background for this study? What are...

09 Jan CRISPR Successfully Restores Gene Function in Animal Model of Duchenne Muscular Dystrophy

Posted at 02:59h in Author Interviews, Genetic Research, UT Southwestern

MedicalResearch.com Interview with: Rhonda Bassel-Duby, Ph.D. and Dr. Chengzu Long, PhD Department of Molecular Biology UT Southwestern Medical Center Dallas, TX 75390-9148 Medical Research: What is the background for this study? What are the main findings? Response: Duchenne muscular dystrophy (DMD), which was first described by Duchenne de Boulogne (1806-1875) in...

24 Dec Immunotherapy with IL-17 Blocker Secukinumab Improves Ankylosing Spondylitis

Posted at 13:36h in Author Interviews, Immunotherapy, NEJM, Rheumatology

MedicalResearch.com Interview with: Prof. dr. D.L.P. Baeten MD Clinical Immunology and Rheumatology Academic Medical Center University of Amsterdam Amsterdam, The Netherlands Medical Research: What is the background for this study? What are the main findings? Prof. Baeten: Ankylosing spondylitis is a debilitating rheumatic condition which affects young adults and with...

12 Dec AML: Kinase Inhibitor Plus Standard Chemotherapy Reduces Relapse Risk

Posted at 00:49h in Author Interviews, Lancet, Leukemia

MedicalResearch.com Interview with: Dr. Christoph Röllig Medizinische Klinik und Poliklinik I Universitätsklinikum der Technischen Universitä Dresden, Germany Medical Research: What is the background for this study? What are the main findings? Dr. Röllig: When this trial began in 2009, standard treatment for Acute Myelogenous Leukemia (AML) consisted of a combination of...

09 Dec Skin Problems Common With anti-TNF therapy For IBD

Posted at 16:04h in Annals Internal Medicine, Author Interviews, Dermatology, Gastrointestinal Disease, Immunotherapy

MedicalResearch.com Interview with: Isabelle Cleynen PhD University of Leuven Medical Research: What is the background for this study? What are the main findings? Dr. Cleynen : Ulcerative colitis and Crohn’s disease, together inflammatory bowel disease (IBD), are characterized by chronic inflammation of the gastrointestinal tract. Treatment for IBD usually involves drug...

08 Dec Cognitive Therapy and Antidepressants Have Equivalent Outcomes in Major Depressive Disorder

Posted at 23:53h in Author Interviews, BMJ, Depression

MedicalResearch.com Interview with: Halle Amick, research associate Sheps Center for Health Services Research University of North Carolina at Chapel Hill Chapel Hill, NC Medical Research: What is the background for this study? What are the main findings? Response: Major depressive disorder (MDD) affects more than 32 million Americans and millions...

07 Dec Combination Targeted Therapy Improves Survival in BRAF+ Metastatic Melanoma

Posted at 21:49h in Author Interviews, Melanoma, Pharmacology

MedicalResearch.com Interview with: Jeff Legos Senior Vice President Global Program Head Novartis Oncology Medical Research: What is the background for this study? What are the main findings? Response: Melanoma is the most serious form of skin cancer, and in recent years, research has discovered that melanoma is a diverse disease....

07 Dec Cancer Prone Mutations Common In Breast Cancer Patients With Therapy Related Leukemia

Posted at 17:55h in Author Interviews, Breast Cancer, Cancer, Genetic Research

MedicalResearch.com Interview with: Dr. Jane E. Churpek, MD Assistant Professor of Medicine Co-Director, Comprehensive Cancer Risk and Prevention Program The University of Chicago Medicine Chicago, IL 6063 Medical Research: What is the background for this study? What are the main findings? Dr. Churpek: We designed this study to try...

07 Dec Cellular Target Opens New Pathway For Multiple Sclerosis Therapy

Posted at 15:36h in Author Interviews, Multiple Sclerosis

MedicalResearch.com Interview with: Dr. Vittorio Gallo PhD Center for Neuroscience Research Children’s Research Institute Children’s National Medical Center Washington, DC 20010 Medical Research: What is the background for this study? What are the main findings? Dr. Gallo: Astrocytes are cells in the central nervous system (CNS) that provide nutrients, recycle...

03 Dec Higher Expression of Stem Cell Genes In Young Breast Cancer Patients

Posted at 23:05h in Author Interviews, BMC, BMJ, Genetic Research

MedicalResearch.com Interview with: Hatem A. Azim MD PhD Breast Cancer Translational Research Laboratory Institut Jules Bordet Université Libre de Bruxelles Brussels, Belgium Medical Research: What is the background for this study? What are the main findings? Dr. Azim: As at breast cancer diagnosis is known to impact prognosis, with young...

30 Nov STAMPEDE Trial: Radiation Therapy Reduced Prostate Cancer Relapses

Posted at 20:02h in Author Interviews, JAMA, Prostate Cancer, Radiation Therapy

MedicalResearch.com Interview with: Prof Nicholas James STAMPEDE Trial Chief Investigator Director of the Cancer Research Centre Warwick Medical School University of Warwick Coventry and Professor of Clinical Oncology Cancer Centre, Queen Elizabeth Hospital Birmingham Medical Research: What is the background for this study? What are the main findings? Dr. James: The STAMPEDE...

25 Nov Genetic Links To Fatal Inflammatory Flu Reaction Discovered

Posted at 20:25h in Author Interviews, Genetic Research, Pediatrics

MedicalResearch.com Interview Grant S Schulert MD, PhD Clinical Fellow, Division of Rheumatology Cincinnati Childrens Hospital Medical Research: What is the background for this study? What are the main findings? Dr. Schulert: Influenza infection causes millions of illnesses annually, but most of those are relatively mild. In a subset of cases, patients...

20 Nov Light Therapy May Help Major Depressive Disorder, Not Just SAD

Posted at 22:48h in Author Interviews, Depression, JAMA

MedicalResearch.com Interview with: Raymond W. Lam, MD, FRCPC Professor and Associate Head for Research Department of Psychiatry, University of British Columbia Director, Mood Disorders Centre, Djavad Mowafaghian Centre for Brain Health Executive Chair, Canadian Network for Mood and Anxiety Treatments (CANMAT) Vancouver, BC, Canada Medical Research: What is the background for...

20 Nov New Step Toward Gene Cure For Cystic Fibrosis

Posted at 14:36h in Author Interviews, Critical Care - Intensive Care - ICUs, Genetic Research, Pulmonary Disease

MedicalResearch.com Interview with: Dragana Vidovic and Marianne Carlon Laboratory for Molecular Virology and Gene Therapy KU Leuven, Belgium Medical Research: What is the background for this study? What are the main findings? Response: Cystic fibrosis (CF) or mucoviscidosis is a genetic disorder caused by mutations in the CFTR gene which...

14 Nov Study Highlights Need To Look For Changes in Multiple Genes From Cancers

Posted at 21:01h in Author Interviews, Cancer Research, Genetic Research, JAMA

MedicalResearch.com Interview with: Samuel Klempner, M.D. Assistant Professor Division of Hematology/Oncology UC Irvine Health Orange, CA 92868 Medical Research: What is the background for this study? What are the main findings? Dr. Klempner: The background for our series is the concept that little is known about the genetic landscape of...

07 Nov Menopausal Hormone Therapy May Raise Risk Of Basal Cell Carcinoma

Posted at 02:29h in Author Interviews, Cancer Research, Endocrinology, Journal Clinical Oncology, Menopause, NIH

MedicalResearch.com Interview with: Elizabeth K. Cahoon, PhD Radiation Epidemiology Branch Division of Cancer Epidemiology and Genetics, National Cancer Institute National Institutes of Health Department of Health and Human Services Bethesda, MD Medical Research: What is the background for this study? What are the main findings? Dr. Cahoon: Although basal cell...

04 Nov Combination Therapy Effective Against Mantle Cell Lymphoma

Posted at 23:33h in Author Interviews, Chemotherapy, Lymphoma, NEJM

MedicalResearch.com Interview with: Jia Ruan, M.D., Ph.D. Associate Professor of Clinical Medicine Weill Cornell Medicine Lymphoma Program Division of Hematology & Medical Oncology New York, NY 10021 Medical Research: What is the background for this study? What are the main findings? Dr. Ruan: Mantle cell lymphoma is an uncommon...

24 Oct Gene-edited Kidney Organoids Re-Create Human Disease

Posted at 15:16h in Author Interviews, Genetic Research, Kidney Disease, Nature, Stem Cells

MedicalResearch.com Interview with: Benjamin Freedman, Ph.D. Assistant Professor | University of Washington Department of Medicine | Division of Nephrology Member, Kidney Research Institute Member, Institute for Stem Cell and Regenerative Medicine Seattle WA 98109 Medical Research: What is the background for this study? What are the main findings? Dr. Freedman:...

07 Oct Genotyping May Lead To Personalized Lung Cancer Therapy

Posted at 11:29h in Author Interviews, Genetic Research, Lung Cancer, PLoS

MedicalResearch.com Interview with: Keiji Tanimoto, D.D.S., Ph.D Assistant Professor Research Institute for Radiation Biology and Medicine Hiroshima University Hiroshima Japan Medical Research: What is the background for this study? Dr. Tanimoto: Hypoxia-inducible factor-2α (HIF-2αor EPAS1) is important for cancer progression, and its overexpression is considered a putative biomarker for poor...

17 Sep Third Generation CAR T cells For Relapsed Lymphoma and Leukemia

Posted at 01:08h in Author Interviews, Cancer Research, Leukemia, Lymphoma

MedicalResearch.com Interview with: Angelica Loskog, PhD Professor of Immunotherapy (adjunct) Dept of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden Medical Research: What is the background for this study? What are the main findings? Dr. Loskog: CAR T cells have shown remarkable effect in patients with B cell malignancy in...

02 Sep Genetic Signatures May Lead To Precision Treatments For Childhood Brain Tumors

Posted at 00:09h in Author Interviews, Brain Cancer - Brain Tumors, Genetic Research

Medicalresearch.com Interview with: Roger Packer MD Senior Vice President Center for Neuroscience & Behavioral Health Children’s National Medical Center Washington, D.C. MedicalResearch: What is the background for this study? What are the main findings? Dr. Packer: The background is that medulloblastoma is the most common childhood malignant brain tumor....

28 Aug Sublingual Immunotherapy Not Currently Recommended For Asthma Control

Posted at 11:25h in Allergies, Asthma, Author Interviews, Microbiome, Pulmonary Disease

MedicalResearch.com Interview with: Rebecca Normansell MA MB BChir Cochrane Airways Population Health Research Institute St George’s, University of London Medical Research: What is the background for this study? Response: Asthma is a common, long-term, respiratory condition which affects over 300 million people worldwide. It is a burden not...

27 Aug Oncotype DX Assay Can Help Guide Adjuvant Breast Cancer Chemotherapy

Posted at 13:18h in Author Interviews, Breast Cancer, Duke, Genetic Research, JAMA

MedicalResearch.com Interview with: Michaela Ann Dinan Ph.D. Assistant Professor in Medicine Member of Duke Cancer Institute Duke University School of Medicine Medical Research: What is the background for this study? What are the main findings? Dr. Dinan: For many years we have known that overall, women with early stage, hormone...

20 Aug Chemotherapy and Radiation For Brain Cancer Lead To Brain Shrinkage

Posted at 14:54h in Author Interviews, Biomarkers, Brain Cancer - Brain Tumors, Chemotherapy, Neurology, Radiation Therapy

MedicalResearch.com Interview with: Jorg Dietrich, MBA MMSc MD PhD Director, Cancer & Neurotoxicity Clinic and Brain Repair Research Program Massachusetts General Hospital Cancer Center Assistant Professor of Neurology Harvard Medical School Medical Research: What is the background for this study? What are the main findings? Dr. Dietrich: Understanding the adverse...