Author Interviews, Cancer Research, Mental Health Research, Pediatrics, Social Issues / 09.10.2013

Dr. Elisabeth Jeppesen MPH, PhD-fellow National Resource Center for Late Effects after Cancer Treatment, Department of Oncology, Oslo University, Hospital, The Norwegian Radiumhospitalet, OslMedicalResearch.com Interview with: Dr. Elisabeth Jeppesen MPH, PhD-fellow National Resource Center for Late Effects after Cancer Treatment, Department of Oncology, Oslo University, Hospital, The Norwegian Radiumhospitalet, Oslo, Norway mobil +47 951 05271 
Wisit: Ullernchaussen 70 (Radiumhospitalet) www.oslo-universitetssykehus.no MedicalResearch.com: What is the background of this study? Answer: Each year a considerable number of parents with children younger than 18 years of age are affected by cancer in a parent. Cancer in one of the parents might represent a potentially traumatic event and thereby may be a risk factor for psychosocial problems in the offspring. So far, teenagers’ psychosocial responses to parental cancer have only been studied to a limited extent in controlled trials. Using a trauma theory perspective many studies have shown significant direct associations between parental cancer and psychosocial problems in teenagers. However, the literature also indicates that most children and teenagers have normal stress reactions to such events. In order to identify the need for eventual prevention and intervention among teenagers exposed to such a stressor, we need more empirical knowledge of their psychosocial situation. (more…)
Author Interviews, Gastrointestinal Disease, Gluten, Nutrition, Pediatrics / 08.10.2013

Ketil Stordal Researcher/consultant paediatrician National Institute of Public Health NorwayMedicalResearch.com Interview with: Ketil Stordal Researcher/consultant paediatrician National Institute of Public Health Norway MedicalResearch.com: What are the main findings of the study? Answer: The study identified 324 children with celiac disease from a cohort of 82 000. Start of gluten in the diet later than 6 months was associated with a 27% increased risk of celiac disease compared to those starting during the 5th or 6th month of life. Breastfeeding was not protective; the duration of breastfeeding was slightly longer among children with celiac disease (10.4 vs 9.9 months) and breastfeeding at the time of gluten introduction was not associated with the later risk of celiac disease. The participating mothers had submitted detailed data since pregnancy including infant feeding practices, and these were collected before onset of the disease. (more…)
Author Interviews, JAMA, UT Southwestern / 08.10.2013

Roshni Rao, MD Division of Surgical Oncology, Department of Surgery University of Texas Southwestern Medical Center, DallasMedicalResearch.com Interview with: Roshni Rao, MD Division of Surgical Oncology, Department of Surgery University of Texas Southwestern Medical Center, Dallas MedicalResearch.com: What are the main findings of the study?  Dr. Rao: That in most women with small breast cancer (<3.0cm in size), it is not necessary to removal all the lymph nodes underneath the arm, even if those nodes do have cancer. Radiation therapy, which is required after a partial mastectomy for breast cancer, can prevent these nodes from growing or becoming clinically significant. (more…)
Cancer Research, Heart Disease, MD Anderson, Ovarian Cancer / 08.10.2013

Anil K. Sood MD Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center Unit 1362, PO Box 301439, Houston, TX, 77030MedicalResearch.com Interview with: Anil K. Sood MD Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center Unit 1362, PO Box 301439, Houston, TX, 77030 MedicalResearch.com: What are the main findings of the study? Dr. Sood: For women with newly diagnosed ovarian cancer, high heart rate at diagnosis (tachycardia), venous thromboembolism (VTE) occurring after diagnosis and pulmonary hypertension post-diagnosis are independently related to reduced survival after controlling for tumor stage, grade, and extent of cytoreduction.  Women with tachycardia lived an average of 4.0 years after diagnosis compared with 5.9 years for women without tachycardia, a 32% reduction in duration of survival.  Patients who experienced VTE lived a median 4.1 years after diagnosis, compared with 6.4 yrs for patients who did not experience VTE. (more…)
Author Interviews, Breast Cancer, JAMA, MD Anderson / 08.10.2013

Kelly K. Hunt, MD F.A.C.S. Professor, Department of Surgical Oncology, Division of Surgery Chief, Breast Surgical Oncology Section, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TXMedicalResearch.com Interview with: Kelly K. Hunt, MD F.A.C.S. Professor, Department of Surgical Oncology, Division of Surgery Chief, Breast Surgical Oncology Section, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX MedicalResearch.com: What are the main findings of the study? Dr. Hunt: We found that 40% of women who had node positive disease at initial presentation (confirmed by needle biopsy) had no evidence of residual cancer in the lymph nodes after chemotherapy. We performed sentinel lymph node (SLN) surgery followed by axillary lymph node dissection in all of the patients and found a false negative rate of 12.6% with the SLN procedure. The false negative rate was lower when surgeons used two mapping agents (blue dye and radioisotope) to identify the sentinel nodes and when they removed more than 2 sentinel nodes. (more…)
Author Interviews, Infections / 07.10.2013

George Alangaden MD Senior Staff Physician, Transplant Infectious Diseases Medical Director of Infection Prevention Henry Ford Hospital Professor of Medicine, Wayne State University Infectious Diseases, CFP-316 Detroit, MI 48202MedicalResearch.com Interview with: George Alangaden MD Senior Staff Physician, Transplant Infectious Diseases Medical Director of Infection Prevention Henry Ford Hospital Professor of Medicine, Wayne State University Infectious Diseases, CFP-316 Detroit, MI  48202 MedicalResearch.com: What are the main findings of the study? Dr. Alangaden:
  • Infections caused by Mycobacterium marinum infections are rare. A total of 5 patients were identified in our hospital over a 10 year period.
  • In all instances the infection affected the skin and soft tissues of the hand and arm and presented as sores or bumps on the skin that did not improve after usual antibiotic therapy.
  • All patients had an history of some trauma to the hand and subsequent exposure to water  from home aquariums
  • The time to onset of infection after exposure ranged from 11 days to 56 days.
  • The median time from infection to diagnosis and appropriate therapy was 161 days (range 33-379 days).
  • In all cases the diagnosis was made by doing a skin biopsy.
  • All patients were cured after several weeks of treatment with appropriate antibiotics. (more…)
Author Interviews, Hand Washing, JAMA, MRSA / 07.10.2013

Anthony Harris, MD, MPH Department of Epidemiology and Public Health Professor University of Maryland School of Medicine Acting Medical Director of Infection Control University of Maryland Medical CenterMedicalResearch.com Interview with: Anthony Harris, MD, MPH Department of Epidemiology and Public Health Professor University of Maryland School of Medicine Acting Medical Director of Infection Control University of Maryland Medical Center     MedicalResearch.com: What are the main findings of the study? Dr. Harris: The aim of the study was to understand if wearing disposable gowns and gloves for all patient contact in the ICU could help prevent the spread of MRSA and similar antibiotic-resistant bacteria. Secondarily we wanted to make sure this type of patient isolation did not result in any harm to patients. The results of the study were that gowns and gloves worn by healthcare workers for contact with all patients in the ICU did not decrease the number of patients who acquired VRE but did decrease MRSA about 40 percent.  Also, wearing gloves and gowns did not adversely impact patient care.  For our goal of studying all types of infection, we did not find a benefit to universal gown and glove use. However, for transmission of MRSA alone, the intervention decreased transmission by about 40 percent. Although previous studies have showed isolation is associated with falls, bed sores and other adverse events, we found gowns and gloves did not produce more of these negative events. (more…)
Hospital Acquired, Infections, Outcomes & Safety, Pediatrics / 07.10.2013

MedicalResearch.com Interview with: Elias Iosifidis, MD, PhD Pediatric Infectious Disease Fellow Aristotle University of Thessaloniki Hippokration Hospital Thessaloniki, Greece MedicalResearch.com: What are the main findings of the study? Dr. Iosifidis: A large outbreak of VRE colonization was found in neonates hospitalized in an intensive care unit (Neonatal Intensive Care Unit, NICU) after the implementation of an active surveillance program. Both high incidence of VRE colonization (or “colonization pressure”) and antibiotic use promoted VRE spread according to the results of the case control study. No proven sources of VRE were found (in local hospital or even in local livestock). A multifaceted management was implemented and included enhanced infection control measures, active surveillance cultures, cohorting of colonized patients, daily audits and optimization of antibiotic therapy. Although the outbreak had a biphasic pattern (monoclonal first wave followed by a polyclonal second wave) strict adherence to the aforementioned bundle of actions was proved essential for reducing VRE colonized cases. During the study period no new VRE infection occurred in neonates. (more…)
Author Interviews, Cognitive Issues, Johns Hopkins, Mental Health Research / 07.10.2013

MedicalResearch.com Interview with: Dr. Seth S. Martin, MD Division of Cardiology, Johns Hopkins Hospital 600 North Wolfe Street Baltimore, Maryland 21287 Johns Hopkins Hospital Baltimore, MD 21287. MedicalResearch.com: What are the main findings of the study? Dr. Martin: Our systematic review identified 16 studies for qualitative synthesis and 11 for quantitative synthesis. In individuals without baseline cognitive dysfunction, statins did not adversely affect memory when used in the short-term (<1 year). Long-term cognition studies including 23,433 patients with a mean exposure duration of 3 to 24.9 years showed a 29% relative reduction in incident dementia related to statin use (hazard ratio, 0.71; 95% CI 0.61-0.82) and a 2% absolute risk reduction (number needed to treat for 6.2 years: 50). (more…)
Author Interviews, BMJ, Mental Health Research / 04.10.2013

Shu-Sen Chang, MD, MSc, PhD Research Assistant Professor HKJC Centre for Suicide Research and Prevention The University of Hong Kong 2/F, The Hong Kong Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road Pokfulam, Hong KongMedicalResearch.com Interview with: Shu-Sen Chang, MD, MSc, PhD Research Assistant Professor HKJC Centre for Suicide Research and Prevention The University of Hong Kong 2/F, The Hong Kong Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road Pokfulam, Hong Kong MedicalResearch.com: What are the main findings of the study? Dr. Chang: The study shows a marked increase in suicide in 2009 following the 2008 global economic crisis, particularly in men in the 27 European and 18 American countries included in the study. There were estimated approximately 5000 excess suicides across all 54 study countries in 2009. The largest increase in Europe was seen in 15-24 year old men and in 45-64 year old men in America. (more…)
ADHD, Author Interviews, Mental Health Research, Pediatrics / 04.10.2013

Tanya Froehlich, MD, MS Associate Professor Division of Developmental and Behavioral Pediatrics Cincinnati Children's Hospital Medical Center 3333 Burnet Avenue, MLC 4002 Cincinnati, OH 45229MedicalResearch.com Interview with: Tanya Froehlich, MD, MS Associate Professor Division of Developmental and Behavioral Pediatrics Cincinnati Children's Hospital Medical Center 3333 Burnet Avenue, MLC 4002 Cincinnati, OH  45229 MedicalResearch.com: What are the main findings of the study? Dr. Froehlich: In a national sample of 2 to 5 year olds, the likelihood of psychotropic prescription peaked in the mid-2000s (at 1.5%), then stabilized in the late 2000s (to 1.0%). Increased psychotropic use in boys, white children, and those lacking private health insurance was documented. (more…)
Author Interviews, BMJ, Rheumatology / 03.10.2013

MedicalResearch.com Interview with A/Prof Susanna M Proudman MB BS (Hons) FRACP Discipline of Medicine, University of Adelaide Senior Consultant in Rheumatology Royal Adelaide Hospital North Terrace, Adelaide, 5000 MedicalResearch.com: What are the main findings of the study? Answer: In patients with early DMARD-naïve rheumatoid arthritis (RA), fish oil (delivering an average daily dose of 3.7 g dose of omega-3 fats) was associated with benefits additional to those achieved by combination treat-to-target DMARDs with similar methotrexate use. These included significantly reduced risk of triple DMARD failure, defined as needing the addition of leflunomide, and a higher rate of ACR remission. Because a structured treatment algorithm that was responsive to disease activity and tolerance was used, drug use could be used as an outcome measure for the effects of fish oil. This is one of the novel features of this study as the study design allows for a RCT to be performed on a background of treat-to-target therapy for early RA. (more…)
Author Interviews, Blood Pressure - Hypertension, Exercise - Fitness, JAMA / 03.10.2013

MedicalResearch.com Interview Ma, Wei Department of Epidemiology and Health Statistics School of Public Health Shandong University Jinan, Shandong Province, 250012 China MedicalResearch.com: What are the main findings of the study? Answer: The results of this meta-analysis suggested that there was an inverse dose-response association between levels of recreational physical activity and risk of hypertension. Individuals who participated in high levels of recreational physical activity had a 19% lower risk of hypertension than those who didn’t exercise much. In addition, those with moderate levels of recreational physical activity had an 11% lower risk of hypertension. However, there was no significant association between occupational physical activity and risk of hypertension. (more…)
Author Interviews, Heart Disease, JAMA / 03.10.2013

Mads Wissenberg, MD Department of Cardiology Gentofte Hospital, University of Copenhagen Niels Andersens Vej 65 2900 Hellerup, Denmark Post 635MedicalResearch.com Interview with: Mads Wissenberg, MD Department of Cardiology Gentofte Hospital, University of Copenhagen Niels Andersens Vej 65 2900 Hellerup, Denmark Post 635 MedicalResearch.com: What are the main findings of the study? Answer: Our main findings from this nationwide study are that during a 10-year period where several national initiatives were taken to increase bystander CPR and improve advanced care, bystander CPR increased more than a two-fold from 21 % in 2001 to 45% in 2010. In the same period survival on arrival at the hospital increased more than a two-fold from 8% in 2001 to 22% in 2010, and 30-day survival more than a three-fold from 3.5% in 2001 to 11% in 2010. (more…)
Author Interviews, Biomarkers, Cancer Research / 03.10.2013

MedicalResearch.com Interview with: Dr. Muy-Teck Teh BSc, PhD Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry Barts & The London School of Medicine and Dentistry Queen Mary University of London, England, United Kingdom MedicalResearch.com: What are the main findings of the study? Answer: We found unique DNA markings (epigenetic methylation) on certain genes that may “predict” the risk of developing head and neck cancer. We identified certain DNA methylation marks unique to cancer cells and not found in normal healthy cells. DNA methylation marks act as ‘switches’ that regulate the ‘on or off’ statuses of genes. Abnormal DNA methylation is known to precede cancer initiation. Hence, the presence of these abnormal DNA methylation marks in cells may be tell-tale signs of early cancer initiation. The chemically distinctive properties of methylated DNA provide ample opportunities for clinical exploitation as nucleic acid-based biomarkers potentially detectable in non-invasive samples such as blood, buccal scrapes, or even saliva. (more…)
Author Interviews, Menopause, University of Pennsylvania / 03.10.2013

MedicalResearch.com Interview with: Katherine Newton, PhD Senior Investigator at Group Health Research Institute in Seattle MedicalResearch.com: What are the main findings of the study? Answer: We found that when women took a 12-week yoga class and practiced yoga at home, they had significantly less insomnia than did women who did not. This was the only statistically significant finding in this MsFLASH (Menopause Strategies: Finding Lasting Answers for Symptoms and Health) Network randomized controlled trial. We also found that being in the yoga class did not decrease the number of hot flashes or night sweats. Yoga  was linked to better sleep quality and less depression—but  these effects were not statistically significant. In separate papers, published slightly earlier, our MsFLASH group reported that a non-yoga exercise program seemed linked to slightly improved sleep and less insomnia and depression—but these effects were not statistically significant. And an omega-3 (fish oil) supplement was not linked to any improvement in hot flashes, night sweats, sleep, or mood.   (more…)
Alzheimer's - Dementia, Author Interviews / 03.10.2013

MedicalResearch.com Interview with: Keiichi Yamamoto, MD, PhD Department of Geriatric Medicine and Neurology, Osaka City University Graduate School of Medicine Osaka, Japan. MedicalResearch.com: What are the main findings of the study? Answer: Aβ is normally bound to and transported by albumin in blood. We therefore hypothesized that decreased blood levels of Albumin-Aβ complexes may be associated with decreased Aβ removal from brain to blood, resulting in Aβ accumulation in the brain. This is the first study demonstrated that decreased serum level of albumin-Aβ complexes was strongly associated with a higher prevalence of Alzheimer’s disease (AD). This association was independent of age, sex, and ApoE4 allele. In addition, decreased serum level of albumin-Aβ complexes was correlated with decreased levels of Aβ42 in the CSF and increased levels of p-tau in the CSF, findings that have been shown to be associated with specific neuropathologic findings and AD progression. (more…)
Author Interviews, JAMA, Pediatrics / 02.10.2013

Shaon Sengupta, MD MBBS MPH Division of Neonatology, Department of Pediatrics Children’s Hospital of Philadelphia, Philadelphia, PennsylvaniaMedicalResearch.com Interview with: Shaon Sengupta, MD MBBS MPH Division of Neonatology, Department of Pediatrics Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania MedicalResearch.com: What are the main findings of the study? Dr. Sengupta: In this study we looked at all full-term neonates, which are defined as those born between 37 weeks 0 days to 41 weeks 6 days. Early term deliveries (37–38 weeks) are a significant part of all full-term deliveries, but are not the norm. In our study, 27% of neonates were born early term (37-38 weeks) while almost 62% were born at or after 39 weeks (term neonates). Similar data has been reported by other established sources of vital statistics. While traditionally, full term neonates are perceived to be a homogenous low-risk group, the findings from our study urge the pediatrics/neonatal provider to recognize early term (37-38 weeks) neonates as a higher risk group. They have significantly higher risk of NICU admission, respiratory morbidity, hypoglycemia, need for IV fluids and antibiotics. (more…)
Author Interviews, JAMA, Opiods, Pharmacology, Weight Research / 02.10.2013

Marsha A. Raebel, PharmD, BCPS, FCCP Investigator in Pharmacotherapy Institute for Health Research 10065 E. Harvard Ave Suite 300 Denver, CO 80231.MedicalResearch.com Interview with: Marsha A. Raebel, PharmD, BCPS, FCCP Investigator in Pharmacotherapy Institute for Health Research 10065 E. Harvard Ave Suite 300 Denver, CO 80231. MedicalResearch.com: What are the main findings of the study? Answer: We found that in a group of patients who took chronic opioids for non-cancer pain and who underwent bariatric surgery there was greater chronic use of opioids after surgery compared with before surgery, findings that suggest the need for proactive management of chronic pain in these patients after surgery. (more…)
Author Interviews, Cognitive Issues, PNAS / 02.10.2013

Agnieszka Anna Tymula Lecturer (Assistant Professor) School of Economics The University of Sydney NSW 2006, AustraliaMedicalResearch.com Interview with: Agnieszka Anna Tymula Lecturer (Assistant Professor) School of Economics The University of Sydney NSW 2006, Australia MedicalResearch.com: What are the main findings of the study? Answer: We found that individual risk preferences as well as consistency and rationality in choice change with age. Just like cognitive abilities, the ability to make consistent and rational decisions considerably declines in older adulthood. Tolerance to risk in the domain of gains follows an inverted U-shaped pattern along the life span, with older adults (65+ y. o.) and adolescents being more risk averse than young or midlife adults. Interestingly, in the domain of losses, older adults are willing to accept significantly more risks than adolescents, young and midlife adults. (more…)
Author Interviews, Cognitive Issues, PLoS / 02.10.2013

Professor of Neuroscience Programme Director for BSc and MSci Pharmacology degrees School of Physiology & Pharmacology Medical and Veterinary Sciences University Walk University of Bristol Bristol, BS8 1TD.Neil V. Marrion, PhD Professor of Neuroscience Programme Director for BSc and MSci Pharmacology degrees School of Physiology & Pharmacology Medical and Veterinary Sciences University Walk University of Bristol Bristol, BS8 1TD. MedicalResearch.com: What are the main findings of the study? Dr. Marrion: We tested pravastatin and atorvostatin (two commonly prescribed statins) in rat learning and memory models.  Rats were treated daily with pravastatin (brand name - Pravachol) or atorvostatin (brand name - Lipitor) for 18 days. The rodents were tested in a simple learning task before, during and after treatment, where they had to learn where to find a food reward. On the last day of treatment and following one week withdrawal, the rats were also tested in a task which measures their ability to recognise a previously encountered object (recognition memory). The study’s findings showed that pravastatin tended to impair learning over the last few days of treatment although this effect was fully reversed once treatment ceased. However, in the novel object discrimination task, pravastatin impaired object recognition memory.  While no effects were observed for atorvostatin in either task. (more…)
Author Interviews, Nature, UT Southwestern, Weight Research / 01.10.2013

Philipp E. Scherer, PhD Professor, Department of Internal Medicine Gifford O. Touchstone Jr. and Randolph G. Touchstone Distinguished Chair in Diabetes Research Director, Touchstone Diabetes Center The University of Texas Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, TX 75390-8549MedicalResearch.com Interview with: Philipp E. Scherer, PhD Professor, Department of Internal Medicine Director, Touchstone Diabetes Center The University of Texas Southwestern Medical Center Dallas, TX 75390-8549 MedicalResearch.com: What are the main findings of the study? Dr. Scherer: This is the first study that tracks the emergence of new fat cells in response to various physiological stimuli, such as high fat diet and cold exposure.  (more…)
Author Interviews, Global Health, Infections, Lancet / 01.10.2013

Prof Didier Pittet, MD, MS Director of the Infection Control Programme and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals, Geneva, SwitzerlandMedicalResearch.com Interview with : Prof Didier Pittet, MD, MS Director of the Infection Control Programme and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals, Geneva, Switzerland   MedicalResearch.com : What are the main findings of the study? Prof. Pittet: The main finding is that the WHO hand hygiene promotion strategy is feasible and sustainable across healthcare settings worldwide. For the first time, we have evidence of its feasibility and successful effects to improve hand hygiene in a variety of different geographical and income settings, with an even greater impact in low-/middle-income countries than in high-income countries. (more…)
Author Interviews, Heart Disease, Medical Imaging / 30.09.2013

Dr. Afshin Farzaneh-Far, M.D. University of Illinois at ChicagoMedicalResearch.com Interview with: Dr. Afshin Farzaneh-Far, M.D. University of Illinois at Chicago MedicalResearch.com: What are the main findings of the study? Answer: Traditionally SPECT MPI has been performed with adenosine which has a significant body of published prognostic data. Regadenoson is a selective A2A receptor agonist and is now the stress agent most widely used in the United States. Unlike adenosine, regadenoson is given as a bolus rather than as an infusion, simplifying the testing protocol and is better-tolerated. However, despite increasing use of regadenoson, there is very limited data on risk prediction using this agent. This study showed that the ability of SPECT MPI to predict heart attacks and death is the same for the new stress agent Regadenoson as it is for the old agent Adenosine. (more…)
Alzheimer's - Dementia, Author Interviews, Cognitive Issues / 30.09.2013

Teppo Särkämö PhD Institute of Behavioural Sciences PL 9 (Siltavuorenpenger 1A), 363 FI-00014, HELSINGIN YLIOPISTO FinlandMedicalResearch.com: Teppo Särkämö PhD Institute of Behavioural Sciences PL 9 (Siltavuorenpenger 1A), 363 FI-00014, HELSINGIN YLIOPISTO Finland MedicalResearch.com: What are the main findings of the study? Answer: We found that caregiver-implemented musical leisure activities, such as singing and music listening, are beneficial for elderly persons with mild-moderate dementia (PWD). Compared to standard care, regular singing and music listening improved mood, orientation level, episodic memory and to a lesser extent, also attention and executive function and general cognition. Singing also enhanced verbal working memory and caregiver well-being, whereas music listening had a positive effect on quality of life. (more…)
Author Interviews, Lung Cancer / 30.09.2013

MedicalResearch.com: Interview with: Dr. Atul Butte, MD, PhDDr.  Atul Butte, MD, PhD and Julien Sage Ph. DJulien Sage PhD Departments of Pediatrics and Genetics Department of Internal Medicine, University of California Davis Cancer Center University of California Davis School of Medicine Sacramento, California MedicalResearch.com: What are the main findings of the study? Answer: A major finding of the study is the identification of first-generation anti-depressants as possible drugs effective against a lethal subtype of lung cancer, small cell lung cancer. A second important aspect of this work is the use of a bioinformatics-based drug repositioning pipeline developed by the Butte lab, which allowed us, when combined with advanced mouse models of lung cancer developed by the Sage lab, to identify a novel targeted therapy against SCLC and initiate a clinical trial in less than 2 years. (more…)
Author Interviews, Prostate Cancer / 26.09.2013

Robert G Bristow MD, PhD, FRCPC Clinician-Scientist, Ontario Cancer Institute/Princess Margaret Cancer Centre Professor, Depts. of Radiation Oncology and Medical Biophysics, University of Toronto Director, Core I - STTARR Innovation Facility Canadian Cancer Society Research Scientist MedicalResearch.com Interview with: Robert G Bristow MD, PhD, FRCPC Clinician-Scientist, Ontario Cancer Institute/Princess Margaret Cancer Centre Professor, Depts. of Radiation Oncology and Medical Biophysics, University of Toronto Director, Core I - STTARR Innovation Facility Canadian Cancer Society Research Scientist http://www.uhnres.utoronto.ca/researchers/profile.php?lookup=645 MedicalResearch.com: What are the main findings of the study? Dr. Bristow: We studied the more than 7 years of outcome of close to 250 patients with localized (intermediate risk) prostate cancer that received precision radiotherapy or surgery for cure. We found that up to one third of these patients fail initial radiotherapy or prostate surgery. By using a patient’s initial diagnostic core biopsy, we studied the DNA fingerprints of the tumors. We noticed a pattern in which the patients that had failed treatment had abnormal levels of breaks at sites within the chromosomes that are sensitive to DNA damage called, “common fragile sites” (CFS). These CFS break abnormalities have been linked to cancer in general and usually are associated with instability of the cell’s DNA-a phenomenon that is particularly associated with cancer. So patients who have unstable chromosomes are more likely to fail precision radiotherapy or surgery. (more…)
Author Interviews, Cancer Research, Diabetes, NYU, Weight Research / 26.09.2013

Niyati Parekh, PhD, RD Assistant Professor of Nutrition and Public Health, Director of Doctoral Program in Clinical Nutrition, Department of Nutrition, Food Studies and Public Health, Steinhardt School and Department of Population Health, NYU Langone School of Medicine, New York University 411 Lafayette Street NY. NY-10003.MedicalResearch.com Interview with: Niyati Parekh, PhD, RD Assistant Professor of Nutrition and Public Health, Director of Doctoral Program in Clinical Nutrition, Department of Nutrition, Food Studies and Public Health, Steinhardt School and Department of Population Health, NYU Langone School of Medicine, New York University 411 Lafayette Street NY. NY-10003. MedicalResearch.com: What are the main findings of the study? Dr. Parekh: The objective of the study was to investigate disturbances in blood glucose levels in relation to risk of obesity-related cancers. We observed an increased risk of obesity-related cancers, specifically colon cancer among persons with abnormal glucose values. These findings were stronger among persons who had this abnormality for longer duration (>10years). (more…)
Author Interviews, Pancreatic, Radiation Therapy / 26.09.2013

MedicalResearch.com Interview with: Dr. Raphael Yechieli Department of Radiation Oncology at Henry Ford Hospital in Detroit: MedicalResearch.com: What are the main findings of the study? Dr. Yechieli:  The main findings of the study are that elderly patients with pancreatic cancer who also have significant co-morbidities can still be safely and effectively treated with a short course of radiation treatment. Furthermore, the local control and survival data from our study are similar to previously published data, where patients were treated with more intense and longer courses of treatment. (more…)