Author Interviews, Infections, JAMA, Vaccine Studies / 25.02.2014
Routine Vaccinations May Also Protect Against Unrelated Infections
MedicalResearch.com Interview with:
Signe Sørup, PhD
Research Center for Vitamins and Vaccines (CVIVA)
Bandim Health Project, Statens Serum Institut
Artillerivej 5, DK-2300 Copenhagen S, Denmark
MedicalResearch.com: What are the main findings of the study?
Dr. Sørup: We found that admissions with any type of infection was reduced with 14 % for Danish children having the live, attenuated vaccine against measles, mumps, and rubella (MMR) as the most recent vaccine compared with children having the inactivated vaccine against Diphtheria, Tetanus, Pertussis, Polio, and Haemophilus Influenzae type b (DTaP-IPV-Hib) as the most recent vaccine. In Denmark herd immunity against measles, mumps, and rubella is high and only 26 of the more 42,000 admissions was related to measles, mumps, and rubella; so this finding cannot be explained by the specific protection against the targeted diseases.
In Denmark MMR vaccination is recommended at 15 months of age, but only 50% of the children in the study had received MMR before 16 months of age. We estimated that one hospital admission between 16 and 24 months of age could be avoided for 201 children vaccinated with MMR before 16 months of age rather than later.
These results are based on a retrospective cohort study including approximately half a million Danish children. The analyses are adjusted for age and a long range of background factors, including socio-economic factors.
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