Author Interviews, C. difficile, Infections, Nutrition, Probiotics / 07.06.2013

MedicalResearch.com eInterview with: Dr. Reena Pattani MD Department of Medicine St. Michael’s Hospital 30 Bond Street, Toronto ON M5B 1W8 MedicalResearch.com: What are the main findings of the study? Dr. Pattani: We performed a meta-analysis of 16 studies that assessed the effectiveness of probiotics administered concurrently with antibiotics compared to the use of antibiotics alone. The use of probiotics among patients in these trials reduced the risk of antibiotic-associated diarrhea by almost 40% and decreased the rate of Clostridium difficile infection by 63%. On subgroup analysis, the reduction remained statistically significant for the subgroups of good quality trials, trials in which a primarily Lactobacillus-based regimen was used, and those studies which had a follow-up period of less than 4 weeks.
Author Interviews, JAMA, Nutrition, Outcomes & Safety, Vegetarians / 06.06.2013

MedicalResearch.com eInterview with: Michael J. Orlich, M.D. Program Director Preventive Medicine Residency Loma Linda University www.lluprevmedres.org Research Fellow, Adventist Health Studies www.adventisthealthstudy.org MedicalResearch.com: What are the main findings of the study? Dr. Orlich: The main findings were these. Vegetarians, as we defined them, had reduced risk of death during the study period compared to non-vegetarians. This was true also for particular vegetarian diets including for vegans, lacto-ovo-vegetarians, and pesco-vegetarians.  Reduced risk was seen in particular for deaths related to disease of the heart, kidneys, and diabetes. Findings were stronger in men than women.
Author Interviews, Brigham & Women's - Harvard, Diabetes, Kidney Disease, Medical Research Centers, Mediterranean Diet, Nutrition / 29.05.2013

MedicalResearch.com eInterview with Iris Shai, RD, PhD PI of the DIRECT trial Ben Gurion University of the Negev, Israel MedicalResearch.com: What are the main findings of the study? Dr. Shai: Low-carbohydrate is as effective as Mediterranean or low-fat diets in improving renal function among moderately obese participants with or without type 2 diabetes, with baseline serum creatinine<176µmol/L (not sever renal stage).  The effect is likely to be mediated by weight-loss induced improvements in insulin sensitivity and blood pressure.
Author Interviews, JAMA, Nutrition / 14.05.2013

MedicalResearch.com eInterview with: Mary Scourboutakos PhD student at the University of Toronto Mary R. L'Abbe, PhD Earle W. McHenry Professor, and Chair, Department of Nutritional Sciences Faculty of Medicine, University of Toronto FitzGerald Building, 150 College Street, Rm 315 Toronto, ON, Canada M5S 3E2 MedicalResearch.com: What are the main findings of the study? Answer: We found that chain restaurant meals on average contained half a day's worth of calories, almost a full day's worth of fat and saturated fat, and more than a day's worth of sodium.
Author Interviews, Diabetes, Nutrition / 30.04.2013

This interview content is written by Dr Dae-Kyu Song, the corresponding and responsible author of the manuscript shown at “Park, Jae-Hyung et al. (2013). Green tea extract with polyethylene glycol-3350 reduces body weight and improves glucose tolerance in db/db and high-fat diet mice. Naunyn-Schmiedeberg’s Archives of Pharmacology. DOI 10.1007/s00210-013-0869-9“. Dr Jae-Hyung Park is the first author of the manuscript and a graduate student of Dr. Dae-Kyu Song MedicalResearch.com: What are the main findings of the study? Answer: At doses which could be achieved by drinking green tea on a daily basis, it has been known that green tea extract (GTE) inhibits intestinal glucose and lipid absorption when it is present in the intestinal tract. It is a reason why green tea consumption has been known to be beneficial for controlling obesity and type 2 diabetes. However, we have found that, after the intestinal absorption of GTE itself, the circulating GTE can elevate blood glucose levels by blocking cellular glucose uptake in most tissues, thereby limiting glucose utilization of the tissues. Therefore, we have tried to prolong the residence time of GTE in the intestine and block the intestinal absorption of GTE, by adding non-toxic polymer polyethylene glycol (PEG) to GTE. As a result, in 4 week treatment, the GTE+PEG regimen dramatically helps obesity-induced diabetic mice lose body weight and ameliorate glucose intolerance. Interestingly, GTE alone is without any effect.
Author Interviews, Nature, Nutrition, Pediatrics / 12.04.2013

MedicalResearch.com eInterview with Dr Emma Boyland Biopsychology Research Group. Liverpool Obesity Research Network. University of Liverpool. MedicalResearch.com: What are the main findings of the study? Dr. Boyland: Children who were exposed to a TV commercial for Walker’s potato chips featuring a celebrity endorser showed a greater brand preference for Walker’s and consumed more Walker’s chips than a purported ‘supermarket brand’. Exposure to the celebrity endorser in a different, non-promotional context (presenting a soccer highlights TV program) also had a similar impact on brand choice and intake. This effect was not seen in response to another snack food commercial or a non-food commercial. Importantly, children did not reduce their consumption of the perceived ‘supermarket brand’ to compensate, they simply consumed more Walker’s crisps so this effect could contribute to overconsumption.
Author Interviews, BMJ, Diabetes, Exercise - Fitness, Nutrition, Weight Research / 10.04.2013

MedicalResearch.com eInterview with

Manuel Franco MD, PhD Associate Professor Department of Health Sciences, Public Health Unit Universidad de Alcalá mfranco@uah.es http://www.uah.es/pdi/manuel_franco Adjunct Associate Professor Department of Epidemiology Johns Hopkins Bloomberg School of Public Health mfranco@jhsph.eduManuel Franco MD, PhD Associate Professor Department of Health Sciences, Public Health Unit Universidad de Alcalá Johns Hopkins Bloomberg School of Public Health Adjunct Associate Professor Dept. of Epidemiology mfranco@jhsph.edu

MedicalResearch.com: What are the main findings of the study? Dr. Franco: Population wide weight loss of about 5 kg was related with large decreases in diabetes and cardiovascular mortality. On the contrary, Body weight regain was related with an increase in diabetes prevalence, incidence, and mortality, as well as a deceleration in the previously declining rates of cardiovascular death.
Author Interviews, Nutrition / 18.03.2013

MedicalResearch.com Interview with: Yoshihiro Kokubo, MD, PhD, FACC, FAHA, FESC Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, 5-7-1, Fujishiro-dai, Suita, Osaka, MedicalResearch.com: What are the main findings of the study? Dr. Kokubo:  In this study, higher green tea (2 or more cups/day) and coffee (3 to 6 times/week, 1 or more cups/day) consumption were found to be inversely associated with the incidences of cardiovascular disease and stroke. Higher green tea (2 or more cups/day) or coffee (1 or more cups/day) consumption reduced the risks of cardiovascular disease, strokes, and its subtypes, especially in intracerebral hemorrhage (P for interaction between green tea and coffee=0.04).
Author Interviews, Nutrition, OBGYNE, Pediatrics / 17.03.2013

MedicalResearch.com Interview with : Verena Sengpiel, researcher Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg MedicalResearch.com: What are the main findings of the study? Response: 1. Coffee, but not caffeine, consumption was associated with marginally increased gestational length but not with the risk of spontaneous preterm delivery. 2. Caffeine intake was consistently associated with decreased birth weight and increased odds of SGA (small for gestational age). This might have clinical implications as even caffeine consumption below the recommended maximum (200 mg/d in the Nordic countries and USA, 300 mg/d according to WHO) was associated with increased risk for SGA.