Author Interviews, Nutrition, Pancreatic / 05.06.2014
Green Tea Ingredient Changes Metabolism of Pancreatic Cancer Cells
MedicalResearch.com Interview with:
Wai-Nang Paul Lee, M.D.
Division Chief, Division of Pediatric Endocrinology and Metabolism
Professor of Pediatrics
Director of Biomedical Mass Spectrometry Laboratory
Harbor-UCLA
MedicalResearch: What are the main findings of the study?
Dr. Wai-Nang Lee: The study reports that EGCG, the active biologic constituent in green tea, changed the metabolism of pancreatic cancer cells by suppressing the
expression of an enzyme associated with cancer, LDHA.
The researchers also compared the effects of EGCG with those of an enzyme
inhibitor, oxamate, which is known to reduce LDHA activity, and found that
they both operated in a similar manner by disrupting the pancreatic cancer
cells metabolic system.
Scientists had believed they needed a molecular mechanism to treat cancer,
but this study shows that they can change the metabolic system and have an
impact on cancer.
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