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10 Dec PRIMO Trial: Dose Optimization of Duvelisib in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma
This was the first phase of the larger primo study. The main expansion phase of this registration-directed study is currently underway in the United States and is opening in Germany, UK, Italy, and Japan.
09 Dec Biomarker for Response to Treatment of Acute Graft-Versus-Host Disease
The MAGIC Algorithm Probability is the first validated biomarker of response to acute GVHD treatment and more accurately predicts long-term mortality than the gold standard, clinical response to treatment.
06 Dec Phase I Study of Duvelisib and Venetoclax in Relapsed or Refractory CLL / SLL
Exploring the combination of duvelisib plus venetoclax in this patient population is a promising pathway for future study
04 Dec Study Refutes “Sterile Womb Dogma”: How the Cold Virus Can Spread to Fetus from Mother
We have known for many years that several infections - such as toxoplasmosis, rubella, CMV, herpes – can be transmitted to the fetus and cause severe structural deformities manifesting at birth.
27 Nov Association of Disability With Mortality From Opioid Overdose
The 1.7 million adult Medicare enrollees who qualified for disability—14.9% of the Medicare population—accounted for 80.6% of all opioid overdose deaths among all Medicare enrollees.
20 Nov FDA Approves VUMERITY™ For Relapsing Forms of Multiple Sclerosis
Multiple Scleroisis is a heterogeneous disease, and real-world patient circumstances can vary, reinforcing the benefits of having therapeutic choices to support the diverse range of treatment considerations
17 Nov Pediatric Dermatology Journal Offers Practical Advice For Caring For Sexual and Gender Minority Children
My personal experience has been that sexual and gender minority teens appreciate a provider who is making an effort and wants to “do better” for this population.
13 Nov Government Spending on Biologic Anti-Rheumatic Drugs Doubles Over 4 Years
Posted at 01:37h
in Author Interviews, Brigham & Women's - Harvard, Cost of Health Care, Rheumatology
Spending on Medicare and Medicaid claims for bDMARDs nearly doubled from $5.3 billion in 2012 to $10.3 billion in 2016.
30 Oct Racial Disparities Persist in Access to Specialized Heart Failure Hospital Services
Like at many institutions, it is often easier for patients to be accepted to an inpatient cardiology service with limited beds if they are known to an institutional cardiologist or if their cardiologist can advocate for them for appropriate admission.
25 Oct Highly Prevalent Atopic Dermatitis (Eczema) Is Not Just a Childhood Disease
Atopic Dermatitis substantially affects the life of patients and their families, and this burden is higher with greater AD severity.
09 Oct Long Term Treatment With Dabigatran Reduces Alzheimer’s Symptoms in Mouse Model
Long-term treatment with an oral direct anticoagulant ameliorates Alzheimer´s disease pathogenesis in a mouse model of the disease.
03 Oct Wistar Researchers Identify Mitochondrial Factor That Keeps Cancer Cells Alive
MedicalResearch.com Interview with: Ekta Agarwal, Ph.D. Postdoctoral fellow in the lab of Dario Altieri, M.D. Wistar president and CEO ,Director of the Institute’s Cancer Center Robert & Penny Fox Distinguished Professor and co-first author on the study. MedicalResearch.com: What is the background for this study? Response: Mitochondrial reprogramming is...
25 Sep Apple Cider Vinegar Soaks Did Not Improve Skin Barrier in Atopic Dermatitis – Eczema
There was no change after the 2 weeks of apple cider vinegar soaks in the “skin barrier function” which we measured as the amount of water lost from the skin
24 Sep Increased Hypertension Risk in Patients With Periodontitis – Gum Disease
Looking after oral health is often neglected and instead should be considered as important as managing other general health problems.
24 Sep Bispecific Inhibitor Helps Overcome Pancreatic Cancer Drug Resistance
While novel immunotherapies and target cancer therapies have shown promising results, the percentage of patients responding to single-agent checkpoint inhibitor drugs is only 12.46% on average for all tumor types.
16 Sep Atopic Dermatitis: Antibiotic Choice in Pediatric Superinfections
Systemic therapy for pediatric atopic dermatitis is advancing
08 Sep THEMIS-PCI Trial: Ticagrelor in Patients with Diabetes and Stable CAD with History of PCI
Posted at 00:30h
in Author Interviews, Brigham & Women's - Harvard, Clots - Coagulation, Diabetes, Heart Disease, Lancet
In carefully selected patients with diabetes and stable coronary artery disease who have a history of previous coronary stenting and have presumably tolerated DAPT in the past without bleeding complications, the combination of ticagrelor plus low-dose aspirin should be considered.
06 Sep Bacterial Microbiome Could Enhance Effects of Metformin
Our research opens up the avenue for the development of specific dietary guidelines or even genetically modified bacteria that could enhance the effects of metformin and reduce its side-effects.
21 Aug Meaningful PTSD Improvement Associated with Lower Risk of Diabetes
Patients may consider the secondary health benefits when deciding to complete PTSD psychotherapy.
19 Aug Lavender Oil Linked to Abnormal Breast Development in Girls and Boys
It is still unknown why a small portion of these children experience abnormal, early breast growth and others are unaffected.
16 Aug Men With Dementia More Likely to Receive Aggressive Care at End of Life
Our study findings suggest that this gender bias may persist at the end of life, when more aggressive care—something that may have been valued at a younger age—is still provided despite such care no longer being necessarily optimal.
14 Aug FDA Identifies No New Safety Concerns Associated with Prostate Cancer Treatment Vaccine Sipuleucel-T
While this is the largest post-marketing study of safety and sipuleucel-T, our results should be considered in the context of study limitations.
11 Aug Nanovaccine Opens New Approach to Melanoma Treatment
We believe that vaccination will play an important role in cancer therapies in the future, particularly in modulating the patients’ own immune system, turning it into its functional state
06 Aug Treatment and Recovery Services Appear Particularly Important For Sustained Recovery in Opioid Addiction
Our findings suggests that an estimated 1.18 million American adults have resolved a primary opioid use problem.
05 Aug Application of Romulus and Remus Hypothesis Can Help Autistic Children Improve Language Skills
The Romulus and Remus hypothesis cannot be tested in extinct hominins, but can be applied to children who don’t naturally acquire full recursive language.
27 Jul Can We Learn From Advice We Would Give Our Younger Selves?
While people should not wallow in the past, it’s important to think about the advice we would offer our younger selves
18 Jul Older Patients May Benefit from Combination of Simvastatin-Ezetimibe After Acute Coronary Syndrome
Our data show that elderly patients after an acute coronary syndrome may derive significant benefit with preserved safety from higher-intensity lipid-lowering therapy with ezetimibe-simvastatin versus simvastatin alone
17 Jul HIV Incidence: Effect of Universal Testing and Treatment
Delivery of an HIV prevention strategy that includes offering in-home HIV testing to everyone, with immediate referral to HIV care, and rapid initiation of treatment for people living with HIV, can substantially reduce new HIV infections