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22 Sep High-Risk Gleason 5 Prostate Cancers Not Resistant to Androgen Deprivation Therapy
MedicalResearch.com Interview with: Amar U. Kishan, MD Assistant Professor Department of Radiation Oncology University of California, Los Angeles MedicalResearch.com: What is the background for this study? What are the main findings? Response: Three large randomized trials demonstrated an overall survival (OS) benefit when androgen deprivation therapy (ADT) is combined with...
20 Sep Amyloid Targeting Therapy More Likely To Be Effective Early in Alzheimer’s Disease
3. By identifying key molecules and signalling pathways underpinning Alzheimer’s Disease pathogenesis we may be able to identify drugs already in the clinic which may be repurposed.
11 Sep IMPRES Score Predicts Melanoma Response to Immunotherapy
IMPRES outperforms existing predictors for all treatment groups and captures almost all true responders while misclassifying less than half of the nonresponders
01 Aug Pancreatic Cancer: Cannabidiol + Chemotherapy Improved Survival (in mice)
MedicalResearch.com Interview with: Prof Marco Falasca Head Metabolic Signalling Group School of Pharmacy & Biomedical Sciences Faculty of Health Sciences Curtin University Western University MedicalResearch.com: What is the background for this study? What are the main findings? Response: Each year around 9,800 people in the UK are diagnosed with pancreatic...
21 Jul Gene Biomarker Can Predict Brain Tumor Patients Who Have Better Outcomes
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in Author Interviews, Biomarkers, Brain Cancer - Brain Tumors, Cancer Research, Genetic Research
MedicalResearch.com Interview with: Arnab Chakravarti MD Professor and Chair of Radiation Oncology Arthur G. James Cancer Hospital and Richard J. Solove Research Institute The Ohio State University Comprehensive Cancer Center MedicalResearch.com: What is the background for this study? Response: Historically, the treatment for grade two gliomas has been a...
21 Jun Anti-PD1 Immunotherapy May Work Better in Older Melanoma Patients
Ashani Weeraratna, Ph.D. The Ira Brind professor and Co-program leader of the Immunology, Microenvironment and Metastasis Program The Wistar Institute Member of Wistar’s Melanoma Research Center Philadelphia MedicalResearch.com: What is the background for this study? What are the main findings? Response: This study shows for the first time that older patients, especially those who have had prior MAPKi therapy fare better than younger patients when treated with anti-PD1. We found that tumors in younger patients and younger mice have higher levels of Tregulatory cells, the cells that regulate other immune cells. This is not true systemically, only within the tumor microenvironment. We were surprised because we expected that, as with targeted therapy, older patients would have a poorer response to immunotherapy, given what we perceive as a poorer immune system in older patients.16 Jun Synovial tissue profiling in autoantibody positive at risk individuals reveals gene signatures associated with later development of rheumatoid arthritis
MedicalResearch.com Interview with: Dr. Lisa van Baarsen PhD Principal Investigator at the Amsterdam Rheumatology and Immunology Cente Academic Medical Center the Netherlands MedicalResearch.com: What is the background for this study? What are the main findings? Response: The discovery that autoantibodies can be present years before the onset of clinical symptoms...05 Jun Everolimus Plus Exemestane vs Monotherapy for ER+ HER2- Advanced Breast Cancer
MedicalResearch.com Interview with: Dr. Guy Jerusalem, MD, PhD CHU Sart Tilman Liege and Liege University Liege, Belgium MedicalResearch.com: What is the background for this study? What are the main findings? Response: BOLERO-6 was conducted to fulfill postapproval regulatory commitments to the FDA and EMA to estimate treatment benefit with EVE + EXE...29 May SUNSET Trial Supports Bronchodilators as Foundation of COPD Therapy
MedicalResearch.com Interview with: Kenneth R. Chapman, MD MSc FRCPC FACP FCCP, FERS Director, Asthma & Airway Centre, University Health Network, Professor of Medicine, University of Toronto, GSK-CIHR Research Chair in Respiratory Health Care Delivery, Toronto, Ontario MedicalResearch.com: What is the background for this study? What are the main findings? Response:...18 Apr Chemotherapy Choice Can Be Aided By Assessing TDP Profile
MedicalResearch.com Interview with: Ed Liu, M.D President and CEO The Jackson Laboratory (JAX) MedicalResearch.com: What is the background for this study? What are the main findings? Response: A few years ago we and others identified a complex genomic instability profile commonly found in the genomes of breast, ovarian and endometrial...26 Mar Everolimus plus Endocrine Therapy: Effective 1st Line Option for Postmenopausal Women with HR+/HER2- Advanced Breast Cancer
MedicalResearch.com Interview with: Melanie E. Royce, MD, PhD Division of Hematology/Oncology University of New Mexico Comprehensive Cancer Center Albuquerque MedicalResearch.com: What is the background for this study? What are the main findings? Response: BOLERO-4 is an open label, single-arm, Phase II study that evaluates the combination of everolimus plus letrozole as a first-line treatment...22 Mar Obesity Fuels Resistance To Anti-VEGF Therapy in Breast Cancer Patients
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in Author Interviews, Breast Cancer, Brigham & Women's - Harvard, Science, Weight Research
MedicalResearch.com Interview with: Dai Fukumura, M.D., Ph.D Associate Professor, Radiation Oncology Harvard Medical School Deputy Director, Edwin L. Steele Laboratory, Radiation Oncology, Massachusetts General Hospital Boston, MA Dr. Joao Incio PhD Post-Doc, Edwin L. Steele Laboratory Dr. Rakesh K. Jain PhD Andrew Werk Cook Professor of Tumor...
26 Feb Genetic Variant of p53 Associated With Poor Breast Cancer Survival
MedicalResearch.com Interview with: Maureen E. Murphy, Ph.D. Program Leader and Professor Molecular and Cellular Oncogenesis and Subhasree Basu PhD Postdoctoral researcher The Wistar Institute Philadelphia, PA 19104 MedicalResearch.com: What is the background for this study? What are the main findings? Response: Unlike most other genes that are intimately involved in...06 Feb ASPIRE: Combination Therapy With KYPROLIS (carfilzomib) Extended Overall Survival in Relapsed/Refractory Multiple Myeloma
MedicalResearch.com Interview with: David S. Siegel, MD, PhD Chief, Myeloma Division John Theurer Cancer Center Hackensack University Medical Center Hackensack, NJ 07601 MedicalResearch.com: What is the background for this study? What are the main findings? We reported results from the prospectively planned final analysis of overall survival (OS) from the...27 Jan Adjuvant vs Early-Salvage Postprostatectomy Radiotherapy for Prostate Cancer
MedicalResearch.com Interview with: Jason Alexander Efstathiou, D., PH.D Director, Genitourinary Division Department of Radiation Oncology Clinical Co-Director, The Claire and John Bertucci Center for Genitourinary Cancers Multidisciplinary Clinic Massachusetts General Hospital MedicalResearch.com: What is the background for this study? What are the main findings? Response: When surgery has probably failed to cure a...23 Jan BEACON Triplet Therapy for BRAF Mutant Metastatic Colorectal Cancer Shows Promise
MedicalResearch.com Interview with: Scott Kopetz, M.D., Ph.D., FACP Associate Professor Department of Gastrointestinal Medical Oncology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston, TX MedicalResearch.com: What is the background for this study? What are the main findings? Response: The BRAF mutation carries a very poor prognosis...17 Jan Melanoma: New Combination Therapy Targets Resistant Tumors
MedicalResearch.com Interview with: Daniel S. Peeper, PhD Professor of Functional Oncogenomics (VUmc) Member of Oncode Institute Head, Division of Molecular Oncology & Immunology Chair, Scientific Faculty Council Chair, Translational Research Board The Netherlands Cancer Institute Amsterdam The Netherlands MedicalResearch.com: What is the background for this study? What are the main...08 Dec Older Diabetes Drug Metformin May Resensitize Tumors to Chemotherapy
MedicalResearch.com Interview with: Terra G Arnason, MD PhD, Associate Professor, Division of Endocrinology, Department of Medicine University of Saskatchewan Saskatoon, SK, Canada MedicalResearch.com: What is the background for this study? What are the main findings? Response: Response: Metformin has been used worldwide for decades to treat Type diabetes. Metformin is a...07 Dec Experimental Chemotherapy and Diabetes Medication Combination Shows Potential In Huntington’s Disease
MedicalResearch.com Interview with: Audrey S. Dickey, Ph.D. Assistant Professor Department of Neurology, DUMC 2900 Durham, NC 27710 MedicalResearch.com: What is the background for this study? What are the main findings? Response: A drug already used to treat certain forms of cancer may also be an effective therapy for Huntington’s disease, according...20 Nov PTK6 Inhibitors May Target Endocrine Therapy-Resistant ER+ Breast Cancer
MedicalResearch.com Interview with: Hanna Irie MD PhD, senior author Assistant Professor of Medicine (Hematology and Medical Oncology) and Oncological Sciences at The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? What are the main findings? Response: Our study identified PTK6...17 Nov Testicular Cancer Stem Cells Highly Sensitive To Chemotherapy, Resulting In High Cure Rates
MedicalResearch.com Interview with: Amy M. Lyndaker, Ph.D. Assistant Professor of Biology Division of Mathematics and Natural Sciences Elmira College This work was completed when I was a Research Associate in the laboratory of Dr. Robert S. Weiss at: Department of Biomedical Sciences College of Veterinary Medicine Cornell University Ithaca,...07 Nov Medical Tetrahydrocannabinol May Be Beneficial For Seizures and Chemotherapy Side Effects
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in Author Interviews, Brigham & Women's - Harvard, Cannabis, Pediatrics, Pediatrics
MedicalResearch.com Interview with: Shane Shucheng Wong, MD Massachusetts General Hospital Boston, Massachusetts MedicalResearch.com: What is the background for this study? Response: Medical cannabis is now legal in 29 states and the District of Columbia, and in those areas with active programs, children and adolescents can legally access medical cannabis with...
07 Nov Single Injection of Klotho Gene Protected Animals From Cognitive Decline
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in Alzheimer's - Dementia, Author Interviews, Cognitive Issues, Genetic Research, Nature
MedicalResearch.com Interview with: Dr Miguel Chillon PhD Department of Biochemistry and Molecular Biology Universitat Autonoma Barcelona Spain MedicalResearch.com: What is the background for this study? What are the main findings? Response: Klotho is a protein with an anti-aging and neuroprotective role. Recent studies show it prevents the development of cognitive...
14 Sep Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation
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in Author Interviews, Boehringer Ingelheim, Columbia, Heart Disease, J&J-Janssen, Merck, NEJM
MedicalResearch.com Interview with: Professor Christopher P. Cannon MD Executive Director, Cardiometabolic Trials, Baim Institute Cardiologist Brigham and Women’s Hospital Baim Institute for Clinical Research Columbia University College of Physicians and Surgeons MedicalResearch.com: What is the background for this study? What are the main findings? Response: The trial explored whether a...
07 Sep Genetic Variants Demonstrate Humans Continue To Evolve Through Natural Selection
MedicalResearch.com Interview with: Hakhamanesh Mostafavi, MS PhD student Department of Biological Sciences Columbia University MedicalResearch.com: What is the background for this study? Response: We know very little about the genetic variants that underlie adaptation in humans. This is in part because we have mostly been limited to methods that search...29 Aug Gene Helps Explain Why More Women Than Men Have Alzheimer’s
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in Alzheimer's - Dementia, Author Interviews, Gender Differences, Genetic Research, JAMA
MedicalResearch.com Interview with: Arthur W. Toga PhD Provost Professor of Ophthalmology, Neurology, Psychiatry and The Behavioral Sciences, Radiology and Engineering Ghada Irani Chair in Neuroscience Director, USC Mark and Mary Stevens Neuroimaging and informatics institute USC Institute for Neuroimaging and Informatics Keck School of Medicine of USC University of Southern...
27 Jul Cross-Sex Hormone Therapy Associated With Medical Risks and Psychosocial Benefits in Transgender Patients
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in Annals Internal Medicine, Author Interviews, Brigham & Women's - Harvard, Hormone Therapy, Sexual Health, Testosterone
MedicalResearch.com Interview with: Carl G Streed Jr. M.D. Pronouns: he, him, his, himself Fellow, Division General Internal Medicine & Primary Care Brigham & Women’s Hospital MedicalResearch.com: What is the background for this study? What are the main findings? Response: Recent reports estimate that 0.6% of adults in the United States,...