Author Interviews, Circadian Rhythm, Heart Disease, Occupational Health, Sleep Disorders / 27.04.2021
Social Jetlag Linked to Increased Cardiovascular Risk in Shift Workers
Circadian misalignment is associated with a high cardiovascular risk among shift workers:
MedicalResearch.com Interview with:
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Dr. Gamboa Madeira[/caption]
Sara Gamboa Madeira
Medical Doctor - General & Family Physician
PhD Student - EnviHealth&Co - Faculty of Medicine
Lisbon University
MedicalResearch.com: What is the background for this study?
Response: One in every five employees work in shifts across Europe1. Shift work have been associated with an increased risk for several cardiovascular diseases2 and three main mechanism have been proposed: unhealthy behaviours, disturbed sleep, and circadian misalignment.
This study focused on the role of circadian misalignment, which we assessed via social jetlag. Social jetlag is calculated using the Munich Chronotype Questionnaire3 by the difference between sleep behaviour on free-days (mainly driven by the individual “biological clock”, also called chronotype) and sleep behaviour on workdays (mainly drive by the “social clock”, namely work schedules). Chronotype is an individual feature which ranges from early/morning people to late/evening people (from proverbial lark to owls), with the majority of the population falling in between as a Gaussian distribution. Therefore higher levels of social jetlag mean a greater mismatch between what your biological clock need (e.g. go to sleep at 9pm) and what your social obligations impose on you (e.g. work until midnight).
Dr. Gamboa Madeira[/caption]
Sara Gamboa Madeira
Medical Doctor - General & Family Physician
PhD Student - EnviHealth&Co - Faculty of Medicine
Lisbon University
MedicalResearch.com: What is the background for this study?
Response: One in every five employees work in shifts across Europe1. Shift work have been associated with an increased risk for several cardiovascular diseases2 and three main mechanism have been proposed: unhealthy behaviours, disturbed sleep, and circadian misalignment.
This study focused on the role of circadian misalignment, which we assessed via social jetlag. Social jetlag is calculated using the Munich Chronotype Questionnaire3 by the difference between sleep behaviour on free-days (mainly driven by the individual “biological clock”, also called chronotype) and sleep behaviour on workdays (mainly drive by the “social clock”, namely work schedules). Chronotype is an individual feature which ranges from early/morning people to late/evening people (from proverbial lark to owls), with the majority of the population falling in between as a Gaussian distribution. Therefore higher levels of social jetlag mean a greater mismatch between what your biological clock need (e.g. go to sleep at 9pm) and what your social obligations impose on you (e.g. work until midnight).
Dr. Barrett[/caption]
Emily Barrett, PhD
Associate Professor
Department of Biostatistics and Epidemiology
Rutgers School of Public Health
MedicalResearch.com: What is the background for this study?
Response: We started this study in the very early stages of the pandemic to look at SARS-CoV-2 viral transmission and disease severity in health care workers as compared to non-health care workers. There was a tremendous amount of fear and uncertainty about the virus and the early anecdotal reports coming out of China and Italy highlighted the plight of many frontline health care workers who had been infected on the job. We knew that our U.S. health care workers would soon be facing this tremendous challenge. We started this study to examine risks of infection in our vulnerable frontline health care workers and a comparison group of non-health care workers. Our results are from the early stages of the U.S. pandemic in March-April 2020.

Dr. Nowell[/caption]
Dr. W. Benjamin Nowell, Ph.D.
Director of Patient-Centered Research
CreakyJoints, study co-author
Co-principal investigator of ArthritisPower
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Rheumatoid Arthritis (RA) can diminish patients’ work productivity and increase the risk of long-term disability, economic insecurity and worsening health, but limited research informs these issues. The purpose of our study was to examine associations between patients’ RA disease activity and their productivity and workplace support, using real-world data from the ArthritisPower research registry.
Our study looked at a sample of participants with RA who had a history of or current treatment with non-biologic and/or biologic disease-modifying antirheumatic drugs (DMARD) (n=296). Among the study sample, 74 percent had high disease activity (HDA) as determined by RAPID3 (>12), a common measure of disease activity in RA.





Prof. Chandola[/caption]
Professor Tarani Chandola
Cathie Marsh Institute and Social Statistics
www.cmist.manchester.ac.uk
University of Manchester
Co-director of the National Centre for Research Methods International Centre for Lifecourse Studies in Society & Health
MedicalResearch.com: What is the background for this study?
Response: The study examined the common perception that “any job is better than no job” to see whether this was true in terms of chronic stress levels. It followed up a group of unemployed adults representative of adults living in the UK, and compared their health and stress levels in terms of those who remained unemployed and those who became re-employed in poor and good quality work.





Dr. David Earnest[/caption]
David Earnest, Ph.D.
Professor in the Department of Neuroscience and Experimental Therapeutics
Texas A&M Health Science Center College of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Dr. Earnest: When body clocks are disrupted, as they are when people engage in shift work or go to bed and get up at radically different times every few days, more severe ischemic strokes can result.
MedicalResearch.com: What should readers take away from your report?
Dr. Earnest: Whenever possible, go to bed and get up at the same time each day and keep regular mealtimes. If you do need to keep an irregular schedule, it is especially important to be mindful of stroke risk and try especially hard to eliminate other risk factors, such as hypertension and obesity.
