MedicalResearch.com Interview with:Alison E. Field, ScD
Associate Professor of Pediatrics Boston Children's Hospital
Division of Adolescent Medicine
Boston, MA 02115
MedicalResearch.com: What are the main findings of the study? Answer: Girls who engage in frequent binge eating are much more likely than their peers with the same BMI to develop diabetes. The risk was greatest among girls with binge eating disorder.
MedicalResearch.com Interview with:Dr. Kathryn Orzech PhD
Postdoctoral fellow,Charting the Digital Lifespan
University of Dundee, Scotland, UK
MedicalResesarch.com: What are the main findings of the study?Dr. Orzech: We found that acute illnesses, such as colds, flu, and gastroenteritis were more common among healthy adolescents with shorter sleep. Specifically, our main analysis found that reported bouts of illness (analyzed on a bouts-of-illness-per-interview basis) declined with longer sleep for both male and female high school students. Longer sleep was also generally protective against school absences that students attributed to illness. There were sex differences, with males reporting fewer illness bouts than females, even with similar sleep durations. This is consistent with another recent study that showed a lower impact of shorter sleep on male adolescents (in that case the outcome was male adiposity), but more research is needed.
We also conducted a secondary analysis to examine total sleep time in matched 6-day windows before illness and before wellness in the same adolescents. Although the number of participants who met our strict criteria for a healthy 6-day window before illness or wellness was only 18 (I was amazed at how difficult it was to find adolescents who reported being completely well for 6 consecutive days), we were able to see a trend in the data toward shorter sleep before illness vs. wellness. Because of the difficulty in comparing sleep before illness vs. wellness, we conducted a qualitative analysis as well, choosing two 17 year old males who were both shorter sleepers, but who reported very different illness profiles - 0 days of illness vs. 35 days of illness across the school term. An in-depth look at notes made by interviewers allowed us to create brief case studies to illustrate that not all shorter sleepers are alike. More irregular sleep timing across weeknights and weekends (much shorter sleep during the week and longer sleep times on the weekend), and a preference for scheduling work and social time later in the evening hours may both contribute to differences in illness outcomes.
Dr. Abigail Powers PhDClinical Psychology Postdoctoral Fellow
Emory University School of MedicineMedicalResearch.com: What are the main findings of the study?Dr. Powers:Personality disorders (i.e., problematic personality patterns that cause significant distress and dysfunction in individuals’ lives across many areas of functioning) are associated with many negative health outcomes in young adulthood. The goal of this research study was to determine the relationship between personality pathology and medical resource utilization as individuals age and develop new physical health problems. Among community-dwelling later middle-aged adults (ages 55-64), we found that personality pathology was related to higher reported medical resource utilization (including doctor visits, hospitalizations, and number of outpatient procedures) independent of health status. Of the 10 DSM-IV personality disorders assessed, narcissistic and antisocial personality disorder features were associated with greater medical resource utilization independent of the presence of physical health problems. Also, among individuals with a greater number of physical health problems, histrionic and dependent personality disorder features were related to greater medical resource utilization, suggesting that important interactions between personality pathology and health conditions may occur in older age and impact resource use.
MedicalResearch.com Interview with: James Murphy, M.D.
Assistant Professor, Department of Radiation Medicine and Applied Sciences, Center for Advanced Radiotherapy Technologies ,UC San Diego Moores Cancer Center
La Jolla, CA 92093
MedicalResearch.com: What are the main findings of the study?Dr. Murphy: This study evaluated racial disparity in metastatic colorectal cancer. In a large population-based cohort we found of over 11,000 patients we found that black patients were less likely to be seen in consultation by a cancer specialist, and were less likely to receive treatment with chemotherapy, surgery, or radiation. Furthermore, we found that this disparity in treatment accounted for a substantial portion of the race-based differences between black and white patients.
MedicalResearch.com Interview with:Mohamed El Shayeb MD, MSc
Health Technology and Policy Unit
University of Alberta
3025 Research Transition Facility
Edmonton, Alberta, Canada T6G2V2
MedicalResearch.com: What are the main findings of the study?Dr. El Shayeb: Our study shows that limited channel level-3 portable devices, used at home, are of good diagnostic value compared to the comprehensive reference-standard level-1 sleep tests conducted in lab in the diagnosis of obstructive sleep apnea (the most common subtype of sleep disordered breathing.) Were any of the findings unexpected?
None of the findings were unexpected. Level-3 portable devices are commonly used in clinical practice; however, this technology has been widely disseminated, without solid evidence about their diagnostic performance or the subpopulation of sleep disordered breathing patients who are most appropriately diagnosed with them. Our research provides a high level of evidence on the diagnostic performance of these devices, and most importantly, defines the subgroup of patients who are eligible for this test (patients with simple obstructive sleep apnea, and without significant comorbidities.)
MedicalResearch.com Interview with:Angela M. Leung, MD, MSc
Clinical Assistant Professor of Medicine
Division of Endocrinology, Department of Medicine
University of California Los Angeles
MedicalResearch.com: What are the main findings of the study?Dr. Leung:Despite current guidelines to screen for thyroid dysfunction as a secondary cause of newly-diagnosed hyperlipidemia, this was performed only about 50% of the time by primary care providers in over 8,700 patients at a large, urban Boston academic medical center. Approximately 5% of patients who had thyroid function checked were found to have hypothyroidism. The majority of hypothyroid patients who received treatment with levothyroxine had successful correction of the initial hyperlipidemia within one year.
Gun Violence Trends in MoviesBrad J. Bushman, PhD
Professor of Communication and Psychology, Margaret Hall and Robert Randal Rinehart Chair of Mass Communication
The Ohio State University, Columbus, Ohio;
VU University Amsterdam, Amsterdam, Netherlands
MedicalResearch.com: What are the main findings of the study?Dr. Bushman: Gun violence in PG-13 movies has tripled since 1985, the year the PG-13 rating was introduced. When the PG-13 rating was introduced, PG-13 films had about as much gun violence as G and PG films. Now PG-13 films have significantly more gun violence than R-rated films.
MedicalResearch.com Interview with:Guang Sun MD, PhD
Professor, Discipline of medicine
Faculty of medicine, Memorial University Canada
MedicalResearch.com: What are the main findings of the study?Dr. Sun: Plenty of anecdotal reports on how ‘Food Addiction’ may be a potential culprit of the rising prevalence of obesity. However to date no scientific study, based on a comprehensive criterion of the diagnosis of Food Addiction, has been performed at the population level. The main findings are in the following fours aspects:
1) Food Addiction is indeed an important contributing factor in the development of obesity.
2) The prevalence of Food Addition was 5.4% and increased concomitantly with
obesity status defined by either body mass index (BMI) or body fat percentage
(%BF). In another word, there is one food addict in every twenty adults (Newfoundland Province, Canada)
3) Clinical Symptom Count(s) of Food Addiction is strongly associated with the severity of obesity.
4) Women are twice as likely to be diagnosed with “Food Addiction” than men.
MedicalResearch.com Interview with:Nina Berentzen
Centre for Nutrition, Prevention and Health Services
National Institute for Public Health and the Environment Bilthoven
MedicalResearch.com: What are the main findings of the study?Answer: This study in 11-12 year old children shows that self-reported characteristics of sleep quality were not associated with blood pressure and HbA1c; and that in girls, but not in boys, some sleep characteristics were associated with anthropometric outcomes (BMI, waist circumference) and cholesterol levels. More specifically, in girls, longer time in bed was associated with lower BMI and waist circumference; having night-time awakenings with higher total cholesterol, going late to bed while rising early with higher total and HDL cholesterol; and feeling sleepy/tired during daytime with lower HDL cholesterol and with higher total-to-HDL cholesterol ratio. We report new findings for daytime outcomes of sleep quality that were not studied before in relation to cardiometabolic risk; e.g. difficulty with getting up in the morning, feeling rested after waking, and feeling sleepy or tired during the day. Our study therefore offers insight not only in characteristics of sleep at night, but also in consequences of sleep during the day.
MedicalResearch.com Interview with:Hugh C. Hendrie, MB ChB, DSc
Professor, Department of Psychiatry, Indiana University School of Medicine
Center Scientist, Indiana University Center for Aging Research
Research Scientist, Regenstrief Institute, Inc.
MedicalResearch.com: What are the main findings of the study?
Answer: Our findings of higher rates of emergency care, longer hospitalizations and increased frequency of falls, substance abuse and alcoholism suggest that seriously mentally ill older adults remain a vulnerable population.
MedicalResearch.com: Interview with:Olof Stephansson MD, PhD
Associate professor, senior consultant in obstetrics and gynaecologyDepartment of Medicine, Clinical Epidemiology Unit, Karolinska InstitutetDepartment of Women’s and Children’s Health, Division of Obstetrics and Gynaecology
Karolinska Institutet, Stockholm, Sweden
MedicalResearch.com: What are the main findings of the study?Answer: Women with a history of bariatric surgery have an increased risk of preterm delivery, a doubled risk for small-for-gestational-age births and a reduction in large-for-gestational-age births. Also when considering maternal weight, education, age, parity and year of birth. There was no increased for stillbirth or neonatal mortality.
MedicalResearch.com Interview with:
MedicalResearch.com Interview with:Dr. Emilia Mazzuca
Biomedical Department of Internal and Specialistic Medicine (DIBIMIS)
Section of Pneumology and
Dr. Maria R Bonsignore, MD
Associate Professor in Respiratory Medicine
University of Palermo, Palermo, Italy
MedicalResearch.com: What are the main findings of the study?Answer: Our main goal was to investigate gender-related interactions between obstructive sleep apnea (OSA) and obesity while taking associated metabolic abnormalities into account. We analyzed 423 men and 105 women previously studied for the association of OSA and the Metabolic Syndrome (MetS) (Bonsignore et al, Eur Respir J, 2012), to assess whether markers of general and visceral obesity were differently associated with OSA in men and women. Multivariate analysis showed that in men the apnea-hypopnea index (AHI), an indicator of OSA severity, was associated with waist circumference, a marker of visceral obesity, and body mass index (BMI); conversely, in women AHI was associated with hip circumference, a marker of subcutaneous fat deposition, and neck size. The results were similar when patients without a diagnosis of MetS were analyzed; conversely, in patients with MetS, waist circumference was the only significant marker of OSA in both genders.
MedicalResearch.com Interview with:Thomas M. Hooton M.D.
Professor of Medicine and Vice Chair for VA Affairs,
University of Miami Miller School of Medicine
Associate Chief of Staff, Medical Service, Miami VA Healthcare System
Clinical Director, Division of Infectious Diseases
MedicalResearch.com: What are the main findings of the study?Dr. Hooten:The main findings from this study are:
· Voided urine colony counts of E. coli as low as 101 to 102 cfu/mL are highly sensitive and specific for their presence in bladder urine in symptomatic women (growth of bacteria in bladder urine is the gold standard for the etiology of UTI). Moreover, even when E. coli is found along with other mixed flora in voided urine, it should not be considered a contaminant since it likely represents true bladder infection.
· On the other hand, enterococci and Group B streptococci, which are frequently isolated from voided urine, are rarely isolated from paired catheter specimens, suggesting that these organisms only rarely cause acute uncomplicated cystitis. In our study, E. coli frequently grew from the urines of these women and is the likely cause for UTI symptoms in such episodes.
· Organisms usually considered contaminants, such as lactobacilli, occasionally grow from catheter urines, but they are rarely found alone with pyuria, suggesting that these bacteria rarely cause acute uncomplicated cystitis.
· The etiology of a quarter of acute uncomplicated cystitis episodes is unknown. It is possible that some of these women have E. coli urethritis, which has been documented in some women with UTI symptoms, but we did not do further studies to evaluate this. It is possible also that enterococci and Group B streptococci may also cause urethritis, but there is no published evidence of this in young women with UTI symptoms.
· Although voided urine cultures growing mixed flora are common in women with acute cystitis, true polymicrobic cystitis, as determined by sampling bladder urine, appears to be rare in this population.
MedicalResearch.com Interview with:MedicalResearch.com: Matteo Nicola Dario Di Minno, MD
Dept. of Clinical Medicine and Surgery
Regional Reference Center for Coagulation Disorders
Federico II University, Naples, Italy
MedicalResearch.com: What are the main findings of the study? Answer: In our study, patients with unprovoked VTE treated for a definite time with oral anticoagulants (ie, 3–12 months) had annual recurrence rates >5% in the presence of both overt and mild antithrombin deficiency and <5% with normal antithrombin levels, with these differences being statistically significant. Although these findings should be confirmed in further studies, a life-long oral anticoagulation might be considered in patients with unprovoked VTE.
MedicalResearch.com Interview with:Magdalena Cuenca García, PhD
University of Granada
Department of Physiology, School of Medicine
Avd. Madrid 12; 18012 Granada (Spain)
MedicalResearch.com: What are the main findings of the study?Answer: In conclusion, the results of the present study showed that a higher chocolate consumption was associated with lower levels of central and total fatness in European adolescents. Of note is that the observed association was independent of total energy intake and saturated fat intake as well as objectively measured physical activity. In addition, results remained unchanged after adjusting for foods with high catechins concentration as fruit, vegetables and tea; as well as other products such as coffee that could influence the observed association between chocolate consumption and markers of total and central body fat.
MedicalResearch.com with:Dr Kate Mandeville MD MPH
Clinical Research Fellow, London School of Hygiene and Tropical Medicine
MedicalResearch.com: What is the background for your study?Dr. Mandeville: The UK spent nearly one billion pounds on pharmaceutical drugs during the swine flu pandemic, including vaccine and antiviral drugs. After the swine flu pandemic, it was revealed that some scientists on the World Health Organization’s advisory committee had links with the pharmaceutical industry. Scientists often provide commentary for journalists on emerging health risks and we set out to see whether scientists commentating on swine flu were also more likely to have links to pharmaceutical companies. We analysed UK newspaper coverage of the swine flu pandemic between April and July 2009. This was the period in which the UK government was making decisions on how best to respond to the emerging pandemic, including providing the public with vaccine and antiviral drugs. We looked for how often scientists were quoted in articles on the pandemic from a wide range of newspapers. We then examined these comments in more detail to see if scientists made an assessment of the risk to the public from swine flu, and compared these against assessments made by official agencies like the Department of Health. We also judged whether the scientists promoted or rejected the use of vaccines or antiviral drugs. For each scientist, we then looked for links with the pharmaceutical industry – or what we formally call competing interests - from a variety of sources, including scientific papers and the internet.
MedicalResearch.com Interview with:Yogesh Moradiya MBBS
From the Neurosciences Critical Care Division
Johns Hopkins University, Baltimore, MD;
MedicalResearch.com: What are the main findings of the study?Answer: We studied 712,433 stroke cases in 6,839 hospital samples in United States over 11-year study period (2000-2010) and found that hospitals with neurology residency training program treated stroke patients with tissue plasminogen activator (tPA) more frequently than other teaching or non-teaching hospitals. The higher tPA utilization in hospitals with neurology residencies was independent of patient age, gender, ethnicity, insurance status, comorbidities, hospital geographic location, stroke case volume, calendar year and the Joint Commission Primary Stroke Center certification.
MedicalResearch.com Interview with:Prof David K Menon MD PhD FRCP FRCA FFICM FMedSci
Head, Division of Anaesthesia, University of Cambridge Consultant,
Neurosciences Critical Care Unit BOC Professor,
Royal College of Anaesthetists
Professorial Fellow, Queens' College, Cambridge
Senior Investigator, National Institute for Health Research
Box 93, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
MedicalResearch.com: What is the background for your study?Dr. Menon:We have known for some time that a history of traumatic brain injury (TBI) results in a significant (between 2 and 10 fold) increase in the likelihood of getting dementia in later life. On possible mechanistic explanation for this comes from the finding that about a third of individuals who died of TBI, regardless of age, are found at autopsy to have deposits of β-amyloid in the brain, often Aβ42, which is the same variant of amyloid seen in the brain of patients who have Alzheimer’s Disease.
However, such detection after death has made it impossible to examine the linkage of such early amyloid deposition to late dementia. More recently, imaging with positron emission tomography (PET) and Pittsburgh compound B (PIB) has been used to image amyloid deposits in Alzheimer’s Disease. However, the technique had not been validated in traumatic brain injury.
MedicalResearch.com Interview with:Guy Fagherazzi, PhD
Scientific manager – E4N cohort study (www.e4n.fr)
Inserm U1018 Team 9
Nutrition,hormones and women’s health
MedicalResearch.com: What are the main findings of the study? Dr. Fagherazzi: Our study of more than 60 000 French women from the E3N cohort study has shown that higher overall acidity of the diet, regardless of the individual foods making up that diet, was associated with a higher risk of type 2 diabetes.
MedicalResearch.com Interview with:
Sung Kyun Park, Sc.D., M.P.H
Assistant Professor, Epidemiology
Assistant Professor, Environmental Health Sciences
Departments of Epidemiology and Environmental Health Sciences
University of Michigan School of Public Health
Ann Arbor, MI
MedicalResearch.com: What are the main findings of the study? Answer: This study reports that persons who eat more dietary antioxidants (beta carotene and vitamin C) or magnesium have a lower risk of hearing loss. This finding was seen in the levels currently observed in the general US population and independent of demographic and socioeconomic factors, noise exposures from workplaces, recreations or firearms, and other potential risk factors.
MedicalResearch.com Interview with: Jonas D. Finger and Dr. Gert B.M. Mensink
Jonas Finger, MPhil (Epidemiology) MA (Sports Sc) MA (Political Sc)
Robert Koch-Institute - Department of Epidemiology and Health MonitoringDivision 24 - Interview surveys and European collaboration
General-Pape-Straße 62-66, 12101 Berlin Germany
MedicalResearch.com: What are the main findings of the study?Answer:People with a low level of education consume energy dense foods (sugar- and fat-rich foods) more frequently and low energy foods (fruit and vegetables) and alcohol less frequently compared to people with a high level of education. A new study aspect is that the role of physical activity level for the link between education and high energy food intake was also investigated. People with a low level of education have more frequently physically-demanding jobs leading to a higher level of total energy expenditure compared to sedentary office workers (mainly high educated). The latter are more active in their leisure time. The study provides some evidence to support the hypothesis that the low educated consumed more energy dense foods than the high educated because they expend more energy due to the physical work they do.
MedicalResearch.com Interview with:Prof Jayant S Vaidya PhD
Clinical Trials Group, Division of Surgery and Interventional Science
University College London, London, UK
MedicalResearch.com: What are the main findings of the study?Dr. Vaidya:The main findings are
a) these are longer term results that have confirmed our original publication in 201
(b) We found that when TARGIT intraoperative radiotherapy is given at the time of lumpectomy for breast cancer, the local control and survival from breast cancer is similar to several weeks of whole breast radiotherapy
c) we also found that with TARGIT there are significantly fewer deaths from other causes - i.e., fewer deaths from cardiovascular causes and other cancers
MedicalResearch.com interview with: Mark A D’Andrea, MD, FACRO
University Cancer and Diagnostic Centers
MedicalResearch.com: What are the main findings of the study?D’Andrea: Human exposure to benzene is associated with multiple adverse health effects leading to hematological malignancies including leukemia, lymphoma, aplastic anemia, pancytopenia and chromosomal aberrations. In addition, benzene exposure can affect a variety of organs such as the liver, kidney, and brain. Compared to adults, children have a higher susceptibility to environmental chemical exposures including benzene. In this study, we assessed the adverse health effects of the benzene exposure in children (< 17 years) following a flaring incident at the British petroleum refinery in the Texas City, Texas. The findings were compared with those children not exposed to the benzene. We found that white blood cell counts were significantly decreased in benzene exposed children compared with the unexposed children. Conversely, platelet counts were increased significantly in the benzene exposed group compared with the unexposed group. Similarly, benzene exposed children had significantly higher levels of serum creatinine levels than those unexposed to benzene. Furthermore, considered indicators of hepatic damage, the serum levels of alkaline phosphatase, aspartate amino transferase, and alanine amino transferase were elevated in the benzene exposed children compared with the unexposed children. Moreover, children exposed to benzene experienced somatic symptoms, with headache, unsteady gait, and memory loss being reported the most frequently occurring events, followed by upper respiratory symptoms cough, nausea/vomiting, skin rash, shortness of breath, wheezing, dizziness, chest pain, painful joints, and weight loss.
MedicalResearch.com interview with:Martha Mullett, MD MPH
West Virginia Universty Ped&Neo 1 Medical Center Dr
Morgantown, WV 26506
MedicalResearch.com: What are the main findings of the study?Dr. Mullett:The unique findings in this study relate to differences in triglycerides (TG) in premature infants and small for gestational age (SGA) infants when in 5th grade, at which time the children are approximately 11 years old. Premature infants have higher triglyceride levels in 5th grade than term infants.(p<.05) This difference appears in those premature infants who become overweight/obese by this age, but this reaches only a trend level. (p=.058) SGA infants who become overweight/obese by 5th grade (BMI ≥ 85th percentile) have TG that are significantly higher than all other 5th grade groups.
MedicalResearch.com Interview with:Joshua Lewis, Ph.D
Raine Foundation / Alan Robson Fellow
Bone and Vascular Research Group
School of Medicine and Pharmacology
University of Western Australia
Department of Endocrinology and Diabetes
Sir Charles Gairdner Hospital
Hospital Avenue, Nedlands 6009
MedicalResearch.com: What are the main findings of the study?Dr. Lewis: The paper reports the findings from an ancillary study of the effects of 1200 mg per day of calcium supplementation on a major predictor of heart disease risk, carotid artery intima-medial thickness and atherosclerosis. The principle study was a large five-year double blind randomized controlled trial of calcium supplements or a placebo. After 3 years of calcium supplementation or placebo measures of carotid artery intima-medial thickness were identical in the placebo and calcium treated patients. Atherosclerotic plaque was reduced in calcium treated patients when analysed as total calcium intake. These findings argue strongly against an adverse effect of high dose calcium tablets on cardiovascular risk.
MedicalResearch.com Interview with: John Ney, MD, MPH
Clinical Assistant Professor,
Department of Neurology,
University of Washington
[email protected]MedicalResearch.com: What are the main findings of the study?Dr. Ney: My colleagues and I used a large, publicly available dataset to examine the usage and effectiveness of electroencephalography (EEG) in adult intensive care units (ICUs) in the United States over a five year period. We compared routine EEG, which consists of a portable machine hooked up to the patient to record brainwaves for a short duration, usually 20-40 minutes, with continuous EEG monitoring, where a patient’s brainwaves are recorded continuously for 24 hours or more and examined, ideally in real-time. Because most patients in the ICU are comatose, we have generally poor and crude indicators of their brain function. ICU patients are particularly at risk for non-convulsive seizures, where the brain is seizing, but there are few outward signs of a seizure. EEG is the only means of detecting non-convulsive seizures, and is useful in determining the brain’s reactions to drugs, monitoring for stroke and other abnormal activity.
Our main finding is that ICU patients receiving continuous EEG monitoring was associated with increased survival relative to those who received routine EEG only. In our sample, 39% of ICU patients who received routine EEG died compared to only 25% of those with continuous EEG monitoring. This finding was both substantial and statistically significant, even after adjustment for age and other demographics, clinical disease comorbidity severity measures, and hospital factors. Although continuous EEG monitoring was more expensive, the increase in hospital charges were not significant after adjustment.
MedicalResearch.com Interview with:Alastair Sutcliffe M.D., Ph.D.
From the Institute of Child Health
University College London
MedicalResearch.com: What are the main findings of the study? Dr. Sutcliffe:Good NEWS for couples who need assisted conception. All the births (106,000) from Great Britain over 18 years were linked to the National Childhood Cancer Registry from the Human Fertilisation and Embryology Authority (which has recorded all births sine 1991 by law.)Those children who showed up on both registries, had IVF conception and childhood cancer.
We predicted the number we would expect from the known national childhood cancer rates. We found ALMOST IDENTICAL rates 108 in our group and 109 predicted. NO INCREASED RISK OF CANCER AFTER IVF CONCEPTION IN OFFSPRING.
MedicalResearch.com Interview with:Dr. Colin Derdeyn
Mallinckrodt Institute of Radiology and the Departments of Neurology and Neurosurgery
Washington University School of Medicine, St Louis, MO, USA
MedicalResearch.com: What are the main findings of the study? Dr. Derdeyn: The primary results indicate that medical management, consisting of dual antiplatelets for 3 months after a transient ischemic attack (TIA) or stroke, and rapid, effective control of blood pressure (systolic BP less than 140 mm Hg and 130 mm Hg if diabetic) and LDL-cholesterol (less than 70 mg/dl), in addition to management of other risk factors, is superior to angioplasty and stenting in addition to the same medical regimen for reducing the risk of future stroke in patients with severe atherosclerotic stenosis (>70%) of a major intracranial artery. In addition, while there were subgroups at higher risk for stroke on medical treatment (older age, female gender, prior stroke in the territory), none of these subgroups appeared to have a benefit from stenting (i.e. stroke rates in the stenting groups in these subgroups was higher too).
MedicalResearch.com Interview with:Richard L. Kravitz, MD, MSPH
Professor and Co-vice Chair (Research)
Interim Director, UC Center Sacramento
Co-Editor in Chief, Journal of General Internal Medicine
MedicalResearch.com: What is the background for your study?Dr. Kravitz: Depression in the United States is both undertreated and overtreated. As the de facto mental health care system for many, primary care is at the nexus of this problem. Up to 30% of patients with major depression in primary care go undiagnosed. At the same time, partly as a result of marketing, lots of patients who don’t need meds are started on antidepressants. So we were interested in finding ways to get more truly depressed patients into treatment without overtreating patients who don’t need it.
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